iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000162191.13	ENST00000294119.6	ENSP00000294119.2
ENSG00000162191.13	ENST00000301935.9	ENSP00000303991.5
ENSG00000162191.13	ENST00000533000.5	ENSP00000432189.1
ENSG00000162191.13	ENST00000529640.5	ENSP00000435964.1
ENSG00000162191.13	ENST00000616865.4	ENSP00000478250.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15362974; 20351172
ULD/UDP/UFD/UBX	UBX	15362974; 21135095

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.60e-08	36.1	4	42
ULD/UDP/UFD/UBX	3.50e-20	74.0	210	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
             +le l+eMGF+r +a +aL+ + n  +eaA+++L+++
   Q: 4    LTALESLIEMGFPRGRAEKALALTgNQGIEAAMDWLMEH 42
           5689********************************987 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve....yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++q+++q+RlpdG  l+++F+++++l +++ +ve    ++l+  +dp +L+s+fPrr +++ ++++ lqe+gLvps++l+v
   Q: 210  EYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVElhrgEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIV 291
           578*****************************************************************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1.

Protein Sequence
(Fasta)

MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLGHIL 60
GREPTSSEQG GLEGSGSAAG EGKPALSEEE RQEQTKRMLE LVAQKQRERE EREEREALER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTGACCCA AACAGATCCG GCACTTCCGC TTCCCCTCGG CTTTCTTCTC GTCGGTGTTC 60
CCGGCTGCTA TAGAGCCGGG TGAGAGAGCG AGCGCCCGTC GGCGGGTGTC GAGGGCGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50030--UBA
PS50033--UBX

Pfam

PF00627--UBA
PF00789--UBX

SMART

SM00165--UBA
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005783--C:endoplasmic reticulum
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0051117--F:ATPase binding
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071796--F:K6-linked polyubiquitin binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1904293--P:negative regulation of ERAD pathway
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903094--P:negative regulation of protein K48-linked deubiquitination
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000157--P:negative regulation of ubiquitin-specific protease activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006457--P:protein folding

KEGG

hsa:51035

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002325	Ailuropoda melanoleuca	92.52	2.00e-113	401.00
IUUC-Atr-002867	Amborella trichopoda	33.33	8.00e-10	58.50
IUUC-Aca-004329	Anolis carolinensis	71.43	3.00e-48	184.00
IUUC-Aly-005639	Arabidopsis lyrata	41.67	3.00e-12	66.60
IUUC-Ath-006887	Arabidopsis thaliana	42.86	1.00e-12	67.80
IUUC-Ago-007989	Ashbya gossypii	37.18	1.00e-06	47.00
IUUC-Ame-011399	Astyanax mexicanus	53.09	6.00e-61	227.00
IUUC-Bta-013151	Bos taurus	93.92	3.00e-119	421.00
IUUC-Bol-016537	Brassica oleracea	41.67	1.00e-11	64.30
IUUC-Bra-017906	Brassica rapa	59.09	3.00e-11	63.90
IUUC-Cel-018300	Caenorhabditis elegans	34.85	1.00e-13	70.10
IUUC-Cja-019084	Callithrix jacchus	97.89	2.00e-104	372.00
IUUC-Cfa-020997	Canis familiaris	89.08	4.00e-90	324.00
IUUC-Cpo-021736	Cavia porcellus	78.11	8.00e-80	290.00
IUUC-Csa-024040	Chlorocebus sabaeus	98.99	2.00e-103	369.00
IUUC-Cho-024543	Choloepus hoffmanni	95.05	8.00e-64	236.00
IUUC-Cin-025719	Ciona intestinalis	39.12	1.00e-35	143.00
IUUC-Csv-025854	Ciona savignyi	37.33	1.00e-34	140.00
IUUC-Cme-027235	Cyanidioschyzon merolae	47.73	4.00e-08	52.80
IUUC-Dre-027745	Danio rerio	51.66	1.00e-58	219.00
IUUC-Dno-029598	Dasypus novemcinctus	93.27	1.00e-104	372.00
IUUC-Dor-030917	Dipodomys ordii	81.69	1.00e-89	322.00
IUUC-Dme-032055	Drosophila melanogaster	43.03	2.00e-23	102.00
IUUC-Ete-032960	Echinops telfairi	74.47	3.00e-71	261.00
IUUC-Eca-034294	Equus caballus	94.28	1.00e-107	382.00
IUUC-Eeu-034906	Erinaceus europaeus	89.82	1.00e-97	349.00
IUUC-Fca-035653	Felis catus	90.85	2.00e-96	345.00
IUUC-Gmo-038755	Gadus morhua	48.06	2.00e-52	199.00
IUUC-Gac-042481	Gasterosteus aculeatus	53.23	2.00e-57	216.00
IUUC-Ggo-044821	Gorilla gorilla	98.24	2.00e-96	345.00
IUUC-Itr-048850	Ictidomys tridecemlineatus	94.61	8.00e-115	406.00
IUUC-Lch-049508	Latimeria chalumnae	67.37	6.00e-33	134.00
IUUC-Laf-053932	Loxodonta africana	94.95	2.00e-125	441.00
IUUC-Mcc-055300	Macaca mulatta	98.65	2.00e-103	368.00
IUUC-Mtr-058774	Medicago truncatula	50.00	1.00e-09	57.40
IUUC-Mvi-060245	Microbotryum violaceum	42.17	1.00e-11	63.90
IUUC-Mmr-060979	Microcebus murinus	93.94	2.00e-107	382.00
IUUC-Mdo-062299	Monodelphis domestica	86.62	9.00e-94	336.00
IUUC-Mmu-063212	Mus musculus	92.93	5.00e-110	390.00
IUUC-Mac-065072	Musa acuminata	60.53	1.00e-10	60.80
IUUC-Mpu-066540	Mustela putorius furo	92.93	1.00e-115	409.00
IUUC-Mlu-067589	Myotis lucifugus	90.24	4.00e-105	374.00
IUUC-Nle-069045	Nomascus leucogenys	98.79	2.00e-77	281.00
IUUC-Opr-070772	Ochotona princeps	87.58	4.00e-89	321.00
IUUC-Ont-072006	Oreochromis niloticus	53.50	2.00e-57	216.00
IUUC-Oan-073244	Ornithorhynchus anatinus	86.08	1.00e-34	139.00
IUUC-Ocu-074333	Oryctolagus cuniculus	94.95	3.00e-106	377.00
IUUC-Oba-075451	Oryza barthii	50.94	5.00e-11	62.40
IUUC-Obr-076923	Oryza brachyantha	55.10	2.00e-11	63.50
IUUC-Ogl-077259	Oryza glaberrima	38.36	4.00e-10	59.30
IUUC-Ogu-078589	Oryza glumaepatula	50.94	5.00e-11	62.40
IUUC-Ome-081253	Oryza meridionalis	50.94	4.00e-11	62.80
IUUC-Oni-082110	Oryza nivara	38.36	1.00e-10	60.50
IUUC-Opu-083336	Oryza punctata	50.94	5.00e-11	62.40
IUUC-Oru-085235	Oryza rufipogon	50.94	5.00e-11	62.40
IUUC-Osa-085611	Oryza sativa	50.94	5.00e-11	62.40
IUUC-Ola-086781	Oryzias latipes	54.69	8.00e-56	210.00
IUUC-Oga-088429	Otolemur garnettii	95.62	5.00e-105	374.00
IUUC-Oar-089885	Ovis aries	93.58	2.00e-119	421.00
IUUC-Ptr-091315	Pan troglodytes	99.29	4.00e-98	351.00
IUUC-Pan-092885	Papio anubis	98.99	2.00e-103	369.00
IUUC-Psi-093299	Pelodiscus sinensis	71.90	4.00e-63	234.00
IUUC-Pma-094221	Petromyzon marinus	64.37	2.00e-28	117.00
IUUC-Ppa-095484	Physcomitrella patens	51.11	2.00e-10	60.10
IUUC-Pfo-096188	Poecilia formosa	52.92	2.00e-54	206.00
IUUC-Pab-097881	Pongo abelii	91.58	8.00e-102	363.00
IUUC-Pop-098863	Populus trichocarpa	52.94	1.00e-11	64.70
IUUC-Pca-100977	Procavia capensis	94.33	7.00e-101	360.00
IUUC-Ppe-101243	Prunus persica	47.06	9.00e-10	57.80
IUUC-Pva-102169	Pteropus vampyrus	94.37	4.00e-99	354.00
IUUC-Rno-105459	Rattus norvegicus	92.59	9.00e-110	389.00
IUUC-Sha-107526	Sarcophilus harrisii	88.55	6.00e-93	333.00
IUUC-Ssl-108389	Sclerotinia sclerotiorum	25.74	5.00e-06	45.80
IUUC-Sit-110434	Setaria italica	35.23	2.00e-09	56.60
IUUC-Sar-112945	Sorex araneus	92.64	5.00e-65	240.00
IUUC-Sbi-114159	Sorghum bicolor	33.33	2.00e-10	60.10
IUUC-Ssc-116114	Sus scrofa	95.62	5.00e-105	374.00
IUUC-Tru-117839	Takifugu rubripes	52.27	4.00e-54	204.00
IUUC-Tsy-118813	Tarsius syrichta	72.18	3.00e-92	331.00
IUUC-Tni-120504	Tetraodon nigroviridis	53.95	6.00e-55	207.00
IUUC-Tbe-128034	Tupaia belangeri	94.37	9.00e-106	376.00
IUUC-Ttr-128468	Tursiops truncatus	89.19	6.00e-106	377.00
IUUC-Uma-129569	Ustilago maydis	34.62	2.00e-05	43.10
IUUC-Vpa-130179	Vicugna pacos	88.31	1.00e-70	259.00
IUUC-Xtr-132119	Xenopus tropicalis	62.75	8.00e-69	253.00
IUUC-Xma-134067	Xiphophorus maculatus	52.27	2.00e-54	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence