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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046356
UUCD1 version UUC-HoS-00398
Ensembl Protein ID ENSP00000277458.4
UniProt Accession Q9NWX5; Q5SZB7; Q9BV15; ASB6_HUMAN
Genbank Protein ID BAA91250.1; BAB14355.1; CAI14509.1; CAI14510.1; EAW87899.1; EAW87900.1; AAH01719.1; AAH65913.1
Protein Name Ankyrin repeat and SOCS box protein 6
Genbank Nucleotide ID AK000555; AK023004; AL590369; AL590369; CH471090; CH471090; BC001719; BC065913
Gene Name ASB6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000148331.11 ENST00000277459.8 ENSP00000277459.4
ENSG00000148331.11 ENST00000277458.4 ENSP00000277458.4
ENSG00000148331.11 ENST00000450050.6 ENSP00000416172.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16325183
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 6.30e-16 59.6 363 413
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrl.kaidkLPLPksLkdYLlyed 51
            +l++l+s p++L+hLCR+aIr +l+ + +  ++++LPLP++Lk+YLl+e+
   Q: 363  FSLRQLESYPPPLKHLCRVAIRLYLQPWPVdVKVKALPLPDRLKWYLLSEH 413
           57899********************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLERKA 60
HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046356|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCACTTCCG GCGGGGGCGC GGCTTGGACT GAGGAGCGGA CCCGGCCGGG CGCAGGGGCT 60
GGACTGGCGG AGCAGGTGGG GTCCGCGGCC GCCGGAGCGT TCCGGTCGGC GTCTGGGCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046356|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:140459
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002347 Ailuropoda melanoleuca 95.25 0.00e+00 824.00
IUUC-Apl-004040 Anas platyrhynchos 69.10 5.00e-172 597.00
IUUC-Aca-005115 Anolis carolinensis 62.11 2.00e-112 399.00
IUUC-Bta-013038 Bos taurus 94.54 0.00e+00 817.00
IUUC-Cja-019234 Callithrix jacchus 97.67 0.00e+00 776.00
IUUC-Cfa-021244 Canis familiaris 95.96 0.00e+00 827.00
IUUC-Cpo-021929 Cavia porcellus 91.90 0.00e+00 796.00
IUUC-Csa-023836 Chlorocebus sabaeus 98.57 0.00e+00 854.00
IUUC-Cho-024476 Choloepus hoffmanni 71.13 4.00e-89 320.00
IUUC-Dre-028690 Danio rerio 49.88 2.00e-92 333.00
IUUC-Dno-029283 Dasypus novemcinctus 85.21 0.00e+00 716.00
IUUC-Dor-030485 Dipodomys ordii 87.96 0.00e+00 635.00
IUUC-Ete-032418 Echinops telfairi 85.09 4.00e-163 566.00
IUUC-Eca-033988 Equus caballus 95.31 0.00e+00 745.00
IUUC-Eeu-034941 Erinaceus europaeus 92.40 0.00e+00 798.00
IUUC-Fca-036496 Felis catus 95.49 0.00e+00 826.00
IUUC-Fal-036984 Ficedula albicollis 68.24 2.00e-158 551.00
IUUC-Gmo-039150 Gadus morhua 63.13 7.00e-66 244.00
IUUC-Gga-041266 Gallus gallus 65.89 6.00e-157 547.00
IUUC-Gac-042080 Gasterosteus aculeatus 53.32 4.00e-108 384.00
IUUC-Ggo-044937 Gorilla gorilla 99.76 0.00e+00 858.00
IUUC-Itr-048455 Ictidomys tridecemlineatus 94.52 0.00e+00 744.00
IUUC-Lch-050601 Latimeria chalumnae 68.27 5.00e-153 533.00
IUUC-Loc-052854 Lepisosteus oculatus 54.04 5.00e-109 387.00
IUUC-Laf-054179 Loxodonta africana 95.96 0.00e+00 828.00
IUUC-Mcc-054853 Macaca mulatta 98.81 0.00e+00 855.00
IUUC-Meu-056311 Macropus eugenii 89.62 9.00e-166 575.00
IUUC-Mga-059491 Meleagris gallopavo 62.85 6.00e-144 504.00
IUUC-Mmr-060741 Microcebus murinus 96.20 0.00e+00 834.00
IUUC-Mdo-061962 Monodelphis domestica 85.27 0.00e+00 706.00
IUUC-Mmu-063538 Mus musculus 90.14 0.00e+00 761.00
IUUC-Mpu-066576 Mustela putorius furo 94.30 0.00e+00 817.00
IUUC-Mlu-067582 Myotis lucifugus 92.49 0.00e+00 731.00
IUUC-Nle-069380 Nomascus leucogenys 98.19 0.00e+00 772.00
IUUC-Opr-070468 Ochotona princeps 84.29 0.00e+00 719.00
IUUC-Ont-071911 Oreochromis niloticus 53.18 5.00e-105 374.00
IUUC-Ola-087028 Oryzias latipes 53.08 2.00e-112 399.00
IUUC-Oga-088844 Otolemur garnettii 95.49 0.00e+00 832.00
IUUC-Oar-089960 Ovis aries 86.85 0.00e+00 734.00
IUUC-Ptr-091084 Pan troglodytes 100.00 0.00e+00 861.00
IUUC-Pan-092635 Papio anubis 98.44 0.00e+00 781.00
IUUC-Psi-093269 Pelodiscus sinensis 78.30 0.00e+00 658.00
IUUC-Pfo-096198 Poecilia formosa 53.90 2.00e-101 363.00
IUUC-Pab-098489 Pongo abelii 95.74 0.00e+00 680.00
IUUC-Pca-100298 Procavia capensis 89.82 0.00e+00 683.00
IUUC-Pva-102166 Pteropus vampyrus 96.30 0.00e+00 693.00
IUUC-Rno-105914 Rattus norvegicus 91.28 0.00e+00 639.00
IUUC-Sha-106776 Sarcophilus harrisii 85.27 0.00e+00 726.00
IUUC-Ssc-116376 Sus scrofa 96.91 0.00e+00 835.00
IUUC-Tgu-116627 Taeniopygia guttata 68.81 1.00e-154 539.00
IUUC-Tru-118229 Takifugu rubripes 52.59 6.00e-108 384.00
IUUC-Tni-120261 Tetraodon nigroviridis 52.87 4.00e-109 388.00
IUUC-Tbe-127507 Tupaia belangeri 95.29 4.00e-89 322.00
IUUC-Ttr-128163 Tursiops truncatus 96.67 0.00e+00 834.00
IUUC-Xtr-132889 Xenopus tropicalis 72.77 1.00e-180 625.00
Created Date 25-Jun-2017

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