iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090743

UUCD1 version

UUC-PaT-00576

Ensembl Protein ID

ENSPTRP00000028804.4

UniProt Accession

H2QQS0; H2QQS0_PANTR

Genbank Protein ID

JAA05865.1; JAA19747.1; JAA25794.1; JAA33533.1

Protein Name

S-phase kinase-associated protein 2 (P45)

Genbank Nucleotide ID

AACZ03040786; GABF01002398; GABD01007306; GABE01011206

Gene Name

SKP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016797.4	ENSPTRT00000031184.4	ENSPTRP00000028804.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.70e-06	26.7	95	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 101  glldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            ++d+lp+e+l+ i++ l  +ell+++ vc+rw++las+++lw+t+
   Q: 95   VSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTL 140
           57899**************************************997 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG 60
HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCTGTAG CGCCTTGCGC GCGCGGTGGG GATGGAACGT TGCTAGGCTT AGCGGGTCTA 60
GCTGCTGGGG GCCCGAGCAG CACGCTCGGA GCCGCCGCGC GCCAAAGCGG GAATCTGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0016301--F:kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002197	Ailuropoda melanoleuca	92.92	0.00e+00	778.00
IUUC-Atr-002711	Amborella trichopoda	25.00	1.00e-09	58.50
IUUC-Apl-003453	Anas platyrhynchos	68.17	4.00e-120	424.00
IUUC-Aca-005185	Anolis carolinensis	62.21	5.00e-141	493.00
IUUC-Ame-010665	Astyanax mexicanus	47.12	7.00e-91	327.00
IUUC-Bta-013450	Bos taurus	90.57	0.00e+00	795.00
IUUC-Bra-016626	Brassica rapa	23.46	1.00e-10	62.40
IUUC-Cel-018410	Caenorhabditis elegans	28.13	2.00e-26	113.00
IUUC-Cja-019834	Callithrix jacchus	96.70	0.00e+00	834.00
IUUC-Cfa-020401	Canis familiaris	92.69	0.00e+00	805.00
IUUC-Cpo-022183	Cavia porcellus	90.33	0.00e+00	789.00
IUUC-Csa-023418	Chlorocebus sabaeus	98.35	0.00e+00	848.00
IUUC-Cho-024412	Choloepus hoffmanni	88.14	2.00e-180	625.00
IUUC-Cin-025248	Ciona intestinalis	29.88	2.00e-39	156.00
IUUC-Csv-026189	Ciona savignyi	29.67	7.00e-37	148.00
IUUC-Cme-027297	Cyanidioschyzon merolae	37.14	2.00e-07	50.10
IUUC-Dre-028032	Danio rerio	47.59	2.00e-102	365.00
IUUC-Dno-029222	Dasypus novemcinctus	91.75	0.00e+00	795.00
IUUC-Dor-030505	Dipodomys ordii	86.16	2.00e-172	598.00
IUUC-Dme-031972	Drosophila melanogaster	33.72	5.00e-51	195.00
IUUC-Ete-032234	Echinops telfairi	82.59	3.00e-115	408.00
IUUC-Eca-033944	Equus caballus	92.92	0.00e+00	809.00
IUUC-Eeu-035008	Erinaceus europaeus	75.58	1.00e-119	422.00
IUUC-Fca-035412	Felis catus	91.75	0.00e+00	796.00
IUUC-Fal-037337	Ficedula albicollis	63.98	3.00e-139	488.00
IUUC-Gmo-038934	Gadus morhua	42.69	5.00e-39	154.00
IUUC-Gga-041152	Gallus gallus	67.30	4.00e-159	554.00
IUUC-Gac-041819	Gasterosteus aculeatus	46.37	1.00e-76	280.00
IUUC-Ggo-045479	Gorilla gorilla	99.72	0.00e+00	719.00
IUUC-Hsa-046512	Homo sapiens	100.00	0.00e+00	862.00
IUUC-Itr-048515	Ictidomys tridecemlineatus	91.89	0.00e+00	764.00
IUUC-Lch-050115	Latimeria chalumnae	57.76	9.00e-136	476.00
IUUC-Loc-052554	Lepisosteus oculatus	49.30	3.00e-105	375.00
IUUC-Laf-053563	Loxodonta africana	91.00	0.00e+00	749.00
IUUC-Mcc-055143	Macaca mulatta	98.34	0.00e+00	843.00
IUUC-Meu-056593	Macropus eugenii	56.40	6.00e-104	370.00
IUUC-Mga-060084	Meleagris gallopavo	59.77	1.00e-83	302.00
IUUC-Mmr-060660	Microcebus murinus	95.28	0.00e+00	828.00
IUUC-Mdo-062363	Monodelphis domestica	69.58	4.00e-161	560.00
IUUC-Mmu-063287	Mus musculus	86.32	0.00e+00	756.00
IUUC-Mpu-065791	Mustela putorius furo	91.98	0.00e+00	802.00
IUUC-Mlu-067714	Myotis lucifugus	88.47	0.00e+00	749.00
IUUC-Nle-069823	Nomascus leucogenys	99.53	0.00e+00	858.00
IUUC-Opr-071046	Ochotona princeps	72.27	3.00e-103	368.00
IUUC-Ont-071820	Oreochromis niloticus	45.93	2.00e-68	253.00
IUUC-Ocu-074868	Oryctolagus cuniculus	91.75	0.00e+00	796.00
IUUC-Ola-086608	Oryzias latipes	46.46	5.00e-74	271.00
IUUC-Oga-089044	Otolemur garnettii	93.87	0.00e+00	817.00
IUUC-Oar-089650	Ovis aries	90.80	0.00e+00	793.00
IUUC-Pan-092501	Papio anubis	98.35	0.00e+00	849.00
IUUC-Psi-094032	Pelodiscus sinensis	68.48	2.00e-164	571.00
IUUC-Pfo-097279	Poecilia formosa	46.68	3.00e-63	235.00
IUUC-Pab-097821	Pongo abelii	99.44	0.00e+00	714.00
IUUC-Pca-100100	Procavia capensis	90.40	9.00e-178	615.00
IUUC-Pva-103181	Pteropus vampyrus	90.68	0.00e+00	629.00
IUUC-Rno-105091	Rattus norvegicus	88.15	0.00e+00	765.00
IUUC-Sha-107226	Sarcophilus harrisii	70.85	6.00e-168	583.00
IUUC-Ssc-115665	Sus scrofa	94.34	0.00e+00	820.00
IUUC-Tgu-116982	Taeniopygia guttata	63.51	1.00e-136	479.00
IUUC-Tru-118276	Takifugu rubripes	46.51	2.00e-74	272.00
IUUC-Tsy-119074	Tarsius syrichta	92.09	0.00e+00	665.00
IUUC-Tni-120702	Tetraodon nigroviridis	47.55	1.00e-51	196.00
IUUC-Tbe-127990	Tupaia belangeri	91.95	1.00e-159	555.00
IUUC-Ttr-128661	Tursiops truncatus	76.92	3.00e-111	395.00
IUUC-Xtr-132166	Xenopus tropicalis	57.18	2.00e-128	452.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence