iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046699

UUCD1 version

UUC-HoS-01190

Ensembl Protein ID

ENSP00000428209.1

UniProt Accession

Q15819; UB2V2_HUMAN

Genbank Protein ID

CAA66717.1; AAC05381.1; AAB04758.2; AAP35390.1; CAG28556.1; AAH07051.1; AAH16332.1; AAH16710.1; AAH28673.1; AAH62418.1

Protein Name

Ubiquitin-conjugating enzyme E2 variant 2; DDVit 1; Enterocyte differentiation-associated factor 1; Enterocyte differentiation-promoting factor 1; MMS2 homolog; Vitamin D3-inducible protein

Genbank Nucleotide ID

X98091; AF049140; U62136; BT006744; CR407628; BC007051; BC016332; BC016710; BC028673; BC062418

Gene Name

UBE2V2; MMS2; UEV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000169139.11	ENST00000523111.6	ENSP00000428209.1
ENSG00000169139.11	ENST00000523432.5	ENSP00000430019.1
ENSG00000169139.11	ENST00000518360.5	ENSP00000430491.1
ENSG00000169139.11	ENST00000520595.2	ENSP00000430741.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UEV	E2_UEV	17108083; 21143188

Classification

Family	E-value	Score	Start	End
E2/UBC	6.40e-19	69.8	30	136
E2/UEV	2.20e-65	220.6	5	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsvesv 101
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s++ v
   Q: 30   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSsGMVdarSIPVL---AKWQNSYSIKVV 118
           456667777776689******************************************99999999899943335555...7*********** PP
   S: 102  llsiqsll.aepnpespl 118
           l ++ +l+ ++ n++ p+
   Q: 119  LQELRRLMmSKENMKLPQ 136
           ******996667777775 PP

E2/UEV

   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnG 98
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PP vrf++kinm+++n+s+G
   Q: 5    TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSG 96
           689***************************************************************************************** PP
   S: 99   vvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           +vd+r++pvLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 97   MVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 143
           ********************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Protein Sequence
(Fasta)

MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN 60
RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGCGCGAC GGTTCGTGCG TGCGTGCGGG CGGCTGCGTC GGGCTGCAGG AGAAGATGGC 60
GGTCTCCACA GGTCGGTTCC CGGGCCGGGC TGCGTGATTT TCCGCTCCGA CCCGGCTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031372--C:UBC13-MMS2 complex
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008283--P:cell proliferation
GO:0000729--P:DNA double-strand break processing
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0042275--P:error-free postreplication DNA repair
GO:0070911--P:global genome nucleotide-excision repair
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0045739--P:positive regulation of DNA repair
GO:0010976--P:positive regulation of neuron projection development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051965--P:positive regulation of synapse assembly
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006282--P:regulation of DNA repair

KEGG

hsa:7336

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001275	Ailuropoda melanoleuca	100.00	6.00e-80	288.00
IUUC-Apl-003790	Anas platyrhynchos	98.56	2.00e-70	257.00
IUUC-Aca-004448	Anolis carolinensis	97.12	4.00e-69	253.00
IUUC-Aly-006115	Arabidopsis lyrata	54.14	1.00e-37	149.00
IUUC-Ani-009325	Aspergillus nidulans	49.65	3.00e-36	143.00
IUUC-Ang-009631	Aspergillus niger	50.00	4.00e-35	140.00
IUUC-Ate-010471	Aspergillus terreus	44.93	3.00e-29	120.00
IUUC-Bta-012471	Bos taurus	100.00	1.00e-82	298.00
IUUC-Cja-019506	Callithrix jacchus	99.31	2.00e-82	297.00
IUUC-Cfa-020370	Canis familiaris	100.00	1.00e-82	298.00
IUUC-Cpo-021317	Cavia porcellus	97.24	3.00e-80	290.00
IUUC-Csa-023412	Chlorocebus sabaeus	100.00	1.00e-82	298.00
IUUC-Cho-025024	Choloepus hoffmanni	100.00	2.00e-49	186.00
IUUC-Cin-025219	Ciona intestinalis	49.04	2.00e-25	107.00
IUUC-Dre-028062	Danio rerio	93.79	9.00e-79	285.00
IUUC-Dno-029546	Dasypus novemcinctus	100.00	5.00e-80	289.00
IUUC-Dse-031272	Dothistroma septosporum	49.28	6.00e-34	136.00
IUUC-Fca-035746	Felis catus	100.00	8.00e-80	288.00
IUUC-Fal-037369	Ficedula albicollis	97.24	5.00e-71	259.00
IUUC-Gmo-039696	Gadus morhua	84.03	3.00e-68	249.00
IUUC-Ggr-039839	Gaeumannomyces graminis	46.50	3.00e-30	124.00
IUUC-Gga-040634	Gallus gallus	97.24	5.00e-71	259.00
IUUC-Gac-041936	Gasterosteus aculeatus	82.64	3.00e-61	227.00
IUUC-Ggo-044696	Gorilla gorilla	100.00	1.00e-82	298.00
IUUC-Itr-048151	Ictidomys tridecemlineatus	100.00	1.00e-82	298.00
IUUC-Loc-052012	Lepisosteus oculatus	93.79	2.00e-78	284.00
IUUC-Lma-053194	Leptosphaeria maculans	50.72	4.00e-35	140.00
IUUC-Laf-053991	Loxodonta africana	99.29	2.00e-79	287.00
IUUC-Mcc-055850	Macaca mulatta	100.00	4.00e-80	289.00
IUUC-Mla-058919	Melampsora laricipopulina	53.24	4.00e-34	136.00
IUUC-Mga-059210	Meleagris gallopavo	98.56	1.00e-70	258.00
IUUC-Mmr-061751	Microcebus murinus	97.24	9.00e-80	288.00
IUUC-Mdo-062503	Monodelphis domestica	97.93	2.00e-73	267.00
IUUC-Mmu-063294	Mus musculus	98.62	8.00e-82	295.00
IUUC-Mpu-065942	Mustela putorius furo	100.00	1.00e-82	298.00
IUUC-Mlu-067702	Myotis lucifugus	100.00	8.00e-80	288.00
IUUC-Nle-069327	Nomascus leucogenys	100.00	1.00e-82	298.00
IUUC-Opr-070697	Ochotona princeps	84.17	1.00e-62	231.00
IUUC-Ont-072098	Oreochromis niloticus	88.89	7.00e-67	245.00
IUUC-Oan-073215	Ornithorhynchus anatinus	90.48	5.00e-67	246.00
IUUC-Ocu-073859	Oryctolagus cuniculus	100.00	1.00e-82	298.00
IUUC-Oba-075005	Oryza barthii	52.99	9.00e-38	149.00
IUUC-Ogl-077233	Oryza glaberrima	52.99	9.00e-38	149.00
IUUC-Ogu-078374	Oryza glumaepatula	52.99	9.00e-38	149.00
IUUC-Oin-079721	Oryza indica	52.99	9.00e-38	149.00
IUUC-Olo-080242	Oryza longistaminata	48.94	4.00e-39	154.00
IUUC-Ome-081761	Oryza meridionalis	52.99	6.00e-38	150.00
IUUC-Oni-082346	Oryza nivara	52.99	9.00e-38	149.00
IUUC-Opu-083148	Oryza punctata	52.99	9.00e-38	149.00
IUUC-Oru-084359	Oryza rufipogon	52.99	9.00e-38	149.00
IUUC-Osa-085664	Oryza sativa	52.99	9.00e-38	149.00
IUUC-Ola-087529	Oryzias latipes	87.50	5.00e-66	243.00
IUUC-Olu-087815	Ostreococcus lucimarinus	40.35	3.00e-20	90.90
IUUC-Oar-090010	Ovis aries	100.00	9.00e-80	288.00
IUUC-Ptr-091024	Pan troglodytes	100.00	9.00e-80	288.00
IUUC-Pan-091955	Papio anubis	100.00	1.00e-82	298.00
IUUC-Psi-093138	Pelodiscus sinensis	97.24	5.00e-71	259.00
IUUC-Pno-095070	Phaeosphaeria nodorum	51.45	5.00e-36	142.00
IUUC-Pfo-096483	Poecilia formosa	89.58	4.00e-67	246.00
IUUC-Pab-098753	Pongo abelii	100.00	1.00e-82	298.00
IUUC-Pva-102989	Pteropus vampyrus	100.00	1.00e-82	298.00
IUUC-Pgr-103617	Puccinia graminis	52.17	4.00e-32	130.00
IUUC-Ptt-104008	Puccinia triticina	44.93	3.00e-16	77.40
IUUC-Pte-104176	Pyrenophora teres	50.72	8.00e-36	142.00
IUUC-Pyt-104517	Pyrenophora triticirepentis	50.72	8.00e-36	142.00
IUUC-Rno-105839	Rattus norvegicus	99.31	5.00e-82	295.00
IUUC-Sce-106349	Saccharomyces cerevisiae	50.00	4.00e-33	133.00
IUUC-Sha-106779	Sarcophilus harrisii	96.55	3.00e-72	263.00
IUUC-Sar-113406	Sorex araneus	70.00	9.00e-49	185.00
IUUC-Ssc-115259	Sus scrofa	97.92	1.00e-80	291.00
IUUC-Tgu-116732	Taeniopygia guttata	98.55	5.00e-70	256.00
IUUC-Tru-118526	Takifugu rubripes	87.68	1.00e-54	205.00
IUUC-Tni-120169	Tetraodon nigroviridis	84.83	2.00e-55	207.00
IUUC-Tbe-127265	Tupaia belangeri	93.57	6.00e-65	239.00
IUUC-Ttr-128959	Tursiops truncatus	99.31	2.00e-82	297.00
IUUC-Uma-129419	Ustilago maydis	51.82	1.00e-34	138.00
IUUC-Xtr-131975	Xenopus tropicalis	93.10	2.00e-78	284.00
IUUC-Xma-133222	Xiphophorus maculatus	89.58	3.00e-67	247.00
IUUC-Yli-134591	Yarrowia lipolytica	51.49	1.00e-28	117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence