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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046589
UUCD1 version UUC-HoS-00421
Ensembl Protein ID ENSP00000255977.2
UniProt Accession Q9UHC7; A4D1T7; B3KXB4; Q256Y7; Q59G11; Q6GSF1; Q9H0G0; Q9UEZ7; Q9UHW2; MKRN1_HUMAN
Genbank Protein ID AAF17487.1; AAF18979.1; AAF18979.1; AAF18979.1; AAF18979.1; AAF18979.1; CAJ84705.1; AAF17214.1; CAB66746.1; BAG54426.1; BAG37929.1; EAL24026.1; EAW83949.1; AAH25955.1; AAH37400.1; AAH64838.1; BAD92535.1
Protein Name E3 ubiquitin-protein ligase makorin-1; RING finger protein 61; RING-type E3 ubiquitin transferase makorin-1
Genbank Nucleotide ID AF192784; AF192793; AF192789; AF192790; AF192791; AF192792; AM236048; AF117233; AL136812; AK127030; AK315552; AC069335; CH471070; BC025955; BC037400; BC064838; AB209298
Gene Name MKRN1; RNF61
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000133606.10 ENST00000255977.6 ENSP00000255977.2
ENSG00000133606.10 ENST00000495305.5 ENSP00000417640.1
ENSG00000133606.10 ENST00000463142.1 ENSP00000417346.1
ENSG00000133606.10 ENST00000496169.5 ENSP00000417907.1
ENSG00000133606.10 ENST00000498535.1 ENSP00000419695.1
ENSG00000133606.10 ENST00000473444.1 ENSP00000418620.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21172006; 19846531
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.70e-05 25.8 281 335
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf........kdg.plvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C iC+e          +    ++ +C+H+++++C+ kw   ++ +s+   +CP Cr
   Q: 281  CGICMEVVyekanpseR-RfGILSNCNHTYCLKCIRKWrSAKQFESKIIKSCPECR 335
           99**9977666555432.1233577*************4444444444558****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Protein Sequence
(Fasta)
MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT 60
CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046589|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCAATGAGC GGCGCCGTGG GCGGGCCGCG GGCGCGCATG CTCTGGGCCC GCAGTTGAAG 60
TGGCGAGAGC GCTCAGATAC GCGACGCGTA GCAGGCGGGG ACCGAACGGG TGCCTCAGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046589|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR026290--Makorin-1
IPR031644--MKRN1_C
IPR018957--Znf_C3HC4_RING-type
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF15815--MKRN1_C
PF00097--zf-C3HC4
PF00642--zf-CCCH
SMART

SM00184--RING
SM00356--ZnF_C3H1
Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination
KEGG hsa:23608
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000297 Aegilops tauschii 44.02 3.00e-42 166.00
IUUC-Aml-001937 Ailuropoda melanoleuca 96.67 0.00e+00 689.00
IUUC-Atr-003024 Amborella trichopoda 35.31 8.00e-64 237.00
IUUC-Apl-004110 Anas platyrhynchos 77.46 3.00e-161 561.00
IUUC-Aca-005385 Anolis carolinensis 82.22 0.00e+00 634.00
IUUC-Aly-006124 Arabidopsis lyrata 31.65 6.00e-54 204.00
IUUC-Ath-006918 Arabidopsis thaliana 40.20 5.00e-42 164.00
IUUC-Ame-011246 Astyanax mexicanus 66.51 4.00e-138 484.00
IUUC-Bta-012318 Bos taurus 95.04 0.00e+00 717.00
IUUC-Bdi-015008 Brachypodium distachyon 34.10 3.00e-54 205.00
IUUC-Bol-015688 Brassica oleracea 38.62 1.00e-35 144.00
IUUC-Bra-017861 Brassica rapa 41.21 2.00e-42 166.00
IUUC-Cel-018642 Caenorhabditis elegans 36.00 8.00e-55 207.00
IUUC-Cja-019550 Callithrix jacchus 97.88 0.00e+00 652.00
IUUC-Cfa-020166 Canis familiaris 95.79 0.00e+00 718.00
IUUC-Cpo-021887 Cavia porcellus 92.45 0.00e+00 731.00
IUUC-Cre-022707 Chlamydomonas reinhardtii 38.12 7.00e-35 141.00
IUUC-Csa-023930 Chlorocebus sabaeus 99.76 0.00e+00 768.00
IUUC-Cho-024307 Choloepus hoffmanni 96.73 0.00e+00 738.00
IUUC-Cin-025619 Ciona intestinalis 46.30 5.00e-100 358.00
IUUC-Csv-026322 Ciona savignyi 46.03 1.00e-94 339.00
IUUC-Dre-027762 Danio rerio 67.91 2.00e-145 508.00
IUUC-Dno-029666 Dasypus novemcinctus 94.88 0.00e+00 733.00
IUUC-Dor-030133 Dipodomys ordii 95.56 8.00e-104 370.00
IUUC-Dme-031705 Drosophila melanogaster 37.12 3.00e-60 225.00
IUUC-Ete-032356 Echinops telfairi 76.87 3.00e-113 401.00
IUUC-Eca-033340 Equus caballus 97.86 0.00e+00 744.00
IUUC-Eeu-035167 Erinaceus europaeus 90.98 9.00e-171 592.00
IUUC-Fca-035536 Felis catus 95.01 0.00e+00 725.00
IUUC-Fal-036881 Ficedula albicollis 80.64 2.00e-175 608.00
IUUC-Gmo-039495 Gadus morhua 72.83 7.00e-103 367.00
IUUC-Ggr-039835 Gaeumannomyces graminis 42.86 8.00e-09 55.80
IUUC-Gga-041148 Gallus gallus 79.90 2.00e-167 581.00
IUUC-Gac-041790 Gasterosteus aculeatus 66.34 2.00e-148 518.00
IUUC-Ggo-045245 Gorilla gorilla 99.78 0.00e+00 800.00
IUUC-Hvu-047044 Hordeum vulgare 34.98 3.00e-48 185.00
IUUC-Itr-048468 Ictidomys tridecemlineatus 84.17 3.00e-111 394.00
IUUC-Lch-049777 Latimeria chalumnae 70.97 4.00e-145 508.00
IUUC-Loc-052281 Lepisosteus oculatus 70.21 2.00e-168 585.00
IUUC-Laf-054551 Loxodonta africana 92.29 0.00e+00 693.00
IUUC-Mcc-055160 Macaca mulatta 96.67 0.00e+00 739.00
IUUC-Meu-056809 Macropus eugenii 88.14 0.00e+00 662.00
IUUC-Mla-059005 Melampsora laricipopulina 28.02 5.00e-20 92.80
IUUC-Mga-059767 Meleagris gallopavo 80.29 5.00e-167 580.00
IUUC-Mmr-061574 Microcebus murinus 95.88 0.00e+00 723.00
IUUC-Mdo-061974 Monodelphis domestica 87.11 0.00e+00 672.00
IUUC-Mmu-063887 Mus musculus 94.47 0.00e+00 734.00
IUUC-Mac-064993 Musa acuminata 34.64 3.00e-61 228.00
IUUC-Mpu-066756 Mustela putorius furo 94.26 0.00e+00 667.00
IUUC-Mlu-067691 Myotis lucifugus 92.91 0.00e+00 710.00
IUUC-Nle-069845 Nomascus leucogenys 99.33 0.00e+00 770.00
IUUC-Opr-070262 Ochotona princeps 89.56 0.00e+00 691.00
IUUC-Ont-071561 Oreochromis niloticus 65.13 2.00e-161 561.00
IUUC-Oan-073517 Ornithorhynchus anatinus 43.42 5.00e-50 191.00
IUUC-Ocu-074869 Oryctolagus cuniculus 84.29 1.00e-169 589.00
IUUC-Ola-086506 Oryzias latipes 65.44 2.00e-152 532.00
IUUC-Olu-087870 Ostreococcus lucimarinus 43.22 3.00e-27 114.00
IUUC-Oga-088871 Otolemur garnettii 96.96 0.00e+00 771.00
IUUC-Oar-090436 Ovis aries 93.21 0.00e+00 686.00
IUUC-Ptr-091519 Pan troglodytes 99.77 0.00e+00 769.00
IUUC-Pan-092582 Papio anubis 98.61 0.00e+00 765.00
IUUC-Psi-093168 Pelodiscus sinensis 84.03 0.00e+00 634.00
IUUC-Pfo-096075 Poecilia formosa 66.05 8.00e-162 563.00
IUUC-Pab-098764 Pongo abelii 99.28 0.00e+00 764.00
IUUC-Pop-099909 Populus trichocarpa 34.54 5.00e-62 231.00
IUUC-Pca-100903 Procavia capensis 85.24 0.00e+00 694.00
IUUC-Ppe-101248 Prunus persica 43.85 2.00e-43 169.00
IUUC-Pva-103124 Pteropus vampyrus 84.81 3.00e-170 591.00
IUUC-Rno-104976 Rattus norvegicus 94.47 0.00e+00 739.00
IUUC-Sha-107572 Sarcophilus harrisii 87.40 0.00e+00 628.00
IUUC-Smo-109483 Selaginella moellendorffii 41.58 3.00e-47 182.00
IUUC-Sit-110077 Setaria italica 42.93 6.00e-47 181.00
IUUC-Sar-113068 Sorex araneus 88.10 0.00e+00 675.00
IUUC-Sbi-114884 Sorghum bicolor 35.04 8.00e-58 217.00
IUUC-Ssc-115272 Sus scrofa 95.56 0.00e+00 728.00
IUUC-Tgu-116537 Taeniopygia guttata 80.73 6.00e-177 613.00
IUUC-Tru-118205 Takifugu rubripes 63.53 2.00e-152 532.00
IUUC-Tsy-118929 Tarsius syrichta 98.00 4.00e-152 531.00
IUUC-Tni-120744 Tetraodon nigroviridis 61.82 7.00e-140 490.00
IUUC-Tca-121675 Theobroma cacao 34.11 8.00e-56 211.00
IUUC-Tur-126806 Triticum urartu 34.55 2.00e-46 179.00
IUUC-Tme-127048 Tuber melanosporum 26.25 2.00e-16 80.10
IUUC-Tbe-128131 Tupaia belangeri 91.26 1.00e-152 531.00
IUUC-Ttr-129099 Tursiops truncatus 96.73 0.00e+00 746.00
IUUC-Vpa-130663 Vicugna pacos 90.45 2.00e-160 558.00
IUUC-Xtr-132036 Xenopus tropicalis 79.52 9.00e-105 373.00
IUUC-Xma-134162 Xiphophorus maculatus 65.82 5.00e-161 560.00
Created Date 25-Jun-2017

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