iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000016963.7	ENSRNOT00000022822.4	ENSRNOP00000022822.3
ENSRNOG00000016963.7	ENSRNOT00000079452.1	ENSRNOP00000068991.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-95	320.6	1659	2038

Active Site

Position(s)	Description	Evidence
2005	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1659 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1741
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1742 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1828
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1829 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLSHLQYF 1903
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1904 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1990
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei+++kLl+A +e+ ++F+ls
   Q: 1991 stENPDDFLPSVMTCVNYLKLPDYSSIEIMRDKLLIAAREGqQSFHLS 2038
           988888***************************************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK RKGYIPPESR KSNFKAPKVQ 60
SNTTSELSRG HLSKRSCSSS SAVIVPQPED PDRANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGCCGCCG CCGTCGCCGC CGCTGGGGGG GGTGGGGGGA GCCAGTGGAA GTTGCCGTCG 60
CGCCACGGAG TCCGGACCAG AGACTTTGGG GCCTAACTAG GTAATTGGGA CGCCGTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.83	2.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.74	0.00e+00	3575.00
IUUC-Atr-002821	Amborella trichopoda	37.45	6.00e-117	416.00
IUUC-Apl-003531	Anas platyrhynchos	89.69	0.00e+00	3284.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	6.00e-114	406.00
IUUC-Ath-006636	Arabidopsis thaliana	44.49	3.00e-113	404.00
IUUC-Ago-007875	Ashbya gossypii	36.20	2.00e-81	298.00
IUUC-Acl-008242	Aspergillus clavatus	35.70	3.00e-113	404.00
IUUC-Afl-008736	Aspergillus flavus	38.83	2.00e-110	394.00
IUUC-Afu-008812	Aspergillus fumigatus	34.95	2.00e-113	405.00
IUUC-Ani-009407	Aspergillus nidulans	36.67	6.00e-110	393.00
IUUC-Ang-009763	Aspergillus niger	39.82	1.00e-105	379.00
IUUC-Aor-009941	Aspergillus oryzae	30.77	1.00e-111	398.00
IUUC-Ate-010459	Aspergillus terreus	37.31	2.00e-85	311.00
IUUC-Ame-011761	Astyanax mexicanus	87.19	0.00e+00	2929.00
IUUC-Bgr-012265	Blumeria graminis	34.70	7.00e-104	372.00
IUUC-Bta-013070	Bos taurus	93.74	0.00e+00	3425.00
IUUC-Bci-013890	Botrytis cinerea	39.72	2.00e-102	368.00
IUUC-Bdi-014046	Brachypodium distachyon	38.76	6.00e-122	432.00
IUUC-Bol-015942	Brassica oleracea	44.23	3.00e-114	407.00
IUUC-Bra-016849	Brassica rapa	44.23	9.00e-114	405.00
IUUC-Cja-019046	Callithrix jacchus	94.64	0.00e+00	3519.00
IUUC-Cfa-020521	Canis familiaris	96.91	0.00e+00	3522.00
IUUC-Cpo-021639	Cavia porcellus	91.74	0.00e+00	3448.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	2.00e-89	322.00
IUUC-Csa-023231	Chlorocebus sabaeus	97.05	0.00e+00	3598.00
IUUC-Cho-024380	Choloepus hoffmanni	92.96	0.00e+00	2135.00
IUUC-Cin-025482	Ciona intestinalis	51.02	3.00e-159	555.00
IUUC-Csv-026121	Ciona savignyi	48.12	0.00e+00	1527.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	40.07	2.00e-110	394.00
IUUC-Cne-026857	Cryptococcus neoformans	39.77	2.00e-94	341.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.34	9.00e-75	276.00
IUUC-Dre-028174	Danio rerio	86.97	0.00e+00	2956.00
IUUC-Dor-030939	Dipodomys ordii	87.01	0.00e+00	2772.00
IUUC-Dse-031444	Dothistroma septosporum	39.11	6.00e-105	376.00
IUUC-Dme-032162	Drosophila melanogaster	60.00	0.00e+00	740.00
IUUC-Ete-032345	Echinops telfairi	90.35	0.00e+00	2272.00
IUUC-Eca-033229	Equus caballus	95.21	0.00e+00	3479.00
IUUC-Eeu-035205	Erinaceus europaeus	82.73	0.00e+00	2967.00
IUUC-Fca-036444	Felis catus	94.97	0.00e+00	3514.00
IUUC-Fal-037131	Ficedula albicollis	92.60	0.00e+00	3435.00
IUUC-Fox-038035	Fusarium oxysporum	36.91	3.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	37.07	3.00e-110	394.00
IUUC-Gmo-039497	Gadus morhua	78.75	0.00e+00	2965.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.05	3.00e-108	387.00
IUUC-Gga-041021	Gallus gallus	93.13	0.00e+00	3447.00
IUUC-Gac-042474	Gasterosteus aculeatus	79.48	0.00e+00	2974.00
IUUC-Gma-043060	Glycine max	39.06	9.00e-122	432.00
IUUC-Ggo-044855	Gorilla gorilla	94.64	0.00e+00	3518.00
IUUC-Hsa-046147	Homo sapiens	92.31	0.00e+00	3430.00
IUUC-Hvu-047775	Hordeum vulgare	38.83	1.00e-124	441.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.97	0.00e+00	3454.00
IUUC-Kpa-049098	Komagataella pastoris	38.10	2.00e-85	311.00
IUUC-Lch-049818	Latimeria chalumnae	83.50	0.00e+00	3015.00
IUUC-Lpe-051017	Leersia perrieri	38.44	2.00e-118	421.00
IUUC-Loc-051777	Lepisosteus oculatus	86.71	0.00e+00	3298.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	1.00e-111	398.00
IUUC-Laf-053727	Loxodonta africana	95.07	0.00e+00	3519.00
IUUC-Mcc-055799	Macaca mulatta	98.48	0.00e+00	3599.00
IUUC-Meu-056065	Macropus eugenii	93.96	0.00e+00	2082.00
IUUC-Mor-057054	Magnaporthe oryzae	34.55	2.00e-107	384.00
IUUC-Mpo-057417	Magnaporthe poae	39.55	3.00e-109	390.00
IUUC-Mtr-057849	Medicago truncatula	37.50	2.00e-113	404.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	2.00e-106	381.00
IUUC-Mga-059580	Meleagris gallopavo	91.22	0.00e+00	2907.00
IUUC-Mvi-060507	Microbotryum violaceum	40.00	2.00e-112	401.00
IUUC-Mmr-060816	Microcebus murinus	96.86	0.00e+00	3582.00
IUUC-Mdo-062866	Monodelphis domestica	95.90	0.00e+00	3435.00
IUUC-Mmu-063906	Mus musculus	95.55	0.00e+00	3544.00
IUUC-Mac-064675	Musa acuminata	41.08	6.00e-111	395.00
IUUC-Mpu-066199	Mustela putorius furo	98.09	0.00e+00	3579.00
IUUC-Mlu-067110	Myotis lucifugus	94.34	0.00e+00	3492.00
IUUC-Nfi-068482	Neosartorya fischeri	35.10	1.00e-113	405.00
IUUC-Ncr-068906	Neurospora crassa	39.13	7.00e-109	389.00
IUUC-Nle-069410	Nomascus leucogenys	95.36	0.00e+00	3507.00
IUUC-Opr-070401	Ochotona princeps	86.26	0.00e+00	1925.00
IUUC-Ont-072100	Oreochromis niloticus	82.19	0.00e+00	3067.00
IUUC-Oan-073121	Ornithorhynchus anatinus	93.28	0.00e+00	3567.00
IUUC-Ocu-074623	Oryctolagus cuniculus	97.94	0.00e+00	3609.00
IUUC-Oba-075380	Oryza barthii	40.77	9.00e-113	402.00
IUUC-Obr-076915	Oryza brachyantha	37.62	2.00e-118	421.00
IUUC-Ogl-077055	Oryza glaberrima	38.70	5.00e-118	419.00
IUUC-Ogu-078892	Oryza glumaepatula	40.77	3.00e-112	400.00
IUUC-Oin-079256	Oryza indica	38.52	6.00e-117	416.00
IUUC-Olo-080343	Oryza longistaminata	38.52	3.00e-117	417.00
IUUC-Ome-081422	Oryza meridionalis	38.24	9.00e-117	415.00
IUUC-Oni-083047	Oryza nivara	40.95	4.00e-114	406.00
IUUC-Opu-083641	Oryza punctata	40.40	7.00e-110	392.00
IUUC-Oru-084439	Oryza rufipogon	40.77	8.00e-113	402.00
IUUC-Osa-085972	Oryza sativa	38.44	3.00e-116	412.00
IUUC-Ola-087173	Oryzias latipes	80.49	0.00e+00	3001.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	2.00e-88	319.00
IUUC-Oga-087908	Otolemur garnettii	94.54	0.00e+00	3518.00
IUUC-Oar-090277	Ovis aries	95.66	0.00e+00	3496.00
IUUC-Ptr-091543	Pan troglodytes	92.36	0.00e+00	3434.00
IUUC-Pan-092243	Papio anubis	98.48	0.00e+00	3599.00
IUUC-Psi-093150	Pelodiscus sinensis	92.07	0.00e+00	3469.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.90	1.00e-112	402.00
IUUC-Ppa-095181	Physcomitrella patens	37.10	2.00e-107	383.00
IUUC-Pfo-096267	Poecilia formosa	81.61	0.00e+00	3022.00
IUUC-Pab-098072	Pongo abelii	95.65	0.00e+00	3519.00
IUUC-Pop-099190	Populus trichocarpa	41.34	1.00e-115	412.00
IUUC-Pca-100311	Procavia capensis	88.42	0.00e+00	3152.00
IUUC-Ppe-101284	Prunus persica	37.66	4.00e-116	413.00
IUUC-Pva-102215	Pteropus vampyrus	90.37	0.00e+00	1262.00
IUUC-Pgr-103694	Puccinia graminis	40.48	7.00e-104	373.00
IUUC-Ptt-103916	Puccinia triticina	38.80	8.00e-98	353.00
IUUC-Pte-104346	Pyrenophora teres	39.41	1.00e-109	392.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	6.00e-110	393.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.00	8.00e-71	262.00
IUUC-Sha-106835	Sarcophilus harrisii	94.92	0.00e+00	3589.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.58	4.00e-94	340.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.54	2.00e-94	341.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.92	6.00e-106	379.00
IUUC-Smo-109590	Selaginella moellendorffii	42.91	2.00e-111	397.00
IUUC-Sit-110717	Setaria italica	37.80	2.00e-119	424.00
IUUC-Sly-111469	Solanum lycopersicum	39.26	5.00e-122	433.00
IUUC-Stu-112896	Solanum tuberosum	38.36	8.00e-106	378.00
IUUC-Sar-113224	Sorex araneus	83.04	0.00e+00	1783.00
IUUC-Sbi-114313	Sorghum bicolor	38.16	2.00e-123	437.00
IUUC-Sre-114993	Sporisorium reilianum	33.95	4.00e-100	360.00
IUUC-Ssc-115535	Sus scrofa	90.45	0.00e+00	3365.00
IUUC-Tgu-117493	Taeniopygia guttata	90.48	0.00e+00	2640.00
IUUC-Tru-118669	Takifugu rubripes	79.67	0.00e+00	2966.00
IUUC-Tsy-119373	Tarsius syrichta	94.18	0.00e+00	1838.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.80	0.00e+00	867.00
IUUC-Tca-121779	Theobroma cacao	38.76	5.00e-115	410.00
IUUC-Tre-122195	Trichoderma reesei	36.05	3.00e-105	377.00
IUUC-Tvi-122650	Trichoderma virens	36.32	6.00e-109	389.00
IUUC-Tae-123580	Triticum aestivum	38.73	2.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.69	4.00e-125	443.00
IUUC-Tme-126964	Tuber melanosporum	40.48	2.00e-105	378.00
IUUC-Tbe-128149	Tupaia belangeri	81.42	0.00e+00	1446.00
IUUC-Ttr-128165	Tursiops truncatus	94.66	0.00e+00	3024.00
IUUC-Uma-129365	Ustilago maydis	35.89	3.00e-88	321.00
IUUC-Vda-129725	Verticillium dahliae	41.08	9.00e-109	389.00
IUUC-Vpa-130678	Vicugna pacos	96.58	0.00e+00	2646.00
IUUC-Vvi-131147	Vitis vinifera	39.09	7.00e-122	432.00
IUUC-Xtr-132636	Xenopus tropicalis	85.47	0.00e+00	3170.00
IUUC-Xma-133458	Xiphophorus maculatus	82.04	0.00e+00	3061.00
IUUC-Yli-134481	Yarrowia lipolytica	39.36	2.00e-97	351.00
IUUC-Zma-135782	Zea mays	38.01	6.00e-118	419.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence