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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046909
UUCD1 version UUC-HoS-00012
Ensembl Protein ID ENSP00000330341.2
UniProt Accession O14543; O14509; SOCS3_HUMAN
Genbank Protein ID BAA22430.1; BAA22537.1; AAD42231.1; AAH60858.1
Protein Name Suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; STAT-induced STAT inhibitor 3
Genbank Nucleotide ID AB004904; AB006967; AF159854; BC060858
Gene Name SOCS3; CIS3; SSI3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000184557.4 ENST00000330871.3 ENSP00000330341.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
miRecordsRepTarmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16616006; 12228220; 25939384
Organism Homo sapiens
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Protein Sequence
(Fasta)
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046909|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGCTCCGACT TGGACTCCCT GCTCCGCTGC TGCCGCTTCG GCCCCGCACG CAGCCAGCCG 60
CCAGCCGCCC GCCCGGCCCA GCTCCCGCCG CGGCCCCTTG CCGCGGTCCC TCTCCTGGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046909|E3,SOCS|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0582--Pharmaceutical
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0042517--P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation
KEGG hsa:9021
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001529 Ailuropoda melanoleuca 96.44 1.00e-107 382.00
IUUC-Apl-003607 Anas platyrhynchos 82.22 9.00e-97 345.00
IUUC-Aca-005063 Anolis carolinensis 82.38 2.00e-103 367.00
IUUC-Ath-006990 Arabidopsis thaliana 32.94 9.00e-03 36.20
IUUC-Ame-010859 Astyanax mexicanus 57.39 5.00e-71 260.00
IUUC-Bta-012817 Bos taurus 91.70 2.00e-111 394.00
IUUC-Bra-017963 Brassica rapa 30.00 6.20e-02 32.30
IUUC-Cja-019605 Callithrix jacchus 99.11 2.00e-114 404.00
IUUC-Cfa-021231 Canis familiaris 97.78 4.00e-109 387.00
IUUC-Cpo-022003 Cavia porcellus 91.23 2.00e-107 381.00
IUUC-Csa-023511 Chlorocebus sabaeus 100.00 7.00e-113 399.00
IUUC-Dre-028536 Danio rerio 59.57 1.00e-73 269.00
IUUC-Dno-029003 Dasypus novemcinctus 92.44 5.00e-110 390.00
IUUC-Eca-034205 Equus caballus 83.80 4.00e-68 250.00
IUUC-Fca-036317 Felis catus 95.96 2.00e-108 384.00
IUUC-Gmo-038777 Gadus morhua 63.89 9.00e-36 142.00
IUUC-Gga-041258 Gallus gallus 83.11 7.00e-97 346.00
IUUC-Gac-041837 Gasterosteus aculeatus 55.90 2.00e-65 241.00
IUUC-Ggo-045620 Gorilla gorilla 100.00 7.00e-113 399.00
IUUC-Itr-048023 Ictidomys tridecemlineatus 91.91 7.00e-112 396.00
IUUC-Lch-049510 Latimeria chalumnae 68.12 8.00e-85 306.00
IUUC-Loc-052863 Lepisosteus oculatus 63.04 1.00e-79 288.00
IUUC-Laf-054136 Loxodonta africana 92.54 2.00e-109 387.00
IUUC-Mcc-055383 Macaca mulatta 100.00 7.00e-113 399.00
IUUC-Meu-056153 Macropus eugenii 88.50 2.00e-110 391.00
IUUC-Mmr-061185 Microcebus murinus 95.13 3.00e-107 380.00
IUUC-Mdo-061819 Monodelphis domestica 89.33 1.00e-113 402.00
IUUC-Mmu-064231 Mus musculus 96.89 2.00e-119 421.00
IUUC-Mpu-066691 Mustela putorius furo 98.67 4.00e-109 387.00
IUUC-Mlu-067673 Myotis lucifugus 96.02 3.00e-116 410.00
IUUC-Ont-072406 Oreochromis niloticus 55.02 2.00e-68 251.00
IUUC-Oan-073249 Ornithorhynchus anatinus 74.67 7.00e-94 336.00
IUUC-Ocu-074935 Oryctolagus cuniculus 88.41 6.00e-32 128.00
IUUC-Ola-087373 Oryzias latipes 48.04 3.00e-48 184.00
IUUC-Oga-088041 Otolemur garnettii 92.89 1.00e-109 388.00
IUUC-Oar-089646 Ovis aries 90.39 2.00e-103 368.00
IUUC-Ptr-091502 Pan troglodytes 100.00 7.00e-113 399.00
IUUC-Pan-091934 Papio anubis 100.00 7.00e-113 399.00
IUUC-Pfo-096412 Poecilia formosa 42.79 3.00e-48 184.00
IUUC-Pab-098554 Pongo abelii 100.00 7.00e-113 399.00
IUUC-Rno-105874 Rattus norvegicus 96.44 4.00e-119 420.00
IUUC-Sha-107151 Sarcophilus harrisii 87.28 3.00e-110 390.00
IUUC-Ssc-115722 Sus scrofa 88.37 2.00e-65 240.00
IUUC-Tgu-117151 Taeniopygia guttata 84.00 4.00e-97 347.00
IUUC-Tru-118428 Takifugu rubripes 54.15 2.00e-68 251.00
IUUC-Tni-120590 Tetraodon nigroviridis 54.59 4.00e-67 247.00
IUUC-Ttr-129065 Tursiops truncatus 93.01 4.00e-111 393.00
IUUC-Xtr-132167 Xenopus tropicalis 65.78 1.00e-81 295.00
Created Date 25-Jun-2017

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