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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105165
UUCD1 version UUC-RaN-00006
Ensembl Protein ID ENSRNOP00000025500.1
UniProt Accession Q8CJB9; BRE1B_RAT
Genbank Protein ID AAN16401.1
Protein Name E3 ubiquitin-protein ligase BRE1B; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B; Syntaxin-1-interacting RING finger protein
Genbank Nucleotide ID AF352815
Gene Name Rnf40; Bre1b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000018840.2 ENSRNOT00000025499.2 ENSRNOP00000025500.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17329546; 12121982
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.019 15.9 949 988
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+ C ++ kd  +++ C Hvf+++C+  ++      + ++ +CP C+
   Q: 949  CPCCNTRKKD-AVLTKCFHVFCFECVrGRY------EARQRKCPKCN 988
           9***999999.888************9999......**********7 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Protein Sequence
(Fasta)
MSGLSNKRAA GDGGSGPPEK KLNREEKTTT TLIEPIRLGG ISSTEEMDSK VLQFKNKKLA 60
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLQ CYENQRELSS 120
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Protein Fasta Sequence


>IUUC-Rno-105165|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GGCGCTTGGC TGACCCTACC GTAAGTGCGG ACCCTCGGCT GGCGGGGGCG GGGTCCTGCA 60
GATGTGTCCA GGAGGACGCT CGGGACTACA GAACTCTGGA CGCATTCACA GGTCTGCTCT 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105165|E3,RING|Rattus norvegicus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0043679--C:axon terminus
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0033503--C:HULC complex
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0032403--F:protein complex binding
GO:0017075--F:syntaxin-1 binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0043434--P:response to peptide hormone
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:266712
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001027 Aegilops tauschii 28.65 7.00e-13 69.30
IUUC-Aml-002295 Ailuropoda melanoleuca 93.81 0.00e+00 1669.00
IUUC-Atr-002836 Amborella trichopoda 30.82 6.00e-27 116.00
IUUC-Aca-004850 Anolis carolinensis 74.30 0.00e+00 664.00
IUUC-Aly-006055 Arabidopsis lyrata 28.16 1.00e-29 125.00
IUUC-Ath-007462 Arabidopsis thaliana 28.68 6.00e-30 126.00
IUUC-Ang-009601 Aspergillus niger 26.58 9.00e-17 82.40
IUUC-Ame-011745 Astyanax mexicanus 80.95 1.00e-151 530.00
IUUC-Bta-013173 Bos taurus 92.61 0.00e+00 1643.00
IUUC-Bci-013926 Botrytis cinerea 37.74 3.00e-08 53.90
IUUC-Bdi-015006 Brachypodium distachyon 51.52 2.00e-16 81.60
IUUC-Bol-015421 Brassica oleracea 28.65 9.00e-29 122.00
IUUC-Bra-016804 Brassica rapa 28.77 5.00e-35 143.00
IUUC-Cel-018659 Caenorhabditis elegans 30.24 1.00e-40 161.00
IUUC-Cja-019042 Callithrix jacchus 92.02 0.00e+00 1597.00
IUUC-Cfa-020318 Canis familiaris 93.41 0.00e+00 1662.00
IUUC-Cpo-021539 Cavia porcellus 93.11 0.00e+00 1666.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 37.93 9.00e-09 55.50
IUUC-Csa-024051 Chlorocebus sabaeus 92.91 0.00e+00 1567.00
IUUC-Cin-025174 Ciona intestinalis 61.98 5.00e-113 402.00
IUUC-Csv-025830 Ciona savignyi 54.52 1.00e-96 348.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 42.31 1.00e-09 58.20
IUUC-Cne-026878 Cryptococcus neoformans 26.57 2.00e-15 78.20
IUUC-Dre-028171 Danio rerio 80.11 1.00e-152 534.00
IUUC-Dno-028892 Dasypus novemcinctus 93.71 0.00e+00 1625.00
IUUC-Dor-030268 Dipodomys ordii 92.03 0.00e+00 761.00
IUUC-Dme-032034 Drosophila melanogaster 42.98 0.00e+00 739.00
IUUC-Ete-032505 Echinops telfairi 89.56 5.00e-180 624.00
IUUC-Eca-033436 Equus caballus 93.31 0.00e+00 1684.00
IUUC-Eeu-035291 Erinaceus europaeus 87.49 0.00e+00 1311.00
IUUC-Fca-035720 Felis catus 93.61 0.00e+00 1671.00
IUUC-Fox-038017 Fusarium oxysporum 27.39 1.00e-10 61.60
IUUC-Fso-038414 Fusarium solani 26.36 3.00e-10 60.50
IUUC-Gmo-039269 Gadus morhua 79.82 8.00e-143 501.00
IUUC-Gac-041303 Gasterosteus aculeatus 63.71 5.00e-151 528.00
IUUC-Gma-042797 Glycine max 28.65 1.00e-37 152.00
IUUC-Ggo-045426 Gorilla gorilla 92.71 0.00e+00 1634.00
IUUC-Hsa-045732 Homo sapiens 92.51 0.00e+00 1669.00
IUUC-Hvu-047689 Hordeum vulgare 28.93 1.00e-29 124.00
IUUC-Itr-048724 Ictidomys tridecemlineatus 93.91 0.00e+00 1657.00
IUUC-Kpa-049345 Komagataella pastoris 27.59 3.00e-10 60.80
IUUC-Lpe-051253 Leersia perrieri 31.30 1.00e-34 141.00
IUUC-Laf-054267 Loxodonta africana 93.41 0.00e+00 1654.00
IUUC-Mcc-055240 Macaca mulatta 92.91 0.00e+00 1569.00
IUUC-Meu-056750 Macropus eugenii 82.32 0.00e+00 1420.00
IUUC-Mor-057068 Magnaporthe oryzae 45.28 4.00e-12 66.60
IUUC-Mtr-057632 Medicago truncatula 29.70 4.00e-34 140.00
IUUC-Mla-059072 Melampsora laricipopulina 28.57 1.00e-29 125.00
IUUC-Mvi-060341 Microbotryum violaceum 29.93 6.00e-23 103.00
IUUC-Mmr-061177 Microcebus murinus 93.61 0.00e+00 1658.00
IUUC-Mdo-062415 Monodelphis domestica 82.86 0.00e+00 1419.00
IUUC-Mmu-063981 Mus musculus 98.10 0.00e+00 1818.00
IUUC-Mac-065103 Musa acuminata 30.58 9.00e-43 169.00
IUUC-Mpu-066498 Mustela putorius furo 93.21 0.00e+00 1593.00
IUUC-Mlu-067242 Myotis lucifugus 92.71 0.00e+00 1635.00
IUUC-Nle-069320 Nomascus leucogenys 93.14 0.00e+00 834.00
IUUC-Opr-070286 Ochotona princeps 87.91 0.00e+00 1026.00
IUUC-Ont-071299 Oreochromis niloticus 79.50 3.00e-153 536.00
IUUC-Oan-073538 Ornithorhynchus anatinus 74.80 8.00e-175 607.00
IUUC-Ocu-073799 Oryctolagus cuniculus 92.81 0.00e+00 1644.00
IUUC-Oba-075000 Oryza barthii 28.50 8.00e-31 129.00
IUUC-Obr-076532 Oryza brachyantha 29.72 1.00e-33 138.00
IUUC-Ogl-077200 Oryza glaberrima 30.21 2.00e-33 137.00
IUUC-Ogu-078279 Oryza glumaepatula 28.50 6.00e-31 129.00
IUUC-Oin-079097 Oryza indica 30.21 2.00e-33 137.00
IUUC-Olo-080612 Oryza longistaminata 53.33 3.00e-15 77.80
IUUC-Ome-081304 Oryza meridionalis 30.08 3.00e-32 133.00
IUUC-Oni-082162 Oryza nivara 28.50 6.00e-31 129.00
IUUC-Opu-083683 Oryza punctata 51.52 2.00e-16 81.60
IUUC-Oru-084382 Oryza rufipogon 28.50 6.00e-31 129.00
IUUC-Osa-085839 Oryza sativa 51.52 2.00e-16 81.30
IUUC-Ola-086435 Oryzias latipes 66.60 2.00e-154 540.00
IUUC-Oga-089016 Otolemur garnettii 87.23 0.00e+00 1523.00
IUUC-Oar-089589 Ovis aries 92.91 0.00e+00 1650.00
IUUC-Ptr-090530 Pan troglodytes 91.47 0.00e+00 1248.00
IUUC-Pan-092502 Papio anubis 92.91 0.00e+00 1571.00
IUUC-Psi-093155 Pelodiscus sinensis 84.82 1.00e-140 493.00
IUUC-Pno-095079 Phaeosphaeria nodorum 27.52 2.00e-13 70.90
IUUC-Ppa-095735 Physcomitrella patens 34.71 4.00e-44 173.00
IUUC-Pfo-097527 Poecilia formosa 52.47 0.00e+00 745.00
IUUC-Pab-098619 Pongo abelii 93.31 0.00e+00 1654.00
IUUC-Pop-099376 Populus trichocarpa 29.71 4.00e-36 146.00
IUUC-Pca-100544 Procavia capensis 92.32 0.00e+00 1636.00
IUUC-Ppe-102065 Prunus persica 29.39 8.00e-32 132.00
IUUC-Pva-102479 Pteropus vampyrus 94.60 0.00e+00 1391.00
IUUC-Pgr-103536 Puccinia graminis 25.75 2.00e-22 101.00
IUUC-Ptt-104014 Puccinia triticina 26.98 4.00e-05 43.90
IUUC-Pte-104415 Pyrenophora teres 33.33 2.00e-13 70.90
IUUC-Pyt-104762 Pyrenophora triticirepentis 30.39 2.00e-13 71.20
IUUC-Sce-106384 Saccharomyces cerevisiae 25.14 8.00e-17 82.40
IUUC-Sha-107602 Sarcophilus harrisii 84.24 0.00e+00 1458.00
IUUC-Ssl-108546 Sclerotinia sclerotiorum 37.74 1.00e-08 55.10
IUUC-Smo-109550 Selaginella moellendorffii 30.46 2.00e-39 157.00
IUUC-Sit-109889 Setaria italica 29.25 4.00e-32 133.00
IUUC-Sly-111490 Solanum lycopersicum 32.73 5.00e-42 166.00
IUUC-Sar-113755 Sorex araneus 90.61 0.00e+00 1303.00
IUUC-Sbi-114734 Sorghum bicolor 30.90 5.00e-24 104.00
IUUC-Sre-115087 Sporisorium reilianum 24.91 6.00e-16 79.70
IUUC-Ssc-116134 Sus scrofa 91.72 0.00e+00 1646.00
IUUC-Tru-117867 Takifugu rubripes 79.50 1.00e-153 537.00
IUUC-Tsy-119065 Tarsius syrichta 88.36 0.00e+00 1425.00
IUUC-Tca-121060 Theobroma cacao 33.61 3.00e-40 160.00
IUUC-Tre-122150 Trichoderma reesei 41.51 2.00e-10 60.80
IUUC-Tvi-122431 Trichoderma virens 41.51 4.00e-10 60.10
IUUC-Tae-124308 Triticum aestivum 29.56 7.00e-32 132.00
IUUC-Tur-126160 Triticum urartu 50.00 6.00e-16 79.70
IUUC-Tme-127177 Tuber melanosporum 23.27 1.00e-12 68.60
IUUC-Tbe-127597 Tupaia belangeri 85.17 0.00e+00 1035.00
IUUC-Ttr-128303 Tursiops truncatus 91.54 0.00e+00 1595.00
IUUC-Uma-129488 Ustilago maydis 27.68 9.00e-19 89.00
IUUC-Vda-129815 Verticillium dahliae 40.38 2.00e-09 57.80
IUUC-Vvi-131316 Vitis vinifera 32.10 7.00e-36 145.00
IUUC-Xma-133607 Xiphophorus maculatus 78.95 1.00e-150 527.00
IUUC-Yli-134445 Yarrowia lipolytica 40.62 9.00e-13 68.90
Created Date 25-Jun-2017

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