iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/DCUN1	45.61	5.00e-47	186.00	IUUC-Hsa-046288

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Drosophila melanogaster

Functional Description
(View)

Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Protein Sequence
(Fasta)

MGNCLKCFQS AAEQSMPTNA SSPNSHNSNS NACQTATSLA NCYESVGINP NANERCALET 60
DELLSSRTPL KPAKANNCDT KRNSFKSLGL LNGSAPTMSD IITTAVQESM EVSHQTLSKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCCTGGTT GACTAGTGCC GCCCTGGTCC GATTGCCAGA AAAAAACAAG ACAAGTGAAA 60
AAGCGAGATA AATCAAATTA AAAATATTGT AAAAAATTGT AGTTAAACAC GCGCTGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0005737--C:cytoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:2000436--P:positive regulation of protein neddylation
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0009314--P:response to radiation

KEGG

dme:Dmel_CG13322

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001689	Ailuropoda melanoleuca	48.97	1.00e-47	182.00
IUUC-Apl-003497	Anas platyrhynchos	49.02	9.00e-50	189.00
IUUC-Aca-004961	Anolis carolinensis	43.24	3.00e-49	187.00
IUUC-Ame-011413	Astyanax mexicanus	47.96	2.00e-49	188.00
IUUC-Bta-013338	Bos taurus	48.97	2.00e-47	182.00
IUUC-Cja-019458	Callithrix jacchus	48.97	2.00e-47	182.00
IUUC-Cfa-020160	Canis familiaris	48.97	1.00e-47	182.00
IUUC-Cpo-021835	Cavia porcellus	47.39	7.00e-48	183.00
IUUC-Csa-023328	Chlorocebus sabaeus	47.14	1.00e-47	182.00
IUUC-Cho-024888	Choloepus hoffmanni	49.23	9.00e-48	182.00
IUUC-Cin-025134	Ciona intestinalis	50.80	2.00e-48	185.00
IUUC-Dre-027780	Danio rerio	45.05	1.00e-47	182.00
IUUC-Dno-028866	Dasypus novemcinctus	48.97	2.00e-47	182.00
IUUC-Dor-030387	Dipodomys ordii	48.96	5.00e-47	180.00
IUUC-Eca-033857	Equus caballus	48.97	1.00e-47	182.00
IUUC-Fca-036130	Felis catus	48.97	2.00e-47	181.00
IUUC-Fal-037296	Ficedula albicollis	49.52	6.00e-50	190.00
IUUC-Gmo-039626	Gadus morhua	46.11	1.00e-45	175.00
IUUC-Ggr-039959	Gaeumannomyces graminis	24.77	3.00e-14	72.80
IUUC-Gga-040741	Gallus gallus	48.53	2.00e-49	187.00
IUUC-Gac-042271	Gasterosteus aculeatus	49.73	4.00e-45	174.00
IUUC-Ggo-044727	Gorilla gorilla	47.14	1.00e-47	182.00
IUUC-Hsa-046288	Homo sapiens	47.14	1.00e-47	182.00
IUUC-Itr-049054	Ictidomys tridecemlineatus	47.20	3.00e-48	184.00
IUUC-Lch-050289	Latimeria chalumnae	49.24	9.00e-50	189.00
IUUC-Loc-052455	Lepisosteus oculatus	47.67	1.00e-44	172.00
IUUC-Laf-054369	Loxodonta africana	49.48	4.00e-48	184.00
IUUC-Meu-056535	Macropus eugenii	50.00	6.00e-50	190.00
IUUC-Mga-059290	Meleagris gallopavo	47.85	2.00e-49	187.00
IUUC-Mmr-060689	Microcebus murinus	47.14	9.00e-48	182.00
IUUC-Mdo-062128	Monodelphis domestica	50.00	8.00e-49	186.00
IUUC-Mmu-064396	Mus musculus	45.61	2.00e-48	185.00
IUUC-Mpu-065926	Mustela putorius furo	48.97	1.00e-47	182.00
IUUC-Mlu-067044	Myotis lucifugus	47.20	3.00e-49	187.00
IUUC-Nle-069346	Nomascus leucogenys	47.14	1.00e-47	182.00
IUUC-Opr-070682	Ochotona princeps	47.14	2.00e-47	181.00
IUUC-Ont-071772	Oreochromis niloticus	45.09	1.00e-46	179.00
IUUC-Oan-072765	Ornithorhynchus anatinus	47.17	2.00e-49	188.00
IUUC-Ocu-074272	Oryctolagus cuniculus	46.15	4.00e-47	180.00
IUUC-Ola-087561	Oryzias latipes	47.72	2.00e-47	181.00
IUUC-Oga-088440	Otolemur garnettii	45.77	5.00e-45	173.00
IUUC-Oar-089403	Ovis aries	48.97	1.00e-47	182.00
IUUC-Ptr-091384	Pan troglodytes	47.14	1.00e-47	182.00
IUUC-Pan-092650	Papio anubis	47.14	1.00e-47	182.00
IUUC-Psi-093806	Pelodiscus sinensis	48.08	3.00e-47	181.00
IUUC-Pma-094196	Petromyzon marinus	43.96	1.00e-46	179.00
IUUC-Pfo-096584	Poecilia formosa	44.89	9.00e-48	182.00
IUUC-Pab-098605	Pongo abelii	47.14	1.00e-47	182.00
IUUC-Pva-102172	Pteropus vampyrus	47.69	3.00e-47	181.00
IUUC-Rno-105406	Rattus norvegicus	45.61	1.00e-48	185.00
IUUC-Sha-106531	Sarcophilus harrisii	50.00	7.00e-50	189.00
IUUC-Sja-107938	Schizosaccharomyces japonicus	30.37	2.00e-21	94.70
IUUC-Sar-113051	Sorex araneus	45.16	1.00e-37	149.00
IUUC-Ssc-115555	Sus scrofa	48.97	1.00e-47	182.00
IUUC-Tgu-117178	Taeniopygia guttata	49.52	8.00e-50	189.00
IUUC-Tru-117876	Takifugu rubripes	47.94	1.00e-46	179.00
IUUC-Tsy-118790	Tarsius syrichta	46.15	5.00e-45	173.00
IUUC-Tni-119673	Tetraodon nigroviridis	43.86	2.00e-47	181.00
IUUC-Tbe-127429	Tupaia belangeri	47.14	1.00e-47	182.00
IUUC-Ttr-128467	Tursiops truncatus	48.97	2.00e-47	182.00
IUUC-Xtr-132134	Xenopus tropicalis	49.47	1.00e-45	176.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence