iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.50e-07	30.1	183	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlrtg 33
           H ++  +laf  s+t l+++s  gt i+v+++ +g
   Q: 183  HDSPLAALAFdaSGTKLATASEKGTvIRVFSIPEG 217
           9999999***9877***********9999987665 PP

Organism

Rattus norvegicus

Functional Description
(View)

Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.

Protein Sequence
(Fasta)

MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 60
VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGGGTGGG CGGGACCGCG CAAGCGCGCA GCCCGTCCCG GCTCTGGAGC ATAAACAAGA 60
GTGGGGACGG TATGAGGCGG CAGTTGGTCC CCGCGCAGCG AGAGGGGGCG AGCGGGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032911--WIPI2

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0000045--P:autophagosome assembly

KEGG

rno:288498

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001842	Ailuropoda melanoleuca	91.90	0.00e+00	759.00
IUUC-Apl-003390	Anas platyrhynchos	91.67	0.00e+00	802.00
IUUC-Aca-004975	Anolis carolinensis	91.24	0.00e+00	841.00
IUUC-Ago-007948	Ashbya gossypii	42.57	8.00e-27	115.00
IUUC-Acl-008148	Aspergillus clavatus	44.15	2.00e-55	209.00
IUUC-Afl-008562	Aspergillus flavus	44.53	2.00e-56	212.00
IUUC-Afu-008936	Aspergillus fumigatus	35.39	2.00e-58	219.00
IUUC-Ani-009254	Aspergillus nidulans	44.53	2.00e-56	212.00
IUUC-Ang-009798	Aspergillus niger	35.24	2.00e-63	236.00
IUUC-Aor-010066	Aspergillus oryzae	44.53	2.00e-56	212.00
IUUC-Ate-010266	Aspergillus terreus	35.01	6.00e-59	221.00
IUUC-Ame-010727	Astyanax mexicanus	83.60	0.00e+00	776.00
IUUC-Bta-012655	Bos taurus	91.46	0.00e+00	816.00
IUUC-Bci-013627	Botrytis cinerea	34.11	1.00e-62	233.00
IUUC-Cel-018503	Caenorhabditis elegans	42.39	2.00e-84	306.00
IUUC-Cja-018829	Callithrix jacchus	90.50	0.00e+00	820.00
IUUC-Cfa-020858	Canis familiaris	88.65	0.00e+00	815.00
IUUC-Cpo-022235	Cavia porcellus	95.96	0.00e+00	845.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	31.85	6.00e-32	131.00
IUUC-Csa-023963	Chlorocebus sabaeus	89.20	0.00e+00	806.00
IUUC-Cho-024328	Choloepus hoffmanni	81.66	0.00e+00	653.00
IUUC-Cin-025343	Ciona intestinalis	58.19	4.00e-138	484.00
IUUC-Csv-025920	Ciona savignyi	70.56	8.00e-152	529.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	46.45	2.00e-29	123.00
IUUC-Cne-026947	Cryptococcus neoformans	36.34	2.00e-62	233.00
IUUC-Dre-027490	Danio rerio	83.15	0.00e+00	771.00
IUUC-Dno-030057	Dasypus novemcinctus	85.50	0.00e+00	754.00
IUUC-Dor-030472	Dipodomys ordii	88.98	0.00e+00	801.00
IUUC-Dse-031215	Dothistroma septosporum	31.22	3.00e-52	199.00
IUUC-Ete-032362	Echinops telfairi	80.52	0.00e+00	747.00
IUUC-Eca-034362	Equus caballus	93.57	0.00e+00	816.00
IUUC-Fca-036230	Felis catus	93.06	0.00e+00	757.00
IUUC-Fal-036782	Ficedula albicollis	91.67	0.00e+00	802.00
IUUC-Fox-037797	Fusarium oxysporum	42.32	3.00e-53	202.00
IUUC-Fso-038174	Fusarium solani	43.07	3.00e-54	205.00
IUUC-Gmo-039706	Gadus morhua	57.14	1.00e-134	472.00
IUUC-Ggr-040113	Gaeumannomyces graminis	42.44	3.00e-53	202.00
IUUC-Gga-040690	Gallus gallus	91.24	0.00e+00	847.00
IUUC-Gac-041360	Gasterosteus aculeatus	83.15	0.00e+00	746.00
IUUC-Gma-043876	Glycine max	35.92	4.00e-39	155.00
IUUC-Hsa-046782	Homo sapiens	91.79	0.00e+00	838.00
IUUC-Itr-048693	Ictidomys tridecemlineatus	93.09	0.00e+00	847.00
IUUC-Kpa-049378	Komagataella pastoris	41.81	4.00e-55	209.00
IUUC-Lch-050413	Latimeria chalumnae	79.33	0.00e+00	711.00
IUUC-Lma-052948	Leptosphaeria maculans	33.86	5.00e-61	228.00
IUUC-Laf-054007	Loxodonta africana	95.06	0.00e+00	882.00
IUUC-Mor-057125	Magnaporthe oryzae	41.95	6.00e-52	198.00
IUUC-Mga-059795	Meleagris gallopavo	89.47	0.00e+00	812.00
IUUC-Mvi-060219	Microbotryum violaceum	39.93	4.00e-46	178.00
IUUC-Mmr-061096	Microcebus murinus	89.20	0.00e+00	842.00
IUUC-Mdo-061815	Monodelphis domestica	88.15	0.00e+00	837.00
IUUC-Mmu-063787	Mus musculus	99.55	0.00e+00	923.00
IUUC-Mpu-066019	Mustela putorius furo	86.44	0.00e+00	757.00
IUUC-Mlu-068016	Myotis lucifugus	92.58	0.00e+00	825.00
IUUC-Nfi-068424	Neosartorya fischeri	35.25	2.00e-59	223.00
IUUC-Ncr-068833	Neurospora crassa	34.55	2.00e-60	226.00
IUUC-Opr-070933	Ochotona princeps	78.62	0.00e+00	636.00
IUUC-Ont-072495	Oreochromis niloticus	83.37	0.00e+00	748.00
IUUC-Oan-073084	Ornithorhynchus anatinus	83.26	0.00e+00	759.00
IUUC-Ocu-074689	Oryctolagus cuniculus	94.31	0.00e+00	824.00
IUUC-Oba-075601	Oryza barthii	30.30	6.00e-31	128.00
IUUC-Oga-088894	Otolemur garnettii	92.74	0.00e+00	783.00
IUUC-Oar-089850	Ovis aries	91.67	0.00e+00	801.00
IUUC-Ptr-090456	Pan troglodytes	89.63	0.00e+00	813.00
IUUC-Pan-092111	Papio anubis	97.30	0.00e+00	872.00
IUUC-Psi-094095	Pelodiscus sinensis	92.14	0.00e+00	804.00
IUUC-Pno-095015	Phaeosphaeria nodorum	34.44	3.00e-54	205.00
IUUC-Pfo-096987	Poecilia formosa	82.10	0.00e+00	737.00
IUUC-Pab-097754	Pongo abelii	95.48	0.00e+00	800.00
IUUC-Pva-103047	Pteropus vampyrus	81.64	0.00e+00	756.00
IUUC-Pte-104139	Pyrenophora teres	34.32	2.00e-56	213.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	33.94	2.00e-56	213.00
IUUC-Sha-106581	Sarcophilus harrisii	91.90	0.00e+00	803.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	35.52	3.00e-52	198.00
IUUC-Spo-108068	Schizosaccharomyces pombe	37.50	3.00e-49	189.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	35.87	1.00e-67	249.00
IUUC-Sre-115219	Sporisorium reilianum	42.11	3.00e-49	189.00
IUUC-Ssc-116360	Sus scrofa	92.58	0.00e+00	800.00
IUUC-Tgu-116951	Taeniopygia guttata	92.14	0.00e+00	810.00
IUUC-Tru-117889	Takifugu rubripes	80.22	0.00e+00	737.00
IUUC-Tre-121895	Trichoderma reesei	41.95	1.00e-56	213.00
IUUC-Tvi-122311	Trichoderma virens	41.57	1.00e-56	213.00
IUUC-Uma-129438	Ustilago maydis	44.69	3.00e-44	172.00
IUUC-Vda-129782	Verticillium dahliae	46.28	6.00e-38	151.00
IUUC-Xma-133370	Xiphophorus maculatus	82.10	0.00e+00	737.00
IUUC-Yli-134337	Yarrowia lipolytica	38.10	4.00e-57	215.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence