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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046194
UUCD1 version UUC-HoS-00258
Ensembl Protein ID ENSP00000355077.4
UniProt Accession Q8WV22; D3DWF6; Q9P045; Q9P049; NSE1_HUMAN
Genbank Protein ID AAF29011.1; AAF29015.1; EAW55756.1; EAW55757.1; AAH18938.4
Protein Name Non-structural maintenance of chromosomes element 1 homolog
Genbank Nucleotide ID AF161451; AF161455; AC106739; CH471145; BC018938
Gene Name NSMCE1; HSPC333; HSPC337
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169189.16 ENST00000361439.8 ENSP00000355077.4
ENSG00000169189.16 ENST00000569236.5 ENSP00000456053.1
ENSG00000169189.16 ENST00000562039.1 ENSP00000457893.1
ENSG00000169189.16 ENST00000563273.5 ENSP00000458859.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20864041
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.9 10.2 191 232
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ + +g  +  Cg  +h+ C+ k+     +s+ e rCP C+
   Q: 191  CNICHSLLIQGQSCETCGIRMHLPCVAKY----FQSNAEPRCPHCN 232
           9999998866655588***9*****9999....99**********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.
 Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.
Protein Sequence
(Fasta)
MQGSTRRMGV MTDVHRRFLQ LLMTHGVLEE WDVKRLQTHC YKVHDRNATV DKLEDFINNI 60
NSVLESLYIE IKRGVTEDDG RPIYALVNLA TTSISKMATD FAENELDLFR KALELIIDSE 120
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Protein Fasta Sequence


>IUUC-Hsa-046194|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGTTCGCGT TCGCCCCGCC TCAAAGGAAG AAGAGTCCAC CTTGCGACCG TATCCGCTAG 60
CGCGGCCTGG GATGCGCTTG GGCTCCCTGG TGGGTAACGT GGGGAGCTAG GGGTTGGAGG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046194|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011513--Nse1
IPR002219--PE/DAG-bd
IPR001841--Znf_RING
IPR014857--Znf_RING-like
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF07574--SMC_Nse1
PF08746--zf-RING-like
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000724--P:double-strand break repair via homologous recombination
GO:0035556--P:intracellular signal transduction
GO:2001022--P:positive regulation of response to DNA damage stimulus
GO:0006301--P:postreplication repair
KEGG hsa:197370
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000235 Aegilops tauschii 25.44 2.00e-17 82.80
IUUC-Aml-002226 Ailuropoda melanoleuca 89.14 5.00e-146 509.00
IUUC-Atr-003071 Amborella trichopoda 24.91 8.00e-18 84.30
IUUC-Apl-003221 Anas platyrhynchos 61.41 1.00e-85 309.00
IUUC-Aca-004369 Anolis carolinensis 54.11 1.00e-73 269.00
IUUC-Aly-005460 Arabidopsis lyrata 23.47 2.00e-13 70.10
IUUC-Ath-007414 Arabidopsis thaliana 24.90 1.00e-13 70.90
IUUC-Acl-008122 Aspergillus clavatus 21.58 1.00e-18 87.40
IUUC-Afl-008641 Aspergillus flavus 22.66 2.00e-21 96.30
IUUC-Afu-008941 Aspergillus fumigatus 21.30 4.00e-18 85.50
IUUC-Ang-009852 Aspergillus niger 22.63 7.00e-19 88.20
IUUC-Aor-010041 Aspergillus oryzae 22.66 1.00e-21 97.40
IUUC-Ame-011050 Astyanax mexicanus 52.14 1.00e-75 276.00
IUUC-Bgr-012061 Blumeria graminis 25.70 2.00e-16 80.50
IUUC-Bta-012376 Bos taurus 89.55 1.00e-120 425.00
IUUC-Bci-013706 Botrytis cinerea 26.89 5.00e-22 98.60
IUUC-Bdi-014858 Brachypodium distachyon 23.23 2.00e-17 83.20
IUUC-Bol-015509 Brassica oleracea 23.27 1.00e-12 67.40
IUUC-Bra-017956 Brassica rapa 23.27 8.00e-13 67.80
IUUC-Cja-019666 Callithrix jacchus 88.14 4.00e-128 450.00
IUUC-Cfa-020418 Canis familiaris 91.35 3.00e-150 524.00
IUUC-Cpo-022527 Cavia porcellus 93.88 3.00e-135 474.00
IUUC-Csa-023268 Chlorocebus sabaeus 98.50 3.00e-159 553.00
IUUC-Cin-025337 Ciona intestinalis 33.91 7.00e-35 140.00
IUUC-Csv-025935 Ciona savignyi 36.25 9.00e-16 75.50
IUUC-Cgl-026400 Colletotrichum gloeosporioides 21.13 5.00e-14 72.00
IUUC-Cne-027096 Cryptococcus neoformans 25.19 4.00e-22 99.00
IUUC-Dre-028628 Danio rerio 49.58 2.00e-63 235.00
IUUC-Dno-029636 Dasypus novemcinctus 91.35 1.00e-148 518.00
IUUC-Dor-030523 Dipodomys ordii 87.45 9.00e-142 495.00
IUUC-Dse-031163 Dothistroma septosporum 22.51 1.00e-17 84.00
IUUC-Dme-032062 Drosophila melanogaster 26.63 1.00e-14 73.20
IUUC-Ete-032673 Echinops telfairi 86.82 5.00e-128 450.00
IUUC-Eca-034155 Equus caballus 91.35 2.00e-149 521.00
IUUC-Eeu-034647 Erinaceus europaeus 87.27 6.00e-117 412.00
IUUC-Fca-036073 Felis catus 75.85 4.00e-117 414.00
IUUC-Fal-037212 Ficedula albicollis 56.90 2.00e-75 275.00
IUUC-Fox-037947 Fusarium oxysporum 20.37 3.00e-13 69.70
IUUC-Fso-038221 Fusarium solani 22.01 7.00e-17 81.60
IUUC-Gmo-039682 Gadus morhua 41.92 3.00e-53 201.00
IUUC-Ggr-039809 Gaeumannomyces graminis 23.33 4.00e-14 72.80
IUUC-Gga-040407 Gallus gallus 60.87 5.00e-83 300.00
IUUC-Gac-042107 Gasterosteus aculeatus 51.45 4.00e-68 251.00
IUUC-Gma-043783 Glycine max 24.11 2.00e-17 83.20
IUUC-Ggo-044492 Gorilla gorilla 98.87 3.00e-159 553.00
IUUC-Hvu-047237 Hordeum vulgare 23.90 2.00e-16 80.10
IUUC-Itr-048287 Ictidomys tridecemlineatus 93.03 8.00e-138 482.00
IUUC-Kpa-049342 Komagataella pastoris 26.88 6.00e-21 94.40
IUUC-Lch-049840 Latimeria chalumnae 59.32 9.00e-89 319.00
IUUC-Lpe-051000 Leersia perrieri 23.81 3.00e-14 72.80
IUUC-Loc-052108 Lepisosteus oculatus 53.91 6.00e-80 290.00
IUUC-Lma-053012 Leptosphaeria maculans 22.89 4.00e-14 72.40
IUUC-Laf-054200 Loxodonta africana 89.47 1.00e-144 505.00
IUUC-Meu-056409 Macropus eugenii 49.78 7.00e-64 236.00
IUUC-Mor-056929 Magnaporthe oryzae 21.32 1.00e-13 70.10
IUUC-Mpo-057365 Magnaporthe poae 21.94 4.00e-14 72.40
IUUC-Mtr-057860 Medicago truncatula 24.01 7.00e-19 88.20
IUUC-Mla-059092 Melampsora laricipopulina 24.39 1.00e-12 67.40
IUUC-Mga-059471 Meleagris gallopavo 61.50 3.00e-83 301.00
IUUC-Mvi-060458 Microbotryum violaceum 28.37 3.00e-08 52.80
IUUC-Mmr-060817 Microcebus murinus 92.88 4.00e-151 526.00
IUUC-Mdo-062697 Monodelphis domestica 55.88 1.00e-71 263.00
IUUC-Mmu-064233 Mus musculus 89.47 8.00e-148 516.00
IUUC-Mac-065253 Musa acuminata 19.61 3.00e-07 50.10
IUUC-Mpu-066266 Mustela putorius furo 90.19 8.00e-148 516.00
IUUC-Mlu-068073 Myotis lucifugus 89.81 2.00e-144 504.00
IUUC-Nfi-068425 Neosartorya fischeri 21.15 2.00e-17 83.20
IUUC-Ncr-068940 Neurospora crassa 21.85 1.00e-12 67.00
IUUC-Nle-069922 Nomascus leucogenys 98.12 2.00e-158 551.00
IUUC-Ont-071615 Oreochromis niloticus 54.00 1.00e-65 242.00
IUUC-Oan-073522 Ornithorhynchus anatinus 60.00 8.00e-66 243.00
IUUC-Ocu-074543 Oryctolagus cuniculus 90.60 4.00e-147 513.00
IUUC-Oba-075231 Oryza barthii 24.70 3.00e-17 82.80
IUUC-Obr-076211 Oryza brachyantha 22.83 3.00e-13 69.30
IUUC-Ogl-077548 Oryza glaberrima 24.70 3.00e-17 82.80
IUUC-Ogu-078723 Oryza glumaepatula 25.10 7.00e-18 84.70
IUUC-Oin-079772 Oryza indica 25.10 3.00e-18 85.90
IUUC-Olo-080397 Oryza longistaminata 24.30 8.00e-12 64.70
IUUC-Ome-081537 Oryza meridionalis 24.57 3.00e-16 79.00
IUUC-Oni-082597 Oryza nivara 25.10 3.00e-18 85.90
IUUC-Opu-083649 Oryza punctata 24.70 2.00e-16 79.70
IUUC-Oru-084611 Oryza rufipogon 25.10 3.00e-18 85.90
IUUC-Osa-086105 Oryza sativa 25.10 3.00e-18 85.90
IUUC-Oga-088199 Otolemur garnettii 92.86 6.00e-152 529.00
IUUC-Oar-089966 Ovis aries 77.07 6.00e-120 423.00
IUUC-Ptr-090997 Pan troglodytes 99.25 1.00e-159 555.00
IUUC-Pan-092860 Papio anubis 98.50 1.00e-158 551.00
IUUC-Psi-093622 Pelodiscus sinensis 59.67 2.00e-84 305.00
IUUC-Pma-094103 Petromyzon marinus 40.87 3.00e-54 204.00
IUUC-Pno-095144 Phaeosphaeria nodorum 23.13 5.00e-17 81.60
IUUC-Ppa-095269 Physcomitrella patens 27.31 2.00e-21 96.70
IUUC-Pfo-096929 Poecilia formosa 51.49 8.00e-75 273.00
IUUC-Pab-098338 Pongo abelii 86.99 1.00e-136 478.00
IUUC-Pop-099934 Populus trichocarpa 23.51 2.00e-12 66.20
IUUC-Pca-100836 Procavia capensis 71.67 5.00e-101 360.00
IUUC-Ppe-102017 Prunus persica 23.32 3.00e-14 72.40
IUUC-Pva-102220 Pteropus vampyrus 89.04 2.00e-117 414.00
IUUC-Pgr-103577 Puccinia graminis 31.17 6.00e-12 64.70
IUUC-Ptt-103924 Puccinia triticina 31.17 1.00e-11 63.50
IUUC-Pte-104393 Pyrenophora teres 24.63 1.00e-16 80.50
IUUC-Pyt-104539 Pyrenophora triticirepentis 26.52 3.00e-18 85.50
IUUC-Rno-105065 Rattus norvegicus 91.73 1.00e-151 528.00
IUUC-Sce-106408 Saccharomyces cerevisiae 25.54 2.00e-08 53.50
IUUC-Sha-107648 Sarcophilus harrisii 58.78 4.00e-86 311.00
IUUC-Sja-107856 Schizosaccharomyces japonicus 31.79 6.00e-26 110.00
IUUC-Spo-108064 Schizosaccharomyces pombe 29.18 8.00e-20 90.50
IUUC-Ssl-108419 Sclerotinia sclerotiorum 24.62 1.00e-19 90.50
IUUC-Smo-109269 Selaginella moellendorffii 25.00 5.00e-14 71.20
IUUC-Sit-110804 Setaria italica 24.71 8.00e-20 90.90
IUUC-Sly-111075 Solanum lycopersicum 24.03 2.00e-19 89.70
IUUC-Stu-112619 Solanum tuberosum 23.17 2.00e-18 86.30
IUUC-Sbi-114444 Sorghum bicolor 23.78 7.00e-11 61.60
IUUC-Sre-115122 Sporisorium reilianum 23.90 1.00e-11 63.90
IUUC-Tgu-117379 Taeniopygia guttata 59.91 5.00e-80 290.00
IUUC-Tru-118342 Takifugu rubripes 48.95 2.00e-69 254.00
IUUC-Tsy-119378 Tarsius syrichta 93.17 2.00e-88 317.00
IUUC-Tni-120275 Tetraodon nigroviridis 50.43 7.00e-70 257.00
IUUC-Tca-121152 Theobroma cacao 22.43 6.00e-14 71.60
IUUC-Tre-121956 Trichoderma reesei 20.83 7.00e-08 51.20
IUUC-Tvi-122418 Trichoderma virens 21.96 9.00e-10 57.80
IUUC-Tae-123908 Triticum aestivum 24.70 5.00e-17 82.00
IUUC-Tur-126685 Triticum urartu 25.44 2.00e-17 83.20
IUUC-Tme-126983 Tuber melanosporum 24.14 6.00e-15 75.10
IUUC-Tbe-127855 Tupaia belangeri 87.73 4.00e-108 383.00
IUUC-Ttr-129282 Tursiops truncatus 93.61 1.00e-152 531.00
IUUC-Uma-129501 Ustilago maydis 23.47 1.00e-10 60.80
IUUC-Vda-129809 Verticillium dahliae 23.17 3.00e-15 75.90
IUUC-Vvi-131264 Vitis vinifera 23.67 4.00e-15 75.50
IUUC-Xtr-131816 Xenopus tropicalis 51.57 4.00e-76 277.00
IUUC-Xma-134145 Xiphophorus maculatus 50.83 1.00e-73 269.00
IUUC-Zma-134965 Zea mays 26.07 1.00e-17 84.30
Created Date 25-Jun-2017

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