iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000120925.14	ENST00000319104.7	ENSP00000326138.3
ENSG00000120925.14	ENST00000527424.5	ENSP00000434797.1
ENSG00000120925.14	ENST00000240159.8	ENSP00000240159.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
TRANSFAC	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21115467; 25882839

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.80e-05	25.0	87	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskef....rCPlCr 46
           C+iCl   +  p+ ++CgH+f+  C+   w       ++++    +CP+Cr
   Q: 87   CPICLHQASF-PVETNCGHLFCGACIiAYW------RYGSWlgaiSCPICR 130
           ****986655.999***********97777......5555533337****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.

Protein Sequence
(Fasta)

MAKYQGEVQS LKLDDDSVIE GVSDQVLVAV VVSFALIATL VYALFRNVHQ NIHPENQELV 60
RVLREQLQTE QDAPAATRQQ FYTDMYCPIC LHQASFPVET NCGHLFCGAC IIAYWRYGSW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCACCGTCG CCCGCAGCGC TCGCCCCACG GGCCGCGCGT GGAGGGTCCC GGTAGGTGGC 60
GGGGGGAGGG GGTCTTCCCG CCGGCCCGCG GCCCCCACGT ACCCAAGTGA GGAGGCTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR010652--DUF1232
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF06803--DUF1232
PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:81790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000837	Aegilops tauschii	34.76	1.00e-21	96.30
IUUC-Aml-002276	Ailuropoda melanoleuca	95.74	6.00e-125	439.00
IUUC-Atr-003163	Amborella trichopoda	36.93	4.00e-28	117.00
IUUC-Apl-003771	Anas platyrhynchos	77.13	4.00e-101	360.00
IUUC-Aca-004706	Anolis carolinensis	74.81	1.00e-94	338.00
IUUC-Aly-006202	Arabidopsis lyrata	40.74	6.00e-19	87.00
IUUC-Ath-007325	Arabidopsis thaliana	35.47	9.00e-25	106.00
IUUC-Ame-011453	Astyanax mexicanus	68.60	4.00e-96	343.00
IUUC-Bta-013272	Bos taurus	94.98	1.00e-120	425.00
IUUC-Bdi-014259	Brachypodium distachyon	36.00	7.00e-26	110.00
IUUC-Bol-016302	Brassica oleracea	35.23	2.00e-25	108.00
IUUC-Bra-017738	Brassica rapa	34.50	2.00e-24	105.00
IUUC-Cel-018593	Caenorhabditis elegans	34.85	9.00e-28	117.00
IUUC-Cja-019253	Callithrix jacchus	98.45	4.00e-128	450.00
IUUC-Cfa-020844	Canis familiaris	96.89	5.00e-126	445.00
IUUC-Cpo-021645	Cavia porcellus	96.12	2.00e-125	441.00
IUUC-Csa-024012	Chlorocebus sabaeus	99.22	3.00e-129	454.00
IUUC-Cho-024304	Choloepus hoffmanni	75.97	1.00e-91	329.00
IUUC-Cin-025256	Ciona intestinalis	46.33	4.00e-57	214.00
IUUC-Dre-028166	Danio rerio	68.49	5.00e-79	287.00
IUUC-Dno-029494	Dasypus novemcinctus	96.12	2.00e-125	441.00
IUUC-Dor-030259	Dipodomys ordii	96.90	2.00e-126	444.00
IUUC-Ete-032614	Echinops telfairi	83.72	6.00e-100	356.00
IUUC-Eca-033557	Equus caballus	95.74	6.00e-124	436.00
IUUC-Eeu-035324	Erinaceus europaeus	98.88	5.00e-31	128.00
IUUC-Fca-035812	Felis catus	96.12	9.00e-125	439.00
IUUC-Fal-036654	Ficedula albicollis	81.40	6.00e-110	390.00
IUUC-Gmo-039635	Gadus morhua	67.31	3.00e-91	328.00
IUUC-Gga-040345	Gallus gallus	80.62	4.00e-109	387.00
IUUC-Gac-041668	Gasterosteus aculeatus	65.90	9.00e-89	319.00
IUUC-Gma-043890	Glycine max	34.88	4.00e-25	107.00
IUUC-Ggo-045000	Gorilla gorilla	99.22	3.00e-129	454.00
IUUC-Hvu-047464	Hordeum vulgare	36.57	2.00e-26	112.00
IUUC-Itr-048988	Ictidomys tridecemlineatus	97.29	5.00e-127	446.00
IUUC-Lch-049846	Latimeria chalumnae	78.45	3.00e-62	230.00
IUUC-Loc-051785	Lepisosteus oculatus	69.32	4.00e-106	377.00
IUUC-Laf-054542	Loxodonta africana	91.47	7.00e-117	413.00
IUUC-Mcc-055234	Macaca mulatta	99.22	3.00e-129	454.00
IUUC-Meu-056544	Macropus eugenii	69.77	5.00e-75	273.00
IUUC-Mtr-057996	Medicago truncatula	32.43	5.00e-18	84.00
IUUC-Mmr-060609	Microcebus murinus	95.74	8.00e-132	462.00
IUUC-Mdo-062853	Monodelphis domestica	88.37	9.00e-120	422.00
IUUC-Mmu-064383	Mus musculus	90.70	1.00e-111	396.00
IUUC-Mac-065250	Musa acuminata	36.42	1.00e-27	115.00
IUUC-Mlu-067410	Myotis lucifugus	94.96	1.00e-123	435.00
IUUC-Nle-069537	Nomascus leucogenys	98.85	4.00e-86	310.00
IUUC-Opr-070637	Ochotona princeps	96.00	7.00e-67	247.00
IUUC-Ont-071800	Oreochromis niloticus	67.18	1.00e-84	306.00
IUUC-Oan-073190	Ornithorhynchus anatinus	87.60	7.00e-119	420.00
IUUC-Ocu-073899	Oryctolagus cuniculus	98.06	6.00e-127	446.00
IUUC-Obr-076075	Oryza brachyantha	36.36	1.00e-23	102.00
IUUC-Oin-079850	Oryza indica	34.51	2.00e-23	102.00
IUUC-Ome-081191	Oryza meridionalis	35.21	7.00e-23	100.00
IUUC-Oni-082886	Oryza nivara	34.51	1.00e-23	102.00
IUUC-Osa-085833	Oryza sativa	34.51	2.00e-23	102.00
IUUC-Ola-086372	Oryzias latipes	68.32	1.00e-88	319.00
IUUC-Oga-087988	Otolemur garnettii	97.67	2.00e-123	434.00
IUUC-Oar-089976	Ovis aries	94.21	5.00e-120	423.00
IUUC-Ptr-091377	Pan troglodytes	98.84	3.00e-129	454.00
IUUC-Pan-092348	Papio anubis	98.84	2.00e-128	451.00
IUUC-Psi-092982	Pelodiscus sinensis	80.23	3.00e-102	364.00
IUUC-Ppa-095627	Physcomitrella patens	31.91	6.00e-23	101.00
IUUC-Pfo-096366	Poecilia formosa	66.79	1.00e-85	309.00
IUUC-Pab-098242	Pongo abelii	99.53	5.00e-111	393.00
IUUC-Pop-099622	Populus trichocarpa	28.81	1.00e-20	92.80
IUUC-Pca-100637	Procavia capensis	98.88	2.00e-30	125.00
IUUC-Ppe-101586	Prunus persica	33.33	4.00e-15	73.60
IUUC-Pva-102627	Pteropus vampyrus	95.74	5.00e-132	463.00
IUUC-Rno-105344	Rattus norvegicus	91.09	1.00e-115	409.00
IUUC-Sha-107420	Sarcophilus harrisii	86.87	3.00e-117	414.00
IUUC-Smo-109218	Selaginella moellendorffii	32.56	8.00e-26	109.00
IUUC-Sly-111612	Solanum lycopersicum	31.69	3.00e-18	85.90
IUUC-Stu-112127	Solanum tuberosum	35.75	4.00e-22	97.80
IUUC-Sar-113762	Sorex araneus	95.35	2.00e-123	434.00
IUUC-Sbi-113997	Sorghum bicolor	34.48	2.00e-24	105.00
IUUC-Ssc-115764	Sus scrofa	98.86	4.00e-30	122.00
IUUC-Tgu-116969	Taeniopygia guttata	81.78	2.00e-110	392.00
IUUC-Tru-118414	Takifugu rubripes	69.96	6.00e-82	296.00
IUUC-Tsy-119312	Tarsius syrichta	86.82	6.00e-115	406.00
IUUC-Tni-120687	Tetraodon nigroviridis	72.13	1.00e-85	309.00
IUUC-Tca-121028	Theobroma cacao	36.21	6.00e-18	84.00
IUUC-Tae-122873	Triticum aestivum	38.46	4.00e-26	110.00
IUUC-Tur-126558	Triticum urartu	36.42	3.00e-20	91.30
IUUC-Tbe-127751	Tupaia belangeri	88.37	6.00e-107	380.00
IUUC-Ttr-128731	Tursiops truncatus	85.66	4.00e-110	390.00
IUUC-Vpa-130187	Vicugna pacos	94.96	1.00e-123	435.00
IUUC-Vvi-131393	Vitis vinifera	36.05	9.00e-24	103.00
IUUC-Xtr-132512	Xenopus tropicalis	70.77	4.00e-93	334.00
IUUC-Xma-133203	Xiphophorus maculatus	67.18	3.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence