iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132004.12	ENST00000587296.1	ENSP00000465854.1
ENSG00000132004.12	ENST00000393261.7	ENSP00000376945.3
ENSG00000132004.12	ENST00000587955.1	ENSP00000465387.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	microRNA
TRANSFAC	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-23	82.5	214	244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlr 31
           +H+++v++la +d++++sGs+D t+k+WD+ 
   Q: 214  THEGWVWSLAAQDHRVCSGSWDSTVKLWDMA 244
           5********99789***************86 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP SQLSTPAASP 60
SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL HVLSRVCHAL RDLVSDHVTW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTGCCC TCGTGCTGCC TAGGAGACAA GACGCGAGGC CGGCAGCGCC CACCCGGTCG 60
CAATGGAGCT TCCCCTAGGG CGGTGCGATG ATTCCCGCAC CTGGGACGAT GACTCGGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

hsa:84261

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001913	Ailuropoda melanoleuca	72.95	0.00e+00	663.00
IUUC-Aca-004823	Anolis carolinensis	63.48	2.00e-142	499.00
IUUC-Bta-012687	Bos taurus	74.80	0.00e+00	636.00
IUUC-Cel-018433	Caenorhabditis elegans	25.80	2.00e-23	103.00
IUUC-Cja-018873	Callithrix jacchus	84.84	0.00e+00	709.00
IUUC-Cfa-020350	Canis familiaris	75.20	0.00e+00	653.00
IUUC-Cpo-021990	Cavia porcellus	70.70	0.00e+00	632.00
IUUC-Csa-023590	Chlorocebus sabaeus	83.40	0.00e+00	660.00
IUUC-Dre-028778	Danio rerio	42.46	6.00e-60	224.00
IUUC-Dor-030840	Dipodomys ordii	66.38	1.00e-149	523.00
IUUC-Eca-034232	Equus caballus	65.60	1.00e-143	502.00
IUUC-Fca-036533	Felis catus	76.14	0.00e+00	664.00
IUUC-Gmo-038675	Gadus morhua	42.59	3.00e-71	262.00
IUUC-Gac-041443	Gasterosteus aculeatus	42.11	7.00e-84	304.00
IUUC-Ggo-044439	Gorilla gorilla	96.52	0.00e+00	799.00
IUUC-Itr-048482	Ictidomys tridecemlineatus	72.45	0.00e+00	639.00
IUUC-Lch-049736	Latimeria chalumnae	46.67	1.00e-106	379.00
IUUC-Loc-051918	Lepisosteus oculatus	48.25	5.00e-57	213.00
IUUC-Laf-054045	Loxodonta africana	77.70	9.00e-112	396.00
IUUC-Mcc-054869	Macaca mulatta	83.40	0.00e+00	658.00
IUUC-Meu-056621	Macropus eugenii	66.16	3.00e-144	504.00
IUUC-Mmr-061740	Microcebus murinus	80.54	0.00e+00	680.00
IUUC-Mdo-062012	Monodelphis domestica	63.36	1.00e-159	556.00
IUUC-Mmu-063107	Mus musculus	70.70	1.00e-180	625.00
IUUC-Mpu-065889	Mustela putorius furo	75.05	0.00e+00	659.00
IUUC-Mlu-067453	Myotis lucifugus	74.80	0.00e+00	633.00
IUUC-Nle-070132	Nomascus leucogenys	88.93	0.00e+00	708.00
IUUC-Opr-070719	Ochotona princeps	60.52	2.00e-128	452.00
IUUC-Ont-072613	Oreochromis niloticus	42.75	1.00e-75	276.00
IUUC-Ocu-074377	Oryctolagus cuniculus	63.67	2.00e-89	323.00
IUUC-Ola-087040	Oryzias latipes	37.10	3.00e-58	218.00
IUUC-Oga-089018	Otolemur garnettii	76.10	0.00e+00	678.00
IUUC-Oar-089327	Ovis aries	73.77	3.00e-179	621.00
IUUC-Ptr-090748	Pan troglodytes	88.96	0.00e+00	741.00
IUUC-Pan-091879	Papio anubis	79.47	1.00e-118	419.00
IUUC-Psi-093031	Pelodiscus sinensis	59.83	1.00e-153	536.00
IUUC-Pfo-096738	Poecilia formosa	42.46	1.00e-63	237.00
IUUC-Pab-097958	Pongo abelii	89.34	0.00e+00	698.00
IUUC-Pca-101049	Procavia capensis	68.72	1.00e-166	579.00
IUUC-Pva-102123	Pteropus vampyrus	77.87	0.00e+00	698.00
IUUC-Rno-105239	Rattus norvegicus	71.11	0.00e+00	631.00
IUUC-Sha-107531	Sarcophilus harrisii	71.88	8.00e-147	513.00
IUUC-Sar-113257	Sorex araneus	73.71	2.00e-168	585.00
IUUC-Ssc-115236	Sus scrofa	75.00	0.00e+00	650.00
IUUC-Tru-117762	Takifugu rubripes	39.00	1.00e-76	280.00
IUUC-Tni-120085	Tetraodon nigroviridis	41.65	4.00e-79	288.00
IUUC-Ttr-128831	Tursiops truncatus	82.62	3.00e-167	581.00
IUUC-Xtr-132712	Xenopus tropicalis	43.36	1.00e-86	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence