iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106449

UUCD1 version

UUC-SaC-00043

Ensembl Protein ID

YDR457W

UniProt Accession

Q03280; D6VT81; Q7LIK7; TOM1_YEAST

Genbank Protein ID

AAB64910.1; BAA21482.1; DAA12291.1

Protein Name

E3 ubiquitin-protein ligase TOM1; HECT-type E3 ubiquitin transferase TOM1; Suppressor of snRNA protein 2; Temperature-dependent organization in mitotic nucleus protein 1

Genbank Nucleotide ID

U33050; D63905; BK006938

Gene Name

TOM1; SSR2; YDR457W; D8035.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YDR457W	YDR457W	YDR457W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	9753545; 20810649

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	2.30e-118	393.9	2937	3267

Active Site

Position(s)	Description	Evidence
3235	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    k.krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkk 104
           k ++le++f+gE+g+d+gGvtre+++ ls++++npd+ lfl  ++dk+t++pn++sg+ npehl++F+f+G+++gka++d+ +ld+++s+ +yk +lg++
   Q: 2937 KnSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGI-NPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRP 3035
           52599****************************************************9.89*************************************** PP
   S: 105  lsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviple 204
           +sl+d+e++dp++yksl +i+en   di+++ ++ tfsv+++ +ge k+ +L++gG++i Vt++Nk++Yvk+vvey+l++++keq+++f  Gf+ +i+++
   Q: 3036 VSLKDMESLDPDYYKSLVWILEN---DITDI-IEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKD 3131
           *********************99...99999.9******************************************************************* PP
   S: 205  llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlP 299
           l+++F+e+elelli+G ++idv+d+k++t+y + yt++ +++ +Fw+++++f++eer+++LqFvTg+s++Pl+Gf+el+      +f i++  +s +rlP
   Q: 3132 LITIFDEQELELLISGLPDIDVDDWKNNTTYVN-YTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSgvngVCKFSIHRdFGSSERLP 3230
           *******************************77.**********************************************9997778888867888**** PP
   S: 300  ssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ss+TCfn+L+LP+Y+s+e+l+  Ll+Ai+e+ +gF+l
   Q: 3231 SSHTCFNQLNLPPYESYETLRGSLLLAINEGhEGFGL 3267
           ***********************************97 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.

Protein Sequence
(Fasta)

MVLFTRCEKA RKEKLAAGYK PLVDYLIDCD TPTFLERIEA IQEWDRSRDD LYVWIPILDR 60
MDGLLLKVAE KYKYKQDPKK ECEVKLVEME AHDVDYCLKM LKFTRRLLLN TENRFVYSSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCTTT TTACTCGGTG TGAAAAGGCA AGAAAGGAGA AACTCGCCGC TGGTTATAAG 60
CCCTTAGTTG ATTATTTGAT TGATTGTGAT ACTCCCACAT TTTTAGAAAG AATTGAGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0698--rRNA processing
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005730--C:nucleolus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000448--P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480--P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000447--P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472--P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0006913--P:nucleocytoplasmic transport
GO:0006997--P:nucleus organization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YDR457W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	37.48	2.00e-100	360.00
IUUC-Aml-001684	Ailuropoda melanoleuca	52.02	6.00e-126	445.00
IUUC-Atr-003044	Amborella trichopoda	40.17	6.00e-123	435.00
IUUC-Apl-003729	Anas platyrhynchos	49.42	1.00e-93	334.00
IUUC-Aca-005263	Anolis carolinensis	52.49	5.00e-127	449.00
IUUC-Aly-006157	Arabidopsis lyrata	39.94	2.00e-125	443.00
IUUC-Ath-007160	Arabidopsis thaliana	31.50	7.00e-123	434.00
IUUC-Ago-008005	Ashbya gossypii	51.11	0.00e+00	3061.00
IUUC-Acl-008254	Aspergillus clavatus	55.62	0.00e+00	734.00
IUUC-Afl-008712	Aspergillus flavus	54.46	0.00e+00	722.00
IUUC-Afu-009022	Aspergillus fumigatus	55.85	0.00e+00	729.00
IUUC-Ani-009412	Aspergillus nidulans	55.75	0.00e+00	714.00
IUUC-Ang-009771	Aspergillus niger	55.97	0.00e+00	728.00
IUUC-Aor-010186	Aspergillus oryzae	54.28	0.00e+00	687.00
IUUC-Ate-010253	Aspergillus terreus	56.42	0.00e+00	731.00
IUUC-Ame-011067	Astyanax mexicanus	51.90	9.00e-126	444.00
IUUC-Bgr-012043	Blumeria graminis	54.46	0.00e+00	697.00
IUUC-Bta-012813	Bos taurus	52.02	9.00e-126	444.00
IUUC-Bci-013995	Botrytis cinerea	55.12	0.00e+00	713.00
IUUC-Bdi-014884	Brachypodium distachyon	40.07	5.00e-121	428.00
IUUC-Bol-016533	Brassica oleracea	52.00	7.00e-84	301.00
IUUC-Bra-016726	Brassica rapa	42.01	1.00e-125	444.00
IUUC-Cel-018179	Caenorhabditis elegans	50.71	3.00e-125	442.00
IUUC-Cja-018741	Callithrix jacchus	51.66	2.00e-123	437.00
IUUC-Cfa-020083	Canis familiaris	52.02	5.00e-126	445.00
IUUC-Cpo-021923	Cavia porcellus	43.72	1.00e-92	334.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.94	2.00e-126	443.00
IUUC-Csa-023853	Chlorocebus sabaeus	52.02	6.00e-126	445.00
IUUC-Cho-024718	Choloepus hoffmanni	54.32	1.00e-114	407.00
IUUC-Cin-025627	Ciona intestinalis	51.66	1.00e-123	437.00
IUUC-Csv-025872	Ciona savignyi	51.90	2.00e-123	433.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	54.52	0.00e+00	712.00
IUUC-Cne-027095	Cryptococcus neoformans	34.49	7.00e-151	527.00
IUUC-Cme-027267	Cyanidioschyzon merolae	45.32	1.00e-103	369.00
IUUC-Dre-028525	Danio rerio	49.61	2.00e-110	393.00
IUUC-Dno-029680	Dasypus novemcinctus	52.02	6.00e-126	445.00
IUUC-Dor-030902	Dipodomys ordii	47.98	6.00e-108	385.00
IUUC-Dse-031197	Dothistroma septosporum	53.62	0.00e+00	688.00
IUUC-Dme-032122	Drosophila melanogaster	50.59	2.00e-123	437.00
IUUC-Eca-033915	Equus caballus	50.95	5.00e-124	439.00
IUUC-Eeu-034963	Erinaceus europaeus	51.66	1.00e-123	437.00
IUUC-Fca-035824	Felis catus	52.02	6.00e-126	445.00
IUUC-Fox-037756	Fusarium oxysporum	41.18	0.00e+00	793.00
IUUC-Fso-038464	Fusarium solani	54.62	0.00e+00	694.00
IUUC-Gmo-039073	Gadus morhua	51.78	6.00e-126	445.00
IUUC-Ggr-039946	Gaeumannomyces graminis	54.86	0.00e+00	701.00
IUUC-Gga-040309	Gallus gallus	54.40	2.00e-98	350.00
IUUC-Gac-042430	Gasterosteus aculeatus	51.78	6.00e-126	445.00
IUUC-Gma-042956	Glycine max	41.59	1.00e-122	434.00
IUUC-Hsa-046879	Homo sapiens	52.02	6.00e-126	445.00
IUUC-Hvu-047697	Hordeum vulgare	40.52	6.00e-121	428.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	52.02	2.00e-126	445.00
IUUC-Kpa-049228	Komagataella pastoris	51.07	0.00e+00	952.00
IUUC-Lch-050252	Latimeria chalumnae	52.13	2.00e-125	444.00
IUUC-Lpe-051550	Leersia perrieri	45.34	9.00e-122	431.00
IUUC-Loc-052472	Lepisosteus oculatus	52.26	1.00e-126	447.00
IUUC-Lma-053159	Leptosphaeria maculans	53.94	0.00e+00	699.00
IUUC-Laf-054154	Loxodonta africana	52.02	6.00e-126	445.00
IUUC-Mcc-055085	Macaca mulatta	52.02	4.00e-126	446.00
IUUC-Mor-057201	Magnaporthe oryzae	53.99	0.00e+00	689.00
IUUC-Mpo-057597	Magnaporthe poae	55.02	0.00e+00	696.00
IUUC-Mtr-058088	Medicago truncatula	31.78	6.00e-124	438.00
IUUC-Mla-058888	Melampsora laricipopulina	51.11	8.00e-123	431.00
IUUC-Mvi-060320	Microbotryum violaceum	45.37	2.00e-160	560.00
IUUC-Mmr-060820	Microcebus murinus	52.02	6.00e-126	445.00
IUUC-Mdo-062930	Monodelphis domestica	52.26	2.00e-126	447.00
IUUC-Mmu-063601	Mus musculus	52.02	5.00e-126	445.00
IUUC-Mac-065229	Musa acuminata	40.62	3.00e-123	436.00
IUUC-Mpu-066653	Mustela putorius furo	52.02	7.00e-126	445.00
IUUC-Mlu-067418	Myotis lucifugus	43.85	1.00e-126	447.00
IUUC-Nfi-068278	Neosartorya fischeri	55.85	0.00e+00	730.00
IUUC-Ncr-068813	Neurospora crassa	55.57	0.00e+00	711.00
IUUC-Nle-069418	Nomascus leucogenys	52.02	9.00e-126	444.00
IUUC-Ont-071300	Oreochromis niloticus	51.78	6.00e-126	445.00
IUUC-Oan-073046	Ornithorhynchus anatinus	52.25	1.00e-125	444.00
IUUC-Ocu-074178	Oryctolagus cuniculus	52.02	5.00e-126	445.00
IUUC-Oba-075757	Oryza barthii	40.34	4.00e-122	432.00
IUUC-Obr-076762	Oryza brachyantha	40.07	2.00e-115	410.00
IUUC-Ogl-077520	Oryza glaberrima	40.34	4.00e-122	432.00
IUUC-Ogu-078278	Oryza glumaepatula	40.34	3.00e-122	432.00
IUUC-Oin-079767	Oryza indica	40.34	4.00e-122	432.00
IUUC-Olo-080326	Oryza longistaminata	39.86	9.00e-114	404.00
IUUC-Ome-081925	Oryza meridionalis	40.41	8.00e-121	428.00
IUUC-Oni-082619	Oryza nivara	40.34	4.00e-122	432.00
IUUC-Opu-083428	Oryza punctata	40.25	1.00e-115	411.00
IUUC-Oru-084501	Oryza rufipogon	40.34	3.00e-122	432.00
IUUC-Osa-086251	Oryza sativa	40.34	2.00e-122	431.00
IUUC-Olu-087813	Ostreococcus lucimarinus	43.49	1.00e-105	374.00
IUUC-Oga-088903	Otolemur garnettii	52.02	6.00e-126	445.00
IUUC-Oar-090210	Ovis aries	52.02	8.00e-126	445.00
IUUC-Pan-092368	Papio anubis	50.13	7.00e-111	395.00
IUUC-Pno-094871	Phaeosphaeria nodorum	54.67	0.00e+00	694.00
IUUC-Ppa-095657	Physcomitrella patens	49.53	1.00e-122	434.00
IUUC-Pfo-096232	Poecilia formosa	52.02	2.00e-126	446.00
IUUC-Pab-098583	Pongo abelii	52.02	5.00e-126	445.00
IUUC-Pop-099468	Populus trichocarpa	42.76	4.00e-127	449.00
IUUC-Ppe-101641	Prunus persica	43.23	5.00e-124	438.00
IUUC-Pva-102116	Pteropus vampyrus	47.98	1.00e-111	397.00
IUUC-Pgr-103465	Puccinia graminis	42.66	2.00e-151	529.00
IUUC-Ptt-103813	Puccinia triticina	40.19	6.00e-135	474.00
IUUC-Pte-104018	Pyrenophora teres	53.79	0.00e+00	694.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.53	0.00e+00	693.00
IUUC-Sha-106961	Sarcophilus harrisii	44.76	9.00e-127	447.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	41.24	0.00e+00	784.00
IUUC-Spo-108024	Schizosaccharomyces pombe	41.77	0.00e+00	759.00
IUUC-Smo-109640	Selaginella moellendorffii	43.98	3.00e-121	429.00
IUUC-Sit-110598	Setaria italica	41.90	6.00e-125	441.00
IUUC-Sly-111706	Solanum lycopersicum	40.48	2.00e-126	447.00
IUUC-Sar-113291	Sorex araneus	52.17	5.00e-122	432.00
IUUC-Sbi-113794	Sorghum bicolor	36.50	5.00e-118	418.00
IUUC-Sre-114958	Sporisorium reilianum	52.61	7.00e-159	551.00
IUUC-Ssc-115754	Sus scrofa	52.02	7.00e-126	445.00
IUUC-Tru-118570	Takifugu rubripes	51.78	5.00e-126	445.00
IUUC-Tni-120836	Tetraodon nigroviridis	51.07	4.00e-121	429.00
IUUC-Tca-121479	Theobroma cacao	43.07	4.00e-124	439.00
IUUC-Tre-121909	Trichoderma reesei	53.79	0.00e+00	705.00
IUUC-Tvi-122370	Trichoderma virens	53.86	0.00e+00	704.00
IUUC-Tae-125214	Triticum aestivum	46.92	7.00e-119	421.00
IUUC-Tur-126774	Triticum urartu	30.62	1.00e-52	199.00
IUUC-Tme-127172	Tuber melanosporum	44.60	0.00e+00	860.00
IUUC-Ttr-129253	Tursiops truncatus	52.02	8.00e-126	444.00
IUUC-Uma-129355	Ustilago maydis	53.77	2.00e-160	556.00
IUUC-Vda-129886	Verticillium dahliae	53.51	0.00e+00	696.00
IUUC-Vpa-130708	Vicugna pacos	52.02	1.00e-125	444.00
IUUC-Vvi-131078	Vitis vinifera	44.86	6.00e-125	441.00
IUUC-Xtr-132123	Xenopus tropicalis	49.88	1.00e-115	411.00
IUUC-Xma-133869	Xiphophorus maculatus	51.78	5.00e-126	445.00
IUUC-Yli-134657	Yarrowia lipolytica	43.74	0.00e+00	831.00
IUUC-Zma-135570	Zea mays	42.72	2.00e-123	436.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence