iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001876

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01000087

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012828.1	ENSAMET00000014175.1	ENSAMEP00000013607.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-09	38.2	997	1103
E3 activity/N-recognin/N-domain	1.10e-39	134.5	129	204
E3 activity/N-recognin/UBR-box	2.80e-25	88.7	4	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC.......................................ledf........kdgplvlpCgHvfhadClqkw........... 29
           C++C                                       +           ++g+++++CgH++ha+C+q++           
   Q: 997  CILCqeeqevkveskamvlaafvqrstvlsknrskfiqdpaekY--DplfmhpdlSCGTHTGSCGHIMHAHCWQRYfdsvqakeqrr 1081
           88884444444444444444444444444433333333333321..02344444455899*************************** PP
   S: 30   ......pglknssskefrCPlC 45
                 + +++++++ef+CPlC
   Q: 1082 qqrlrlHTSYDVENGEFLCPLC 1103
           ********************** PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++n++++++ pLkV+v
   Q: 129  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQV 204
           9*********************************************************************.****98 PP

E3 activity/N-recognin/UBR-box

   S: 5    rvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
            ++k +et+   r+C+vd+t+vlC+eCf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 4    SMMKANETTKLYRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 70
           678999999999****************************************************996 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

LTGSMMKANE TTKLYRDCAV DPTCVLCMEC FLGSIHRDHR YRMTTSGGGG FCDCGDTEAW 60
KEGPYCQKHE LNTSEIEEEE CSCPLSEDVI ARTYNIFAIM FRYAVEILTW EKESELPADL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAACTGGCA GTATGATGAA AGCAAATGAA ACAACCAAAA TGAAATGAAA ATGTGATTTC 60
CCTGAATCTA GTATGAGATA TACACATCCA GTAGTGTGAG AAGCGGGTTC TTAAGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	30.60	2.00e-22	102.00
IUUC-Atr-002501	Amborella trichopoda	32.51	1.00e-26	116.00
IUUC-Apl-003828	Anas platyrhynchos	79.36	0.00e+00	2524.00
IUUC-Aca-005189	Anolis carolinensis	76.47	0.00e+00	2465.00
IUUC-Aly-005901	Arabidopsis lyrata	33.66	2.00e-25	112.00
IUUC-Ath-007148	Arabidopsis thaliana	32.20	3.00e-24	108.00
IUUC-Ago-007752	Ashbya gossypii	24.50	4.00e-26	114.00
IUUC-Ang-009550	Aspergillus niger	23.73	3.00e-40	161.00
IUUC-Ame-011917	Astyanax mexicanus	67.56	0.00e+00	2067.00
IUUC-Bta-012768	Bos taurus	85.36	0.00e+00	2710.00
IUUC-Bdi-014635	Brachypodium distachyon	26.33	7.00e-30	127.00
IUUC-Bol-015669	Brassica oleracea	33.33	1.00e-26	116.00
IUUC-Bra-017776	Brassica rapa	33.33	1.00e-26	116.00
IUUC-Cja-019797	Callithrix jacchus	83.50	0.00e+00	2206.00
IUUC-Cfa-020950	Canis familiaris	87.44	0.00e+00	2757.00
IUUC-Cpo-022385	Cavia porcellus	83.24	0.00e+00	2650.00
IUUC-Csa-024082	Chlorocebus sabaeus	85.59	0.00e+00	2697.00
IUUC-Cho-025029	Choloepus hoffmanni	75.34	0.00e+00	1626.00
IUUC-Dre-028343	Danio rerio	67.03	0.00e+00	2091.00
IUUC-Dno-030002	Dasypus novemcinctus	87.03	0.00e+00	1801.00
IUUC-Dor-030207	Dipodomys ordii	70.36	0.00e+00	1158.00
IUUC-Dse-031531	Dothistroma septosporum	22.79	1.00e-47	186.00
IUUC-Ete-033162	Echinops telfairi	74.33	0.00e+00	1139.00
IUUC-Eca-033454	Equus caballus	84.68	0.00e+00	2671.00
IUUC-Eeu-034783	Erinaceus europaeus	82.56	0.00e+00	1082.00
IUUC-Fca-036588	Felis catus	86.59	0.00e+00	2722.00
IUUC-Fal-036919	Ficedula albicollis	77.94	0.00e+00	2514.00
IUUC-Gmo-039698	Gadus morhua	64.06	0.00e+00	1308.00
IUUC-Gga-041123	Gallus gallus	80.01	0.00e+00	2547.00
IUUC-Gac-042622	Gasterosteus aculeatus	61.38	0.00e+00	1871.00
IUUC-Ggo-045583	Gorilla gorilla	83.50	0.00e+00	2660.00
IUUC-Hsa-046343	Homo sapiens	85.63	0.00e+00	2702.00
IUUC-Hvu-047707	Hordeum vulgare	30.60	8.00e-23	103.00
IUUC-Kpa-049088	Komagataella pastoris	23.64	2.00e-45	178.00
IUUC-Lch-049649	Latimeria chalumnae	68.47	0.00e+00	2117.00
IUUC-Lpe-051516	Leersia perrieri	26.25	1.00e-30	130.00
IUUC-Loc-052818	Lepisosteus oculatus	68.33	0.00e+00	2164.00
IUUC-Laf-054142	Loxodonta africana	83.86	0.00e+00	2664.00
IUUC-Mcc-055677	Macaca mulatta	85.29	0.00e+00	2685.00
IUUC-Meu-056204	Macropus eugenii	90.12	2.00e-154	540.00
IUUC-Mtr-058538	Medicago truncatula	33.33	1.00e-27	119.00
IUUC-Mla-058963	Melampsora laricipopulina	25.63	5.00e-49	190.00
IUUC-Mga-059698	Meleagris gallopavo	79.93	0.00e+00	2551.00
IUUC-Mvi-060535	Microbotryum violaceum	23.79	2.00e-45	178.00
IUUC-Mmr-060901	Microcebus murinus	82.06	0.00e+00	2591.00
IUUC-Mdo-062014	Monodelphis domestica	81.34	0.00e+00	2579.00
IUUC-Mmu-063699	Mus musculus	81.25	0.00e+00	2559.00
IUUC-Mpu-066153	Mustela putorius furo	87.68	0.00e+00	2758.00
IUUC-Mlu-068151	Myotis lucifugus	85.22	0.00e+00	2674.00
IUUC-Nle-069529	Nomascus leucogenys	85.09	0.00e+00	2689.00
IUUC-Opr-071107	Ochotona princeps	82.70	0.00e+00	1244.00
IUUC-Ont-072189	Oreochromis niloticus	61.71	0.00e+00	1841.00
IUUC-Oan-072893	Ornithorhynchus anatinus	80.66	0.00e+00	2561.00
IUUC-Ocu-074082	Oryctolagus cuniculus	82.89	0.00e+00	2628.00
IUUC-Ome-081738	Oryza meridionalis	25.00	3.00e-14	75.10
IUUC-Opu-083202	Oryza punctata	30.28	6.00e-27	117.00
IUUC-Ola-087460	Oryzias latipes	59.92	0.00e+00	1842.00
IUUC-Olu-087832	Ostreococcus lucimarinus	26.23	1.60e-01	32.00
IUUC-Oga-088432	Otolemur garnettii	84.67	0.00e+00	2704.00
IUUC-Oar-090206	Ovis aries	83.69	0.00e+00	2682.00
IUUC-Ptr-091180	Pan troglodytes	84.32	0.00e+00	2650.00
IUUC-Pan-092375	Papio anubis	85.53	0.00e+00	2697.00
IUUC-Psi-093049	Pelodiscus sinensis	79.47	0.00e+00	2491.00
IUUC-Pfo-096524	Poecilia formosa	59.83	0.00e+00	1802.00
IUUC-Pab-097989	Pongo abelii	83.24	0.00e+00	2603.00
IUUC-Pca-100207	Procavia capensis	71.81	0.00e+00	949.00
IUUC-Ppe-101802	Prunus persica	30.71	5.00e-27	117.00
IUUC-Pva-102538	Pteropus vampyrus	85.85	0.00e+00	1102.00
IUUC-Pgr-103372	Puccinia graminis	22.77	9.00e-50	193.00
IUUC-Ptt-103878	Puccinia triticina	23.47	9.00e-41	163.00
IUUC-Rno-105567	Rattus norvegicus	79.65	0.00e+00	2465.00
IUUC-Sce-106200	Saccharomyces cerevisiae	24.91	7.00e-17	84.00
IUUC-Sha-106980	Sarcophilus harrisii	81.09	0.00e+00	2564.00
IUUC-Spo-108084	Schizosaccharomyces pombe	23.20	1.00e-37	152.00
IUUC-Sit-110716	Setaria italica	26.95	1.00e-30	129.00
IUUC-Sar-113332	Sorex araneus	92.98	0.00e+00	1136.00
IUUC-Sbi-114577	Sorghum bicolor	31.34	2.00e-30	129.00
IUUC-Ssc-115525	Sus scrofa	84.51	0.00e+00	2012.00
IUUC-Tgu-116943	Taeniopygia guttata	79.82	0.00e+00	2538.00
IUUC-Tru-117673	Takifugu rubripes	60.73	0.00e+00	1852.00
IUUC-Tsy-119032	Tarsius syrichta	80.43	0.00e+00	1382.00
IUUC-Tni-119987	Tetraodon nigroviridis	60.81	0.00e+00	1816.00
IUUC-Tca-121077	Theobroma cacao	34.48	2.00e-26	115.00
IUUC-Tae-125501	Triticum aestivum	31.69	9.00e-28	119.00
IUUC-Tur-126562	Triticum urartu	31.53	1.00e-27	119.00
IUUC-Tbe-128103	Tupaia belangeri	86.47	0.00e+00	1018.00
IUUC-Ttr-128253	Tursiops truncatus	79.14	0.00e+00	2446.00
IUUC-Vpa-130540	Vicugna pacos	80.39	0.00e+00	2397.00
IUUC-Vvi-131290	Vitis vinifera	31.70	1.00e-28	123.00
IUUC-Xtr-132690	Xenopus tropicalis	74.01	0.00e+00	2353.00
IUUC-Xma-133748	Xiphophorus maculatus	60.79	0.00e+00	1464.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence