iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046470

UUCD1 version

UUC-HoS-00246

Ensembl Protein ID

ENSP00000263925.7

UniProt Accession

Q8TBB1; Q4W5K7; Q8N4C2; Q96MJ7; Q9BY20; LNX1_HUMAN

Genbank Protein ID

AAK15039.1; AAQ88692.1; BAB71291.1; AAY41000.1; AAH22983.1; AAH34737.1

Protein Name

E3 ubiquitin-protein ligase LNX; Ligand of Numb-protein X 1; Numb-binding protein 1; PDZ domain-containing RING finger protein 2; RING-type E3 ubiquitin transferase LNX

Genbank Nucleotide ID

AF237782; AY358326; AK056823; AC058822; BC022983; BC034737

Gene Name

LNX1; LNX; PDZRN2; UNQ574/PRO1136

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000072201.13	ENST00000306888.6	ENSP00000302879.2
ENSG00000072201.13	ENST00000263925.7	ENSP00000263925.7

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	HPRD	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17936276

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0056	18.8	41	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+ + d pl +pCgH++++ Cl ++         ++ CP +r
   Q: 41   CHICLQALLD-PLDTPCGHTYCTLCLTNF------LVEKDFCPMDR 79
           99********.99*************888......55555588765 PP

Organism

Homo sapiens

Functional Description
(View)

Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

Protein Sequence
(Fasta)

MNQPESANDP EPLCAVCGQA HSLEENHFYS YPEEVDDDLI CHICLQALLD PLDTPCGHTY 60
CTLCLTNFLV EKDFCPMDRK PLVLQHCKKS SILVNKLLNK LLVTCPFREH CTQVLQRCDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCATGTTT CTGAGGCCTC CCCAGCCATG TGGAACTGTA AGTCCAATTA AACCTCTTTT 60
CCTTCCCAGT GTCAGGTATG TCTTTATCAG CAGCGTGAAA ACAGACTAAT ACAGTCAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001478--PDZ
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00595--PDZ
PF00097--zf-C3HC4

SMART

SM00228--PDZ
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051260--P:protein homooligomerization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:84708

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002005	Ailuropoda melanoleuca	87.85	0.00e+00	1222.00
IUUC-Apl-003561	Anas platyrhynchos	73.61	0.00e+00	1011.00
IUUC-Aca-005346	Anolis carolinensis	71.93	0.00e+00	1041.00
IUUC-Bta-012970	Bos taurus	88.97	0.00e+00	1255.00
IUUC-Cja-019412	Callithrix jacchus	94.51	0.00e+00	1354.00
IUUC-Cfa-020735	Canis familiaris	88.25	0.00e+00	1289.00
IUUC-Cpo-022198	Cavia porcellus	76.71	0.00e+00	1050.00
IUUC-Dre-028841	Danio rerio	51.15	2.00e-28	118.00
IUUC-Dno-028889	Dasypus novemcinctus	88.97	0.00e+00	1299.00
IUUC-Dor-030810	Dipodomys ordii	79.74	0.00e+00	936.00
IUUC-Fca-036264	Felis catus	89.55	0.00e+00	1236.00
IUUC-Fal-037198	Ficedula albicollis	73.21	0.00e+00	1067.00
IUUC-Gga-040766	Gallus gallus	68.92	0.00e+00	1013.00
IUUC-Ggo-045057	Gorilla gorilla	98.76	0.00e+00	1434.00
IUUC-Itr-048393	Ictidomys tridecemlineatus	89.89	0.00e+00	1329.00
IUUC-Lch-050081	Latimeria chalumnae	66.02	0.00e+00	938.00
IUUC-Loc-052884	Lepisosteus oculatus	62.09	0.00e+00	882.00
IUUC-Laf-054498	Loxodonta africana	89.62	0.00e+00	1297.00
IUUC-Meu-056401	Macropus eugenii	52.56	3.00e-139	489.00
IUUC-Mga-059504	Meleagris gallopavo	72.09	0.00e+00	1044.00
IUUC-Mmr-060696	Microcebus murinus	62.81	0.00e+00	771.00
IUUC-Mdo-062731	Monodelphis domestica	82.17	0.00e+00	1189.00
IUUC-Mmu-063364	Mus musculus	87.98	0.00e+00	1300.00
IUUC-Mpu-066626	Mustela putorius furo	88.11	0.00e+00	1278.00
IUUC-Mlu-068207	Myotis lucifugus	88.30	0.00e+00	1241.00
IUUC-Nle-069304	Nomascus leucogenys	98.76	0.00e+00	1461.00
IUUC-Opr-071080	Ochotona princeps	73.96	0.00e+00	1043.00
IUUC-Ont-072002	Oreochromis niloticus	59.28	0.00e+00	796.00
IUUC-Ola-086477	Oryzias latipes	58.92	0.00e+00	831.00
IUUC-Oga-089142	Otolemur garnettii	87.99	0.00e+00	1257.00
IUUC-Oar-090359	Ovis aries	87.84	0.00e+00	1261.00
IUUC-Ptr-090797	Pan troglodytes	99.59	0.00e+00	1472.00
IUUC-Pan-091910	Papio anubis	97.53	0.00e+00	1438.00
IUUC-Psi-093386	Pelodiscus sinensis	75.31	0.00e+00	1050.00
IUUC-Pfo-096370	Poecilia formosa	59.46	0.00e+00	795.00
IUUC-Pab-097761	Pongo abelii	98.38	0.00e+00	1122.00
IUUC-Pva-102443	Pteropus vampyrus	88.10	0.00e+00	962.00
IUUC-Rno-106030	Rattus norvegicus	87.16	0.00e+00	1282.00
IUUC-Sha-107609	Sarcophilus harrisii	80.11	0.00e+00	1155.00
IUUC-Sar-113333	Sorex araneus	85.20	0.00e+00	1250.00
IUUC-Ssc-116222	Sus scrofa	78.29	0.00e+00	1108.00
IUUC-Tgu-117019	Taeniopygia guttata	74.13	0.00e+00	1046.00
IUUC-Tru-118481	Takifugu rubripes	59.89	0.00e+00	836.00
IUUC-Tni-119796	Tetraodon nigroviridis	52.74	0.00e+00	692.00
IUUC-Tbe-127538	Tupaia belangeri	85.87	0.00e+00	1212.00
IUUC-Ttr-128787	Tursiops truncatus	87.65	0.00e+00	1224.00
IUUC-Xtr-132476	Xenopus tropicalis	63.19	0.00e+00	852.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence