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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105447
Ensembl Protein ID ENSRNOP00000074242.1
UniProt Accession Q53AQ4; TMUB1_RAT
Genbank Protein ID AAU00154.1; EDL99355.1
Protein Name Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein; iHOPS
Genbank Nucleotide ID AY603378; CH474020
Gene Name Tmub1; Hops
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000013383.7 ENSRNOT00000088357.1 ENSRNOP00000074242.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 18665261
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_Other 4.60e-11 42.8 110 174
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 9    dgs.eltlkvnpsdtVaeLKekiekklgip.pe.qqrLiykGkiL.eddktLadyglkdgstihllekksg 75
           ++s    +  +p+dt++ LK+     + +p +e q+rLiy+G++L +d +tL++++l++++++h+ +++++
   Q: 110  NDSeQVAR-AWPQDTIGSLKR-----TQFPgREqQVRLIYQGQLLgDDTQTLGSLHLPPNCVLHCHVSTRV 174
           55533333.49**********.....9999988799******************************99986 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
 iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
Protein Sequence
(Fasta)
MALIEGVGDE VTVLFSVLAC LLVLALAWVS THTTESTDPL PQSSGTTTPA QPSEAMTAID 60
SIREEAPGAE SPSLRHRGPS AQPEPEAGVT ASTPPDSPQE PLLLRLKFLN DSEQVARAWP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105447|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCGGCCCG GAAGTGCCCG AGGAGCCGAA ATGGAGCTGG TGGAGCTGGG CGGTGAGTCT 60
CTGTGCGTGG CCGCGCCCAC CCGGTCGCCC CAGGCCACAG CTGGGACCTG CTTGCCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105447|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
SMART

SM00213--UBQ
Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0055037--C:recycling endosome
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG rno:362301
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001821 Ailuropoda melanoleuca 89.43 2.00e-79 288.00
IUUC-Aca-004375 Anolis carolinensis 46.13 6.00e-33 134.00
IUUC-Bta-012542 Bos taurus 88.21 2.00e-70 258.00
IUUC-Cel-018429 Caenorhabditis elegans 39.81 4.00e-13 69.70
IUUC-Cja-019142 Callithrix jacchus 89.52 2.00e-73 268.00
IUUC-Cfa-020517 Canis familiaris 90.65 8.00e-84 303.00
IUUC-Cpo-021653 Cavia porcellus 86.64 2.00e-66 245.00
IUUC-Csa-023914 Chlorocebus sabaeus 90.24 3.00e-75 274.00
IUUC-Cin-025480 Ciona intestinalis 31.28 2.00e-16 79.30
IUUC-Csv-025923 Ciona savignyi 29.02 1.00e-14 73.90
IUUC-Dno-029028 Dasypus novemcinctus 87.40 1.00e-71 262.00
IUUC-Dor-030758 Dipodomys ordii 90.69 1.00e-77 282.00
IUUC-Ete-032267 Echinops telfairi 89.04 2.00e-53 200.00
IUUC-Eca-034010 Equus caballus 86.18 1.00e-72 265.00
IUUC-Fca-035402 Felis catus 90.24 1.00e-83 302.00
IUUC-Fal-037183 Ficedula albicollis 72.09 5.00e-13 66.20
IUUC-Ggo-045556 Gorilla gorilla 87.40 3.00e-69 254.00
IUUC-Hsa-046639 Homo sapiens 90.24 1.00e-74 272.00
IUUC-Itr-048729 Ictidomys tridecemlineatus 90.65 9.00e-84 303.00
IUUC-Laf-054495 Loxodonta africana 56.10 6.00e-33 133.00
IUUC-Mcc-055870 Macaca mulatta 89.84 1.00e-74 272.00
IUUC-Meu-056759 Macropus eugenii 72.13 1.00e-58 219.00
IUUC-Mdo-062740 Monodelphis domestica 72.54 3.00e-63 234.00
IUUC-Mmu-063171 Mus musculus 96.33 2.00e-83 301.00
IUUC-Mpu-066100 Mustela putorius furo 89.84 2.00e-80 291.00
IUUC-Mlu-067839 Myotis lucifugus 88.16 3.00e-73 267.00
IUUC-Ncr-068784 Neurospora crassa 41.67 2.90e-01 29.60
IUUC-Nle-069603 Nomascus leucogenys 89.84 4.00e-74 270.00
IUUC-Opr-070539 Ochotona princeps 93.38 2.00e-43 167.00
IUUC-Ocu-074589 Oryctolagus cuniculus 89.52 2.00e-73 268.00
IUUC-Ola-087411 Oryzias latipes 46.69 6.00e-42 164.00
IUUC-Oga-088156 Otolemur garnettii 87.80 6.00e-77 280.00
IUUC-Oar-089302 Ovis aries 88.62 6.00e-70 257.00
IUUC-Ptr-091176 Pan troglodytes 90.24 1.00e-74 272.00
IUUC-Pab-098432 Pongo abelii 88.62 5.00e-69 254.00
IUUC-Pca-100595 Procavia capensis 71.36 2.00e-50 191.00
IUUC-Pva-102157 Pteropus vampyrus 47.51 6.00e-27 114.00
IUUC-Sha-106499 Sarcophilus harrisii 73.77 2.00e-65 241.00
IUUC-Ssc-116410 Sus scrofa 87.80 4.00e-75 274.00
IUUC-Tgu-117495 Taeniopygia guttata 69.33 4.00e-25 106.00
IUUC-Tru-118609 Takifugu rubripes 44.87 2.00e-41 162.00
IUUC-Tni-120885 Tetraodon nigroviridis 48.16 8.00e-44 170.00
IUUC-Tbe-127898 Tupaia belangeri 84.50 5.00e-48 182.00
IUUC-Ttr-129209 Tursiops truncatus 88.62 7.00e-77 280.00
Created Date 25-Jun-2017

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