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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063991
UUCD1 version UUC-MuM-00034
Ensembl Protein ID ENSMUSP00000138418.1
UniProt Accession Q80TT8; Q8BKL9; Q8CGC0; Q8R363; CUL9_MOUSE
Genbank Protein ID AAH26469.1; AAH41674.1; BAC65633.1
Protein Name Cullin-9; p53-associated parkin-like cytoplasmic protein
Genbank Nucleotide ID AK051474; BC041674; AK122351
Gene Name Cul9; Kiaa0708; Parc
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040327.16 ENSMUST00000182485.7 ENSMUSP00000138418.1
ENSMUSG00000040327.16 ENSMUST00000066026.7 ENSMUSP00000067736.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINA
Post-translational Modifications (PTMs)
dbPAFdbPTMPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17229476
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 5.70e-122 409.6 1298 1823
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 66   LktynreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvves 152
    L ++W+ freql++ +++f y+ + +++w+++i+ed ++rll+l +l++ +R+++++++r+l++++++
   Q: 1298 LGPKPTFWPLFREQLCRRTCLF------YTIR-----------AQAWSRDIAED-RQRLLQLYPRLNRVLRHEQNFADRFLPDDEAA 1366
    5555689***************......9999...........***********.******************************** PP
   S: 153 lveLslnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhles 238
    +a++k+++Ea++++ +q+++++++ +++ + +d+Yl+++e+ + +a+++++++++++Ll++ve+ +
   Q: 1367 --------QALGKTCWEALVSPLVQNITSPDAGGVSSLgWLLDQYLEHRESTRSRQGPAASFASQVRRLCHLLVHVEAPPGP----- 1440
    ........**************************************************************************..... PP
   S: 239 llaelvallrdkktedlsrmy..kLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnn 321
    ++ ++ +k+++ ++ + + v + +l++l++++ s+++ q++++l+a++++ d +V+r+++l+++lq++ se+F++
   Q: 1441 --SPEPSSQPLSKNSKGQDGSptPAPTPVCPstSLRNLTQCWLSVVQGQVSRFLAAAWRASD---FVPRYCSLYQRLQSAGSELFGP 1522
    ..44444444444444444441156777877899****************************...********************** PP
   S: 322 dakFlkaldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRL 404
    +a+F+ al+++f+ +++++s+l+aa+ +E++Ar+iDq++ ++ ++g+ + ++ +l+++l+ ++++s++++ Fe++Y++++a+RL
   Q: 1523 RAAFTLALRSGFSGALLQQSFLTAAHISEQFARHIDQQIHGGlLGGAAGVGMLGRLQRHLEPIMVLSGLELattFEHFYQHYMADRL 1609
    *************************************************************************************** PP
   S: 405 lsgksasseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk................................eekent 458
    ls ss++E++v+e++ g++f+++L + M+q+l++Se+l++ F+ e ++
   Q: 1610 LS--LGSSWLEGAVLEQI----GPCFPNRLpQLMLQSLHTSEELQHRFHlfqlqqldrqlleqgdqeewrpekveeddegqETGREL 1690
    **..**************....*******************************************************9997667777 PP
   S: 459 eesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyel 533
    ++++++svlvLs+++Wp++ + ++ +L ael++++e+f++fY l+ +++R+LqW++ lgrael++ g ++l
   Q: 1691 FTDPGPAISVLVLSPRCWPVSplCYLhhPRKHLQAELCDALERFSSFYshsqncpvLDIGPHRRLQWTW-LGRAELQF----GDQTL 1772
    789******************98554559****************************************.********....***** PP
   S: 534 qVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlk 584
    +Vst+Qm++LL fn+se+vsve+l ++l++e+L+++l +L+s + +
   Q: 1773 HVSTVQMWLLLNFNQSEEVSVETLLRNSDLSPELLHQALLPLTSDNGPLTL 1823
    *******************************************97744444 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function.
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function.
Protein Sequence
(Fasta)
MVGERRAGNL LVPLGPRLQA YPEELLRQRP GHDGHPEYLI RWSVLKCSEE GKVSSEEEKT 60
EHLLMWLSAP EVYANCPMLL RERPIPKGPQ HEPAGEVGSF PRDPGGLDEL AMTEMEADVR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Mmu-063991|E3,RING;E3,Cullin|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGGCCACC GTAGGACCCG TAGTCGCCCG GGTCGTGCGT GCGCCCGGCG TGTGACCCGG 60
AAAAGAGCTG TGGAGGAGGC GGGCCCAGTT GCGGGACCCG CTGCTGGGTG ACAGCGAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063991|E3,RING;E3,Cullin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031222--CUL9
IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR002867--IBR_dom
IPR011991--WHTH_DNA-bd_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
PS51284--DOC
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF00888--Cullin
PF10557--Cullin_Nedd8
PF01485--IBR

SMART

SM01337--APC10
SM00884--Cullin_Nedd8
SM00647--IBR

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0008270--F:zinc ion binding
GO:0000226--P:microtubule cytoskeleton organization
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001405 Ailuropoda melanoleuca 85.15 0.00e+00 4002.00
IUUC-Apl-003458 Anas platyrhynchos 63.88 0.00e+00 719.00
IUUC-Aca-004815 Anolis carolinensis 55.03 0.00e+00 2450.00
IUUC-Ame-010611 Astyanax mexicanus 50.10 0.00e+00 2226.00
IUUC-Bta-012877 Bos taurus 82.95 0.00e+00 3800.00
IUUC-Cja-019255 Callithrix jacchus 85.33 0.00e+00 3974.00
IUUC-Cfa-020119 Canis familiaris 85.51 0.00e+00 3972.00
IUUC-Cpo-022473 Cavia porcellus 80.40 0.00e+00 3663.00
IUUC-Csa-024157 Chlorocebus sabaeus 84.62 0.00e+00 3982.00
IUUC-Cho-024879 Choloepus hoffmanni 80.93 0.00e+00 836.00
IUUC-Cin-025402 Ciona intestinalis 32.21 0.00e+00 708.00
IUUC-Dno-028904 Dasypus novemcinctus 82.15 0.00e+00 3825.00
IUUC-Dor-030112 Dipodomys ordii 81.23 0.00e+00 1274.00
IUUC-Ete-032516 Echinops telfairi 75.91 0.00e+00 1272.00
IUUC-Eca-034394 Equus caballus 85.28 0.00e+00 3851.00
IUUC-Eeu-035166 Erinaceus europaeus 84.88 0.00e+00 2031.00
IUUC-Fca-035740 Felis catus 85.19 0.00e+00 3952.00
IUUC-Fal-036672 Ficedula albicollis 50.53 0.00e+00 1519.00
IUUC-Gga-040154 Gallus gallus 60.81 0.00e+00 874.00
IUUC-Ggo-045570 Gorilla gorilla 85.66 0.00e+00 3948.00
IUUC-Hsa-046690 Homo sapiens 84.77 0.00e+00 3939.00
IUUC-Itr-048680 Ictidomys tridecemlineatus 85.77 0.00e+00 4023.00
IUUC-Loc-052706 Lepisosteus oculatus 51.24 0.00e+00 2262.00
IUUC-Mcc-055727 Macaca mulatta 84.58 0.00e+00 4021.00
IUUC-Meu-056074 Macropus eugenii 64.58 0.00e+00 1154.00
IUUC-Mga-059683 Meleagris gallopavo 52.59 4.00e-101 361.00
IUUC-Mmr-060869 Microcebus murinus 85.57 0.00e+00 3976.00
IUUC-Mdo-062902 Monodelphis domestica 69.64 0.00e+00 2054.00
IUUC-Mpu-065974 Mustela putorius furo 84.86 0.00e+00 3934.00
IUUC-Nle-069292 Nomascus leucogenys 85.75 0.00e+00 2519.00
IUUC-Opr-071020 Ochotona princeps 82.55 0.00e+00 2048.00
IUUC-Ont-071953 Oreochromis niloticus 50.32 0.00e+00 2134.00
IUUC-Oan-073534 Ornithorhynchus anatinus 57.66 0.00e+00 1989.00
IUUC-Ocu-074244 Oryctolagus cuniculus 83.74 0.00e+00 3916.00
IUUC-Ola-087072 Oryzias latipes 51.10 0.00e+00 1686.00
IUUC-Oga-088310 Otolemur garnettii 82.40 0.00e+00 3879.00
IUUC-Oar-090174 Ovis aries 82.27 0.00e+00 3749.00
IUUC-Ptr-091410 Pan troglodytes 84.73 0.00e+00 3936.00
IUUC-Pan-091856 Papio anubis 85.59 0.00e+00 2553.00
IUUC-Pma-094192 Petromyzon marinus 45.69 0.00e+00 1397.00
IUUC-Pfo-096773 Poecilia formosa 54.23 0.00e+00 915.00
IUUC-Pab-098635 Pongo abelii 84.92 0.00e+00 2713.00
IUUC-Pca-100539 Procavia capensis 85.48 0.00e+00 1271.00
IUUC-Pva-102813 Pteropus vampyrus 80.22 0.00e+00 1528.00
IUUC-Rno-106105 Rattus norvegicus 92.12 0.00e+00 4300.00
IUUC-Sha-106896 Sarcophilus harrisii 76.49 0.00e+00 1128.00
IUUC-Sar-113132 Sorex araneus 77.26 0.00e+00 1220.00
IUUC-Ssc-116000 Sus scrofa 83.43 0.00e+00 3877.00
IUUC-Tgu-116915 Taeniopygia guttata 61.52 1.00e-136 479.00
IUUC-Tru-118013 Takifugu rubripes 54.33 0.00e+00 1509.00
IUUC-Tsy-119037 Tarsius syrichta 75.40 0.00e+00 987.00
IUUC-Tni-120062 Tetraodon nigroviridis 50.24 0.00e+00 2207.00
IUUC-Ttr-128780 Tursiops truncatus 81.55 0.00e+00 2467.00
IUUC-Vpa-130086 Vicugna pacos 78.76 2.00e-171 597.00
IUUC-Xtr-132882 Xenopus tropicalis 49.06 0.00e+00 1790.00
Created Date 25-Jun-2017

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