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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046606
UUCD1 version UUC-HoS-00028
Ensembl Protein ID ENSP00000382487.4
UniProt Accession O60291; A4URL3; A4URL4; Q86W76; MGRN1_HUMAN
Genbank Protein ID ABO69623.2; ABO69624.2; BAA25470.1; AAH50389.1
Protein Name E3 ubiquitin-protein ligase MGRN1; Mahogunin RING finger protein 1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1
Genbank Nucleotide ID EF471397; EF471398; AB011116; AC023830
Gene Name MGRN1; KIAA0544; RNF156
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102858.12 ENST00000262370.11 ENSP00000262370.6
ENSG00000102858.12 ENST00000536343.5 ENSP00000443810.1
ENSG00000102858.12 ENST00000587747.5 ENSP00000467414.1
ENSG00000102858.12 ENST00000399577.9 ENSP00000382487.4
ENSG00000102858.12 ENST00000588994.5 ENSP00000468819.1
ENSG00000102858.12 ENST00000586183.5 ENSP00000465860.1
ENSG00000102858.12 ENST00000590790.5 ENSP00000464811.1
ENSG00000102858.12 ENST00000593224.1 ENSP00000465249.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19703557; 19524515
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00019 23.5 278 317
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C +Cl+d++d +l+lpC H + +++C   +       +++ +CP+Cr
   Q: 278  CVVCLSDLRD-TLILPCRHlCLCTSCADTL------RYQANNCPICR 317
           **********.9*******888****9999......99********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
 E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Protein Sequence
(Fasta)
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL 60
NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046606|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTTTACAGAC CGGCACATGG CGCTTCCGGT TGACGTTGCT GACAGCTAGT GAGGCTTTAG 60
CCCGCTTCGA GCGCCCGGGG GCGGTAAGGC GCGATCATAG CAGCTCTAGG TGACCTTGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046606|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING
PROSITE

PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008333--P:endosome to lysosome transport
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0045744--P:negative regulation of G-protein coupled receptor protein signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
KEGG hsa:23295
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000903 Aegilops tauschii 34.81 1.00e-37 149.00
IUUC-Atr-002864 Amborella trichopoda 34.75 2.00e-38 152.00
IUUC-Apl-004187 Anas platyrhynchos 77.70 0.00e+00 821.00
IUUC-Aca-005114 Anolis carolinensis 74.39 0.00e+00 809.00
IUUC-Aly-005561 Arabidopsis lyrata 35.58 4.00e-36 145.00
IUUC-Afl-008422 Aspergillus flavus 36.71 7.00e-09 53.10
IUUC-Ame-011921 Astyanax mexicanus 66.73 0.00e+00 632.00
IUUC-Bgr-012222 Blumeria graminis 35.38 1.00e-03 39.30
IUUC-Bdi-014817 Brachypodium distachyon 35.27 5.00e-38 152.00
IUUC-Cfa-021099 Canis familiaris 89.51 0.00e+00 914.00
IUUC-Cpo-021611 Cavia porcellus 89.03 0.00e+00 906.00
IUUC-Cre-022780 Chlamydomonas reinhardtii 29.85 1.00e-27 117.00
IUUC-Csa-023582 Chlorocebus sabaeus 98.37 0.00e+00 1078.00
IUUC-Cne-026964 Cryptococcus neoformans 35.71 3.00e-12 67.00
IUUC-Dno-029086 Dasypus novemcinctus 89.13 0.00e+00 966.00
IUUC-Dor-030120 Dipodomys ordii 79.63 0.00e+00 785.00
IUUC-Ete-032561 Echinops telfairi 71.18 3.00e-171 595.00
IUUC-Eca-033875 Equus caballus 85.58 0.00e+00 859.00
IUUC-Eeu-034497 Erinaceus europaeus 73.68 0.00e+00 726.00
IUUC-Fca-036132 Felis catus 88.78 0.00e+00 910.00
IUUC-Fal-036855 Ficedula albicollis 79.36 0.00e+00 850.00
IUUC-Gmo-039258 Gadus morhua 73.84 0.00e+00 801.00
IUUC-Gga-040695 Gallus gallus 81.67 0.00e+00 875.00
IUUC-Gac-041714 Gasterosteus aculeatus 75.27 0.00e+00 817.00
IUUC-Gma-044140 Glycine max 36.40 6.00e-38 151.00
IUUC-Ggo-045064 Gorilla gorilla 98.37 0.00e+00 1086.00
IUUC-Hvu-047318 Hordeum vulgare 36.50 2.00e-34 139.00
IUUC-Lpe-050811 Leersia perrieri 35.02 2.00e-38 153.00
IUUC-Laf-054217 Loxodonta africana 85.33 0.00e+00 855.00
IUUC-Mcc-055466 Macaca mulatta 98.91 0.00e+00 1085.00
IUUC-Meu-056424 Macropus eugenii 78.89 0.00e+00 782.00
IUUC-Mtr-058351 Medicago truncatula 33.58 4.00e-36 145.00
IUUC-Mga-060123 Meleagris gallopavo 82.18 0.00e+00 729.00
IUUC-Mmr-060947 Microcebus murinus 94.29 0.00e+00 865.00
IUUC-Mdo-061853 Monodelphis domestica 88.87 0.00e+00 949.00
IUUC-Mmu-064187 Mus musculus 85.43 0.00e+00 854.00
IUUC-Mac-064637 Musa acuminata 36.67 2.00e-37 149.00
IUUC-Mpu-066218 Mustela putorius furo 88.83 0.00e+00 966.00
IUUC-Mlu-067226 Myotis lucifugus 87.97 0.00e+00 962.00
IUUC-Opr-070507 Ochotona princeps 83.64 0.00e+00 879.00
IUUC-Oan-073619 Ornithorhynchus anatinus 85.19 0.00e+00 815.00
IUUC-Oba-075139 Oryza barthii 36.40 4.00e-35 142.00
IUUC-Obr-076291 Oryza brachyantha 35.35 1.00e-38 154.00
IUUC-Ogl-077178 Oryza glaberrima 35.08 3.00e-39 156.00
IUUC-Ogu-078712 Oryza glumaepatula 36.50 2.00e-40 160.00
IUUC-Oin-080016 Oryza indica 36.50 2.00e-40 160.00
IUUC-Olo-081031 Oryza longistaminata 35.37 3.00e-39 156.00
IUUC-Ome-081566 Oryza meridionalis 35.37 6.00e-39 155.00
IUUC-Oni-082100 Oryza nivara 36.50 2.00e-40 160.00
IUUC-Opu-084142 Oryza punctata 33.95 2.00e-39 156.00
IUUC-Oru-084936 Oryza rufipogon 36.50 2.00e-40 160.00
IUUC-Osa-086062 Oryza sativa 36.50 2.00e-40 160.00
IUUC-Oga-088990 Otolemur garnettii 92.63 0.00e+00 972.00
IUUC-Oar-090173 Ovis aries 74.40 0.00e+00 709.00
IUUC-Pan-091797 Papio anubis 98.15 0.00e+00 1051.00
IUUC-Psi-093844 Pelodiscus sinensis 82.08 0.00e+00 687.00
IUUC-Pno-094880 Phaeosphaeria nodorum 36.73 7.00e-05 42.70
IUUC-Ppa-095271 Physcomitrella patens 28.49 6.00e-26 112.00
IUUC-Pab-097992 Pongo abelii 98.71 0.00e+00 1062.00
IUUC-Pop-099592 Populus trichocarpa 35.71 5.00e-36 145.00
IUUC-Pca-100998 Procavia capensis 80.58 0.00e+00 833.00
IUUC-Ppe-101577 Prunus persica 35.27 6.00e-40 158.00
IUUC-Pva-102362 Pteropus vampyrus 90.56 0.00e+00 975.00
IUUC-Rno-105572 Rattus norvegicus 90.27 0.00e+00 939.00
IUUC-Sha-107374 Sarcophilus harrisii 89.05 0.00e+00 950.00
IUUC-Sit-110038 Setaria italica 36.03 1.00e-37 150.00
IUUC-Sly-110839 Solanum lycopersicum 34.48 9.00e-35 140.00
IUUC-Stu-112804 Solanum tuberosum 34.10 5.00e-34 138.00
IUUC-Sre-115067 Sporisorium reilianum 31.58 1.00e-04 42.40
IUUC-Ssc-116415 Sus scrofa 87.75 0.00e+00 963.00
IUUC-Tgu-116526 Taeniopygia guttata 79.00 0.00e+00 829.00
IUUC-Tru-118173 Takifugu rubripes 76.21 0.00e+00 799.00
IUUC-Tni-119781 Tetraodon nigroviridis 75.45 0.00e+00 797.00
IUUC-Tca-121153 Theobroma cacao 34.19 1.00e-32 134.00
IUUC-Tae-123450 Triticum aestivum 34.31 3.00e-38 152.00
IUUC-Tur-126214 Triticum urartu 34.31 1.00e-38 153.00
IUUC-Tme-127014 Tuber melanosporum 32.20 1.00e-07 47.80
IUUC-Tbe-127685 Tupaia belangeri 70.37 1.00e-144 506.00
Created Date 25-Jun-2017

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