iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046427

Ensembl Protein ID

ENSP00000257570.4

UniProt Accession

Q15646; B2RAZ2; I1YDD2; O75686; Q17R95; Q9Y6K6; Q9Y6K7; OASL_HUMAN

Genbank Protein ID

CAA12396.1; AAD28541.1; AAD28542.1; AFJ00074.1; BAG37039.1; AAI17409.1; AAI17411.1; AAC41733.1

Protein Name

2'-5'-oligoadenylate synthase-like protein; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; p59 OASL

Genbank Nucleotide ID

AJ225089; AF063611; AF063612; JQ792168; AK314419; AC079602; BC117410; L40387

Gene Name

OASL; TRIP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000135114.12	ENST00000257570.9	ENSP00000257570.4
ENSG00000135114.12	ENST00000339275.9	ENSP00000341125.5
ENSG00000135114.12	ENST00000543677.1	ENSP00000444127.1
ENSG00000135114.12	ENST00000620239.4	ENSP00000479512.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	14728690; 17408844; 18931074

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	2.60e-28	99.4	434	506

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekk 73
           +qv+vk++dg ++ + +np ++++ LK++ie+++g+p  qq+L ++G++L+d+  L+ yg++d +t++l  kk
   Q: 434  IQVFVKNPDGGSYAYAINPNSFILGLKQQIEDQQGLPKKQQQLEFQGQVLQDWLGLGIYGIQDSDTLILSKKK 506
           79******************************************************************98776 PP

Organism

Homo sapiens

Functional Description
(View)

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Protein Sequence
(Fasta)

MALMQELYST PASRLDSFVA QWLQPHREWK EEVLDAVRTV EEFLRQEHFQ GKRGLDQDVR 60
VLKVVKVGSF GNGTVLRSTR EVELVAFLSC FHSFQEAAKH HKDVLRLIWK TMWQSQDLLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGACTAGACG GCCAGCCTGT TAAGGTGGCC CCAGATATTC CAGCCTCAGC CCAGAGTCCT 60
CCTGTGCCCC TACTGCAGCA AGGGTGTCTC CAAGAAGGGG GACCTGGAGT CAGCCCGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding

Interpro

IPR006117--2-5-oligoadenylate_synth_CS
IPR006116--2-5-oligoadenylate_synth_N
IPR018952--2-5-oligoAdlate_synth_1_dom2/C
IPR026774--2-5A_synthase
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS00832--25A_SYNTH_1
PS00833--25A_SYNTH_2
PS50152--25A_SYNTH_3
PS50053--UBIQUITIN_2

Pfam

PF10421--OAS1_C
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0003723--F:RNA binding
GO:0046966--F:thyroid hormone receptor binding
GO:0016740--F:transferase activity
GO:0051607--P:defense response to virus
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0045071--P:negative regulation of viral genome replication
GO:0009615--P:response to virus
GO:0060337--P:type I interferon signaling pathway

KEGG

hsa:8638

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002382	Ailuropoda melanoleuca	77.56	9.00e-158	550.00
IUUC-Aca-004872	Anolis carolinensis	42.41	3.00e-76	278.00
IUUC-Bta-013441	Bos taurus	63.84	8.00e-121	426.00
IUUC-Cja-019721	Callithrix jacchus	83.75	0.00e+00	803.00
IUUC-Cfa-020283	Canis familiaris	74.41	0.00e+00	750.00
IUUC-Cpo-022264	Cavia porcellus	73.05	0.00e+00	753.00
IUUC-Csa-024258	Chlorocebus sabaeus	93.59	0.00e+00	957.00
IUUC-Cho-024633	Choloepus hoffmanni	77.78	0.00e+00	751.00
IUUC-Dno-029276	Dasypus novemcinctus	74.42	0.00e+00	743.00
IUUC-Dor-030563	Dipodomys ordii	59.59	4.00e-105	374.00
IUUC-Ete-032293	Echinops telfairi	69.32	0.00e+00	680.00
IUUC-Eca-033538	Equus caballus	78.83	0.00e+00	762.00
IUUC-Eeu-035066	Erinaceus europaeus	51.28	2.00e-89	323.00
IUUC-Fca-036598	Felis catus	75.14	3.00e-153	535.00
IUUC-Fal-036722	Ficedula albicollis	38.52	3.00e-89	322.00
IUUC-Gga-041271	Gallus gallus	37.72	6.00e-84	304.00
IUUC-Ggo-045019	Gorilla gorilla	98.05	0.00e+00	994.00
IUUC-Hvu-047264	Hordeum vulgare	40.74	6.50e-02	33.90
IUUC-Lch-050467	Latimeria chalumnae	41.28	2.00e-76	281.00
IUUC-Laf-054072	Loxodonta africana	77.73	0.00e+00	762.00
IUUC-Mcc-054678	Macaca mulatta	92.62	0.00e+00	947.00
IUUC-Meu-056079	Macropus eugenii	54.60	5.00e-104	370.00
IUUC-Mmr-061797	Microcebus murinus	72.13	0.00e+00	715.00
IUUC-Mdo-062316	Monodelphis domestica	49.20	2.00e-134	472.00
IUUC-Mmu-063442	Mus musculus	70.29	0.00e+00	703.00
IUUC-Mpu-066799	Mustela putorius furo	73.63	0.00e+00	733.00
IUUC-Mlu-067737	Myotis lucifugus	70.45	0.00e+00	634.00
IUUC-Nle-069345	Nomascus leucogenys	96.30	0.00e+00	978.00
IUUC-Opr-070745	Ochotona princeps	67.41	6.00e-162	563.00
IUUC-Ocu-073828	Oryctolagus cuniculus	71.12	0.00e+00	689.00
IUUC-Oga-089118	Otolemur garnettii	72.93	2.00e-139	488.00
IUUC-Oar-089587	Ovis aries	62.24	1.00e-164	572.00
IUUC-Ptr-091642	Pan troglodytes	98.25	0.00e+00	984.00
IUUC-Pan-091943	Papio anubis	93.98	0.00e+00	956.00
IUUC-Psi-093420	Pelodiscus sinensis	41.53	2.00e-61	230.00
IUUC-Pab-097945	Pongo abelii	97.08	0.00e+00	983.00
IUUC-Pca-100234	Procavia capensis	73.28	0.00e+00	716.00
IUUC-Pva-102228	Pteropus vampyrus	70.37	0.00e+00	691.00
IUUC-Rno-105099	Rattus norvegicus	73.72	0.00e+00	722.00
IUUC-Sha-106945	Sarcophilus harrisii	45.70	5.00e-119	421.00
IUUC-Sar-113443	Sorex araneus	61.27	8.00e-138	483.00
IUUC-Ssc-115350	Sus scrofa	61.05	7.00e-111	393.00
IUUC-Tgu-117171	Taeniopygia guttata	37.92	8.00e-87	314.00
IUUC-Tsy-119083	Tarsius syrichta	78.23	7.00e-142	497.00
IUUC-Tbe-127345	Tupaia belangeri	63.62	1.00e-155	543.00
IUUC-Ttr-128992	Tursiops truncatus	61.89	2.00e-114	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence