iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/ULP	1.40e-53	182.0	395	557

Active Site

Position(s)	Description	Evidence
477	N/A	{ECO:0000250}
494		{ECO:0000250}
547	Nucleophile	ECO:0000250}

Domain Profile

DUB/ULP

   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslav 90
            +t+ d+++L++ ++lnD++i+fy++ l++e+ kk+ ++ +h+ s+ffy klk+ ++++vk+wt+ v+lf+++l++vpi++++HWsl+v
   Q: 395  RITRGDIQTLKNYHWLNDEVINFYMN-LLVERSKKQGYPALHALSTFFYPKLKSGGYQAVKRWTKGVNLFDQELVLVPIHRKVHWSLVV 482
           699***********************.9999********************************************************** PP
   S: 91   vcfkkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk...vpqQkNssDCGvyvlqyves 163
           ++++kk++ +lDS+ g++ ++++++l +yl++e+k+k++ +++  ++ ++++k   +pqQ N+sDCG++ ++y+++
   Q: 483  MDLRKKCLKYLDSM-GQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKpheIPQQLNGSDCGMFTCKYADY 557
           **************.********************************999988889*****************986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (By similarity).

Protein Sequence
(Fasta)

MYRWLTKVLG TILRLCERPA PGARALLKRR RSSSSLFSTA VDTDEIPAKR PRLDCFIHQV 60
KNSLYNAASL FGFPFQLTTK PMVSSACNGT RNVAPSGEVF SNSPSCELTT SGSCSSMLKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGCTACGGC CGAAGCGGCG AAGGCGGCAG CGGCGGCGAC AGCTCTGGGG TTCGCGTCTC 60
GGGGTGTGTC GGCCGCCGCT GCTGCTCAGG CCTGGAATGT ACAGATGGCT GACTAAGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0004175--F:endopeptidase activity
GO:0019904--F:protein domain specific binding
GO:0016929--F:SUMO-specific protease activity
GO:0009950--P:dorsal/ventral axis specification
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0060711--P:labyrinthine layer development
GO:0051028--P:mRNA transport
GO:0035562--P:negative regulation of chromatin binding
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0032091--P:negative regulation of protein binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001934--P:positive regulation of protein phosphorylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031648--P:protein destabilization
GO:0016926--P:protein desumoylation
GO:0015031--P:protein transport
GO:0032875--P:regulation of DNA endoreduplication
GO:2000045--P:regulation of G1/S transition of mitotic cell cycle
GO:0051246--P:regulation of protein metabolic process
GO:0060712--P:spongiotrophoblast layer development
GO:0060707--P:trophoblast giant cell differentiation
GO:0016055--P:Wnt signaling pathway

KEGG

rno:78973

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001512	Ailuropoda melanoleuca	85.45	0.00e+00	957.00
IUUC-Apl-003602	Anas platyrhynchos	51.76	2.00e-119	422.00
IUUC-Aca-004819	Anolis carolinensis	63.27	2.00e-102	365.00
IUUC-Aor-010104	Aspergillus oryzae	32.18	3.00e-29	121.00
IUUC-Ame-011519	Astyanax mexicanus	48.73	6.00e-73	268.00
IUUC-Bta-013157	Bos taurus	85.08	0.00e+00	951.00
IUUC-Cja-018720	Callithrix jacchus	86.29	0.00e+00	967.00
IUUC-Cfa-020805	Canis familiaris	86.46	0.00e+00	964.00
IUUC-Cpo-021808	Cavia porcellus	85.93	0.00e+00	985.00
IUUC-Cho-024783	Choloepus hoffmanni	62.50	8.00e-165	573.00
IUUC-Dno-028882	Dasypus novemcinctus	86.78	0.00e+00	974.00
IUUC-Dor-030693	Dipodomys ordii	67.57	0.00e+00	681.00
IUUC-Ete-032724	Echinops telfairi	72.37	0.00e+00	785.00
IUUC-Eca-034052	Equus caballus	86.95	0.00e+00	976.00
IUUC-Eeu-034465	Erinaceus europaeus	84.36	0.00e+00	879.00
IUUC-Fca-036319	Felis catus	86.46	0.00e+00	967.00
IUUC-Fal-037347	Ficedula albicollis	60.09	5.00e-85	307.00
IUUC-Gga-041045	Gallus gallus	52.70	1.00e-100	360.00
IUUC-Ggo-044694	Gorilla gorilla	80.00	0.00e+00	870.00
IUUC-Hsa-045920	Homo sapiens	86.95	0.00e+00	973.00
IUUC-Itr-048799	Ictidomys tridecemlineatus	87.63	0.00e+00	984.00
IUUC-Lch-049790	Latimeria chalumnae	64.53	1.00e-90	325.00
IUUC-Laf-053368	Loxodonta africana	84.75	0.00e+00	949.00
IUUC-Mcc-055057	Macaca mulatta	86.78	0.00e+00	972.00
IUUC-Meu-056435	Macropus eugenii	54.64	4.00e-169	587.00
IUUC-Mmr-061684	Microcebus murinus	87.80	0.00e+00	989.00
IUUC-Mdo-062858	Monodelphis domestica	68.62	5.00e-131	460.00
IUUC-Mmu-063498	Mus musculus	96.60	0.00e+00	1075.00
IUUC-Mpu-066611	Mustela putorius furo	86.08	0.00e+00	914.00
IUUC-Mlu-067118	Myotis lucifugus	81.71	0.00e+00	961.00
IUUC-Nle-069443	Nomascus leucogenys	86.95	0.00e+00	975.00
IUUC-Opr-070806	Ochotona princeps	75.36	0.00e+00	845.00
IUUC-Oan-073590	Ornithorhynchus anatinus	55.23	7.00e-73	267.00
IUUC-Ocu-073901	Oryctolagus cuniculus	85.79	0.00e+00	974.00
IUUC-Oga-089135	Otolemur garnettii	86.95	0.00e+00	976.00
IUUC-Oar-089942	Ovis aries	85.93	0.00e+00	970.00
IUUC-Ptr-090705	Pan troglodytes	86.95	0.00e+00	974.00
IUUC-Pan-092887	Papio anubis	86.18	0.00e+00	814.00
IUUC-Psi-093140	Pelodiscus sinensis	52.15	4.00e-140	491.00
IUUC-Pno-094805	Phaeosphaeria nodorum	35.44	4.00e-22	100.00
IUUC-Pab-098511	Pongo abelii	89.42	5.00e-147	514.00
IUUC-Pca-100253	Procavia capensis	60.41	4.00e-166	578.00
IUUC-Ppe-101189	Prunus persica	40.00	2.00e-33	136.00
IUUC-Pva-103179	Pteropus vampyrus	84.58	0.00e+00	936.00
IUUC-Sar-113372	Sorex araneus	84.10	0.00e+00	845.00
IUUC-Ssc-115700	Sus scrofa	84.82	0.00e+00	932.00
IUUC-Tgu-117433	Taeniopygia guttata	60.35	2.00e-84	305.00
IUUC-Tsy-118960	Tarsius syrichta	77.24	0.00e+00	764.00
IUUC-Tbe-127893	Tupaia belangeri	60.18	1.00e-163	570.00
IUUC-Ttr-128910	Tursiops truncatus	88.22	0.00e+00	933.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence