iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037275

Ensembl Protein ID

ENSFALP00000002438.1

UniProt Accession

U3JI34; U3JI34_FICAL

Genbank Protein ID

ENSFALP00000002438

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01021270

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002335.1	ENSFALT00000002450.1	ENSFALP00000002438.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-131	438.0	408	740

Active Site

Position(s)	Description	Evidence
709	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 408  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 495
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 496  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 580
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 581  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKH-CTPDSNIVKWFWKAVELFDEERRARLLQFV 668
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P Y+s+e+l+ekLl+Aieet gF +
   Q: 669  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPAYESYEKLYEKLLTAIEETCGFAV 740
           **********************************************************************76 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

ISVFLAVLCA KNLVKKDFFR LPDPFAKVVV DGSGQCHSTD TVKNTLDPKW NQHYDLYIGK 60
SDSITISVWN HKKIHKKQGA GFLGCVRLLS NAINRLKDTG YQRLDLCKLG PNDNDTVRGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCTGTTT TTCTTGCAGT ACTGTGTGCA AAAAACTTGG TGAAAAAGGA CTTTTTCCGT 60
AAGTAGCTGC TGTAGTTTTA TACATTTATT TATAGATGGA ATAAATACTA TGCAAGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	97.16	0.00e+00	1469.00
IUUC-Apl-003513	Anas platyrhynchos	97.69	0.00e+00	1497.00
IUUC-Aca-005358	Anolis carolinensis	97.98	0.00e+00	1486.00
IUUC-Aly-006083	Arabidopsis lyrata	45.62	4.00e-92	335.00
IUUC-Ath-007472	Arabidopsis thaliana	45.62	4.00e-92	334.00
IUUC-Ame-011320	Astyanax mexicanus	87.02	0.00e+00	1375.00
IUUC-Bta-013399	Bos taurus	97.28	0.00e+00	1465.00
IUUC-Cja-019355	Callithrix jacchus	97.03	0.00e+00	1467.00
IUUC-Cpo-022200	Cavia porcellus	97.43	0.00e+00	1471.00
IUUC-Cho-024804	Choloepus hoffmanni	98.06	0.00e+00	636.00
IUUC-Cin-025126	Ciona intestinalis	66.18	0.00e+00	968.00
IUUC-Csv-026339	Ciona savignyi	64.09	0.00e+00	999.00
IUUC-Dre-027650	Danio rerio	90.50	0.00e+00	1420.00
IUUC-Dno-029534	Dasypus novemcinctus	96.77	0.00e+00	1469.00
IUUC-Dme-031740	Drosophila melanogaster	72.16	4.00e-173	602.00
IUUC-Ete-032715	Echinops telfairi	92.52	0.00e+00	1377.00
IUUC-Eca-033580	Equus caballus	97.43	0.00e+00	1470.00
IUUC-Eeu-034945	Erinaceus europaeus	95.44	0.00e+00	1363.00
IUUC-Gga-041060	Gallus gallus	94.74	0.00e+00	1418.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.83	0.00e+00	1423.00
IUUC-Hsa-046726	Homo sapiens	96.90	0.00e+00	1469.00
IUUC-Lch-050026	Latimeria chalumnae	95.69	0.00e+00	1444.00
IUUC-Loc-051760	Lepisosteus oculatus	89.36	0.00e+00	1400.00
IUUC-Laf-053753	Loxodonta africana	97.29	0.00e+00	1467.00
IUUC-Mcc-054815	Macaca mulatta	96.63	0.00e+00	1465.00
IUUC-Meu-056436	Macropus eugenii	74.80	0.00e+00	1070.00
IUUC-Mmr-060806	Microcebus murinus	97.29	0.00e+00	1469.00
IUUC-Mdo-062805	Monodelphis domestica	95.55	0.00e+00	1447.00
IUUC-Mmu-064034	Mus musculus	96.36	0.00e+00	1462.00
IUUC-Mpu-066762	Mustela putorius furo	97.16	0.00e+00	1468.00
IUUC-Mlu-066981	Myotis lucifugus	97.29	0.00e+00	1466.00
IUUC-Nle-069804	Nomascus leucogenys	96.90	0.00e+00	1467.00
IUUC-Opr-070591	Ochotona princeps	91.97	0.00e+00	1367.00
IUUC-Ont-071239	Oreochromis niloticus	93.40	0.00e+00	1431.00
IUUC-Oan-072699	Ornithorhynchus anatinus	93.82	0.00e+00	1460.00
IUUC-Ocu-074913	Oryctolagus cuniculus	96.90	0.00e+00	1469.00
IUUC-Ola-086597	Oryzias latipes	85.71	0.00e+00	1309.00
IUUC-Oga-089116	Otolemur garnettii	93.89	0.00e+00	1406.00
IUUC-Oar-089366	Ovis aries	97.15	0.00e+00	1468.00
IUUC-Ptr-091382	Pan troglodytes	96.90	0.00e+00	1469.00
IUUC-Psi-093298	Pelodiscus sinensis	97.42	0.00e+00	1460.00
IUUC-Pma-094354	Petromyzon marinus	73.67	0.00e+00	1113.00
IUUC-Pfo-096071	Poecilia formosa	90.30	0.00e+00	1417.00
IUUC-Pab-098682	Pongo abelii	96.90	0.00e+00	1467.00
IUUC-Pop-099520	Populus trichocarpa	45.82	7.00e-93	337.00
IUUC-Pca-100516	Procavia capensis	89.24	0.00e+00	630.00
IUUC-Pva-102754	Pteropus vampyrus	96.33	0.00e+00	1431.00
IUUC-Rno-105600	Rattus norvegicus	97.35	0.00e+00	1268.00
IUUC-Sha-107144	Sarcophilus harrisii	96.36	0.00e+00	1342.00
IUUC-Sar-113122	Sorex araneus	86.26	0.00e+00	1252.00
IUUC-Tgu-117112	Taeniopygia guttata	98.52	0.00e+00	1492.00
IUUC-Tru-118497	Takifugu rubripes	89.99	0.00e+00	1362.00
IUUC-Tni-120781	Tetraodon nigroviridis	90.39	0.00e+00	1191.00
IUUC-Tme-126897	Tuber melanosporum	39.40	7.00e-151	527.00
IUUC-Tbe-127371	Tupaia belangeri	87.13	0.00e+00	1179.00
IUUC-Ttr-129305	Tursiops truncatus	90.31	0.00e+00	1263.00
IUUC-Vpa-130591	Vicugna pacos	87.07	0.00e+00	1270.00
IUUC-Xtr-132979	Xenopus tropicalis	77.78	0.00e+00	1104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence