iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000003497.4	ENSRNOT00000004672.3	ENSRNOP00000004672.3
ENSRNOG00000003497.4	ENSRNOT00000078647.1	ENSRNOP00000074191.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.20e-12	45.2	166	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gHtd ++cla+   ++ ++sG+ Dg +++WDlr  + 
   Q: 166  GHTDYIHCLALreRSPEVLSGGEDGAVRLWDLRIAKE 202
           8**********98559***************986655 PP

Organism

Rattus norvegicus

Functional Description
(View)

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role in apoptosis negative control involved in brain development (By similarity).

Protein Sequence
(Fasta)

MEHATPLAVP LGQAEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI FSLSAALSSE 60
AKEESKKPMV TFHAHDGPVY SMVSTDRHLL SAGDGEVKGW LWAEILKKGC KELWRRQPPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGTGGCTG GACAGCTCTG GGAGCTGCTT AGCATAAGGG TGCTTCGTGG AGTTCTCCTA 60
GGTTTCTGTG GTTCGAGACA GCACGGACCT GCCGTCTTAG TTGTTGAGCG ATAGGCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0000445--C:THO complex part of transcription export complex
GO:0003723--F:RNA binding
GO:0006915--P:apoptotic process
GO:0007417--P:central nervous system development
GO:0006397--P:mRNA processing
GO:0043066--P:negative regulation of apoptotic process
GO:0008380--P:RNA splicing
GO:0046784--P:viral mRNA export from host cell nucleus

KEGG

rno:79227

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001101	Aegilops tauschii	29.44	2.00e-28	119.00
IUUC-Aml-001693	Ailuropoda melanoleuca	95.89	8.00e-180	622.00
IUUC-Atr-002699	Amborella trichopoda	28.80	3.00e-22	99.00
IUUC-Aca-004231	Anolis carolinensis	69.72	1.00e-125	442.00
IUUC-Aly-006385	Arabidopsis lyrata	29.70	3.00e-28	119.00
IUUC-Ath-006723	Arabidopsis thaliana	29.70	2.00e-28	119.00
IUUC-Ame-010813	Astyanax mexicanus	64.19	2.00e-87	315.00
IUUC-Bta-013458	Bos taurus	95.31	8.00e-177	612.00
IUUC-Bdi-014935	Brachypodium distachyon	29.03	3.00e-28	119.00
IUUC-Bol-015442	Brassica oleracea	29.75	5.00e-28	118.00
IUUC-Bra-017807	Brassica rapa	30.95	2.00e-28	119.00
IUUC-Cja-019061	Callithrix jacchus	95.32	3.00e-177	613.00
IUUC-Cfa-021146	Canis familiaris	95.31	6.00e-178	616.00
IUUC-Cpo-022512	Cavia porcellus	95.31	3.00e-179	620.00
IUUC-Csa-023055	Chlorocebus sabaeus	95.31	6.00e-179	619.00
IUUC-Cho-024693	Choloepus hoffmanni	95.88	2.00e-99	354.00
IUUC-Cin-025181	Ciona intestinalis	35.40	6.00e-56	211.00
IUUC-Csv-025852	Ciona savignyi	35.52	1.00e-49	189.00
IUUC-Dre-028221	Danio rerio	59.94	1.00e-117	415.00
IUUC-Dno-029200	Dasypus novemcinctus	91.01	4.00e-88	316.00
IUUC-Dor-030863	Dipodomys ordii	93.55	3.00e-175	607.00
IUUC-Dme-032016	Drosophila melanogaster	30.82	4.00e-37	148.00
IUUC-Eca-034363	Equus caballus	95.01	5.00e-178	616.00
IUUC-Fca-036546	Felis catus	95.60	6.00e-178	616.00
IUUC-Gmo-038513	Gadus morhua	57.76	7.00e-107	380.00
IUUC-Gac-042606	Gasterosteus aculeatus	56.83	1.00e-110	392.00
IUUC-Gma-043171	Glycine max	28.19	3.00e-31	129.00
IUUC-Ggo-044877	Gorilla gorilla	96.48	2.00e-180	624.00
IUUC-Hsa-045813	Homo sapiens	95.89	4.00e-180	623.00
IUUC-Hvu-047782	Hordeum vulgare	31.08	1.00e-19	89.40
IUUC-Itr-047876	Ictidomys tridecemlineatus	95.60	2.00e-179	621.00
IUUC-Lch-049506	Latimeria chalumnae	63.83	9.00e-119	419.00
IUUC-Lpe-051203	Leersia perrieri	29.83	5.00e-24	105.00
IUUC-Loc-052451	Lepisosteus oculatus	52.48	7.00e-89	320.00
IUUC-Laf-053864	Loxodonta africana	93.55	6.00e-175	606.00
IUUC-Mcc-055705	Macaca mulatta	88.02	6.00e-152	530.00
IUUC-Meu-055926	Macropus eugenii	90.52	1.00e-155	542.00
IUUC-Mtr-058556	Medicago truncatula	28.82	3.00e-31	129.00
IUUC-Mmr-060836	Microcebus murinus	95.60	6.00e-180	622.00
IUUC-Mdo-062534	Monodelphis domestica	90.83	5.00e-155	540.00
IUUC-Mmu-063560	Mus musculus	98.53	0.00e+00	639.00
IUUC-Mac-065134	Musa acuminata	28.23	1.00e-25	110.00
IUUC-Mpu-066031	Mustela putorius furo	95.89	3.00e-179	620.00
IUUC-Mlu-068051	Myotis lucifugus	91.79	6.00e-169	586.00
IUUC-Nle-069080	Nomascus leucogenys	95.31	9.00e-179	619.00
IUUC-Opr-070787	Ochotona princeps	90.03	1.00e-165	575.00
IUUC-Ont-071952	Oreochromis niloticus	55.28	3.00e-109	388.00
IUUC-Oan-073334	Ornithorhynchus anatinus	86.15	3.00e-118	417.00
IUUC-Oba-075175	Oryza barthii	30.39	8.00e-25	107.00
IUUC-Obr-076393	Oryza brachyantha	30.94	1.00e-24	107.00
IUUC-Ogl-077603	Oryza glaberrima	35.59	2.00e-18	85.90
IUUC-Ogu-078211	Oryza glumaepatula	30.39	9.00e-25	107.00
IUUC-Oin-079554	Oryza indica	30.39	4.00e-25	108.00
IUUC-Olo-080922	Oryza longistaminata	30.56	9.00e-23	100.00
IUUC-Ome-081127	Oryza meridionalis	23.76	7.00e-12	65.50
IUUC-Oni-082376	Oryza nivara	30.39	8.00e-25	107.00
IUUC-Opu-083163	Oryza punctata	29.83	3.00e-24	106.00
IUUC-Oru-084311	Oryza rufipogon	30.39	1.00e-24	107.00
IUUC-Osa-085762	Oryza sativa	35.59	3.00e-18	85.50
IUUC-Oga-088804	Otolemur garnettii	95.01	3.00e-179	620.00
IUUC-Oar-090095	Ovis aries	95.31	4.00e-177	613.00
IUUC-Ptr-090731	Pan troglodytes	96.19	4.00e-180	623.00
IUUC-Pan-092595	Papio anubis	95.91	2.00e-178	617.00
IUUC-Psi-093866	Pelodiscus sinensis	69.93	3.00e-117	414.00
IUUC-Pma-094236	Petromyzon marinus	59.57	4.00e-115	407.00
IUUC-Pfo-096095	Poecilia formosa	56.21	1.00e-105	375.00
IUUC-Pab-098385	Pongo abelii	95.89	9.00e-180	622.00
IUUC-Pop-099433	Populus trichocarpa	27.24	9.00e-29	120.00
IUUC-Pca-101119	Procavia capensis	94.98	7.00e-116	410.00
IUUC-Ppe-101677	Prunus persica	28.63	2.00e-26	112.00
IUUC-Pva-102726	Pteropus vampyrus	94.72	1.00e-177	615.00
IUUC-Sha-106774	Sarcophilus harrisii	91.13	2.00e-156	545.00
IUUC-Sit-109988	Setaria italica	27.82	4.00e-26	112.00
IUUC-Sly-110864	Solanum lycopersicum	28.97	2.00e-27	116.00
IUUC-Sar-113060	Sorex araneus	87.07	2.00e-127	447.00
IUUC-Sbi-114699	Sorghum bicolor	28.74	5.00e-27	115.00
IUUC-Ssc-116445	Sus scrofa	95.31	1.00e-178	618.00
IUUC-Tru-117834	Takifugu rubripes	58.39	1.00e-113	402.00
IUUC-Tni-119651	Tetraodon nigroviridis	57.45	1.00e-112	399.00
IUUC-Tca-121318	Theobroma cacao	28.63	3.00e-27	115.00
IUUC-Tae-124184	Triticum aestivum	29.44	2.00e-28	119.00
IUUC-Tur-126226	Triticum urartu	30.39	8.00e-26	110.00
IUUC-Tbe-128079	Tupaia belangeri	80.90	2.00e-106	378.00
IUUC-Ttr-128391	Tursiops truncatus	91.52	4.00e-167	580.00
IUUC-Vvi-131148	Vitis vinifera	27.02	3.00e-24	105.00
IUUC-Xtr-132743	Xenopus tropicalis	61.90	1.00e-116	412.00
IUUC-Xma-133722	Xiphophorus maculatus	56.52	3.00e-110	391.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence