iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000050747.14	ENSMUST00000025329.12	ENSMUSP00000025329.6
ENSMUSG00000050747.14	ENSMUST00000174195.7	ENSMUSP00000133953.1
ENSMUSG00000050747.14	ENSMUST00000173639.1	ENSMUSP00000133638.1

Annotation

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00033	22.2	15	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C  +++d  +++ CgH+ ++ Cl   p  +     + +CPlC+
   Q: 15   CPVCTRPLQD-AVTTACGHTVCLLCL---PRTP--MGAQLLCPLCQ 54
           **********.999***********9...4446..99999*****7 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MPSTRSLRGL HQVACPVCTR PLQDAVTTAC GHTVCLLCLP RTPMGAQLLC PLCQGAEEEK 60
IQAAVAPVSL GPLSETYCEE HGEKIYFFCK TDAELLCVFC REGPAHQAHT VGFLDEAIQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTTTGCTT CTGTGACAGT GACGCACTTA AAAGTGACTC AGTTTCAGGG AAAGGAAATT 60
GGAGTGGACC GAGTCAGAAG ACTGTGGACA GGCAGGGGAA GGCACGGTGA TGCCCTCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013829--Hemagglutn_stalk
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF00097--zf-C3HC4

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:1901253--P:negative regulation of intracellular transport of viral material
GO:1902187--P:negative regulation of viral release from host cell
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0032481--P:positive regulation of type I interferon production

KEGG

mmu:69097

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002170	Ailuropoda melanoleuca	54.39	2.00e-71	262.00
IUUC-Bta-012749	Bos taurus	77.83	5.00e-88	317.00
IUUC-Cja-019423	Callithrix jacchus	72.64	2.00e-110	392.00
IUUC-Csa-023062	Chlorocebus sabaeus	80.44	2.00e-89	322.00
IUUC-Dor-030723	Dipodomys ordii	65.54	8.00e-101	360.00
IUUC-Eca-033832	Equus caballus	69.83	2.00e-106	378.00
IUUC-Eeu-035346	Erinaceus europaeus	71.77	3.00e-104	371.00
IUUC-Fca-035581	Felis catus	57.84	5.00e-68	250.00
IUUC-Ggo-044848	Gorilla gorilla	73.99	1.00e-113	403.00
IUUC-Hsa-046266	Homo sapiens	73.99	1.00e-110	393.00
IUUC-Itr-048326	Ictidomys tridecemlineatus	67.12	3.00e-101	362.00
IUUC-Mcc-055554	Macaca mulatta	73.99	3.00e-108	385.00
IUUC-Nle-069027	Nomascus leucogenys	73.65	4.00e-111	394.00
IUUC-Opr-070615	Ochotona princeps	65.08	2.00e-99	355.00
IUUC-Ocu-074940	Oryctolagus cuniculus	68.92	7.00e-96	344.00
IUUC-Ptr-091302	Pan troglodytes	73.99	6.00e-111	394.00
IUUC-Pan-091860	Papio anubis	74.32	1.00e-108	386.00
IUUC-Pab-097674	Pongo abelii	73.65	2.00e-110	392.00
IUUC-Pva-102190	Pteropus vampyrus	71.19	1.00e-108	386.00
IUUC-Sar-113117	Sorex araneus	63.56	1.00e-72	266.00
IUUC-Ssc-115476	Sus scrofa	70.85	1.00e-97	350.00
IUUC-Tbe-127674	Tupaia belangeri	66.78	5.00e-97	347.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence