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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063183
Ensembl Protein ID ENSMUSP00000079627.7
UniProt Accession Q80YV2; Q3TJE6; Q80Z11; Q8BTW5; Q8CI56; Q8R3U7; NIPA_MOUSE
Genbank Protein ID CAD61162.1; BAC40404.1; BAE30618.1; BAE39549.1; AAH24560.1; AAH37445.1; AAH50141.1
Protein Name Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; Zinc finger C3HC-type protein 1
Genbank Nucleotide ID AJ537495; AK088527; AK151694; AK167465; BC024560; BC037445; BC050141
Gene Name Zc3hc1; Nipa
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039130.18 ENSMUST00000080812.13 ENSMUSP00000079627.7
ENSMUSG00000039130.18 ENSMUST00000152391.8 ENSMUSP00000135447.1
ENSMUSG00000039130.18 ENSMUST00000102992.9 ENSMUSP00000100057.3
ENSMUSG00000039130.18 ENSMUST00000115184.1 ENSMUSP00000110838.1
ENSMUSG00000039130.18 ENSMUST00000147990.1 ENSMUSP00000116484.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 85.54 0.00e+00 809.00 IUUC-Hsa-046932
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal.
 Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal.
Protein Sequence
(Fasta)
MAATSEGPLF AASIEKTWGS VVRSPEGTPQ KVRELIDEGI VPEEGGTEPK DTAATFQSVD 60
GSPQAEQSPL ESTSKEAFFH RVETFSSLKW AGKPPELSPL ICAKYGWVTV ECDMLKCSSC 120
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Protein Fasta Sequence


>IUUC-Mmu-063183|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGACCCAT TTACGGCCGG ACCAAGATGG CGGCTACCAG TGAGGGGCCG CTGTTTGCTG 60
CGAGTATTGA AAAGACTTGG GGTTCAGTCG TTCGTTCCCC TGAAGGGACA CCCCAGAAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063183|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR013909--NIPA/Rsm1
IPR012935--Znf_C3HC-like
Pfam

PF08600--Rsm1
PF07967--zf-C3HC
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0019901--F:protein kinase binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0016567--P:protein ubiquitination
KEGG mmu:232679
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002290 Ailuropoda melanoleuca 85.12 0.00e+00 778.00
IUUC-Atr-003126 Amborella trichopoda 28.70 1.00e-11 65.50
IUUC-Aca-004720 Anolis carolinensis 60.00 4.00e-139 488.00
IUUC-Ath-006863 Arabidopsis thaliana 28.46 7.00e-12 65.90
IUUC-Bgr-012247 Blumeria graminis 19.77 6.10e-01 30.00
IUUC-Bta-012342 Bos taurus 84.86 0.00e+00 787.00
IUUC-Bra-016709 Brassica rapa 32.52 4.00e-11 63.90
IUUC-Cja-019724 Callithrix jacchus 83.56 0.00e+00 775.00
IUUC-Cfa-020918 Canis familiaris 87.05 0.00e+00 818.00
IUUC-Cpo-022028 Cavia porcellus 80.00 0.00e+00 751.00
IUUC-Csa-023238 Chlorocebus sabaeus 86.34 1.00e-160 559.00
IUUC-Cho-024962 Choloepus hoffmanni 85.52 0.00e+00 723.00
IUUC-Dre-027658 Danio rerio 46.14 2.00e-102 365.00
IUUC-Dno-028891 Dasypus novemcinctus 83.67 0.00e+00 783.00
IUUC-Dse-031338 Dothistroma septosporum 23.85 3.00e-06 47.00
IUUC-Eca-033965 Equus caballus 84.33 0.00e+00 740.00
IUUC-Eeu-034997 Erinaceus europaeus 63.57 1.00e-77 283.00
IUUC-Fca-036112 Felis catus 84.26 0.00e+00 761.00
IUUC-Gmo-039188 Gadus morhua 40.41 2.00e-91 329.00
IUUC-Ggr-039778 Gaeumannomyces graminis 22.98 6.00e-10 59.30
IUUC-Gga-040879 Gallus gallus 60.28 1.00e-143 502.00
IUUC-Gac-041886 Gasterosteus aculeatus 42.21 9.00e-89 320.00
IUUC-Gma-043122 Glycine max 26.84 1.00e-12 68.20
IUUC-Ggo-045489 Gorilla gorilla 84.83 0.00e+00 780.00
IUUC-Hsa-046932 Homo sapiens 85.54 0.00e+00 787.00
IUUC-Itr-048776 Ictidomys tridecemlineatus 84.86 0.00e+00 805.00
IUUC-Lch-050627 Latimeria chalumnae 52.17 2.00e-108 385.00
IUUC-Loc-052294 Lepisosteus oculatus 50.61 1.00e-110 393.00
IUUC-Laf-053461 Loxodonta africana 82.61 0.00e+00 785.00
IUUC-Mcc-055411 Macaca mulatta 84.49 0.00e+00 758.00
IUUC-Meu-056049 Macropus eugenii 74.70 0.00e+00 731.00
IUUC-Mga-059941 Meleagris gallopavo 59.76 9.00e-133 466.00
IUUC-Mmr-061230 Microcebus murinus 83.70 0.00e+00 779.00
IUUC-Mdo-062254 Monodelphis domestica 60.58 7.00e-159 553.00
IUUC-Mpu-066430 Mustela putorius furo 84.55 0.00e+00 751.00
IUUC-Mlu-067318 Myotis lucifugus 83.17 0.00e+00 726.00
IUUC-Nle-069871 Nomascus leucogenys 84.54 0.00e+00 780.00
IUUC-Opr-071023 Ochotona princeps 76.36 1.00e-99 356.00
IUUC-Ont-071854 Oreochromis niloticus 42.28 3.00e-87 315.00
IUUC-Ocu-074725 Oryctolagus cuniculus 80.40 0.00e+00 749.00
IUUC-Ogl-076943 Oryza glaberrima 24.87 1.00e-13 72.40
IUUC-Ogu-078596 Oryza glumaepatula 25.93 1.00e-13 71.60
IUUC-Ome-081625 Oryza meridionalis 25.93 4.00e-13 70.50
IUUC-Oru-084191 Oryza rufipogon 25.93 2.00e-13 71.60
IUUC-Osa-085482 Oryza sativa 25.93 1.00e-13 72.00
IUUC-Ola-086385 Oryzias latipes 42.22 2.00e-91 329.00
IUUC-Oga-089112 Otolemur garnettii 78.49 0.00e+00 705.00
IUUC-Oar-089630 Ovis aries 84.55 0.00e+00 783.00
IUUC-Ptr-091222 Pan troglodytes 85.34 0.00e+00 787.00
IUUC-Pan-092930 Papio anubis 85.15 0.00e+00 772.00
IUUC-Psi-093330 Pelodiscus sinensis 59.12 7.00e-126 444.00
IUUC-Ppa-095707 Physcomitrella patens 27.83 4.00e-13 70.50
IUUC-Pfo-096184 Poecilia formosa 40.08 6.00e-85 308.00
IUUC-Pab-097781 Pongo abelii 77.40 0.00e+00 691.00
IUUC-Pop-099933 Populus trichocarpa 22.04 6.00e-08 53.10
IUUC-Pca-101038 Procavia capensis 80.22 0.00e+00 692.00
IUUC-Pva-102707 Pteropus vampyrus 80.57 0.00e+00 696.00
IUUC-Rno-105631 Rattus norvegicus 92.63 0.00e+00 887.00
IUUC-Sha-106923 Sarcophilus harrisii 74.84 0.00e+00 645.00
IUUC-Smo-109192 Selaginella moellendorffii 25.00 6.00e-13 69.30
IUUC-Sly-111755 Solanum lycopersicum 32.79 2.00e-12 68.60
IUUC-Sar-113436 Sorex araneus 74.25 0.00e+00 665.00
IUUC-Ssc-115977 Sus scrofa 83.33 2.00e-149 521.00
IUUC-Tni-120167 Tetraodon nigroviridis 39.83 3.00e-82 298.00
IUUC-Tbe-127998 Tupaia belangeri 74.90 0.00e+00 662.00
IUUC-Ttr-128617 Tursiops truncatus 85.42 0.00e+00 767.00
IUUC-Vda-129867 Verticillium dahliae 23.71 6.00e-06 45.80
IUUC-Xtr-132321 Xenopus tropicalis 52.47 2.00e-105 375.00
Created Date 25-Jun-2017

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