iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000158092.6	ENST00000288986.6	ENSP00000288986.2
ENSG00000158092.6	ENST00000488930.5	ENSP00000417729.1
ENSG00000158092.6	ENST00000496489.5	ENSP00000419544.1
ENSG00000158092.6	ENST00000469404.1	ENSP00000419631.1
ENSG00000158092.6	ENST00000467911.1	ENSP00000418060.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.30e-46	156.1	192	251

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ ++
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTVMQ 251
           689**************************************.59*************9765 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGCGCGTG CCCCGCCTCT CTCCCAAGAG CTACGCGGCG GCGGCGGAGC GCAGGCCTCG 60
TGCCGTTACG GCCATCACGG CGGCCGCAGT GGCGTCCTGG AGCCCTCCTC AGGTGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0810--Translation regulation

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0045296--F:cadherin binding
GO:0008093--F:cytoskeletal adaptor activity
GO:0071074--F:eukaryotic initiation factor eIF2 binding
GO:0030674--F:protein binding, bridging
GO:0004860--F:protein kinase inhibitor activity
GO:0005102--F:receptor binding
GO:0030159--F:receptor signaling complex scaffold activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0007172--P:signal complex assembly
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation
GO:0050852--P:T cell receptor signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:4690

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.94	0.00e+00	738.00
IUUC-Ame-011235	Astyanax mexicanus	78.36	3.00e-180	624.00
IUUC-Bta-013039	Bos taurus	98.94	0.00e+00	738.00
IUUC-Cja-019546	Callithrix jacchus	98.67	0.00e+00	731.00
IUUC-Cfa-020462	Canis familiaris	99.20	0.00e+00	740.00
IUUC-Cpo-022009	Cavia porcellus	98.41	0.00e+00	734.00
IUUC-Csa-023875	Chlorocebus sabaeus	100.00	0.00e+00	741.00
IUUC-Cho-024368	Choloepus hoffmanni	97.38	0.00e+00	651.00
IUUC-Csv-026046	Ciona savignyi	40.85	6.00e-72	264.00
IUUC-Dre-028407	Danio rerio	77.31	1.00e-177	615.00
IUUC-Dno-029593	Dasypus novemcinctus	99.04	6.00e-175	606.00
IUUC-Dor-030730	Dipodomys ordii	98.40	0.00e+00	644.00
IUUC-Dme-031846	Drosophila melanogaster	43.35	6.00e-92	331.00
IUUC-Ete-032906	Echinops telfairi	98.14	0.00e+00	727.00
IUUC-Eca-033378	Equus caballus	98.78	0.00e+00	639.00
IUUC-Eeu-034743	Erinaceus europaeus	88.33	0.00e+00	675.00
IUUC-Fca-035745	Felis catus	98.94	0.00e+00	780.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.84	6.00e-159	553.00
IUUC-Ggo-045487	Gorilla gorilla	100.00	0.00e+00	741.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	99.20	0.00e+00	739.00
IUUC-Lch-050165	Latimeria chalumnae	83.02	0.00e+00	627.00
IUUC-Loc-052523	Lepisosteus oculatus	78.89	2.00e-179	621.00
IUUC-Laf-053845	Loxodonta africana	98.94	0.00e+00	737.00
IUUC-Meu-056139	Macropus eugenii	92.04	0.00e+00	668.00
IUUC-Mmr-061108	Microcebus murinus	87.53	1.00e-174	605.00
IUUC-Mdo-062258	Monodelphis domestica	94.96	0.00e+00	712.00
IUUC-Mmu-063970	Mus musculus	98.94	0.00e+00	780.00
IUUC-Mpu-066093	Mustela putorius furo	98.67	0.00e+00	736.00
IUUC-Mlu-067193	Myotis lucifugus	98.94	0.00e+00	738.00
IUUC-Nle-069611	Nomascus leucogenys	100.00	0.00e+00	741.00
IUUC-Opr-070984	Ochotona princeps	97.67	2.00e-179	620.00
IUUC-Ont-072241	Oreochromis niloticus	75.90	2.00e-171	595.00
IUUC-Oan-072976	Ornithorhynchus anatinus	90.23	1.00e-167	581.00
IUUC-Ocu-073905	Oryctolagus cuniculus	99.47	0.00e+00	740.00
IUUC-Ola-086513	Oryzias latipes	74.87	4.00e-159	554.00
IUUC-Oga-088588	Otolemur garnettii	99.47	0.00e+00	739.00
IUUC-Oar-089973	Ovis aries	99.20	0.00e+00	740.00
IUUC-Ptr-090968	Pan troglodytes	100.00	0.00e+00	741.00
IUUC-Pan-092840	Papio anubis	100.00	6.00e-176	609.00
IUUC-Pfo-096057	Poecilia formosa	74.23	5.00e-169	587.00
IUUC-Pab-097807	Pongo abelii	99.73	0.00e+00	741.00
IUUC-Pca-100522	Procavia capensis	98.40	8.00e-174	602.00
IUUC-Pva-103083	Pteropus vampyrus	99.20	0.00e+00	739.00
IUUC-Rno-104839	Rattus norvegicus	96.55	0.00e+00	743.00
IUUC-Sha-107294	Sarcophilus harrisii	94.43	0.00e+00	706.00
IUUC-Sar-113675	Sorex araneus	97.35	0.00e+00	724.00
IUUC-Ssc-116442	Sus scrofa	97.61	0.00e+00	771.00
IUUC-Tru-118058	Takifugu rubripes	74.55	2.00e-168	585.00
IUUC-Tsy-119184	Tarsius syrichta	91.94	0.00e+00	632.00
IUUC-Tni-119974	Tetraodon nigroviridis	74.74	6.00e-157	546.00
IUUC-Ttr-129155	Tursiops truncatus	96.82	0.00e+00	733.00
IUUC-Vpa-130344	Vicugna pacos	98.94	0.00e+00	739.00
IUUC-Xtr-132372	Xenopus tropicalis	87.50	0.00e+00	659.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence