iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.80e-13	48.5	228	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+ ++t++a+ +d  l+++Gs  +t++++D
   Q: 228  HEHPITSVAWaPDgELFAVGS-FHTLRLCD 256
           99*********9978888887.689*9999 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.

Protein Sequence
(Fasta)

MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETSLI VKLPDDIYPI 60
DLHWFPKSLG IKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCACTATG GTGACGGAAA GGTCGGGAGG CTACTTGGTA ACTGGTCTGA GCTCTGAGAG 60
CAATTGCCAC CGCTTTCCTG GAACTTGAGG TAAATTTTTT CACCTCCAGA GCCTTTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0030992--C:intraciliary transport particle B
GO:0060349--P:bone morphogenesis
GO:0002062--P:chondrocyte differentiation
GO:0060271--P:cilium assembly
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:1905515--P:non-motile cilium assembly
GO:0001649--P:osteoblast differentiation
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0007224--P:smoothened signaling pathway

KEGG

rno:295106

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001564	Ailuropoda melanoleuca	97.29	0.00e+00	897.00
IUUC-Apl-003721	Anas platyrhynchos	84.91	0.00e+00	1374.00
IUUC-Aca-004488	Anolis carolinensis	85.54	0.00e+00	1387.00
IUUC-Ame-011402	Astyanax mexicanus	81.74	0.00e+00	825.00
IUUC-Bta-013037	Bos taurus	85.34	0.00e+00	1323.00
IUUC-Cel-018360	Caenorhabditis elegans	40.13	0.00e+00	656.00
IUUC-Cja-019076	Callithrix jacchus	91.37	0.00e+00	1203.00
IUUC-Cfa-020999	Canis familiaris	95.15	0.00e+00	1512.00
IUUC-Cpo-021333	Cavia porcellus	85.23	0.00e+00	1289.00
IUUC-Cre-022899	Chlamydomonas reinhardtii	46.47	0.00e+00	676.00
IUUC-Csa-023699	Chlorocebus sabaeus	94.25	0.00e+00	1497.00
IUUC-Cho-024904	Choloepus hoffmanni	87.83	0.00e+00	829.00
IUUC-Cin-025399	Ciona intestinalis	57.56	0.00e+00	955.00
IUUC-Csv-026186	Ciona savignyi	55.32	0.00e+00	922.00
IUUC-Dre-028276	Danio rerio	74.67	0.00e+00	1273.00
IUUC-Dno-029824	Dasypus novemcinctus	95.54	0.00e+00	1524.00
IUUC-Dor-031141	Dipodomys ordii	90.72	0.00e+00	1427.00
IUUC-Dme-031620	Drosophila melanogaster	35.56	4.00e-142	498.00
IUUC-Eca-033339	Equus caballus	94.59	0.00e+00	1489.00
IUUC-Eeu-034909	Erinaceus europaeus	93.42	0.00e+00	1008.00
IUUC-Fca-035780	Felis catus	95.55	0.00e+00	1484.00
IUUC-Fal-037447	Ficedula albicollis	78.73	0.00e+00	1261.00
IUUC-Gmo-038657	Gadus morhua	61.48	0.00e+00	833.00
IUUC-Gga-040689	Gallus gallus	85.52	0.00e+00	1379.00
IUUC-Gac-041586	Gasterosteus aculeatus	72.49	0.00e+00	1006.00
IUUC-Hsa-047005	Homo sapiens	94.34	0.00e+00	1519.00
IUUC-Itr-048757	Ictidomys tridecemlineatus	95.73	0.00e+00	1112.00
IUUC-Lch-050459	Latimeria chalumnae	79.90	0.00e+00	1318.00
IUUC-Loc-052774	Lepisosteus oculatus	77.85	0.00e+00	1055.00
IUUC-Laf-053765	Loxodonta africana	93.27	0.00e+00	1458.00
IUUC-Mcc-055052	Macaca mulatta	94.25	0.00e+00	1497.00
IUUC-Meu-056368	Macropus eugenii	80.55	0.00e+00	1267.00
IUUC-Mga-059488	Meleagris gallopavo	85.41	0.00e+00	1379.00
IUUC-Mmr-061527	Microcebus murinus	95.56	0.00e+00	1494.00
IUUC-Mdo-062850	Monodelphis domestica	93.02	0.00e+00	1214.00
IUUC-Mmu-063117	Mus musculus	98.20	0.00e+00	1545.00
IUUC-Mpu-066550	Mustela putorius furo	95.36	0.00e+00	1381.00
IUUC-Mlu-067772	Myotis lucifugus	90.93	0.00e+00	1397.00
IUUC-Nle-069215	Nomascus leucogenys	93.69	0.00e+00	1511.00
IUUC-Opr-070725	Ochotona princeps	73.00	0.00e+00	1113.00
IUUC-Ont-072147	Oreochromis niloticus	73.38	0.00e+00	1254.00
IUUC-Oan-073176	Ornithorhynchus anatinus	86.29	8.00e-63	231.00
IUUC-Ocu-073896	Oryctolagus cuniculus	94.13	0.00e+00	1229.00
IUUC-Ola-086767	Oryzias latipes	68.11	0.00e+00	952.00
IUUC-Oga-088113	Otolemur garnettii	93.91	0.00e+00	1524.00
IUUC-Oar-089683	Ovis aries	90.89	0.00e+00	1444.00
IUUC-Ptr-091563	Pan troglodytes	94.47	0.00e+00	1516.00
IUUC-Pan-092042	Papio anubis	94.25	0.00e+00	1496.00
IUUC-Psi-093306	Pelodiscus sinensis	85.90	0.00e+00	1434.00
IUUC-Ppa-095694	Physcomitrella patens	45.30	0.00e+00	713.00
IUUC-Pfo-096800	Poecilia formosa	73.53	0.00e+00	1239.00
IUUC-Pab-098356	Pongo abelii	94.21	0.00e+00	1517.00
IUUC-Pva-102246	Pteropus vampyrus	90.77	0.00e+00	1418.00
IUUC-Sha-107056	Sarcophilus harrisii	94.00	0.00e+00	1496.00
IUUC-Smo-109240	Selaginella moellendorffii	43.95	1.00e-174	606.00
IUUC-Sar-113301	Sorex araneus	82.99	2.00e-145	509.00
IUUC-Ssc-116040	Sus scrofa	96.06	6.00e-146	509.00
IUUC-Tgu-117127	Taeniopygia guttata	80.88	0.00e+00	1313.00
IUUC-Tru-118663	Takifugu rubripes	70.04	0.00e+00	1199.00
IUUC-Tsy-119207	Tarsius syrichta	83.38	0.00e+00	1298.00
IUUC-Tni-120705	Tetraodon nigroviridis	68.91	0.00e+00	1187.00
IUUC-Tbe-127434	Tupaia belangeri	85.53	0.00e+00	944.00
IUUC-Ttr-128937	Tursiops truncatus	95.35	0.00e+00	1521.00
IUUC-Vpa-130518	Vicugna pacos	90.59	0.00e+00	1407.00
IUUC-Xtr-131879	Xenopus tropicalis	75.81	0.00e+00	1266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence