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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046392
UUCD1 version UUC-HoS-00780
Ensembl Protein ID ENSP00000456743.1
UniProt Accession Q8N4N3; Q8N5G6; Q9H9U6; KLH36_HUMAN
Genbank Protein ID BAB14124.1; AAH32400.1; AAH33821.1
Protein Name Kelch-like protein 36
Genbank Nucleotide ID AK022605; BC032400; BC033821
Gene Name KLHL36; C16orf44
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000135686.12 ENST00000564996.5 ENSP00000456743.1
ENSG00000135686.12 ENST00000258157.9 ENSP00000258157.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.40e-12 48.2 46 110
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv+lv ++++++ah+  La +S++F+++f+ +++e   +++ve+ + ++  ++a+++FlY g+l 
   Q: 46   CDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAF-QKEVELIGASYIGLKAVVDFLYGGELV 110
           8************************************9.************************996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH 60
RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046392|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCTGGCGGA GCCATGGCTG CGCAGCGGGC TGGCCGGGGG TCTCCTGAAC CCGGGCCCCG 60
CCGCCCCGAC CGCCCGGCCC CGCCGCCGGG GCTGTCCCCG CCGCGTCCGT AGCGCGTCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046392|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030585--KLHL36
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
KEGG hsa:79786
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001869 Ailuropoda melanoleuca 96.43 0.00e+00 1140.00
IUUC-Apl-003806 Anas platyrhynchos 85.85 0.00e+00 1067.00
IUUC-Ame-010908 Astyanax mexicanus 65.94 0.00e+00 765.00
IUUC-Bta-013146 Bos taurus 94.64 0.00e+00 1133.00
IUUC-Cja-019679 Callithrix jacchus 98.71 0.00e+00 1060.00
IUUC-Cfa-021265 Canis familiaris 96.59 0.00e+00 1138.00
IUUC-Cpo-021740 Cavia porcellus 88.13 0.00e+00 1042.00
IUUC-Csa-023308 Chlorocebus sabaeus 99.68 0.00e+00 1207.00
IUUC-Dre-028415 Danio rerio 63.65 0.00e+00 736.00
IUUC-Dno-029110 Dasypus novemcinctus 94.80 0.00e+00 1185.00
IUUC-Dor-030909 Dipodomys ordii 93.82 0.00e+00 1139.00
IUUC-Ete-032401 Echinops telfairi 86.83 0.00e+00 1039.00
IUUC-Eca-033226 Equus caballus 96.26 0.00e+00 1134.00
IUUC-Eeu-035083 Erinaceus europaeus 88.58 0.00e+00 979.00
IUUC-Fca-036492 Felis catus 95.60 0.00e+00 1117.00
IUUC-Fal-036853 Ficedula albicollis 81.30 0.00e+00 998.00
IUUC-Gga-040333 Gallus gallus 85.53 0.00e+00 1066.00
IUUC-Ggo-044986 Gorilla gorilla 99.68 0.00e+00 1206.00
IUUC-Itr-048578 Ictidomys tridecemlineatus 95.33 0.00e+00 1143.00
IUUC-Lch-050297 Latimeria chalumnae 78.86 0.00e+00 989.00
IUUC-Loc-052521 Lepisosteus oculatus 77.17 0.00e+00 971.00
IUUC-Laf-054504 Loxodonta africana 95.61 0.00e+00 1163.00
IUUC-Mcc-055755 Macaca mulatta 99.68 0.00e+00 1207.00
IUUC-Mga-059643 Meleagris gallopavo 85.85 0.00e+00 1068.00
IUUC-Mmr-061423 Microcebus murinus 82.73 0.00e+00 852.00
IUUC-Mdo-062792 Monodelphis domestica 89.08 0.00e+00 1064.00
IUUC-Mmu-063252 Mus musculus 85.53 0.00e+00 1065.00
IUUC-Mpu-065736 Mustela putorius furo 93.99 0.00e+00 1172.00
IUUC-Mlu-068053 Myotis lucifugus 95.45 0.00e+00 1163.00
IUUC-Nle-069092 Nomascus leucogenys 87.34 0.00e+00 1041.00
IUUC-Opr-070407 Ochotona princeps 88.57 0.00e+00 1053.00
IUUC-Ont-071640 Oreochromis niloticus 65.27 0.00e+00 768.00
IUUC-Oan-073279 Ornithorhynchus anatinus 87.18 0.00e+00 1116.00
IUUC-Ocu-074611 Oryctolagus cuniculus 93.18 0.00e+00 1147.00
IUUC-Ola-086508 Oryzias latipes 63.84 0.00e+00 790.00
IUUC-Oga-088008 Otolemur garnettii 96.42 0.00e+00 1164.00
IUUC-Oar-089990 Ovis aries 92.89 0.00e+00 1063.00
IUUC-Ptr-091303 Pan troglodytes 99.84 0.00e+00 1208.00
IUUC-Pan-092647 Papio anubis 99.68 0.00e+00 1207.00
IUUC-Pfo-096164 Poecilia formosa 56.60 0.00e+00 704.00
IUUC-Pab-097655 Pongo abelii 99.51 0.00e+00 1201.00
IUUC-Pca-101101 Procavia capensis 93.99 0.00e+00 1142.00
IUUC-Rno-105423 Rattus norvegicus 86.34 0.00e+00 1067.00
IUUC-Sha-107381 Sarcophilus harrisii 89.45 0.00e+00 1120.00
IUUC-Tgu-116910 Taeniopygia guttata 84.90 0.00e+00 1038.00
IUUC-Tru-117937 Takifugu rubripes 61.11 0.00e+00 728.00
IUUC-Tsy-119012 Tarsius syrichta 92.53 0.00e+00 937.00
IUUC-Tni-120541 Tetraodon nigroviridis 61.89 0.00e+00 765.00
IUUC-Tbe-127500 Tupaia belangeri 96.26 0.00e+00 1165.00
IUUC-Ttr-128572 Tursiops truncatus 94.97 0.00e+00 1144.00
IUUC-Xtr-132103 Xenopus tropicalis 76.95 0.00e+00 1012.00
Created Date 25-Jun-2017

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