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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045898
UUCD1 version UUC-HoS-00279
Ensembl Protein ID ENSP00000281708.3
UniProt Accession Q969H0; B7ZLP9; Q68DR0; Q96A16; Q96LE0; Q96RI2; Q9NUX6; FBXW7_HUMAN
Genbank Protein ID AAK57547.1; AAK60269.1; AAL06290.1; AAL06291.1; AAL07271.1; AAG16640.1; CAH18160.1; AAH37320.1; AAI17245.1; AAI17247.1; AAI43945.1; BAA91986.1
Protein Name F-box/WD repeat-containing protein 7; Archipelago homolog; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4
Genbank Nucleotide ID AY033553; AF383178; AF411971; AF411972; AY049984; AY008274; CR749305; BC037320; BC117244; BC117246; BC143944; AK001933
Gene Name FBXW7; FBW7; FBX30; SEL10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109670.13 ENST00000296555.9 ENSP00000296555.4
ENSG00000109670.13 ENST00000281708.8 ENSP00000281708.3
ENSG00000109670.13 ENST00000263981.9 ENSP00000263981.4
ENSG00000109670.13 ENST00000393956.7 ENSP00000377528.3
ENSG00000109670.13 ENST00000604872.5 ENSP00000474751.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProt
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18500245; 11585921; 20208556; 19126544; 17574025; 18765672; 14739463; 20935640; 19660140; 18787170; 19364825; 15520277; 20534483; 20388706; 12354302; 21368833; 20622901; 21254166
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 18500245; 11585921; 20208556; 19126544; 17574025; 18765672; 14739463; 20935640; 18787170; 19364825; 15520277; 20534483; 20388706; 16054087; 12354302; 21368833
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00022 23.0 277 324
E3 adaptor/Cullin RING/DCX/DWD 2.60e-60 199.2 623 656
UBD/Beta-Prp 3.50e-102 343.3 374 656
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 99   daglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           +++ ++ lp+e+ + +l++l++++ll+aa++cr w+ la+++ lw++ 
   Q: 277  QRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 324
           5677899*********************************9****975 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 623  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 656
           9*********449******************976 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghe 94
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl gh+
   Q: 374  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHT 461
           6799************..*******************************************..***************************** PP
   S: 95   dsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
           ++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht++vysl
   Q: 462  STVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HTNRVYSL 547
           **********..************************.****************..***************************9.******** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdn 278
           +fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++v++l+f++n
   Q: 548  QFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN 635
           ***9..9**************************************..********************************************* PP
   S: 279  vlvlgsedskvniwklkknep 299
            +++ s+d++v++w+lk+ e+
   Q: 636  FVITSSDDGTVKLWDLKTGEF 656
           ****************98776 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
 Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
Protein Sequence
(Fasta)
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 60
GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045898|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGCCCCTC TCTCTGGAGT GAGGCGAGAG CCCCGCACAG AGCGAGGGAG ACAGCGAGCT 60
GAGCTCCGGG CGCTGCCGCT GCCGCTGCCG CCGCCGCCGC CGCTGAGACT GAGAGCGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045898|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0043234--C:protein complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030332--F:cyclin binding
GO:0042802--F:identical protein binding
GO:0050816--F:phosphothreonine binding
GO:0030674--F:protein binding, bridging
GO:0031625--F:ubiquitin protein ligase binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0055088--P:lipid homeostasis
GO:0032876--P:negative regulation of DNA endoreduplication
GO:2000346--P:negative regulation of hepatocyte proliferation
GO:0045746--P:negative regulation of Notch signaling pathway
GO:2000639--P:negative regulation of SREBP signaling pathway
GO:0010868--P:negative regulation of triglyceride biosynthetic process
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0031398--P:positive regulation of protein ubiquitination
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1902806--P:regulation of cell cycle G1/S phase transition
GO:0010883--P:regulation of lipid storage
GO:1903146--P:regulation of mitophagy
GO:0032880--P:regulation of protein localization
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion
GO:0001944--P:vasculature development
GO:0016032--P:viral process
KEGG hsa:55294
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 97.88 0.00e+00 1228.00
IUUC-Apl-003489 Anas platyrhynchos 91.09 0.00e+00 1203.00
IUUC-Aca-005318 Anolis carolinensis 98.00 0.00e+00 1099.00
IUUC-Ago-007794 Ashbya gossypii 31.07 9.00e-62 231.00
IUUC-Acl-008123 Aspergillus clavatus 32.40 7.00e-75 275.00
IUUC-Afl-008730 Aspergillus flavus 31.33 8.00e-74 271.00
IUUC-Afu-009014 Aspergillus fumigatus 32.53 3.00e-75 276.00
IUUC-Ani-009332 Aspergillus nidulans 33.47 3.00e-80 293.00
IUUC-Ang-009790 Aspergillus niger 31.71 4.00e-76 279.00
IUUC-Aor-010215 Aspergillus oryzae 30.71 1.00e-74 274.00
IUUC-Ate-010535 Aspergillus terreus 32.09 4.00e-76 279.00
IUUC-Ame-010898 Astyanax mexicanus 94.16 0.00e+00 1047.00
IUUC-Bgr-012075 Blumeria graminis 33.40 2.00e-79 290.00
IUUC-Bta-012391 Bos taurus 98.73 0.00e+00 1109.00
IUUC-Bci-013725 Botrytis cinerea 33.20 2.00e-78 286.00
IUUC-Cel-018495 Caenorhabditis elegans 48.73 2.00e-131 462.00
IUUC-Cja-018902 Callithrix jacchus 99.15 0.00e+00 1229.00
IUUC-Cfa-020237 Canis familiaris 97.47 0.00e+00 1227.00
IUUC-Cpo-022234 Cavia porcellus 98.73 0.00e+00 1111.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.54 8.00e-49 187.00
IUUC-Csa-023532 Chlorocebus sabaeus 99.86 0.00e+00 1207.00
IUUC-Cho-025026 Choloepus hoffmanni 83.83 0.00e+00 773.00
IUUC-Cin-025516 Ciona intestinalis 70.34 4.00e-141 494.00
IUUC-Csv-026312 Ciona savignyi 75.47 0.00e+00 755.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 34.82 5.00e-85 308.00
IUUC-Cne-027018 Cryptococcus neoformans 33.08 4.00e-73 270.00
IUUC-Cme-027168 Cyanidioschyzon merolae 31.10 4.00e-31 130.00
IUUC-Dre-028303 Danio rerio 94.09 0.00e+00 1049.00
IUUC-Dno-029576 Dasypus novemcinctus 97.31 0.00e+00 1214.00
IUUC-Dor-030196 Dipodomys ordii 93.36 0.00e+00 1212.00
IUUC-Dse-031558 Dothistroma septosporum 38.98 2.00e-70 260.00
IUUC-Dme-031702 Drosophila melanogaster 76.61 0.00e+00 802.00
IUUC-Ete-032791 Echinops telfairi 90.93 0.00e+00 1004.00
IUUC-Eca-033424 Equus caballus 98.73 0.00e+00 1110.00
IUUC-Eeu-034996 Erinaceus europaeus 93.80 0.00e+00 1186.00
IUUC-Fca-036422 Felis catus 97.05 0.00e+00 1241.00
IUUC-Fal-037267 Ficedula albicollis 98.36 0.00e+00 1097.00
IUUC-Fox-037800 Fusarium oxysporum 34.07 3.00e-84 306.00
IUUC-Fso-038258 Fusarium solani 34.21 2.00e-83 303.00
IUUC-Gmo-039119 Gadus morhua 83.73 0.00e+00 902.00
IUUC-Ggr-039781 Gaeumannomyces graminis 34.66 3.00e-85 309.00
IUUC-Gga-040667 Gallus gallus 92.93 0.00e+00 1194.00
IUUC-Gac-042423 Gasterosteus aculeatus 74.63 0.00e+00 803.00
IUUC-Ggo-044422 Gorilla gorilla 99.86 0.00e+00 1211.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 99.79 0.00e+00 976.00
IUUC-Kpa-049097 Komagataella pastoris 32.06 3.00e-76 280.00
IUUC-Lch-050414 Latimeria chalumnae 94.53 0.00e+00 1089.00
IUUC-Loc-052348 Lepisosteus oculatus 96.01 0.00e+00 1074.00
IUUC-Lma-053185 Leptosphaeria maculans 32.40 4.00e-72 266.00
IUUC-Laf-054054 Loxodonta africana 97.04 0.00e+00 1241.00
IUUC-Mcc-055056 Macaca mulatta 99.86 0.00e+00 1207.00
IUUC-Meu-056778 Macropus eugenii 93.45 0.00e+00 741.00
IUUC-Mor-057133 Magnaporthe oryzae 39.13 4.00e-74 273.00
IUUC-Mpo-057542 Magnaporthe poae 39.13 4.00e-74 273.00
IUUC-Mla-059081 Melampsora laricipopulina 32.57 1.00e-76 280.00
IUUC-Mga-059255 Meleagris gallopavo 93.35 0.00e+00 1187.00
IUUC-Mvi-060490 Microbotryum violaceum 38.75 2.00e-67 251.00
IUUC-Mmr-061292 Microcebus murinus 99.01 0.00e+00 1231.00
IUUC-Mdo-062304 Monodelphis domestica 93.44 0.00e+00 1206.00
IUUC-Mmu-063610 Mus musculus 93.94 0.00e+00 1271.00
IUUC-Mpu-065931 Mustela putorius furo 98.31 0.00e+00 1230.00
IUUC-Mlu-066976 Myotis lucifugus 97.46 0.00e+00 1265.00
IUUC-Nfi-068428 Neosartorya fischeri 31.93 4.00e-75 276.00
IUUC-Ncr-068688 Neurospora crassa 35.97 2.00e-87 316.00
IUUC-Nle-070174 Nomascus leucogenys 99.86 0.00e+00 1209.00
IUUC-Opr-070851 Ochotona princeps 86.58 0.00e+00 654.00
IUUC-Ont-071997 Oreochromis niloticus 93.28 0.00e+00 1072.00
IUUC-Oan-072936 Ornithorhynchus anatinus 93.50 0.00e+00 1246.00
IUUC-Ocu-074742 Oryctolagus cuniculus 99.64 0.00e+00 1139.00
IUUC-Obr-076806 Oryza brachyantha 31.52 1.00e-29 125.00
IUUC-Oin-079809 Oryza indica 31.52 8.00e-30 126.00
IUUC-Ola-087098 Oryzias latipes 94.09 0.00e+00 1060.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.47 5.00e-38 150.00
IUUC-Oga-088884 Otolemur garnettii 100.00 0.00e+00 786.00
IUUC-Oar-090220 Ovis aries 96.06 0.00e+00 1212.00
IUUC-Ptr-090492 Pan troglodytes 100.00 0.00e+00 1211.00
IUUC-Pan-091770 Papio anubis 99.58 0.00e+00 1203.00
IUUC-Psi-093207 Pelodiscus sinensis 98.73 0.00e+00 1111.00
IUUC-Pma-094749 Petromyzon marinus 83.67 0.00e+00 945.00
IUUC-Pno-095026 Phaeosphaeria nodorum 38.83 7.00e-71 262.00
IUUC-Pfo-096493 Poecilia formosa 94.37 0.00e+00 1060.00
IUUC-Pab-098141 Pongo abelii 98.73 0.00e+00 1110.00
IUUC-Pca-100571 Procavia capensis 97.38 0.00e+00 847.00
IUUC-Pva-102988 Pteropus vampyrus 97.74 0.00e+00 1234.00
IUUC-Pgr-103612 Puccinia graminis 35.66 6.00e-62 232.00
IUUC-Ptt-103698 Puccinia triticina 35.55 2.00e-41 164.00
IUUC-Pte-104275 Pyrenophora teres 32.36 1.00e-73 271.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 39.09 9.00e-70 258.00
IUUC-Rno-105706 Rattus norvegicus 92.99 0.00e+00 1237.00
IUUC-Sce-106314 Saccharomyces cerevisiae 29.39 7.00e-61 228.00
IUUC-Sha-107653 Sarcophilus harrisii 96.05 0.00e+00 1246.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 33.83 3.00e-79 290.00
IUUC-Spo-108115 Schizosaccharomyces pombe 32.14 1.00e-62 234.00
IUUC-Sar-113600 Sorex araneus 93.35 0.00e+00 1120.00
IUUC-Sre-114901 Sporisorium reilianum 44.21 2.00e-67 251.00
IUUC-Ssc-115787 Sus scrofa 96.46 0.00e+00 1198.00
IUUC-Tgu-117510 Taeniopygia guttata 93.35 0.00e+00 1189.00
IUUC-Tru-117819 Takifugu rubripes 93.97 0.00e+00 1082.00
IUUC-Tsy-118828 Tarsius syrichta 98.45 0.00e+00 1245.00
IUUC-Tni-120468 Tetraodon nigroviridis 93.65 0.00e+00 1071.00
IUUC-Tre-122193 Trichoderma reesei 36.25 3.00e-85 309.00
IUUC-Tvi-122615 Trichoderma virens 35.03 8.00e-84 304.00
IUUC-Tme-127021 Tuber melanosporum 34.55 1.00e-83 304.00
IUUC-Tbe-127925 Tupaia belangeri 100.00 0.00e+00 1104.00
IUUC-Ttr-128899 Tursiops truncatus 98.87 0.00e+00 1226.00
IUUC-Uma-129449 Ustilago maydis 43.16 1.00e-66 249.00
IUUC-Vda-129802 Verticillium dahliae 36.20 2.00e-87 317.00
IUUC-Vpa-130082 Vicugna pacos 98.87 0.00e+00 1049.00
IUUC-Xtr-132213 Xenopus tropicalis 87.78 0.00e+00 1163.00
IUUC-Xma-133646 Xiphophorus maculatus 94.71 0.00e+00 1053.00
IUUC-Yli-134429 Yarrowia lipolytica 34.27 1.00e-86 314.00
Created Date 25-Jun-2017

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