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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063830
UUCD1 version UUC-MuM-01067
Ensembl Protein ID ENSMUSP00000005336.2
UniProt Accession Q9EP97; Q5F2A5; Q8BRD5; Q8C2H5; SENP3_MOUSE
Genbank Protein ID AAG28418.1; AAG33253.1; BAC32209.1; BAC40451.1; CAI51945.1; AAH37014.1
Protein Name Sentrin-specific protease 3; SUMO-1-specific protease 3; Sentrin/SUMO-specific protease SENP3; Smt3-specific isopeptidase 1
Genbank Nucleotide ID AF194031; AY008764; AK045071; AK088608; AL603707; BC037014
Gene Name Senp3; Smt3ip; Smt3ip1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000005204.12 ENSMUST00000005336.8 ENSMUSP00000005336.2
ENSMUSG00000005204.12 ENSMUST00000134942.1 ENSMUSP00000114791.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 18639523
Classification
Family E-value Score Start End
DUB/ULP 6.80e-52 177.3 381 536
Active Site
Position(s) Description Evidence
459 N/A {ECO:0000250}
476 {ECO:0000250}
526 {ECO:0000250}
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslav 90
            +t++dl +L  +++lnD+++++y + lv++++     e++h+f+sffy+kl++k+++ vk+wt++vd+f+k+l+++pi+ ++HWsl+ 
   Q: 381  VLTMDDLGTLYGQNWLNDQVMNMYGD-LVMDTVP----EKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHLEVHWSLIS 464
           589***********************.******7....99************************************************* PP
   S: 91   vcfkkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk.vpqQkNssDCGvyvlqyves 163
           v++++++i+++DS+ ++ ++++ k++++yl+ e+ kk++ +f++  +kg++++ v++Q+N+sDCG++vlqy+++
   Q: 465  VDVRRRTITYFDSQ-RTLNRRCPKHIAKYLQAEAVKKDRLDFHQ-GWKGYFKMnVARQNNDSDCGAFVLQYCKH 536
           **************.999*************************9.9***99988******************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
 Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Protein Sequence
(Fasta)
MKETIQGTGS WGPEPPGPGT TYSNPRRERL RWPLPPKPRL KSGGGFGPDP GSGTTVPTRR 60
LPAPRPSFDA SASEEEEEEE EEDEEEVAAW RLPPRWGQLG ASQRSRALRP SHRKTCSQRR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063830|DUB,USP;DUB,ULP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGACTGCCA CACGCGGCAA GCCAGGCGAC TGTGCGCAGG CTCGGCTCCG CGTAGAGCTC 60
GAGGGCGGGA CCGTCCGGTG GCCTAGACGC GCTGAGGTAG GCGGGACTGA GCACGAGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063830|DUB,USP;DUB,ULP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005737--C:cytoplasm
GO:0071339--C:MLL1 complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016926--P:protein desumoylation
GO:0019538--P:protein metabolic process
KEGG mmu:80886
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001848 Ailuropoda melanoleuca 92.33 0.00e+00 867.00
IUUC-Aca-004862 Anolis carolinensis 64.86 9.00e-157 546.00
IUUC-Ame-011239 Astyanax mexicanus 77.66 2.00e-131 462.00
IUUC-Bta-013150 Bos taurus 93.03 0.00e+00 877.00
IUUC-Cja-018905 Callithrix jacchus 90.56 0.00e+00 818.00
IUUC-Cfa-020249 Canis familiaris 93.06 0.00e+00 860.00
IUUC-Cpo-021717 Cavia porcellus 94.58 0.00e+00 896.00
IUUC-Csa-023887 Chlorocebus sabaeus 94.99 0.00e+00 891.00
IUUC-Cho-024579 Choloepus hoffmanni 91.99 0.00e+00 846.00
IUUC-Dre-028347 Danio rerio 78.47 7.00e-134 470.00
IUUC-Dno-029536 Dasypus novemcinctus 93.38 0.00e+00 876.00
IUUC-Dor-030264 Dipodomys ordii 94.39 0.00e+00 823.00
IUUC-Ete-032386 Echinops telfairi 95.75 0.00e+00 715.00
IUUC-Eca-033421 Equus caballus 93.54 0.00e+00 935.00
IUUC-Eeu-035146 Erinaceus europaeus 91.94 0.00e+00 857.00
IUUC-Fca-035634 Felis catus 92.86 0.00e+00 868.00
IUUC-Gmo-038794 Gadus morhua 79.31 7.00e-126 442.00
IUUC-Gac-041935 Gasterosteus aculeatus 78.16 2.00e-126 444.00
IUUC-Ggo-045581 Gorilla gorilla 94.80 0.00e+00 890.00
IUUC-Hsa-046815 Homo sapiens 94.80 0.00e+00 892.00
IUUC-Itr-048878 Ictidomys tridecemlineatus 94.05 0.00e+00 916.00
IUUC-Lch-050003 Latimeria chalumnae 60.37 4.00e-153 534.00
IUUC-Loc-052486 Lepisosteus oculatus 72.11 1.00e-138 486.00
IUUC-Laf-053840 Loxodonta africana 92.42 0.00e+00 851.00
IUUC-Mcc-055153 Macaca mulatta 95.75 0.00e+00 894.00
IUUC-Meu-056597 Macropus eugenii 77.76 0.00e+00 680.00
IUUC-Mmr-060998 Microcebus murinus 94.60 0.00e+00 906.00
IUUC-Mdo-062828 Monodelphis domestica 81.79 0.00e+00 743.00
IUUC-Mpu-065895 Mustela putorius furo 92.86 0.00e+00 853.00
IUUC-Mlu-067260 Myotis lucifugus 94.06 0.00e+00 915.00
IUUC-Nfi-068579 Neosartorya fischeri 33.04 6.00e-28 120.00
IUUC-Nle-069377 Nomascus leucogenys 94.80 0.00e+00 890.00
IUUC-Opr-070768 Ochotona princeps 80.10 0.00e+00 712.00
IUUC-Ocu-074443 Oryctolagus cuniculus 93.03 0.00e+00 874.00
IUUC-Oga-088210 Otolemur garnettii 93.55 0.00e+00 915.00
IUUC-Oar-089328 Ovis aries 93.03 0.00e+00 877.00
IUUC-Ptr-091025 Pan troglodytes 94.99 0.00e+00 893.00
IUUC-Pan-092471 Papio anubis 94.25 0.00e+00 897.00
IUUC-Psi-093896 Pelodiscus sinensis 60.36 8.00e-133 466.00
IUUC-Pfo-096403 Poecilia formosa 69.84 5.00e-126 444.00
IUUC-Pca-101098 Procavia capensis 83.62 0.00e+00 786.00
IUUC-Pva-102858 Pteropus vampyrus 93.21 0.00e+00 891.00
IUUC-Rno-105649 Rattus norvegicus 98.94 0.00e+00 973.00
IUUC-Sha-106798 Sarcophilus harrisii 82.69 0.00e+00 726.00
IUUC-Sar-113602 Sorex araneus 86.60 9.00e-156 542.00
IUUC-Tru-117778 Takifugu rubripes 75.35 2.00e-130 459.00
IUUC-Tsy-119369 Tarsius syrichta 95.02 0.00e+00 704.00
IUUC-Tbe-127410 Tupaia belangeri 80.49 0.00e+00 705.00
IUUC-Ttr-128399 Tursiops truncatus 94.08 0.00e+00 865.00
Created Date 25-Jun-2017

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