• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP
  • SNP
    • dbSNP
  • mRNA Expression
    • GEO
    • ArrayExpress
  • DNA & RNA Element
    • TRANSFAC
    • miRNAMap
    • RAID2
  • PPI
    • IID
    • PINA
    • HINT
  • Drug & target
    • GRAC
  • PTM
    • dbPAF
    • PhosphositePlus
    • dbPTM
    • UniProt
  • Proteomics
    • GPMDB

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046631
Ensembl Protein ID ENSP00000355884.4
UniProt Accession Q9P0L2; D3DTB0; D3DTB1; Q2HIY1; Q5VTF9; Q5VTG0; Q96SW9; Q9P251; MARK1_HUMAN
Genbank Protein ID AAF72103.1; BAA96001.1; BAB55152.1; CAH72462.1; CAH72462.1; CAH72463.1; CAH72463.1; EAW93299.1; EAW93300.1; EAW93302.1; AAI13870.1; AAI14479.1
Protein Name Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c
Genbank Nucleotide ID AF154845; AB040910; AK027493; AL592406; AC096640; AL592406; AC096640; CH471100; CH471100; CH471100; BC113869; BC114478
Gene Name MARK1; KIAA1477; MARK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116141.15 ENST00000366918.8 ENSP00000355885.4
ENSG00000116141.15 ENST00000366917.5 ENSP00000355884.4
ENSG00000116141.15 ENST00000611084.4 ENSP00000483424.1
ENSG00000116141.15 ENST00000402574.5 ENSP00000386017.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Drug and target
KPIDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 16803889
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.003 19.3 332 368
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLl 39
           d+  ++ +v MGF r+e+  aL +  ++  +A++ Ll
   Q: 332  DTKRIDIMVTMGFARDEINDALINQKYDEVMATYILL 368
           6788999*****************9999999999998 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
 Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Protein Sequence
(Fasta)
MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046631|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTGCTCCGC GCGCAGCCGG CTCGGGCCGC TCCTCCTGAC TGAGGCGCGG CGGCGGCGGT 60
GGCTGTGACC GCGCGGACCG AGCCGAGACA TTCGCGCCGG GGGATCGGGC GCCGCCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046631|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1269--Autism
KW-1268--Autism spectrum disorder
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0879--Wnt signaling pathway
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR033627--MARK1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0015630--C:microtubule cytoskeleton
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0070300--F:phosphatidic acid binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786--F:phosphatidylserine binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0007010--P:cytoskeleton organization
GO:0030010--P:establishment of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0001764--P:neuron migration
GO:0006468--P:protein phosphorylation
GO:0016055--P:Wnt signaling pathway
KEGG hsa:4139
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001559 Ailuropoda melanoleuca 97.82 0.00e+00 1456.00
IUUC-Ame-011737 Astyanax mexicanus 71.43 0.00e+00 1035.00
IUUC-Bta-013462 Bos taurus 97.17 0.00e+00 1418.00
IUUC-Cja-019358 Callithrix jacchus 98.74 0.00e+00 1533.00
IUUC-Cfa-020498 Canis familiaris 96.47 0.00e+00 1399.00
IUUC-Cpo-022467 Cavia porcellus 93.30 0.00e+00 1420.00
IUUC-Csa-023035 Chlorocebus sabaeus 99.25 0.00e+00 1546.00
IUUC-Dor-031094 Dipodomys ordii 89.18 0.00e+00 1279.00
IUUC-Ete-032429 Echinops telfairi 85.79 0.00e+00 1253.00
IUUC-Eca-033265 Equus caballus 97.17 0.00e+00 1387.00
IUUC-Fca-035360 Felis catus 91.54 0.00e+00 1333.00
IUUC-Fal-036617 Ficedula albicollis 91.68 0.00e+00 1208.00
IUUC-Gac-041559 Gasterosteus aculeatus 76.91 0.00e+00 1124.00
IUUC-Laf-054266 Loxodonta africana 94.93 0.00e+00 1437.00
IUUC-Mcc-054650 Macaca mulatta 99.37 0.00e+00 1545.00
IUUC-Mdo-061932 Monodelphis domestica 90.15 0.00e+00 1355.00
IUUC-Mmu-064104 Mus musculus 94.34 0.00e+00 1419.00
IUUC-Mpu-065989 Mustela putorius furo 96.06 0.00e+00 1173.00
IUUC-Mlu-067700 Myotis lucifugus 95.06 0.00e+00 1342.00
IUUC-Nle-069385 Nomascus leucogenys 97.98 0.00e+00 1519.00
IUUC-Ont-071262 Oreochromis niloticus 79.20 0.00e+00 1172.00
IUUC-Oan-073352 Ornithorhynchus anatinus 92.83 0.00e+00 1400.00
IUUC-Ocu-073777 Oryctolagus cuniculus 98.36 0.00e+00 1467.00
IUUC-Oar-089313 Ovis aries 93.85 0.00e+00 1395.00
IUUC-Ptr-091421 Pan troglodytes 99.37 0.00e+00 1548.00
IUUC-Psi-093307 Pelodiscus sinensis 91.90 0.00e+00 1342.00
IUUC-Pma-094666 Petromyzon marinus 67.30 0.00e+00 1040.00
IUUC-Pab-098232 Pongo abelii 99.75 0.00e+00 1557.00
IUUC-Pca-100975 Procavia capensis 84.70 0.00e+00 848.00
IUUC-Pva-102596 Pteropus vampyrus 89.80 0.00e+00 1379.00
IUUC-Rno-105027 Rattus norvegicus 94.34 0.00e+00 1412.00
IUUC-Sha-106668 Sarcophilus harrisii 91.70 0.00e+00 1342.00
IUUC-Ssc-115321 Sus scrofa 71.03 0.00e+00 983.00
IUUC-Tgu-116652 Taeniopygia guttata 91.70 0.00e+00 1415.00
IUUC-Tsy-119138 Tarsius syrichta 85.66 0.00e+00 947.00
IUUC-Tni-120412 Tetraodon nigroviridis 78.25 0.00e+00 1154.00
IUUC-Tbe-127841 Tupaia belangeri 97.98 0.00e+00 1223.00
IUUC-Ttr-128406 Tursiops truncatus 97.06 0.00e+00 1445.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved