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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106344
Ensembl Protein ID YJR125C
UniProt Accession P47160; D6VWU4; ENT3_YEAST
Genbank Protein ID CAA89656.1; AAS56410.1; DAA08910.1
Protein Name Epsin-3
Genbank Nucleotide ID Z49625; AY558084; BK006943
Gene Name ENT3; YJR125C; J2048
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YJR125C YJR125C YJR125C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UIM 52.67 1.00e-35 147.00 IUUC-Rno-105746
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
 Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB).
Protein Sequence
(Fasta)
MSLEDTLANM SLYDAKKYFR KAQNVVFNYT EMEGKVREAT NNEPWGASST LMDQISQGTY 60
NFREREEILS MIFRRFTEKA GSEWRQIYKA LQLLDYLIKH GSERFIDDTR NSINLIRILE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106344|UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGTTTAG AGGATACATT AGCCAACATG TCATTATATG ACGCCAAGAA ATATTTTCGT 60
AAAGCTCAAA ATGTTGTTTT CAATTATACT GAGATGGAGG GGAAAGTTCG TGAAGCGACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106344|UBD,UIM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
PROSITE

PS50942--ENTH
Pfam

PF01417--ENTH
SMART

SM00273--ENTH
Gene Ontology

GO:0030479--C:actin cortical patch
GO:0030125--C:clathrin vesicle coat
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0005794--C:Golgi apparatus
GO:0030276--F:clathrin binding
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0000147--P:actin cortical patch assembly
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0034498--P:early endosome to Golgi transport
GO:0006895--P:Golgi to endosome transport
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0071985--P:multivesicular body sorting pathway
GO:0015031--P:protein transport
KEGG sce:YJR125C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000113 Aegilops tauschii 41.61 2.00e-34 139.00
IUUC-Aml-001209 Ailuropoda melanoleuca 49.68 1.00e-42 165.00
IUUC-Atr-002956 Amborella trichopoda 38.60 2.00e-32 132.00
IUUC-Apl-003474 Anas platyrhynchos 49.68 2.00e-42 165.00
IUUC-Aca-005208 Anolis carolinensis 47.62 2.00e-40 158.00
IUUC-Aly-006457 Arabidopsis lyrata 39.61 3.00e-33 135.00
IUUC-Ath-007675 Arabidopsis thaliana 40.26 3.00e-33 135.00
IUUC-Ago-007986 Ashbya gossypii 68.53 1.00e-91 327.00
IUUC-Ame-011423 Astyanax mexicanus 51.32 8.00e-36 142.00
IUUC-Bta-013258 Bos taurus 48.41 2.00e-42 165.00
IUUC-Bdi-014129 Brachypodium distachyon 37.71 7.00e-35 140.00
IUUC-Bol-016058 Brassica oleracea 39.61 1.00e-32 133.00
IUUC-Bra-017893 Brassica rapa 39.61 1.00e-32 133.00
IUUC-Cja-019818 Callithrix jacchus 49.68 2.00e-42 165.00
IUUC-Cfa-020229 Canis familiaris 49.68 1.00e-42 166.00
IUUC-Cpo-022174 Cavia porcellus 49.68 1.00e-42 165.00
IUUC-Cin-025755 Ciona intestinalis 44.59 4.00e-34 135.00
IUUC-Csv-025907 Ciona savignyi 44.59 9.00e-35 139.00
IUUC-Cme-027132 Cyanidioschyzon merolae 32.28 3.00e-20 90.90
IUUC-Dre-028037 Danio rerio 50.66 2.00e-35 141.00
IUUC-Dno-029660 Dasypus novemcinctus 48.41 2.00e-41 161.00
IUUC-Dor-030230 Dipodomys ordii 49.08 1.00e-42 166.00
IUUC-Ete-032944 Echinops telfairi 49.68 7.00e-43 166.00
IUUC-Eca-033636 Equus caballus 49.68 2.00e-42 165.00
IUUC-Fca-036004 Felis catus 49.04 4.00e-42 164.00
IUUC-Fal-036640 Ficedula albicollis 49.68 2.00e-42 165.00
IUUC-Gmo-038468 Gadus morhua 46.75 1.00e-39 155.00
IUUC-Gga-040781 Gallus gallus 49.68 1.00e-42 166.00
IUUC-Gac-042432 Gasterosteus aculeatus 48.08 6.00e-41 159.00
IUUC-Gma-042967 Glycine max 41.61 1.00e-33 136.00
IUUC-Ggo-044421 Gorilla gorilla 49.68 2.00e-42 165.00
IUUC-Hsa-045740 Homo sapiens 49.68 2.00e-42 165.00
IUUC-Hvu-047135 Hordeum vulgare 41.61 2.00e-34 139.00
IUUC-Itr-048835 Ictidomys tridecemlineatus 46.26 6.00e-39 153.00
IUUC-Lch-049618 Latimeria chalumnae 49.68 3.00e-42 164.00
IUUC-Lpe-051296 Leersia perrieri 40.94 5.00e-34 137.00
IUUC-Loc-051728 Lepisosteus oculatus 49.04 4.00e-42 164.00
IUUC-Laf-053389 Loxodonta africana 49.68 2.00e-42 164.00
IUUC-Mcc-055565 Macaca mulatta 49.68 4.00e-42 164.00
IUUC-Meu-056064 Macropus eugenii 44.90 5.00e-38 150.00
IUUC-Mtr-058328 Medicago truncatula 39.29 2.00e-32 132.00
IUUC-Mga-060111 Meleagris gallopavo 49.68 2.00e-42 165.00
IUUC-Mmr-060793 Microcebus murinus 49.68 3.00e-42 164.00
IUUC-Mdo-061941 Monodelphis domestica 49.68 6.00e-42 163.00
IUUC-Mmu-064004 Mus musculus 49.04 1.00e-41 162.00
IUUC-Mac-064643 Musa acuminata 40.94 3.00e-33 135.00
IUUC-Mpu-066625 Mustela putorius furo 49.68 5.00e-42 163.00
IUUC-Mlu-068085 Myotis lucifugus 49.68 5.00e-42 163.00
IUUC-Nle-069825 Nomascus leucogenys 49.68 2.00e-42 165.00
IUUC-Opr-070654 Ochotona princeps 41.14 3.00e-39 154.00
IUUC-Ont-071888 Oreochromis niloticus 48.80 2.00e-35 141.00
IUUC-Oan-073743 Ornithorhynchus anatinus 49.68 2.00e-42 165.00
IUUC-Ocu-074139 Oryctolagus cuniculus 49.04 8.00e-42 162.00
IUUC-Oba-075922 Oryza barthii 37.71 7.00e-35 140.00
IUUC-Obr-076552 Oryza brachyantha 40.94 2.00e-34 139.00
IUUC-Ogl-077885 Oryza glaberrima 37.71 7.00e-35 140.00
IUUC-Ogu-078795 Oryza glumaepatula 37.71 7.00e-35 140.00
IUUC-Oin-080196 Oryza indica 37.71 7.00e-35 140.00
IUUC-Olo-080509 Oryza longistaminata 37.71 6.00e-35 140.00
IUUC-Ome-081531 Oryza meridionalis 37.71 7.00e-35 140.00
IUUC-Oni-083003 Oryza nivara 37.71 7.00e-35 140.00
IUUC-Opu-083829 Oryza punctata 37.71 7.00e-35 140.00
IUUC-Oru-084248 Oryza rufipogon 37.71 7.00e-35 140.00
IUUC-Osa-085910 Oryza sativa 37.71 7.00e-35 140.00
IUUC-Ola-087447 Oryzias latipes 46.84 2.00e-35 141.00
IUUC-Olu-087896 Ostreococcus lucimarinus 31.88 2.00e-17 80.10
IUUC-Oga-088870 Otolemur garnettii 49.68 9.00e-43 166.00
IUUC-Oar-090233 Ovis aries 48.41 1.00e-42 165.00
IUUC-Ptr-091026 Pan troglodytes 49.68 2.00e-42 165.00
IUUC-Pan-092050 Papio anubis 49.68 2.00e-42 164.00
IUUC-Psi-093688 Pelodiscus sinensis 49.68 2.00e-42 165.00
IUUC-Pma-094335 Petromyzon marinus 50.40 9.00e-35 139.00
IUUC-Ppa-095284 Physcomitrella patens 40.00 1.00e-31 129.00
IUUC-Pfo-097478 Poecilia formosa 48.43 2.00e-41 161.00
IUUC-Pab-098209 Pongo abelii 49.68 1.00e-42 165.00
IUUC-Pop-098881 Populus trichocarpa 39.29 4.00e-34 138.00
IUUC-Pca-100479 Procavia capensis 49.04 2.00e-42 164.00
IUUC-Ppe-101157 Prunus persica 38.60 1.00e-33 136.00
IUUC-Pva-102177 Pteropus vampyrus 53.12 5.00e-37 147.00
IUUC-Rno-105746 Rattus norvegicus 49.04 9.00e-42 162.00
IUUC-Sha-107254 Sarcophilus harrisii 49.68 2.00e-42 164.00
IUUC-Smo-109370 Selaginella moellendorffii 40.79 2.00e-33 133.00
IUUC-Sit-109784 Setaria italica 41.61 4.00e-34 138.00
IUUC-Sly-111438 Solanum lycopersicum 39.13 4.00e-34 137.00
IUUC-Stu-112874 Solanum tuberosum 38.10 7.00e-35 140.00
IUUC-Sar-113696 Sorex araneus 49.04 1.00e-41 162.00
IUUC-Sbi-114540 Sorghum bicolor 41.61 1.00e-34 139.00
IUUC-Ssc-115921 Sus scrofa 48.00 4.00e-34 137.00
IUUC-Tgu-117391 Taeniopygia guttata 49.68 2.00e-42 165.00
IUUC-Tru-117791 Takifugu rubripes 46.20 1.00e-35 142.00
IUUC-Tni-120827 Tetraodon nigroviridis 47.44 2.00e-39 154.00
IUUC-Tca-121377 Theobroma cacao 41.61 3.00e-33 135.00
IUUC-Tae-122690 Triticum aestivum 41.61 1.00e-34 139.00
IUUC-Tur-126042 Triticum urartu 41.61 1.00e-34 139.00
IUUC-Tbe-127405 Tupaia belangeri 48.10 2.00e-41 161.00
IUUC-Ttr-128552 Tursiops truncatus 46.26 1.00e-38 152.00
IUUC-Vvi-131209 Vitis vinifera 42.95 2.00e-32 131.00
IUUC-Xtr-131804 Xenopus tropicalis 47.30 2.00e-40 157.00
IUUC-Xma-133599 Xiphophorus maculatus 50.00 4.00e-35 140.00
Created Date 25-Jun-2017

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