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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063855
UUCD1 version UUC-MuM-00116
Ensembl Protein ID ENSMUSP00000040025.8
UniProt Accession A6H6S0; A6H6S0_MOUSE
Genbank Protein ID AAI45979.1; AAI45981.1; EDK98746.1; EDK98747.1; EDK98748.1
Protein Name Hect domain and RLD 3; Hect domain and RLD 3, isoform CRA_b
Genbank Nucleotide ID AC115881; BC145980; CH466523; CH466523; CH466523
Gene Name Herc3; mCG_123509
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029804.16 ENSMUST00000031823.11 ENSMUSP00000031823.5
ENSMUSG00000029804.16 ENSMUST00000041401.10 ENSMUSP00000040025.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Post-translational Modifications (PTMs)
CPLMdbPAFmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.70e-97 326.2 726 1049
Active Site
Position(s) Description Evidence
1018 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEeg+d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k sledl+e+ p+  +sl+e++++  +diee+ ++l+f+v  e++g +++++L+pgG+++ V ++N++e+v+++
   Q: 808  HFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEET-FCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAY 893
           *******************************************98.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +++e ++af++Gf +v+  ++l+lF++ el+ ++ G++++d+e+l++++ y+g+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+a+l+   ++i+  ++ ++ lP ++TC+n+L+LP+Ysskei+k +L+ A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMASLQ---IIIQStATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSL 1049
           *******************...7888867888**************************************97 PP
   
Organism Mus musculus
Protein Sequence
(Fasta)
MLCWGYWSLG QPGISSNLQG IVAEPQVCRF VSDRSIKEVA CGGNHSVFLL EDGEVYTCGV 60
NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063855|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCCCCGCC CCGCTGCCGC CGCCACCATT GGCCAGGCGG GAAGTCGGTC TCCCAGCTCA 60
TTCTGCGCCC GCGGGAGTGC GGGGGAAACT TCATTATTAC TGTGACGCTG AAGGCCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063855|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
KEGG mmu:73998
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001673 Ailuropoda melanoleuca 95.14 0.00e+00 2040.00
IUUC-Apl-003535 Anas platyrhynchos 86.57 0.00e+00 1857.00
IUUC-Aca-005223 Anolis carolinensis 84.67 0.00e+00 1820.00
IUUC-Ame-010816 Astyanax mexicanus 65.47 0.00e+00 1159.00
IUUC-Bta-013373 Bos taurus 94.67 0.00e+00 2041.00
IUUC-Cja-019609 Callithrix jacchus 95.05 0.00e+00 2042.00
IUUC-Cfa-021071 Canis familiaris 94.95 0.00e+00 2036.00
IUUC-Cpo-021548 Cavia porcellus 94.19 0.00e+00 2023.00
IUUC-Csa-023987 Chlorocebus sabaeus 95.52 0.00e+00 2047.00
IUUC-Cho-024325 Choloepus hoffmanni 94.43 0.00e+00 1177.00
IUUC-Dre-027472 Danio rerio 65.40 0.00e+00 1388.00
IUUC-Dno-029241 Dasypus novemcinctus 93.35 0.00e+00 2007.00
IUUC-Dor-030672 Dipodomys ordii 88.98 0.00e+00 1103.00
IUUC-Ete-032642 Echinops telfairi 89.52 0.00e+00 1864.00
IUUC-Eca-033646 Equus caballus 94.76 0.00e+00 2036.00
IUUC-Eeu-035098 Erinaceus europaeus 81.85 0.00e+00 1345.00
IUUC-Fal-036952 Ficedula albicollis 86.38 0.00e+00 1853.00
IUUC-Gmo-039297 Gadus morhua 63.52 0.00e+00 1312.00
IUUC-Gga-040591 Gallus gallus 85.63 0.00e+00 1835.00
IUUC-Gac-041741 Gasterosteus aculeatus 64.33 0.00e+00 1378.00
IUUC-Ggo-044769 Gorilla gorilla 95.24 0.00e+00 2040.00
IUUC-Hsa-046066 Homo sapiens 95.33 0.00e+00 2044.00
IUUC-Itr-048311 Ictidomys tridecemlineatus 95.05 0.00e+00 2039.00
IUUC-Lch-050301 Latimeria chalumnae 72.29 0.00e+00 1604.00
IUUC-Loc-052803 Lepisosteus oculatus 66.23 0.00e+00 1445.00
IUUC-Laf-053364 Loxodonta africana 94.48 0.00e+00 2031.00
IUUC-Mcc-054930 Macaca mulatta 95.52 0.00e+00 2047.00
IUUC-Meu-056274 Macropus eugenii 77.80 0.00e+00 855.00
IUUC-Mtr-058277 Medicago truncatula 37.58 2.00e-52 199.00
IUUC-Mga-059563 Meleagris gallopavo 86.19 0.00e+00 1850.00
IUUC-Mmr-060792 Microcebus murinus 93.24 0.00e+00 1990.00
IUUC-Mdo-062195 Monodelphis domestica 89.15 0.00e+00 1919.00
IUUC-Mpu-066308 Mustela putorius furo 95.14 0.00e+00 2043.00
IUUC-Mlu-066927 Myotis lucifugus 94.29 0.00e+00 2021.00
IUUC-Nle-070090 Nomascus leucogenys 95.33 0.00e+00 2044.00
IUUC-Opr-070891 Ochotona princeps 82.95 0.00e+00 1728.00
IUUC-Ont-072201 Oreochromis niloticus 63.33 0.00e+00 1330.00
IUUC-Ocu-074770 Oryctolagus cuniculus 94.67 0.00e+00 2035.00
IUUC-Ola-086550 Oryzias latipes 64.49 0.00e+00 1384.00
IUUC-Olu-087836 Ostreococcus lucimarinus 33.53 8.00e-41 160.00
IUUC-Oga-088831 Otolemur garnettii 94.76 0.00e+00 2032.00
IUUC-Oar-090449 Ovis aries 94.76 0.00e+00 2038.00
IUUC-Pan-092135 Papio anubis 95.43 0.00e+00 2043.00
IUUC-Psi-093832 Pelodiscus sinensis 84.59 0.00e+00 1860.00
IUUC-Pfo-097268 Poecilia formosa 65.24 0.00e+00 1386.00
IUUC-Pab-098249 Pongo abelii 95.05 0.00e+00 2037.00
IUUC-Pca-100855 Procavia capensis 90.16 0.00e+00 1385.00
IUUC-Pva-102506 Pteropus vampyrus 86.49 0.00e+00 1792.00
IUUC-Rno-105242 Rattus norvegicus 99.14 0.00e+00 2144.00
IUUC-Sha-107186 Sarcophilus harrisii 86.74 0.00e+00 1170.00
IUUC-Sar-113612 Sorex araneus 94.37 0.00e+00 736.00
IUUC-Ssc-115473 Sus scrofa 94.10 0.00e+00 2022.00
IUUC-Tgu-116974 Taeniopygia guttata 86.39 0.00e+00 1831.00
IUUC-Tru-118077 Takifugu rubripes 63.36 0.00e+00 1318.00
IUUC-Tsy-119619 Tarsius syrichta 83.90 0.00e+00 1809.00
IUUC-Tni-120807 Tetraodon nigroviridis 63.08 0.00e+00 1333.00
IUUC-Tbe-127640 Tupaia belangeri 90.95 0.00e+00 1901.00
IUUC-Ttr-129172 Tursiops truncatus 94.57 0.00e+00 2023.00
IUUC-Vpa-130442 Vicugna pacos 80.98 0.00e+00 1681.00
IUUC-Xtr-132194 Xenopus tropicalis 69.47 0.00e+00 1418.00
Created Date 25-Jun-2017

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