iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.40e-17	62.6	46	109
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.00e-06	27.1	147	176

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           aDv ++v++e+++ah+++Laa+S++F+al+++++ e++ +  + ++ v  e+f++ll+++Y+g+l 
   Q: 46   ADVEFIVEEERIPAHRVILAARSEYFRALLYGGMAETT-QRQIPLE-VPLEAFKVLLRYIYSGTLL 109
           7************************************9.9999999.****************985 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkh 30
           l+N++ il++A+ly++++L +++l+f+ ++
   Q: 147  LDNVCMILDAARLYNLEELTEVCLMFMDRN 176
           69************************9887 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis.

Protein Sequence
(Fasta)

MSSQGHHKMS GGGKKGAMEQ DYTDVVDLGD RFSADMARLC MNEQYADVEF IVEEERIPAH 60
RVILAARSEY FRALLYGGMA ETTQRQIPLE VPLEAFKVLL RYIYSGTLLL STLDEDSTID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATATAACA GTTTTTCGCC GCAATAGAAG AATCCCTATT GTGCCATCGA TATTATCGAT 60
ATCACTAACT GTCATCGATG GATTGACGCA GCAGGCGAGA CGAAACGTTA ATTGTCAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR034091--BTBD9_BACK-like_dom
IPR000421--FA58C
IPR008979--Galactose-bd-like
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF00754--F5_F8_type_C

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030674--F:protein binding, bridging
GO:0031625--F:ubiquitin protein ligase binding
GO:0008344--P:adult locomotory behavior
GO:0045938--P:positive regulation of circadian sleep/wake cycle, sleep
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0032225--P:regulation of synaptic transmission, dopaminergic

KEGG

dme:Dmel_CG1826

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001333	Ailuropoda melanoleuca	51.10	3.00e-102	363.00
IUUC-Apl-003275	Anas platyrhynchos	54.06	2.00e-173	601.00
IUUC-Aca-004407	Anolis carolinensis	54.75	6.00e-170	590.00
IUUC-Afl-008477	Aspergillus flavus	30.77	2.00e-06	47.00
IUUC-Aor-010132	Aspergillus oryzae	30.77	2.00e-06	47.00
IUUC-Ame-011576	Astyanax mexicanus	54.26	2.00e-162	565.00
IUUC-Bta-012635	Bos taurus	51.65	1.00e-103	369.00
IUUC-Cel-018453	Caenorhabditis elegans	38.29	5.00e-106	377.00
IUUC-Cja-019564	Callithrix jacchus	50.82	5.00e-103	366.00
IUUC-Cfa-020412	Canis familiaris	50.00	1.00e-103	369.00
IUUC-Cpo-022116	Cavia porcellus	54.48	6.00e-175	606.00
IUUC-Csa-023458	Chlorocebus sabaeus	50.82	2.00e-102	365.00
IUUC-Cho-024472	Choloepus hoffmanni	50.69	6.00e-105	374.00
IUUC-Cin-025433	Ciona intestinalis	48.48	1.00e-153	535.00
IUUC-Csv-025875	Ciona savignyi	46.49	7.00e-141	493.00
IUUC-Cne-026897	Cryptococcus neoformans	26.67	3.70e-01	28.10
IUUC-Dre-028362	Danio rerio	54.11	3.00e-165	574.00
IUUC-Dno-029542	Dasypus novemcinctus	50.82	1.00e-102	365.00
IUUC-Dor-030108	Dipodomys ordii	47.89	2.00e-67	249.00
IUUC-Ete-033062	Echinops telfairi	60.28	3.00e-81	295.00
IUUC-Eca-034168	Equus caballus	54.10	7.00e-174	602.00
IUUC-Eeu-035231	Erinaceus europaeus	50.00	1.00e-39	157.00
IUUC-Fca-035540	Felis catus	35.85	2.00e-78	285.00
IUUC-Fal-037629	Ficedula albicollis	54.43	3.00e-174	603.00
IUUC-Gmo-038968	Gadus morhua	49.85	1.00e-80	292.00
IUUC-Gga-040297	Gallus gallus	53.87	3.00e-173	600.00
IUUC-Gac-042219	Gasterosteus aculeatus	48.31	2.00e-71	261.00
IUUC-Ggo-045584	Gorilla gorilla	53.73	6.00e-172	596.00
IUUC-Hsa-046262	Homo sapiens	54.29	5.00e-174	603.00
IUUC-Itr-047909	Ictidomys tridecemlineatus	51.52	1.00e-102	365.00
IUUC-Lch-050280	Latimeria chalumnae	53.20	9.00e-150	522.00
IUUC-Loc-052601	Lepisosteus oculatus	52.95	7.00e-168	583.00
IUUC-Laf-053474	Loxodonta africana	50.55	7.00e-102	363.00
IUUC-Mcc-055501	Macaca mulatta	54.10	5.00e-174	603.00
IUUC-Meu-056851	Macropus eugenii	58.54	4.00e-105	373.00
IUUC-Mga-059540	Meleagris gallopavo	52.36	1.00e-136	479.00
IUUC-Mmr-061009	Microcebus murinus	53.79	8.00e-174	602.00
IUUC-Mdo-061824	Monodelphis domestica	54.10	2.00e-170	591.00
IUUC-Mmu-064408	Mus musculus	53.97	1.00e-174	605.00
IUUC-Mpu-065943	Mustela putorius furo	51.10	1.00e-102	365.00
IUUC-Mlu-067349	Myotis lucifugus	50.55	2.00e-102	365.00
IUUC-Ncr-068884	Neurospora crassa	32.22	1.00e-07	50.80
IUUC-Nle-069794	Nomascus leucogenys	53.54	9.00e-172	595.00
IUUC-Opr-070569	Ochotona princeps	55.16	5.00e-142	496.00
IUUC-Ont-071668	Oreochromis niloticus	53.80	1.00e-166	578.00
IUUC-Oan-072886	Ornithorhynchus anatinus	52.80	6.00e-140	489.00
IUUC-Ocu-074010	Oryctolagus cuniculus	51.37	3.00e-103	367.00
IUUC-Ola-086345	Oryzias latipes	47.17	3.00e-31	126.00
IUUC-Oga-088389	Otolemur garnettii	54.10	2.00e-173	601.00
IUUC-Oar-089674	Ovis aries	51.37	2.00e-103	368.00
IUUC-Ptr-091004	Pan troglodytes	53.73	6.00e-172	596.00
IUUC-Pan-092824	Papio anubis	52.43	1.00e-167	582.00
IUUC-Psi-093770	Pelodiscus sinensis	54.55	7.00e-173	599.00
IUUC-Pma-094226	Petromyzon marinus	55.01	4.00e-152	530.00
IUUC-Pfo-096112	Poecilia formosa	52.88	5.00e-168	583.00
IUUC-Pab-098462	Pongo abelii	51.33	2.00e-168	585.00
IUUC-Pca-100966	Procavia capensis	43.90	1.00e-107	382.00
IUUC-Pva-102618	Pteropus vampyrus	54.29	2.00e-174	604.00
IUUC-Rno-105840	Rattus norvegicus	54.46	2.00e-175	608.00
IUUC-Sha-106785	Sarcophilus harrisii	53.25	2.00e-164	571.00
IUUC-Ssl-108583	Sclerotinia sclerotiorum	40.43	6.00e-05	42.00
IUUC-Sar-113661	Sorex araneus	53.44	6.00e-139	486.00
IUUC-Ssc-115629	Sus scrofa	61.27	1.00e-65	241.00
IUUC-Tgu-117110	Taeniopygia guttata	54.43	9.00e-174	602.00
IUUC-Tru-117672	Takifugu rubripes	53.06	9.00e-162	562.00
IUUC-Tsy-119176	Tarsius syrichta	53.92	2.00e-173	601.00
IUUC-Tni-120213	Tetraodon nigroviridis	52.50	4.00e-160	557.00
IUUC-Tre-122227	Trichoderma reesei	37.14	1.00e-07	48.50
IUUC-Tme-127039	Tuber melanosporum	27.03	9.00e-11	62.00
IUUC-Tbe-128031	Tupaia belangeri	51.12	4.00e-160	557.00
IUUC-Ttr-129304	Tursiops truncatus	44.50	4.00e-90	324.00
IUUC-Vpa-130638	Vicugna pacos	45.54	4.00e-132	464.00
IUUC-Xtr-132304	Xenopus tropicalis	54.07	6.00e-171	593.00
IUUC-Xma-133520	Xiphophorus maculatus	52.69	1.00e-167	582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence