iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097021

Ensembl Protein ID

ENSPFOP00000013280.2

UniProt Accession

A0A087Y5H7; A0A087Y5H7_POEFO

Genbank Protein ID

ENSPFOP00000013280

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01020171

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000013186.2	ENSPFOT00000013298.2	ENSPFOP00000013280.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-100	336.9	723	1046

Active Site

Position(s)	Description	Evidence
1015	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l++kel +p++g+f+y e+++  ++  ++      e ++lF+++G+++g+a+++  +++l
   Q: 723  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFSHKTF-----EDFDLFNLIGVICGLAIYNFTIVEL 804
           78999*********************************************9987766.....79*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k +ledl+e++p++ +sl+e++++ e+die++ ++l+f+++e+++g t++ eL+p+Geni+V+++N++e+v+++
   Q: 805  NFPLALYKKLLKRKPTLEDLKELMPDVGRSLQELLDYTEDDIEDT-FCLNFTITEDNYGATEVLELVPNGENINVNKSNRQEFVDAY 890
           ********************************************8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y +++ ++  +e f++Gf++v+  ++l+lF+++el+ +i G++++d+ +l+k t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 891  VNYVFNKAVAPLFEGFYSGFHKVCGGRVLDLFQPSELQAMIIGNTNYDWTELEKSTEYKGEYWAEHPTIKLFWEVFHELPLEKKKMF 977
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Yss e+l+ekLl Ai++++gF+l
   Q: 978  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEHYLPVAHTCFNLLDLPKYSSIETLREKLLHAIDHNQGFNL 1046
           *******************...6666658889**************************************87 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDDE IVVEPRRCEF FHGKRVSDVG CGRRHTAFLL DDGTVYTCGC 60
NDLGQLGHDK SRKKPEQVVA LDAQIILALS CGESHTLALN DKGQVFSWGL GSDGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTATTTCC GTACATTTGA CACACTACAT TAATAGCGCC GTACAGCGGT TGTTGACAGA 60
TCTTTTGGAG TTGAGTGGAA GATTTAGTTT CATCCAGTTG ATTGTTAGCT TTCCATGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	73.23	0.00e+00	1523.00
IUUC-Apl-003295	Anas platyrhynchos	72.27	0.00e+00	1548.00
IUUC-Aca-004336	Anolis carolinensis	73.69	0.00e+00	1580.00
IUUC-Ame-010768	Astyanax mexicanus	77.56	0.00e+00	1656.00
IUUC-Bta-013279	Bos taurus	73.13	0.00e+00	1518.00
IUUC-Cel-018150	Caenorhabditis elegans	34.86	4.00e-159	555.00
IUUC-Cja-019023	Callithrix jacchus	73.39	0.00e+00	1518.00
IUUC-Cfa-021074	Canis familiaris	73.32	0.00e+00	1522.00
IUUC-Cpo-021461	Cavia porcellus	71.58	0.00e+00	1479.00
IUUC-Csa-024261	Chlorocebus sabaeus	73.32	0.00e+00	1518.00
IUUC-Cin-025232	Ciona intestinalis	43.38	0.00e+00	835.00
IUUC-Cme-027151	Cyanidioschyzon merolae	31.16	8.00e-109	389.00
IUUC-Dre-028829	Danio rerio	77.76	0.00e+00	1640.00
IUUC-Dno-029445	Dasypus novemcinctus	70.91	0.00e+00	1207.00
IUUC-Dor-030158	Dipodomys ordii	79.07	0.00e+00	728.00
IUUC-Dme-032103	Drosophila melanogaster	45.00	0.00e+00	889.00
IUUC-Ete-033072	Echinops telfairi	66.25	0.00e+00	1346.00
IUUC-Eca-033317	Equus caballus	72.47	0.00e+00	1504.00
IUUC-Fca-035682	Felis catus	73.78	0.00e+00	1528.00
IUUC-Fal-036969	Ficedula albicollis	71.51	0.00e+00	1539.00
IUUC-Gmo-038671	Gadus morhua	80.09	0.00e+00	1716.00
IUUC-Gga-041174	Gallus gallus	72.06	0.00e+00	1548.00
IUUC-Gac-042600	Gasterosteus aculeatus	83.76	0.00e+00	1759.00
IUUC-Gma-043616	Glycine max	37.58	5.00e-52	198.00
IUUC-Ggo-044589	Gorilla gorilla	73.42	0.00e+00	1539.00
IUUC-Hsa-046772	Homo sapiens	73.23	0.00e+00	1533.00
IUUC-Lch-050147	Latimeria chalumnae	72.14	0.00e+00	1274.00
IUUC-Loc-052684	Lepisosteus oculatus	77.29	0.00e+00	1623.00
IUUC-Laf-053844	Loxodonta africana	73.32	0.00e+00	1519.00
IUUC-Mcc-055531	Macaca mulatta	71.60	0.00e+00	1501.00
IUUC-Mga-060151	Meleagris gallopavo	70.27	0.00e+00	1254.00
IUUC-Mmr-060954	Microcebus murinus	73.51	0.00e+00	1522.00
IUUC-Mdo-062246	Monodelphis domestica	72.67	0.00e+00	1403.00
IUUC-Mmu-063369	Mus musculus	73.59	0.00e+00	1560.00
IUUC-Mpu-065936	Mustela putorius furo	73.12	0.00e+00	1393.00
IUUC-Mlu-067326	Myotis lucifugus	72.71	0.00e+00	1483.00
IUUC-Nle-069453	Nomascus leucogenys	73.98	0.00e+00	1525.00
IUUC-Ont-071720	Oreochromis niloticus	85.29	0.00e+00	1807.00
IUUC-Oan-073464	Ornithorhynchus anatinus	72.48	0.00e+00	1407.00
IUUC-Ocu-074207	Oryctolagus cuniculus	70.85	0.00e+00	1376.00
IUUC-Ola-086762	Oryzias latipes	85.14	0.00e+00	1748.00
IUUC-Oga-088435	Otolemur garnettii	73.79	0.00e+00	1527.00
IUUC-Oar-089233	Ovis aries	73.23	0.00e+00	1519.00
IUUC-Ptr-091368	Pan troglodytes	73.51	0.00e+00	1538.00
IUUC-Pan-092300	Papio anubis	73.32	0.00e+00	1518.00
IUUC-Psi-093406	Pelodiscus sinensis	73.04	0.00e+00	1566.00
IUUC-Pma-094113	Petromyzon marinus	66.67	0.00e+00	1073.00
IUUC-Ppa-095354	Physcomitrella patens	33.52	2.00e-152	533.00
IUUC-Pab-098327	Pongo abelii	73.42	0.00e+00	1536.00
IUUC-Pva-102909	Pteropus vampyrus	65.00	0.00e+00	1270.00
IUUC-Rno-105457	Rattus norvegicus	73.42	0.00e+00	1559.00
IUUC-Sha-106632	Sarcophilus harrisii	73.31	0.00e+00	1545.00
IUUC-Sar-113679	Sorex araneus	63.55	0.00e+00	812.00
IUUC-Tgu-116849	Taeniopygia guttata	68.43	0.00e+00	1452.00
IUUC-Tru-118206	Takifugu rubripes	81.02	0.00e+00	1673.00
IUUC-Tsy-119521	Tarsius syrichta	61.21	0.00e+00	1193.00
IUUC-Tni-120233	Tetraodon nigroviridis	81.27	0.00e+00	1666.00
IUUC-Vpa-130448	Vicugna pacos	73.13	0.00e+00	1519.00
IUUC-Xtr-132719	Xenopus tropicalis	64.08	0.00e+00	1240.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence