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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045956
UUCD1 version UUC-HoS-01248
Ensembl Protein ID ENSP00000342262.2
UniProt Accession Q8NFH3; B4E2F0; Q9H8S0; NUP43_HUMAN
Genbank Protein ID AAM76708.1; BAB14536.1; BAG65112.1; AAH65028.1
Protein Name Nucleoporin Nup43; Nup107-160 subcomplex subunit Nup43; p42
Genbank Nucleotide ID AF514997; AK023349; AK304244; AL355312
Gene Name NUP43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120253.13 ENST00000340413.6 ENSP00000342262.2
ENSG00000120253.13 ENST00000367404.8 ENSP00000356374.4
ENSG00000120253.13 ENST00000403890.7 ENSP00000385078.3
ENSG00000120253.13 ENST00000367402.6 ENSP00000356372.2
ENSG00000120253.13 ENST00000543637.1 ENSP00000438031.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.70e-17 62.8 260 299
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++++ ++f  s+  +l ++s Dg++  WD +t+v++ks
   Q: 260  HEAEMWEVHFhpSNpEHLFTCSEDGSLWHWDASTDVPEKS 299
           99999******8778********************99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Protein Sequence
(Fasta)
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG 60
FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF LHHPNNQTLS VNQQWTTAHY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045956|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGCGGGGG AGGCGTGTGG CCCAGCCGCC CGCCCCTGTG GCTGCTACCG CTGCCAGGGG 60
ACTGCAGGGA GGCCGGGCTG AGTCAGCGCC ACTTCCGCTG CTGCGTGTCC CTTTCTGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045956|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0051301--P:cell division
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007067--P:mitotic nuclear division
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0007062--P:sister chromatid cohesion
GO:0006409--P:tRNA export from nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription
KEGG hsa:348995
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001593 Ailuropoda melanoleuca 94.47 0.00e+00 722.00
IUUC-Atr-002526 Amborella trichopoda 26.83 1.00e-10 60.80
IUUC-Apl-003533 Anas platyrhynchos 75.52 1.00e-143 502.00
IUUC-Aca-004965 Anolis carolinensis 71.58 2.00e-164 572.00
IUUC-Aly-006431 Arabidopsis lyrata 30.18 9.00e-14 71.20
IUUC-Ath-007253 Arabidopsis thaliana 30.36 1.00e-13 70.90
IUUC-Ame-011694 Astyanax mexicanus 63.24 2.00e-122 431.00
IUUC-Bta-013161 Bos taurus 94.21 0.00e+00 753.00
IUUC-Bdi-014758 Brachypodium distachyon 25.79 2.00e-12 66.60
IUUC-Bol-016489 Brassica oleracea 27.27 3.00e-07 50.80
IUUC-Bra-017838 Brassica rapa 27.27 4.00e-08 52.40
IUUC-Cel-018567 Caenorhabditis elegans 29.71 3.00e-09 56.20
IUUC-Cja-020000 Callithrix jacchus 83.98 0.00e+00 652.00
IUUC-Cfa-021112 Canis familiaris 95.00 0.00e+00 758.00
IUUC-Cpo-022095 Cavia porcellus 90.53 0.00e+00 714.00
IUUC-Csa-023460 Chlorocebus sabaeus 98.42 0.00e+00 753.00
IUUC-Cho-024279 Choloepus hoffmanni 93.53 5.00e-180 623.00
IUUC-Cin-025360 Ciona intestinalis 35.15 7.00e-61 227.00
IUUC-Csv-026301 Ciona savignyi 37.21 2.00e-53 202.00
IUUC-Dre-028097 Danio rerio 61.64 2.00e-136 478.00
IUUC-Dno-029131 Dasypus novemcinctus 93.68 0.00e+00 741.00
IUUC-Dor-030496 Dipodomys ordii 82.41 0.00e+00 645.00
IUUC-Dme-031834 Drosophila melanogaster 26.33 2.00e-42 166.00
IUUC-Ete-032448 Echinops telfairi 91.78 9.00e-171 592.00
IUUC-Eca-034409 Equus caballus 93.68 0.00e+00 741.00
IUUC-Eeu-035343 Erinaceus europaeus 78.16 3.00e-160 558.00
IUUC-Fca-036177 Felis catus 95.79 0.00e+00 762.00
IUUC-Fal-037657 Ficedula albicollis 70.53 2.00e-157 548.00
IUUC-Gmo-038946 Gadus morhua 65.44 2.00e-142 498.00
IUUC-Gga-041070 Gallus gallus 75.26 3.00e-163 567.00
IUUC-Gac-042442 Gasterosteus aculeatus 66.32 2.00e-146 511.00
IUUC-Gma-043812 Glycine max 26.41 3.00e-12 66.20
IUUC-Ggo-045223 Gorilla gorilla 98.68 0.00e+00 780.00
IUUC-Itr-048116 Ictidomys tridecemlineatus 95.80 0.00e+00 763.00
IUUC-Lch-050035 Latimeria chalumnae 70.90 2.00e-161 561.00
IUUC-Laf-053404 Loxodonta africana 91.05 0.00e+00 717.00
IUUC-Mcc-055813 Macaca mulatta 98.42 0.00e+00 751.00
IUUC-Meu-056388 Macropus eugenii 75.41 3.00e-160 558.00
IUUC-Mga-060193 Meleagris gallopavo 73.42 9.00e-170 589.00
IUUC-Mmr-060818 Microcebus murinus 95.26 0.00e+00 758.00
IUUC-Mdo-062822 Monodelphis domestica 88.68 0.00e+00 706.00
IUUC-Mmu-064182 Mus musculus 93.68 0.00e+00 746.00
IUUC-Mac-065317 Musa acuminata 25.00 3.00e-08 52.80
IUUC-Mpu-066865 Mustela putorius furo 95.29 0.00e+00 675.00
IUUC-Mlu-067329 Myotis lucifugus 93.42 0.00e+00 702.00
IUUC-Nle-069093 Nomascus leucogenys 98.68 0.00e+00 781.00
IUUC-Opr-070481 Ochotona princeps 84.51 0.00e+00 671.00
IUUC-Ont-072445 Oreochromis niloticus 66.84 2.00e-148 518.00
IUUC-Oan-073029 Ornithorhynchus anatinus 77.37 1.00e-173 602.00
IUUC-Ocu-074275 Oryctolagus cuniculus 93.68 0.00e+00 748.00
IUUC-Ola-086862 Oryzias latipes 62.70 2.00e-133 468.00
IUUC-Oga-088952 Otolemur garnettii 95.51 0.00e+00 761.00
IUUC-Oar-089300 Ovis aries 95.00 0.00e+00 758.00
IUUC-Ptr-091389 Pan troglodytes 99.74 0.00e+00 786.00
IUUC-Pan-092174 Papio anubis 98.68 0.00e+00 754.00
IUUC-Psi-093326 Pelodiscus sinensis 79.18 1.00e-164 572.00
IUUC-Pfo-096331 Poecilia formosa 64.88 2.00e-144 505.00
IUUC-Pab-098306 Pongo abelii 98.42 0.00e+00 781.00
IUUC-Pop-099166 Populus trichocarpa 30.50 8.00e-11 61.60
IUUC-Pca-100455 Procavia capensis 91.33 4.00e-81 295.00
IUUC-Ppe-101380 Prunus persica 28.80 3.00e-12 66.20
IUUC-Pva-102578 Pteropus vampyrus 95.00 0.00e+00 723.00
IUUC-Pgr-103555 Puccinia graminis 37.35 2.00e-08 55.80
IUUC-Rno-105146 Rattus norvegicus 92.63 0.00e+00 710.00
IUUC-Sha-107640 Sarcophilus harrisii 89.76 0.00e+00 718.00
IUUC-Sly-111767 Solanum lycopersicum 28.74 5.00e-10 58.90
IUUC-Stu-112515 Solanum tuberosum 28.74 5.00e-10 58.90
IUUC-Sar-113681 Sorex araneus 94.39 2.00e-109 389.00
IUUC-Sbi-113809 Sorghum bicolor 25.79 9.00e-07 47.80
IUUC-Ssc-116129 Sus scrofa 94.74 0.00e+00 728.00
IUUC-Tgu-117456 Taeniopygia guttata 70.89 5.00e-82 296.00
IUUC-Tru-117630 Takifugu rubripes 68.15 4.00e-100 357.00
IUUC-Tsy-119331 Tarsius syrichta 95.53 0.00e+00 763.00
IUUC-Tni-120077 Tetraodon nigroviridis 64.29 5.00e-136 477.00
IUUC-Tca-121814 Theobroma cacao 28.90 7.00e-10 58.50
IUUC-Tae-123605 Triticum aestivum 26.84 1.00e-12 67.00
IUUC-Tbe-127359 Tupaia belangeri 86.21 0.00e+00 664.00
IUUC-Ttr-128461 Tursiops truncatus 95.79 0.00e+00 734.00
IUUC-Vpa-130162 Vicugna pacos 96.32 0.00e+00 730.00
IUUC-Vvi-131114 Vitis vinifera 28.73 7.00e-12 65.10
IUUC-Xtr-132446 Xenopus tropicalis 68.60 5.00e-156 543.00
Created Date 25-Jun-2017

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