iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115945

Ensembl Protein ID

ENSSSCP00000012339.2

UniProt Accession

O62807; O77815; Q6L9M2; PPARG_PIG

Genbank Protein ID

AAC14348.1; AAD19577.1; CAA07224.1; CAA07225.1; BAD20646.1

Protein Name

Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

Genbank Nucleotide ID

AF059245; AF103946; AJ006756; AJ006757; AB097930

Gene Name

PPARG; NR1C3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000011579.2	ENSSSCT00000012672.2	ENSSSCP00000012339.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	97.82	0.00e+00	991.00	IUUC-Hsa-046916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sus scrofa

Functional Description
(View)

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.

Protein Sequence
(Fasta)

MGETLGDSLI DPESDAFDTL SANISQEVTM VDTEMPFWPT NFGISSVDLS VMDDHSHSFD 60
IKPFTTVDFS SISTPHYEDI PFPRADPMVA DYKYDLKLQD YQSAIKVEPV SPPYYSEKTQ 120

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Nucleotide Sequence
(Fasta)

ACTCATTGGT GCCTTCACCA GTTCTACAAC CAGGAATCTT TTCCCTTTAA TGGATTGGCC 60
TTTTGCAAGA AATAGACAAA ATATCAGTGT GAATGACAGC AAACCCCTAT TCCATGCTGT 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048469--P:cell maturation
GO:0032869--P:cellular response to insulin stimulus
GO:0042593--P:glucose homeostasis
GO:0042953--P:lipoprotein transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0010887--P:negative regulation of cholesterol storage
GO:0010629--P:negative regulation of gene expression
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0010875--P:positive regulation of cholesterol efflux
GO:0045600--P:positive regulation of fat cell differentiation
GO:0032385--P:positive regulation of intracellular cholesterol transport
GO:0031394--P:positive regulation of prostaglandin biosynthetic process
GO:0050714--P:positive regulation of protein secretion
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0042752--P:regulation of circadian rhythm
GO:1903076--P:regulation of protein localization to plasma membrane
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0055098--P:response to low-density lipoprotein particle
GO:0032526--P:response to retinoic acid
GO:0048511--P:rhythmic process
GO:0006351--P:transcription, DNA-templated
GO:0050872--P:white fat cell differentiation

KEGG

ssc:397671

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001214	Ailuropoda melanoleuca	95.25	0.00e+00	959.00
IUUC-Aca-005129	Anolis carolinensis	88.55	0.00e+00	873.00
IUUC-Ame-010818	Astyanax mexicanus	65.65	0.00e+00	641.00
IUUC-Bta-013226	Bos taurus	97.03	0.00e+00	986.00
IUUC-Cja-019236	Callithrix jacchus	97.82	0.00e+00	992.00
IUUC-Cfa-020281	Canis familiaris	98.22	0.00e+00	998.00
IUUC-Cpo-021587	Cavia porcellus	96.44	0.00e+00	933.00
IUUC-Csa-023400	Chlorocebus sabaeus	98.53	0.00e+00	944.00
IUUC-Cho-024593	Choloepus hoffmanni	85.15	0.00e+00	842.00
IUUC-Dre-028176	Danio rerio	59.42	7.00e-153	533.00
IUUC-Dno-029063	Dasypus novemcinctus	93.07	0.00e+00	944.00
IUUC-Dme-031794	Drosophila melanogaster	34.89	2.00e-55	211.00
IUUC-Ete-032520	Echinops telfairi	94.46	0.00e+00	947.00
IUUC-Eeu-034683	Erinaceus europaeus	51.56	6.00e-14	71.60
IUUC-Fca-035935	Felis catus	97.82	0.00e+00	995.00
IUUC-Fal-037524	Ficedula albicollis	92.63	0.00e+00	885.00
IUUC-Gga-041223	Gallus gallus	93.68	0.00e+00	893.00
IUUC-Gac-042156	Gasterosteus aculeatus	62.14	0.00e+00	637.00
IUUC-Ggo-045265	Gorilla gorilla	97.82	0.00e+00	993.00
IUUC-Hsa-046916	Homo sapiens	97.82	0.00e+00	992.00
IUUC-Lch-049759	Latimeria chalumnae	79.85	0.00e+00	676.00
IUUC-Loc-051870	Lepisosteus oculatus	74.17	0.00e+00	748.00
IUUC-Laf-054483	Loxodonta africana	96.04	0.00e+00	971.00
IUUC-Meu-056587	Macropus eugenii	94.19	0.00e+00	914.00
IUUC-Mga-059530	Meleagris gallopavo	93.68	0.00e+00	893.00
IUUC-Mmr-060576	Microcebus murinus	95.45	0.00e+00	971.00
IUUC-Mdo-061854	Monodelphis domestica	98.11	0.00e+00	934.00
IUUC-Mmu-063724	Mus musculus	96.04	0.00e+00	976.00
IUUC-Mpu-066888	Mustela putorius furo	99.16	0.00e+00	982.00
IUUC-Mlu-067978	Myotis lucifugus	97.43	0.00e+00	1023.00
IUUC-Nle-070069	Nomascus leucogenys	98.22	0.00e+00	996.00
IUUC-Opr-070630	Ochotona princeps	92.89	0.00e+00	786.00
IUUC-Ont-071399	Oreochromis niloticus	59.70	2.00e-180	624.00
IUUC-Ocu-074862	Oryctolagus cuniculus	97.90	0.00e+00	942.00
IUUC-Ola-087266	Oryzias latipes	56.42	5.00e-159	553.00
IUUC-Oga-089143	Otolemur garnettii	96.24	0.00e+00	979.00
IUUC-Oar-089725	Ovis aries	96.83	0.00e+00	983.00
IUUC-Ptr-091580	Pan troglodytes	98.02	0.00e+00	993.00
IUUC-Psi-093041	Pelodiscus sinensis	90.78	0.00e+00	866.00
IUUC-Pfo-097438	Poecilia formosa	59.21	2.00e-177	614.00
IUUC-Pab-098333	Pongo abelii	97.90	0.00e+00	936.00
IUUC-Pca-100861	Procavia capensis	97.27	0.00e+00	935.00
IUUC-Pva-102186	Pteropus vampyrus	87.52	0.00e+00	867.00
IUUC-Rno-105583	Rattus norvegicus	96.04	0.00e+00	976.00
IUUC-Sha-107484	Sarcophilus harrisii	96.71	0.00e+00	940.00
IUUC-Sja-107787	Schizosaccharomyces japonicus	25.29	6.40e+00	25.40
IUUC-Sar-112996	Sorex araneus	85.04	0.00e+00	646.00
IUUC-Tsy-119098	Tarsius syrichta	87.52	0.00e+00	858.00
IUUC-Tni-120902	Tetraodon nigroviridis	61.11	5.00e-173	600.00
IUUC-Tbe-127225	Tupaia belangeri	76.04	0.00e+00	714.00
IUUC-Ttr-129292	Tursiops truncatus	97.43	0.00e+00	991.00
IUUC-Vpa-130378	Vicugna pacos	91.33	0.00e+00	786.00
IUUC-Xtr-132171	Xenopus tropicalis	31.98	3.00e-17	83.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence