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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063265
UUCD1 version UUC-MuM-00497
Ensembl Protein ID ENSMUSP00000033756.2
UniProt Accession Q91ZT8; Q6GT43; Q9DAF7; ASB9_MOUSE
Genbank Protein ID AAK97492.1; BAB24293.1; CAM16897.1; EDL40751.1; AAH61038.1
Protein Name Ankyrin repeat and SOCS box protein 9
Genbank Nucleotide ID AF398970; AK005878; AL772243; CH466571; BC061038
Gene Name Asb9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031384.2 ENSMUST00000033756.2 ENSMUSP00000033756.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.30e-13 51.7 243 289
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLly 49
           +++l  + p SL +LCRl+Ir+c+g++++++i++L LP++Lk++Ll+
   Q: 243  QIFLQNEGPQSLRQLCRLRIRKCFGIRQHHKISELLLPEDLKRFLLH 289
           56777788**************************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity).
 Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity).
Protein Sequence
(Fasta)
MDGEQRGRSD RPGGSPHLPF LSNPLMGDVV SDWSPLHDAA IHGCLLTLRN LISQGWPVNI 60
ITADHVSPLH EACLRGHLSC ASVLLSHGAQ VNGMTIDWRT PLFNACVSGS QDCVNLLLQH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063265|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTAGTACTC ACATTGCCCT GCCTGTGCTG TTCTCTGCTG CAGTCGGCCT GGACCAAGAC 60
GTGTGCAGTT TAACCAGCCA CAGAACTGGA ATTTCCCAGG GGCTCCGGGA ACATGGCATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063265|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0005739--C:mitochondrion
GO:0035556--P:intracellular signal transduction
GO:0045732--P:positive regulation of protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG mmu:69299
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001511 Ailuropoda melanoleuca 75.77 4.00e-128 450.00
IUUC-Apl-004034 Anas platyrhynchos 70.68 2.00e-108 385.00
IUUC-Aca-004804 Anolis carolinensis 68.50 7.00e-111 393.00
IUUC-Bta-013012 Bos taurus 73.79 2.00e-124 437.00
IUUC-Cja-019500 Callithrix jacchus 73.13 7.00e-124 436.00
IUUC-Cfa-020277 Canis familiaris 76.11 4.00e-126 443.00
IUUC-Cpo-022413 Cavia porcellus 70.41 6.00e-121 426.00
IUUC-Csa-023256 Chlorocebus sabaeus 72.88 5.00e-123 433.00
IUUC-Dno-030092 Dasypus novemcinctus 67.94 2.00e-115 408.00
IUUC-Dor-030215 Dipodomys ordii 66.89 3.00e-115 407.00
IUUC-Ete-032417 Echinops telfairi 65.53 1.00e-90 325.00
IUUC-Eca-033417 Equus caballus 76.19 3.00e-132 464.00
IUUC-Eeu-034447 Erinaceus europaeus 47.93 5.00e-72 264.00
IUUC-Fca-035857 Felis catus 71.67 3.00e-123 434.00
IUUC-Fal-037651 Ficedula albicollis 70.63 6.00e-110 390.00
IUUC-Gmo-039177 Gadus morhua 44.83 7.00e-56 210.00
IUUC-Gga-040657 Gallus gallus 66.79 9.00e-102 363.00
IUUC-Gac-041598 Gasterosteus aculeatus 48.11 1.00e-68 253.00
IUUC-Ggo-044466 Gorilla gorilla 73.22 6.00e-123 433.00
IUUC-Hsa-046556 Homo sapiens 74.15 1.00e-125 442.00
IUUC-Itr-048278 Ictidomys tridecemlineatus 75.63 7.00e-125 439.00
IUUC-Lch-049860 Latimeria chalumnae 61.85 3.00e-99 354.00
IUUC-Laf-054389 Loxodonta africana 77.19 2.00e-118 418.00
IUUC-Mcc-055379 Macaca mulatta 72.54 7.00e-123 433.00
IUUC-Meu-056744 Macropus eugenii 72.62 7.00e-114 403.00
IUUC-Mga-059201 Meleagris gallopavo 69.84 3.00e-99 354.00
IUUC-Mmr-060754 Microcebus murinus 77.78 2.00e-126 444.00
IUUC-Mdo-062259 Monodelphis domestica 72.44 1.00e-95 342.00
IUUC-Mpu-065935 Mustela putorius furo 74.06 2.00e-126 444.00
IUUC-Mlu-066959 Myotis lucifugus 73.33 2.00e-117 415.00
IUUC-Nle-069305 Nomascus leucogenys 73.81 1.00e-124 439.00
IUUC-Opr-070484 Ochotona princeps 73.12 7.00e-108 383.00
IUUC-Ont-072570 Oreochromis niloticus 45.67 5.00e-69 254.00
IUUC-Oan-073662 Ornithorhynchus anatinus 65.65 3.00e-113 401.00
IUUC-Ocu-074056 Oryctolagus cuniculus 75.51 6.00e-124 436.00
IUUC-Ola-087123 Oryzias latipes 50.92 6.00e-71 260.00
IUUC-Oga-089102 Otolemur garnettii 70.85 4.00e-123 434.00
IUUC-Oar-090040 Ovis aries 75.43 1.00e-124 439.00
IUUC-Ptr-090773 Pan troglodytes 74.15 8.00e-126 442.00
IUUC-Pan-092542 Papio anubis 72.54 5.00e-123 433.00
IUUC-Psi-093549 Pelodiscus sinensis 71.75 2.00e-113 401.00
IUUC-Pva-102452 Pteropus vampyrus 67.93 2.00e-116 411.00
IUUC-Rno-105267 Rattus norvegicus 92.07 4.00e-156 543.00
IUUC-Sha-107096 Sarcophilus harrisii 71.88 2.00e-107 382.00
IUUC-Sar-113377 Sorex araneus 62.42 2.00e-53 201.00
IUUC-Ssc-115817 Sus scrofa 76.09 7.00e-82 296.00
IUUC-Tgu-117418 Taeniopygia guttata 68.97 2.00e-103 369.00
IUUC-Tru-117578 Takifugu rubripes 50.00 2.00e-69 255.00
IUUC-Tsy-118843 Tarsius syrichta 65.65 8.00e-105 373.00
IUUC-Tbe-127670 Tupaia belangeri 72.83 3.00e-117 414.00
IUUC-Ttr-129029 Tursiops truncatus 73.81 1.00e-117 416.00
IUUC-Vpa-130055 Vicugna pacos 77.89 7.00e-134 469.00
IUUC-Xtr-132425 Xenopus tropicalis 59.78 9.00e-96 342.00
Created Date 25-Jun-2017

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