• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046481
UUCD1 version UUC-HoS-00008
Ensembl Protein ID ENSP00000225873.3
UniProt Accession O00623; B2R6M2; PEX12_HUMAN
Genbank Protein ID AAC68812.1; AAC68813.1; BAA31559.1; BAG35519.1; EAW80143.1; AAH31085.1
Protein Name Peroxisome assembly protein 12; Peroxin-12; Peroxisome assembly factor 3
Genbank Nucleotide ID U91521; U91522; AB004546; AK312635; CH471147; BC031085
Gene Name PEX12; PAF3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108733.9 ENST00000225873.8 ENSP00000225873.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19687296
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.2 10.5 304 341
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++C+    + +++   g vf+  C+ ++       + ++ CP+
   Q: 304  CPLCRKTRVNDTVLATSGYVFCYRCVFHY------VRSHQACPI 341
           ****9966444888999*********999......899999996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for protein import into peroxisomes.
 Required for protein import into peroxisomes.
Protein Sequence
(Fasta)
MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD 60
EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046481|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGACGTCTGC GCGGTGCCCC AAACAGCTTG TCAAAAAGAC CTCGCAGAGA GAGGTTCAGA 60
GCTGTAGCTT TCCAGCGAGG CTACCATGCA GACCCAGCTA CGAAAAGTAA ACCAAACTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046481|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0958--Peroxisome biogenesis disorder
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR017375--PEX12
IPR006845--Pex_N
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF04757--Pex2_Pex12
Gene Ontology

GO:0005779--C:integral component of peroxisomal membrane
GO:1990429--C:peroxisomal importomer complex
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008022--F:protein C-terminus binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix
GO:0006513--P:protein monoubiquitination
GO:0006625--P:protein targeting to peroxisome
KEGG hsa:5193
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001074 Aegilops tauschii 27.58 3.00e-25 109.00
IUUC-Aml-001787 Ailuropoda melanoleuca 93.04 3.00e-166 577.00
IUUC-Atr-002774 Amborella trichopoda 32.38 2.00e-42 166.00
IUUC-Apl-003884 Anas platyrhynchos 70.40 2.00e-105 375.00
IUUC-Aly-005467 Arabidopsis lyrata 29.74 2.00e-33 136.00
IUUC-Ath-007043 Arabidopsis thaliana 29.38 1.00e-33 137.00
IUUC-Ago-007833 Ashbya gossypii 26.97 1.00e-14 74.30
IUUC-Acl-008074 Aspergillus clavatus 25.25 6.00e-27 115.00
IUUC-Afl-008656 Aspergillus flavus 29.37 2.00e-23 103.00
IUUC-Afu-008808 Aspergillus fumigatus 25.25 1.00e-20 94.70
IUUC-Ani-009154 Aspergillus nidulans 26.59 1.00e-26 114.00
IUUC-Ang-009803 Aspergillus niger 26.23 2.00e-21 97.10
IUUC-Aor-009984 Aspergillus oryzae 29.37 2.00e-23 103.00
IUUC-Ate-010567 Aspergillus terreus 26.50 3.00e-04 39.30
IUUC-Ame-010950 Astyanax mexicanus 61.22 2.00e-106 379.00
IUUC-Bgr-011992 Blumeria graminis 25.75 3.00e-24 106.00
IUUC-Bta-012658 Bos taurus 93.87 2.00e-180 624.00
IUUC-Bci-013586 Botrytis cinerea 27.47 7.00e-23 101.00
IUUC-Bdi-014625 Brachypodium distachyon 30.33 7.00e-37 147.00
IUUC-Bol-015713 Brassica oleracea 30.05 4.00e-26 112.00
IUUC-Bra-017037 Brassica rapa 31.37 3.00e-29 122.00
IUUC-Cel-018483 Caenorhabditis elegans 36.72 5.00e-55 207.00
IUUC-Cja-019601 Callithrix jacchus 95.82 0.00e+00 664.00
IUUC-Cfa-020854 Canis familiaris 92.20 2.00e-175 608.00
IUUC-Cpo-021920 Cavia porcellus 92.48 0.00e+00 637.00
IUUC-Cre-022816 Chlamydomonas reinhardtii 30.17 5.00e-18 86.70
IUUC-Csa-023545 Chlorocebus sabaeus 97.49 0.00e+00 643.00
IUUC-Cin-025523 Ciona intestinalis 37.78 8.00e-62 230.00
IUUC-Csv-026141 Ciona savignyi 33.80 5.00e-56 211.00
IUUC-Cgl-026641 Colletotrichum gloeosporioides 29.61 5.00e-19 88.60
IUUC-Cne-026949 Cryptococcus neoformans 25.81 4.00e-06 46.20
IUUC-Cme-027334 Cyanidioschyzon merolae 28.33 3.00e-31 129.00
IUUC-Dre-027602 Danio rerio 60.17 9.00e-113 399.00
IUUC-Dno-029980 Dasypus novemcinctus 92.20 2.00e-177 614.00
IUUC-Dor-030627 Dipodomys ordii 92.76 2.00e-177 614.00
IUUC-Dse-031219 Dothistroma septosporum 24.57 7.00e-26 112.00
IUUC-Dme-031953 Drosophila melanogaster 28.08 5.00e-20 91.70
IUUC-Ete-032811 Echinops telfairi 84.40 7.00e-171 593.00
IUUC-Eca-033635 Equus caballus 94.15 0.00e+00 654.00
IUUC-Eeu-034584 Erinaceus europaeus 91.09 0.00e+00 657.00
IUUC-Fca-035710 Felis catus 93.59 1.00e-180 625.00
IUUC-Fal-037416 Ficedula albicollis 74.21 1.00e-126 446.00
IUUC-Fox-037908 Fusarium oxysporum 27.39 1.00e-25 110.00
IUUC-Fso-038283 Fusarium solani 26.82 4.00e-27 115.00
IUUC-Gmo-039567 Gadus morhua 52.34 1.00e-21 97.40
IUUC-Ggr-040097 Gaeumannomyces graminis 27.97 7.00e-18 85.10
IUUC-Gga-040757 Gallus gallus 76.04 2.00e-151 528.00
IUUC-Gac-042008 Gasterosteus aculeatus 51.77 1.00e-72 266.00
IUUC-Gma-044278 Glycine max 32.62 9.00e-41 160.00
IUUC-Ggo-044888 Gorilla gorilla 99.72 0.00e+00 689.00
IUUC-Hvu-047274 Hordeum vulgare 42.06 1.00e-18 85.90
IUUC-Itr-048925 Ictidomys tridecemlineatus 91.92 4.00e-175 607.00
IUUC-Kpa-049394 Komagataella pastoris 23.76 8.00e-18 84.70
IUUC-Lch-050347 Latimeria chalumnae 68.42 9.00e-137 479.00
IUUC-Lpe-051711 Leersia perrieri 29.84 3.00e-36 145.00
IUUC-Loc-052943 Lepisosteus oculatus 65.93 1.00e-103 369.00
IUUC-Lma-053231 Leptosphaeria maculans 26.74 1.00e-20 96.30
IUUC-Laf-053506 Loxodonta africana 93.87 5.00e-179 620.00
IUUC-Mcc-055863 Macaca mulatta 97.77 0.00e+00 652.00
IUUC-Meu-056343 Macropus eugenii 85.36 8.00e-168 582.00
IUUC-Mor-057266 Magnaporthe oryzae 29.66 4.00e-19 89.40
IUUC-Mtr-058337 Medicago truncatula 29.16 4.00e-31 129.00
IUUC-Mla-058905 Melampsora laricipopulina 28.39 6.00e-37 148.00
IUUC-Mga-059695 Meleagris gallopavo 73.77 4.00e-130 457.00
IUUC-Mvi-060538 Microbotryum violaceum 26.15 4.00e-31 129.00
IUUC-Mmr-061680 Microcebus murinus 93.31 0.00e+00 645.00
IUUC-Mdo-063013 Monodelphis domestica 85.79 4.00e-170 590.00
IUUC-Mmu-063239 Mus musculus 89.42 0.00e+00 654.00
IUUC-Mac-064765 Musa acuminata 31.01 2.00e-39 156.00
IUUC-Mpu-066866 Mustela putorius furo 93.31 3.00e-162 564.00
IUUC-Mlu-067535 Myotis lucifugus 94.15 0.00e+00 651.00
IUUC-Nfi-068561 Neosartorya fischeri 26.67 5.00e-21 95.90
IUUC-Ncr-068700 Neurospora crassa 30.31 2.00e-21 97.10
IUUC-Nle-069709 Nomascus leucogenys 98.61 0.00e+00 656.00
IUUC-Opr-070983 Ochotona princeps 91.09 0.00e+00 631.00
IUUC-Ont-071734 Oreochromis niloticus 55.15 7.00e-91 327.00
IUUC-Oan-072762 Ornithorhynchus anatinus 65.55 3.00e-51 195.00
IUUC-Ocu-074733 Oryctolagus cuniculus 93.04 0.00e+00 646.00
IUUC-Oba-075943 Oryza barthii 29.24 8.00e-35 141.00
IUUC-Obr-076017 Oryza brachyantha 29.50 1.00e-35 144.00
IUUC-Ogl-077702 Oryza glaberrima 29.24 8.00e-35 141.00
IUUC-Ogu-078692 Oryza glumaepatula 29.09 1.00e-34 140.00
IUUC-Oin-079133 Oryza indica 29.24 9.00e-35 141.00
IUUC-Oni-082667 Oryza nivara 29.24 9.00e-35 141.00
IUUC-Opu-083858 Oryza punctata 29.24 1.00e-35 144.00
IUUC-Oru-084886 Oryza rufipogon 29.24 8.00e-35 141.00
IUUC-Osa-085512 Oryza sativa 29.24 8.00e-35 141.00
IUUC-Ola-087150 Oryzias latipes 50.97 2.00e-91 329.00
IUUC-Olu-087595 Ostreococcus lucimarinus 25.89 1.00e-24 107.00
IUUC-Oga-088647 Otolemur garnettii 93.59 0.00e+00 636.00
IUUC-Oar-089308 Ovis aries 92.76 4.00e-176 610.00
IUUC-Ptr-090543 Pan troglodytes 99.44 0.00e+00 687.00
IUUC-Pan-091907 Papio anubis 97.49 0.00e+00 647.00
IUUC-Psi-093888 Pelodiscus sinensis 79.11 4.00e-156 544.00
IUUC-Pno-094821 Phaeosphaeria nodorum 25.42 5.00e-21 95.90
IUUC-Ppa-095287 Physcomitrella patens 31.73 5.00e-43 168.00
IUUC-Pfo-097238 Poecilia formosa 53.28 8.00e-97 347.00
IUUC-Pab-097938 Pongo abelii 98.61 0.00e+00 682.00
IUUC-Pop-098827 Populus trichocarpa 30.57 1.00e-36 147.00
IUUC-Pca-100488 Procavia capensis 91.56 1.00e-110 392.00
IUUC-Ppe-101914 Prunus persica 31.95 3.00e-40 159.00
IUUC-Pva-102469 Pteropus vampyrus 89.97 4.00e-167 580.00
IUUC-Pgr-103388 Puccinia graminis 25.51 1.00e-28 120.00
IUUC-Ptt-103988 Puccinia triticina 25.38 2.00e-24 106.00
IUUC-Pte-104186 Pyrenophora teres 26.18 2.00e-22 100.00
IUUC-Pyt-104605 Pyrenophora triticirepentis 26.18 2.00e-21 97.40
IUUC-Rno-105071 Rattus norvegicus 88.58 0.00e+00 652.00
IUUC-Sce-106238 Saccharomyces cerevisiae 24.14 2.00e-15 77.00
IUUC-Sha-107200 Sarcophilus harrisii 84.57 1.00e-148 519.00
IUUC-Sja-108008 Schizosaccharomyces japonicus 22.67 5.00e-17 81.60
IUUC-Spo-108077 Schizosaccharomyces pombe 20.73 4.00e-05 42.40
IUUC-Ssl-108559 Sclerotinia sclerotiorum 27.56 1.00e-22 101.00
IUUC-Smo-109083 Selaginella moellendorffii 33.78 4.00e-43 168.00
IUUC-Sit-110306 Setaria italica 31.27 2.00e-37 150.00
IUUC-Sly-111409 Solanum lycopersicum 32.46 6.00e-40 158.00
IUUC-Stu-112852 Solanum tuberosum 32.20 2.00e-39 156.00
IUUC-Sar-112967 Sorex araneus 89.01 5.00e-91 326.00
IUUC-Sbi-114722 Sorghum bicolor 29.50 3.00e-35 142.00
IUUC-Sre-115089 Sporisorium reilianum 29.12 3.00e-27 116.00
IUUC-Ssc-115367 Sus scrofa 93.31 0.00e+00 659.00
IUUC-Tgu-117176 Taeniopygia guttata 71.87 9.00e-141 493.00
IUUC-Tru-118162 Takifugu rubripes 52.62 2.00e-94 339.00
IUUC-Tsy-119231 Tarsius syrichta 94.99 0.00e+00 658.00
IUUC-Tni-119962 Tetraodon nigroviridis 55.15 4.00e-92 331.00
IUUC-Tca-121100 Theobroma cacao 30.63 2.00e-37 150.00
IUUC-Tre-122015 Trichoderma reesei 30.58 8.00e-28 118.00
IUUC-Tvi-122573 Trichoderma virens 26.65 1.00e-29 124.00
IUUC-Tae-123664 Triticum aestivum 28.39 8.00e-34 137.00
IUUC-Tur-126843 Triticum urartu 28.39 8.00e-34 137.00
IUUC-Tme-127060 Tuber melanosporum 27.30 3.00e-35 142.00
IUUC-Ttr-128998 Tursiops truncatus 90.25 0.00e+00 635.00
IUUC-Uma-129524 Ustilago maydis 30.82 1.00e-30 127.00
IUUC-Vvi-130933 Vitis vinifera 31.54 2.00e-36 146.00
IUUC-Xtr-132968 Xenopus tropicalis 64.90 9.00e-127 446.00
IUUC-Xma-133355 Xiphophorus maculatus 52.32 3.00e-98 351.00
IUUC-Yli-134388 Yarrowia lipolytica 27.27 1.00e-28 120.00
IUUC-Zma-135423 Zea mays 29.50 3.00e-35 142.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved