iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-07	32.2	15	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl  f + p+ lpC+H f++ C+ ++w     + s+  rCP C+
   Q: 15   CPICLHVFVE-PVQLPCKHNFCRGCIgEAW----AKDSGLVRCPECN 56
           ********99.999****************....889*********7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN 60
QKPGLEKNLK LTNIVEKFNA LHVEKPPTAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGAGCCTC CTGTTCATTA GCAGTTGAGA AAAATTCCTT TCTAGTTTGA TCAATCCTTG 60
TTTTCCTCAG CGCAGGCGAG GCGCCCGCCC AGCGCGGGGA CAGGGAGTGG GGTCTCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016605--C:PML body
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0019827--P:stem cell population maintenance

KEGG

rno:688785

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001258	Ailuropoda melanoleuca	98.91	0.00e+00	1126.00
IUUC-Apl-004223	Anas platyrhynchos	85.87	0.00e+00	991.00
IUUC-Aca-005106	Anolis carolinensis	85.48	0.00e+00	1011.00
IUUC-Ame-011348	Astyanax mexicanus	66.96	0.00e+00	759.00
IUUC-Bta-012787	Bos taurus	98.55	0.00e+00	1124.00
IUUC-Cja-019471	Callithrix jacchus	98.37	0.00e+00	1123.00
IUUC-Cfa-020052	Canis familiaris	99.09	0.00e+00	1130.00
IUUC-Cpo-022491	Cavia porcellus	96.42	0.00e+00	718.00
IUUC-Csa-023544	Chlorocebus sabaeus	98.37	0.00e+00	1122.00
IUUC-Dre-028013	Danio rerio	67.38	0.00e+00	771.00
IUUC-Dno-029676	Dasypus novemcinctus	98.19	0.00e+00	1123.00
IUUC-Dor-030402	Dipodomys ordii	97.10	0.00e+00	1111.00
IUUC-Ete-033188	Echinops telfairi	89.33	0.00e+00	1008.00
IUUC-Eca-033524	Equus caballus	98.01	0.00e+00	1114.00
IUUC-Eeu-034979	Erinaceus europaeus	97.61	3.00e-143	501.00
IUUC-Fca-036362	Felis catus	98.73	0.00e+00	1124.00
IUUC-Fal-036652	Ficedula albicollis	84.44	0.00e+00	971.00
IUUC-Gmo-039405	Gadus morhua	60.64	0.00e+00	652.00
IUUC-Gga-040813	Gallus gallus	85.66	0.00e+00	992.00
IUUC-Gac-041792	Gasterosteus aculeatus	64.30	0.00e+00	657.00
IUUC-Ggo-044962	Gorilla gorilla	98.00	0.00e+00	1119.00
IUUC-Hsa-046158	Homo sapiens	97.82	0.00e+00	1117.00
IUUC-Itr-048118	Ictidomys tridecemlineatus	98.19	0.00e+00	1120.00
IUUC-Lch-049433	Latimeria chalumnae	79.29	0.00e+00	874.00
IUUC-Loc-052026	Lepisosteus oculatus	76.12	0.00e+00	877.00
IUUC-Laf-054159	Loxodonta africana	95.68	0.00e+00	899.00
IUUC-Mcc-055490	Macaca mulatta	98.37	0.00e+00	1122.00
IUUC-Meu-056549	Macropus eugenii	89.49	0.00e+00	744.00
IUUC-Mga-059334	Meleagris gallopavo	85.84	0.00e+00	988.00
IUUC-Mmr-061672	Microcebus murinus	98.37	0.00e+00	1122.00
IUUC-Mdo-061849	Monodelphis domestica	89.74	0.00e+00	931.00
IUUC-Mmu-063537	Mus musculus	98.73	0.00e+00	1125.00
IUUC-Mpu-065762	Mustela putorius furo	98.91	0.00e+00	1128.00
IUUC-Mlu-066979	Myotis lucifugus	94.85	0.00e+00	749.00
IUUC-Nle-069419	Nomascus leucogenys	98.00	0.00e+00	1119.00
IUUC-Opr-070981	Ochotona princeps	98.19	0.00e+00	1122.00
IUUC-Ont-072053	Oreochromis niloticus	59.39	2.00e-176	612.00
IUUC-Oan-073608	Ornithorhynchus anatinus	86.53	0.00e+00	827.00
IUUC-Ocu-074694	Oryctolagus cuniculus	98.00	0.00e+00	1082.00
IUUC-Ola-086949	Oryzias latipes	60.56	1.00e-177	616.00
IUUC-Oga-089175	Otolemur garnettii	98.19	0.00e+00	1122.00
IUUC-Oar-089591	Ovis aries	88.50	0.00e+00	886.00
IUUC-Ptr-091309	Pan troglodytes	96.91	0.00e+00	1083.00
IUUC-Pan-091903	Papio anubis	98.37	0.00e+00	1122.00
IUUC-Psi-093293	Pelodiscus sinensis	83.96	0.00e+00	971.00
IUUC-Pfo-097191	Poecilia formosa	60.49	1.00e-174	606.00
IUUC-Pab-098251	Pongo abelii	94.56	0.00e+00	1067.00
IUUC-Pca-100504	Procavia capensis	98.37	0.00e+00	1124.00
IUUC-Pva-102320	Pteropus vampyrus	98.37	0.00e+00	1079.00
IUUC-Ssc-116121	Sus scrofa	98.55	0.00e+00	1124.00
IUUC-Tgu-116724	Taeniopygia guttata	85.66	0.00e+00	986.00
IUUC-Tru-118048	Takifugu rubripes	59.59	4.00e-180	624.00
IUUC-Tni-120856	Tetraodon nigroviridis	60.50	6.00e-172	597.00
IUUC-Tbe-127400	Tupaia belangeri	85.56	3.00e-165	574.00
IUUC-Ttr-128233	Tursiops truncatus	97.64	0.00e+00	1100.00
IUUC-Xtr-132578	Xenopus tropicalis	83.85	0.00e+00	970.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence