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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106259
UUCD1 version UUC-SaC-00162
Ensembl Protein ID YGL004C
UniProt Accession P53196; D6VUD4; RPN14_YEAST
Genbank Protein ID CAA96704.1; AAT92618.1; DAA08095.1
Protein Name 26S proteasome regulatory subunit RPN14; Proteasome non-ATPase subunit 14
Genbank Nucleotide ID Z72526; AY692599; BK006941
Gene Name RPN14; YGL004C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YGL004C YGL004C YGL004C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.90e-17 59.2 176 214
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gH + vt++a    ++ ++s+s Dgti++W+  tg+ ++
   Q: 176  GHRATVTDIAIidRGRNVLSASLDGTIRLWECGTGTTIH 214
           8*********98755779*************99998766 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions.
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions.
Protein Sequence
(Fasta)
MTKTITVAHI QYDFKAVLEE NDENDDEFYI NVDKNLNEIK EHKIVVLGNS RGVDAGKGNT 60
FEKVGSHLYK ARLDGHDFLF NTIIRDGSKM LKRADYTAVD TAKLQMRRFI LGTTEGDIKV 120
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Protein Fasta Sequence


>IUUC-Sce-106259|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACTAAGA CCATCACAGT TGCTCATATC CAGTATGATT TTAAAGCTGT TCTGGAAGAA 60
AATGATGAAA ATGACGATGA ATTTTACATC AATGTTGACA AAAACCTAAA TGAAATCAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106259|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0070682--P:proteasome regulatory particle assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG sce:YGL004C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002247 Ailuropoda melanoleuca 31.86 6.00e-24 102.00
IUUC-Apl-003653 Anas platyrhynchos 35.05 9.00e-25 105.00
IUUC-Aca-004747 Anolis carolinensis 30.53 3.00e-24 103.00
IUUC-Ago-007984 Ashbya gossypii 40.28 6.00e-82 295.00
IUUC-Bta-013482 Bos taurus 29.05 5.00e-23 99.80
IUUC-Cel-018693 Caenorhabditis elegans 26.44 3.00e-14 70.90
IUUC-Cja-018842 Callithrix jacchus 30.53 5.00e-24 103.00
IUUC-Cfa-020708 Canis familiaris 31.30 1.00e-23 102.00
IUUC-Cpo-021469 Cavia porcellus 29.65 4.00e-23 100.00
IUUC-Csa-024109 Chlorocebus sabaeus 30.97 7.00e-24 102.00
IUUC-Cin-025576 Ciona intestinalis 30.00 2.00e-24 104.00
IUUC-Cne-027041 Cryptococcus neoformans 34.51 1.00e-17 82.40
IUUC-Dno-029167 Dasypus novemcinctus 29.96 1.00e-23 102.00
IUUC-Dor-030470 Dipodomys ordii 48.15 5.00e-20 89.70
IUUC-Eeu-035251 Erinaceus europaeus 31.82 8.00e-27 112.00
IUUC-Fca-035982 Felis catus 30.53 1.00e-23 102.00
IUUC-Fal-036938 Ficedula albicollis 35.07 5.00e-26 109.00
IUUC-Gga-040796 Gallus gallus 33.18 1.00e-25 108.00
IUUC-Hsa-046552 Homo sapiens 30.49 3.00e-26 110.00
IUUC-Itr-048359 Ictidomys tridecemlineatus 32.13 2.00e-23 100.00
IUUC-Lch-050291 Latimeria chalumnae 38.00 3.00e-24 103.00
IUUC-Loc-052254 Lepisosteus oculatus 29.27 5.00e-24 103.00
IUUC-Laf-053334 Loxodonta africana 31.86 1.00e-24 105.00
IUUC-Mcc-055257 Macaca mulatta 30.97 5.00e-24 103.00
IUUC-Meu-056613 Macropus eugenii 31.09 2.00e-23 100.00
IUUC-Mga-059647 Meleagris gallopavo 30.36 1.00e-25 108.00
IUUC-Mvi-060210 Microbotryum violaceum 37.50 1.00e-17 82.40
IUUC-Mmr-061119 Microcebus murinus 31.42 6.00e-24 102.00
IUUC-Mdo-062819 Monodelphis domestica 30.04 4.00e-22 96.70
IUUC-Mpu-066654 Mustela putorius furo 30.53 2.00e-23 101.00
IUUC-Mlu-067875 Myotis lucifugus 30.97 4.00e-24 103.00
IUUC-Nle-069290 Nomascus leucogenys 30.97 3.00e-24 103.00
IUUC-Opr-070348 Ochotona princeps 31.63 1.00e-20 92.00
IUUC-Oan-072693 Ornithorhynchus anatinus 28.57 5.00e-26 109.00
IUUC-Ocu-074103 Oryctolagus cuniculus 35.71 5.00e-20 89.70
IUUC-Oga-089096 Otolemur garnettii 31.14 2.00e-24 104.00
IUUC-Oar-089389 Ovis aries 29.46 1.00e-23 102.00
IUUC-Ptr-090483 Pan troglodytes 31.42 8.00e-25 105.00
IUUC-Pan-091915 Papio anubis 45.05 9.00e-21 91.70
IUUC-Psi-093034 Pelodiscus sinensis 31.72 7.00e-25 105.00
IUUC-Pab-097969 Pongo abelii 30.53 4.00e-24 103.00
IUUC-Pca-100381 Procavia capensis 32.47 8.00e-27 112.00
IUUC-Sha-106604 Sarcophilus harrisii 33.18 2.00e-25 107.00
IUUC-Sar-113535 Sorex araneus 31.03 5.00e-21 93.20
IUUC-Sre-115228 Sporisorium reilianum 29.02 6.00e-18 83.60
IUUC-Ssc-115947 Sus scrofa 29.65 6.00e-22 96.30
IUUC-Tgu-117085 Taeniopygia guttata 34.12 6.00e-26 109.00
IUUC-Ttr-129277 Tursiops truncatus 43.96 3.00e-20 90.50
IUUC-Uma-129603 Ustilago maydis 29.47 1.00e-17 82.40
IUUC-Vpa-130349 Vicugna pacos 41.67 9.00e-20 89.00
Created Date 25-Jun-2017

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