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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063545
UUCD1 version UUC-MuM-00386
Ensembl Protein ID ENSMUSP00000050388.5
UniProt Accession Q3U2C5; E9QAH5; Q14BF0; Q8CGR2; RN149_MOUSE
Genbank Protein ID BAE33216.1; AAI15969.1; AAN75220.1
Protein Name E3 ubiquitin-protein ligase RNF149; Goliath-related E3 ubiquitin-protein ligase 4; RING finger protein 149; RING-type E3 ubiquitin transferase RNF149
Genbank Nucleotide ID AK155360; AC119809; AY155439
Gene Name Rnf149; Greul4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000048234.13 ENSMUST00000062525.10 ENSMUSP00000050388.5
ENSMUSG00000048234.13 ENSMUST00000195136.1 ENSMUSP00000141667.1
ENSMUSG00000048234.13 ENSMUST00000195705.1 ENSMUSP00000141233.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.90e-06 29.4 265 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f  kd  ++lpC+H+fh+ C+  w         + +CP C+
   Q: 265  CAVCIENFkvKDVIRILPCKHIFHRICIDPW------LLDHRTCPMCK 306
           ********9988899****************......9999******6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
 E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Protein Sequence
(Fasta)
MAARRRPAAG VGARDALAVL ALALCTPGVG GGALEWYSAM VSIEYVDPQS NLTVWSVSES 60
GRFGESSLRE ERQGLVGVPR APAPAEGCAP DTRFVAPGAL GNAPWVALVA RGGCTFKDKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063545|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGTCCGCCC CCGCCGCGCT CGGCGGTCTC TCGCGAGCCG CCGCCGTCTC CTCAAAGCTG 60
TGGGCCAGCC TGGAGTGAGT CGCCTCGTTC TGACTCGCGC TCTTCTTCCT CAGTAGCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063545|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035690--P:cellular response to drug
GO:0043409--P:negative regulation of MAPK cascade
GO:0031647--P:regulation of protein stability
KEGG mmu:67702
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001968 Ailuropoda melanoleuca 77.99 1.00e-160 559.00
IUUC-Apl-004109 Anas platyrhynchos 70.61 7.00e-100 356.00
IUUC-Bta-012340 Bos taurus 75.00 6.00e-154 536.00
IUUC-Cja-019566 Callithrix jacchus 75.27 1.00e-159 555.00
IUUC-Cfa-020289 Canis familiaris 80.17 1.00e-107 382.00
IUUC-Cpo-021916 Cavia porcellus 66.03 9.00e-76 276.00
IUUC-Csa-024084 Chlorocebus sabaeus 76.92 6.00e-157 546.00
IUUC-Cho-024305 Choloepus hoffmanni 77.35 9.00e-124 436.00
IUUC-Cgl-026578 Colletotrichum gloeosporioides 48.08 3.00e-12 66.20
IUUC-Dno-030098 Dasypus novemcinctus 76.83 2.00e-165 575.00
IUUC-Dor-030620 Dipodomys ordii 74.54 1.00e-144 506.00
IUUC-Ete-032306 Echinops telfairi 78.06 3.00e-157 548.00
IUUC-Fca-035950 Felis catus 79.75 5.00e-111 393.00
IUUC-Fal-037429 Ficedula albicollis 65.94 7.00e-131 460.00
IUUC-Fox-038011 Fusarium oxysporum 41.10 2.00e-13 70.50
IUUC-Fso-038141 Fusarium solani 43.53 4.00e-16 79.30
IUUC-Gga-041201 Gallus gallus 63.85 5.00e-129 454.00
IUUC-Ggo-045429 Gorilla gorilla 77.44 1.00e-154 539.00
IUUC-Hsa-046191 Homo sapiens 75.75 8.00e-161 559.00
IUUC-Itr-048018 Ictidomys tridecemlineatus 78.59 1.00e-146 512.00
IUUC-Lch-049498 Latimeria chalumnae 60.16 5.00e-128 451.00
IUUC-Laf-054239 Loxodonta africana 69.63 5.00e-124 437.00
IUUC-Meu-056382 Macropus eugenii 70.95 1.00e-142 499.00
IUUC-Mor-056917 Magnaporthe oryzae 39.08 5.00e-13 69.30
IUUC-Mla-058935 Melampsora laricipopulina 36.59 2.00e-08 54.70
IUUC-Mga-059435 Meleagris gallopavo 70.59 2.00e-68 251.00
IUUC-Mmr-061513 Microcebus murinus 77.13 3.00e-159 554.00
IUUC-Mdo-063028 Monodelphis domestica 70.03 3.00e-145 508.00
IUUC-Mpu-066370 Mustela putorius furo 78.09 1.00e-160 559.00
IUUC-Mlu-067271 Myotis lucifugus 71.47 7.00e-126 443.00
IUUC-Nle-069207 Nomascus leucogenys 77.27 3.00e-161 561.00
IUUC-Opr-070704 Ochotona princeps 72.54 5.00e-95 340.00
IUUC-Oan-072837 Ornithorhynchus anatinus 66.94 2.00e-134 471.00
IUUC-Ocu-074671 Oryctolagus cuniculus 78.45 1.00e-119 422.00
IUUC-Oga-089083 Otolemur garnettii 76.83 3.00e-164 571.00
IUUC-Oar-089254 Ovis aries 76.61 4.00e-106 377.00
IUUC-Ptr-090940 Pan troglodytes 77.45 1.00e-158 552.00
IUUC-Pan-092636 Papio anubis 76.37 3.00e-156 544.00
IUUC-Psi-093435 Pelodiscus sinensis 73.08 3.00e-92 331.00
IUUC-Pab-098525 Pongo abelii 77.84 1.00e-156 546.00
IUUC-Pva-102395 Pteropus vampyrus 74.69 1.00e-158 552.00
IUUC-Pgr-103263 Puccinia graminis 42.47 1.00e-10 62.40
IUUC-Rno-105789 Rattus norvegicus 95.28 0.00e+00 645.00
IUUC-Sha-107305 Sarcophilus harrisii 74.44 4.00e-95 340.00
IUUC-Ssc-115598 Sus scrofa 76.49 2.00e-153 535.00
IUUC-Tgu-116463 Taeniopygia guttata 65.35 1.00e-124 439.00
IUUC-Tsy-118915 Tarsius syrichta 77.55 3.00e-105 374.00
IUUC-Tme-126970 Tuber melanosporum 49.06 1.00e-12 68.20
IUUC-Tbe-127906 Tupaia belangeri 64.05 3.00e-79 287.00
Created Date 25-Jun-2017

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