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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046503
UUCD1 version UUC-HoS-00349
Ensembl Protein ID ENSP00000298355.3
UniProt Accession Q9C026; D3DSB7; D3DSB8; Q92557; Q96D24; Q96NI4; Q9C025; Q9C027; TRIM9_HUMAN
Genbank Protein ID AAG53490.1; AAG53491.1; AAG53492.1; BAA13398.2; BAB70913.1; EAW65680.1; EAW65681.1; EAW65682.1; EAW65684.1; AAH13414.1; AAH63872.1
Protein Name E3 ubiquitin-protein ligase TRIM9; RING finger protein 91; RING-type E3 ubiquitin transferase TRIM9; Tripartite motif-containing protein 9
Genbank Nucleotide ID AF220036; AF220037; AF220038; D87458; AK055388; CH471078; CH471078; CH471078; CH471078; BC013414; BC063872
Gene Name TRIM9; KIAA0282; RNF91
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100505.13 ENST00000298355.7 ENSP00000298355.3
ENSG00000100505.13 ENST00000338969.9 ENSP00000342970.5
ENSG00000100505.13 ENST00000360392.4 ENSP00000353561.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20085810; 18248090; 19702650
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 37.45 1.00e-144 509.00 IUUC-Cel-018432
E3 activity/RING/RING 97.89 0.00e+00 1426.00 IUUC-Rno-105306
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
 E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Protein Sequence
(Fasta)
MEEMEEELKC PVCGSFYREP IILPCSHNLC QACARNILVQ TPESESPQSH RAAGSGVSDY 60
DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALAPV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046503|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACTACGGG CACTCAGAAA TAGACAAACT GTTCTTGCCT CAACCGAACC AAAGGCCCAG 60
CGGGCCTCGA AAAAGCTCAG CCAGGTGCTT TGGGAGGCCG CGAGGAGGAA GAAGGATCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046503|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF00622--SPRY
PF00643--zf-B_box
SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0008021--C:synaptic vesicle
GO:0042803--F:protein homodimerization activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045955--P:negative regulation of calcium ion-dependent exocytosis
GO:0035544--P:negative regulation of SNARE complex assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016079--P:synaptic vesicle exocytosis
KEGG hsa:114088
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002033 Ailuropoda melanoleuca 96.57 0.00e+00 890.00
IUUC-Apl-004004 Anas platyrhynchos 91.72 0.00e+00 1144.00
IUUC-Aca-004773 Anolis carolinensis 65.18 0.00e+00 975.00
IUUC-Ame-011429 Astyanax mexicanus 61.51 0.00e+00 912.00
IUUC-Bta-013184 Bos taurus 97.75 0.00e+00 1442.00
IUUC-Cel-018432 Caenorhabditis elegans 36.95 6.00e-134 471.00
IUUC-Cja-019517 Callithrix jacchus 66.90 0.00e+00 985.00
IUUC-Cfa-020744 Canis familiaris 98.88 0.00e+00 1083.00
IUUC-Cpo-021775 Cavia porcellus 98.88 0.00e+00 1043.00
IUUC-Csa-024085 Chlorocebus sabaeus 99.63 0.00e+00 1089.00
IUUC-Cho-024738 Choloepus hoffmanni 86.54 5.00e-127 447.00
IUUC-Cin-025387 Ciona intestinalis 43.08 6.00e-173 601.00
IUUC-Csv-025851 Ciona savignyi 45.59 0.00e+00 649.00
IUUC-Dre-027691 Danio rerio 83.94 0.00e+00 1286.00
IUUC-Dno-029047 Dasypus novemcinctus 98.03 0.00e+00 1446.00
IUUC-Dor-030823 Dipodomys ordii 82.21 0.00e+00 819.00
IUUC-Dme-031822 Drosophila melanogaster 45.27 3.00e-165 575.00
IUUC-Ete-032674 Echinops telfairi 61.47 0.00e+00 811.00
IUUC-Eca-034107 Equus caballus 67.84 0.00e+00 976.00
IUUC-Eeu-034494 Erinaceus europaeus 97.92 0.00e+00 787.00
IUUC-Fca-036046 Felis catus 93.49 0.00e+00 1005.00
IUUC-Fal-036997 Ficedula albicollis 76.31 0.00e+00 793.00
IUUC-Gmo-039639 Gadus morhua 77.17 0.00e+00 1164.00
IUUC-Gga-040951 Gallus gallus 90.69 0.00e+00 1325.00
IUUC-Gac-041390 Gasterosteus aculeatus 78.86 0.00e+00 1210.00
IUUC-Ggo-045059 Gorilla gorilla 100.00 0.00e+00 1093.00
IUUC-Itr-049084 Ictidomys tridecemlineatus 98.51 0.00e+00 1041.00
IUUC-Lch-049521 Latimeria chalumnae 93.63 0.00e+00 1004.00
IUUC-Loc-052213 Lepisosteus oculatus 83.24 0.00e+00 1226.00
IUUC-Laf-054442 Loxodonta africana 98.17 0.00e+00 1447.00
IUUC-Mcc-054887 Macaca mulatta 99.44 0.00e+00 1461.00
IUUC-Meu-056251 Macropus eugenii 88.39 0.00e+00 934.00
IUUC-Mga-059961 Meleagris gallopavo 76.34 0.00e+00 771.00
IUUC-Mmr-061677 Microcebus murinus 98.31 0.00e+00 1452.00
IUUC-Mdo-062987 Monodelphis domestica 96.25 0.00e+00 1042.00
IUUC-Mmu-063314 Mus musculus 92.35 0.00e+00 1338.00
IUUC-Mpu-066785 Mustela putorius furo 98.88 0.00e+00 1083.00
IUUC-Mlu-067137 Myotis lucifugus 98.03 0.00e+00 1447.00
IUUC-Nle-070127 Nomascus leucogenys 99.58 0.00e+00 1462.00
IUUC-Opr-070763 Ochotona princeps 84.99 0.00e+00 1308.00
IUUC-Ont-071416 Oreochromis niloticus 84.33 0.00e+00 1291.00
IUUC-Oan-072901 Ornithorhynchus anatinus 93.00 1.00e-139 489.00
IUUC-Ocu-074241 Oryctolagus cuniculus 99.06 0.00e+00 1086.00
IUUC-Ola-086349 Oryzias latipes 78.30 2.00e-102 364.00
IUUC-Oga-088969 Otolemur garnettii 98.88 0.00e+00 1084.00
IUUC-Oar-089807 Ovis aries 96.90 0.00e+00 1422.00
IUUC-Ptr-090952 Pan troglodytes 99.25 0.00e+00 1080.00
IUUC-Pan-092565 Papio anubis 90.69 0.00e+00 1417.00
IUUC-Psi-093885 Pelodiscus sinensis 92.57 0.00e+00 934.00
IUUC-Pfo-096684 Poecilia formosa 83.80 0.00e+00 1287.00
IUUC-Pab-097638 Pongo abelii 99.58 0.00e+00 1457.00
IUUC-Pca-101102 Procavia capensis 97.75 0.00e+00 1070.00
IUUC-Pva-103204 Pteropus vampyrus 97.31 1.00e-145 510.00
IUUC-Rno-105306 Rattus norvegicus 97.89 0.00e+00 1405.00
IUUC-Sha-106771 Sarcophilus harrisii 75.78 0.00e+00 790.00
IUUC-Sar-113631 Sorex araneus 97.94 0.00e+00 1065.00
IUUC-Sbi-114403 Sorghum bicolor 26.89 4.00e-05 42.00
IUUC-Ssc-115634 Sus scrofa 98.31 0.00e+00 1451.00
IUUC-Tgu-117319 Taeniopygia guttata 71.82 0.00e+00 890.00
IUUC-Tru-117583 Takifugu rubripes 84.23 0.00e+00 1274.00
IUUC-Tsy-119427 Tarsius syrichta 97.69 2.00e-147 515.00
IUUC-Tni-120847 Tetraodon nigroviridis 84.20 0.00e+00 1276.00
IUUC-Tbe-127239 Tupaia belangeri 97.65 0.00e+00 677.00
IUUC-Ttr-129238 Tursiops truncatus 95.38 1.00e-140 493.00
IUUC-Vpa-130241 Vicugna pacos 95.47 0.00e+00 986.00
IUUC-Xtr-131998 Xenopus tropicalis 89.50 0.00e+00 1311.00
Created Date 25-Jun-2017

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