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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Dme-032196
Ensembl Protein ID FBpp0083658
UniProt Accession Q9VCY3; CSN6_DROME
Genbank Protein ID AAF56022.1; AAL48078.1
Protein Name COP9 signalosome complex subunit 6
Genbank Nucleotide ID AE014297; AY070607
Gene Name CSN6; CG6932
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0028837 FBtr0084265 FBpp0083658
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 60.94 4.00e-113 405.00 IUUC-Dre-028843
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description



     Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Protein Sequence
(Fasta)
MEQMEVDVDM SAKPSTSSSA AAGSSMAVDK TADQNPQPQG NIMAAAGTSG SVTISLHPLV 60
IMNISEHWTR FRAQHGEPRQ VYGALIGKQK GRNIEIMNSF ELKTDVIGDE TVINKDYYNK 120
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Protein Fasta Sequence



>IUUC-Dme-032196|DUB,JAMM|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
ATCGTACTAC TGAGAGACCA CCAATAACGA TAACGACAGC TTATACCGGA GCTTGTCAAA 60
CAAAAAGAAG TAAAATTAAG TTTATACCGC AAACTACGTG TAAATAAAGG CCCCCCGACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dme-032196|DUB,JAMM|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0539--Nucleus
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0736--Signalosome

Interpro

IPR000555--JAMM/MPN+_dom
IPR033859--MPN_CSN6
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0042802--F:identical protein binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0046983--F:protein dimerization activity
GO:0036099--P:female germ-line stem cell population maintenance
GO:0007281--P:germ cell development
GO:0046331--P:lateral inhibition
GO:0048140--P:male germ-line cyst encapsulation
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0007275--P:multicellular organism development
GO:0048477--P:oogenesis
GO:0000338--P:protein deneddylation
GO:0050821--P:protein stabilization

KEGG dme:Dmel_CG6932
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000900 Aegilops tauschii 34.33 2.00e-51 195.00
IUUC-Aml-001678 Ailuropoda melanoleuca 61.95 4.00e-108 383.00
IUUC-Atr-002442 Amborella trichopoda 37.79 2.00e-45 174.00
IUUC-Aca-004366 Anolis carolinensis 48.72 1.00e-58 218.00
IUUC-Aly-005748 Arabidopsis lyrata 38.39 6.00e-55 206.00
IUUC-Ath-006830 Arabidopsis thaliana 38.39 2.00e-54 204.00
IUUC-Acl-008087 Aspergillus clavatus 28.03 3.00e-23 102.00
IUUC-Afl-008629 Aspergillus flavus 26.78 1.00e-19 89.40
IUUC-Afu-008973 Aspergillus fumigatus 28.61 2.00e-26 112.00
IUUC-Ani-009239 Aspergillus nidulans 27.57 3.00e-20 92.00
IUUC-Ang-009845 Aspergillus niger 30.00 1.00e-27 116.00
IUUC-Aor-010137 Aspergillus oryzae 27.67 1.00e-23 103.00
IUUC-Ate-010588 Aspergillus terreus 32.89 4.00e-20 91.70
IUUC-Ame-011532 Astyanax mexicanus 62.24 6.00e-37 144.00
IUUC-Bgr-012126 Blumeria graminis 33.67 3.00e-21 95.10
IUUC-Bta-012891 Bos taurus 61.95 4.00e-108 383.00
IUUC-Bci-013650 Botrytis cinerea 29.84 2.00e-28 119.00
IUUC-Bdi-014189 Brachypodium distachyon 39.34 6.00e-55 206.00
IUUC-Bol-015194 Brassica oleracea 36.71 9.00e-56 209.00
IUUC-Bra-017180 Brassica rapa 38.10 3.00e-55 207.00
IUUC-Cel-018511 Caenorhabditis elegans 32.12 8.00e-38 150.00
IUUC-Cja-019862 Callithrix jacchus 61.95 7.00e-108 382.00
IUUC-Cfa-020552 Canis familiaris 61.95 1.00e-107 382.00
IUUC-Cpo-022433 Cavia porcellus 61.95 5.00e-108 382.00
IUUC-Cre-022699 Chlamydomonas reinhardtii 35.00 2.00e-41 162.00
IUUC-Csa-023484 Chlorocebus sabaeus 61.95 5.00e-108 383.00
IUUC-Cho-024874 Choloepus hoffmanni 55.48 2.00e-79 288.00
IUUC-Cin-025747 Ciona intestinalis 54.34 2.00e-91 327.00
IUUC-Csv-025914 Ciona savignyi 52.84 4.00e-89 320.00
IUUC-Cgl-026665 Colletotrichum gloeosporioides 28.91 1.00e-26 113.00
IUUC-Cne-026818 Cryptococcus neoformans 38.82 5.00e-48 183.00
IUUC-Dre-028843 Danio rerio 60.94 9.00e-115 405.00
IUUC-Dno-029674 Dasypus novemcinctus 61.95 4.00e-108 383.00
IUUC-Ete-032593 Echinops telfairi 43.52 2.00e-39 154.00
IUUC-Eca-033933 Equus caballus 61.95 3.00e-108 383.00
IUUC-Fca-035946 Felis catus 61.95 4.00e-108 383.00
IUUC-Fso-038175 Fusarium solani 26.10 1.00e-21 96.30
IUUC-Gmo-038747 Gadus morhua 61.95 3.00e-107 380.00
IUUC-Gac-042199 Gasterosteus aculeatus 61.95 6.00e-108 382.00
IUUC-Gma-043702 Glycine max 38.32 5.00e-55 206.00
IUUC-Ggo-044978 Gorilla gorilla 61.95 1.00e-107 382.00
IUUC-Hsa-045797 Homo sapiens 61.95 9.00e-108 382.00
IUUC-Hvu-047511 Hordeum vulgare 36.83 2.00e-55 208.00
IUUC-Itr-048615 Ictidomys tridecemlineatus 61.95 5.00e-108 383.00
IUUC-Lch-049546 Latimeria chalumnae 57.65 3.00e-89 320.00
IUUC-Lpe-051207 Leersia perrieri 37.58 4.00e-55 207.00
IUUC-Loc-052106 Lepisosteus oculatus 62.29 8.00e-108 382.00
IUUC-Lma-053122 Leptosphaeria maculans 23.24 2.00e-18 86.30
IUUC-Laf-054454 Loxodonta africana 61.95 7.00e-108 382.00
IUUC-Mcc-054679 Macaca mulatta 61.95 1.00e-107 381.00
IUUC-Meu-056427 Macropus eugenii 59.93 7.00e-104 369.00
IUUC-Mor-057093 Magnaporthe oryzae 23.21 3.00e-21 95.10
IUUC-Mpo-057412 Magnaporthe poae 37.84 3.00e+00 26.90
IUUC-Mtr-058343 Medicago truncatula 37.94 9.00e-54 202.00
IUUC-Mla-059002 Melampsora laricipopulina 34.41 3.00e-39 154.00
IUUC-Mvi-060487 Microbotryum violaceum 35.64 2.00e-49 188.00
IUUC-Mmr-060577 Microcebus murinus 61.95 5.00e-108 383.00
IUUC-Mdo-061918 Monodelphis domestica 61.95 8.00e-108 382.00
IUUC-Mmu-063355 Mus musculus 61.95 4.00e-108 383.00
IUUC-Mac-064465 Musa acuminata 38.89 5.00e-57 213.00
IUUC-Mpu-066813 Mustela putorius furo 61.95 1.00e-107 382.00
IUUC-Mlu-067500 Myotis lucifugus 61.95 6.00e-108 382.00
IUUC-Nfi-068452 Neosartorya fischeri 28.61 8.00e-27 113.00
IUUC-Nle-070166 Nomascus leucogenys 61.95 5.00e-108 383.00
IUUC-Opr-071028 Ochotona princeps 61.95 4.00e-108 383.00
IUUC-Ont-072575 Oreochromis niloticus 62.63 2.00e-108 384.00
IUUC-Ocu-074744 Oryctolagus cuniculus 61.95 6.00e-108 382.00
IUUC-Oba-075665 Oryza barthii 37.93 6.00e-57 213.00
IUUC-Obr-076094 Oryza brachyantha 37.40 1.00e-46 179.00
IUUC-Ogl-077223 Oryza glaberrima 37.93 6.00e-57 213.00
IUUC-Ogu-077975 Oryza glumaepatula 37.93 6.00e-57 213.00
IUUC-Oin-079690 Oryza indica 37.62 4.00e-54 204.00
IUUC-Ome-081114 Oryza meridionalis 37.95 2.00e-55 208.00
IUUC-Oni-082275 Oryza nivara 37.93 1.00e-55 209.00
IUUC-Opu-083281 Oryza punctata 37.81 1.00e-55 209.00
IUUC-Oru-084767 Oryza rufipogon 37.93 1.00e-55 209.00
IUUC-Osa-085506 Oryza sativa 37.93 1.00e-55 209.00
IUUC-Ola-086468 Oryzias latipes 62.63 1.00e-108 385.00
IUUC-Oga-088732 Otolemur garnettii 61.95 6.00e-108 382.00
IUUC-Oar-089714 Ovis aries 61.95 5.00e-108 382.00
IUUC-Ptr-091383 Pan troglodytes 61.95 8.00e-108 382.00
IUUC-Pan-091752 Papio anubis 61.95 5.00e-108 383.00
IUUC-Psi-094080 Pelodiscus sinensis 59.60 3.00e-110 390.00
IUUC-Pma-094665 Petromyzon marinus 64.38 9.00e-22 94.40
IUUC-Ppa-095312 Physcomitrella patens 40.48 9.00e-64 236.00
IUUC-Pfo-096180 Poecilia formosa 61.95 1.00e-107 382.00
IUUC-Pab-098521 Pongo abelii 61.95 6.00e-108 382.00
IUUC-Pop-099014 Populus trichocarpa 38.49 9.00e-56 209.00
IUUC-Pca-100331 Procavia capensis 61.78 4.00e-100 356.00
IUUC-Ppe-101223 Prunus persica 34.66 1.00e-49 189.00
IUUC-Pva-103061 Pteropus vampyrus 61.95 4.00e-108 383.00
IUUC-Pgr-103302 Puccinia graminis 32.30 4.00e-37 147.00
IUUC-Ptt-103773 Puccinia triticina 35.83 4.00e-44 171.00
IUUC-Pte-104297 Pyrenophora teres 30.14 5.00e-18 84.70
IUUC-Rno-105606 Rattus norvegicus 61.95 2.00e-107 381.00
IUUC-Sha-106621 Sarcophilus harrisii 61.95 5.00e-108 383.00
IUUC-Ssl-108446 Sclerotinia sclerotiorum 30.42 1.00e-24 106.00
IUUC-Smo-108791 Selaginella moellendorffii 40.46 3.00e-59 221.00
IUUC-Sit-110800 Setaria italica 37.38 2.00e-54 204.00
IUUC-Sly-111003 Solanum lycopersicum 36.45 8.00e-54 202.00
IUUC-Stu-112083 Solanum tuberosum 36.69 2.00e-53 201.00
IUUC-Sar-113677 Sorex araneus 71.43 1.00e-18 85.90
IUUC-Sbi-113936 Sorghum bicolor 37.01 5.00e-54 203.00
IUUC-Sre-114955 Sporisorium reilianum 40.36 5.00e-57 213.00
IUUC-Tru-118518 Takifugu rubripes 62.63 3.00e-108 384.00
IUUC-Tsy-119285 Tarsius syrichta 73.91 7.00e-18 82.40
IUUC-Tni-120511 Tetraodon nigroviridis 62.63 2.00e-108 384.00
IUUC-Tca-121233 Theobroma cacao 36.96 5.00e-54 203.00
IUUC-Tae-123297 Triticum aestivum 37.14 1.00e-55 209.00
IUUC-Tur-126485 Triticum urartu 30.57 3.00e-36 144.00
IUUC-Tme-127071 Tuber melanosporum 33.23 9.00e-35 140.00
IUUC-Tbe-127457 Tupaia belangeri 60.27 2.00e-100 358.00
IUUC-Ttr-128708 Tursiops truncatus 59.93 1.00e-100 358.00
IUUC-Uma-129646 Ustilago maydis 38.81 4.00e-57 214.00
IUUC-Vpa-130606 Vicugna pacos 53.44 2.00e-41 161.00
IUUC-Vvi-131045 Vitis vinifera 37.42 2.00e-54 204.00
IUUC-Xtr-132674 Xenopus tropicalis 61.95 2.00e-115 408.00
IUUC-Xma-133413 Xiphophorus maculatus 62.29 3.00e-108 383.00
IUUC-Yli-134661 Yarrowia lipolytica 36.57 2.00e-31 128.00
IUUC-Zma-135166 Zea mays 37.54 2.00e-54 204.00
Created Date 25-Jun-2017

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