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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064022
Ensembl Protein ID ENSMUSP00000093485.3
UniProt Accession O35099; Q14AY5; M3K5_MOUSE
Genbank Protein ID BAA23648.3; AAI16628.1; AAI33698.1
Protein Name Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; MAPK/ERK kinase kinase 5
Genbank Nucleotide ID AB006787; BC116627; BC133697
Gene Name Map3k5; Ask1; Mekk5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000071369.11 ENSMUST00000095806.9 ENSMUSP00000093485.3
ENSMUSG00000071369.11 ENSMUST00000120259.7 ENSMUSP00000112864.1
ENSMUSG00000071369.11 ENSMUST00000138994.1 ENSMUSP00000150155.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 94.13 0.00e+00 2430.00 IUUC-Hsa-046906
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
 Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Protein Sequence
(Fasta)
MGTEAGEGIT FSVPPFASVG FCTIPEGGSC RRGGGAATAA EGEPSLQPLL VPPPPPPPGS 60
FWNVESAAAP GTSCPTTAPG SSATRGRGNS GSGGGRRTTV AYVINEASQG QLVVAESEAL 120
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Protein Fasta Sequence


>IUUC-Mmu-064022|ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GCGGTGAAGG CGCGGCGCGC GATGGCAGCT GCCTAGCCCG GCGCGCGCGG AGCAGCCCGG 60
AGCTGTGGCT AGCCAGACGG TGCGTCTGGG CTGGGGACTC CGGGGTCGCC GCCGTGGCAG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064022|ULD,UBQ_Other|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR025136--DUF4071
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR013761--SAM/pointed
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF13281--DUF4071
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0009897--C:external side of plasma membrane
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:1902911--C:protein kinase complex
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0000187--P:activation of MAPK activity
GO:0000186--P:activation of MAPKK activity
GO:0070301--P:cellular response to hydrogen peroxide
GO:1902170--P:cellular response to reactive nitrogen species
GO:0071356--P:cellular response to tumor necrosis factor
GO:0072577--P:endothelial cell apoptotic process
GO:0045087--P:innate immune response
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254--P:JNK cascade
GO:0000165--P:MAPK cascade
GO:0038066--P:p38MAPK cascade
GO:0043065--P:positive regulation of apoptotic process
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901216--P:positive regulation of neuron death
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0097300--P:programmed necrotic cell death
GO:0006468--P:protein phosphorylation
GO:0010941--P:regulation of cell death
GO:0034976--P:response to endoplasmic reticulum stress
GO:0002931--P:response to ischemia
GO:0042060--P:wound healing
KEGG mmu:26408
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002318 Ailuropoda melanoleuca 95.38 0.00e+00 2315.00
IUUC-Apl-003713 Anas platyrhynchos 88.49 0.00e+00 2079.00
IUUC-Aca-005331 Anolis carolinensis 87.25 0.00e+00 2072.00
IUUC-Ame-011158 Astyanax mexicanus 75.97 0.00e+00 1852.00
IUUC-Bta-012770 Bos taurus 93.18 0.00e+00 2415.00
IUUC-Cja-019656 Callithrix jacchus 94.05 0.00e+00 2447.00
IUUC-Cfa-020488 Canis familiaris 93.03 0.00e+00 2410.00
IUUC-Cpo-022516 Cavia porcellus 94.32 0.00e+00 2306.00
IUUC-Csa-023104 Chlorocebus sabaeus 96.55 0.00e+00 2291.00
IUUC-Cho-024379 Choloepus hoffmanni 89.45 0.00e+00 1228.00
IUUC-Dre-028836 Danio rerio 74.90 0.00e+00 1870.00
IUUC-Dno-029842 Dasypus novemcinctus 92.75 0.00e+00 2188.00
IUUC-Dor-030990 Dipodomys ordii 94.81 0.00e+00 1927.00
IUUC-Ete-032693 Echinops telfairi 82.86 0.00e+00 1954.00
IUUC-Eca-033337 Equus caballus 94.46 0.00e+00 2297.00
IUUC-Eeu-034602 Erinaceus europaeus 78.32 0.00e+00 1981.00
IUUC-Fca-035954 Felis catus 95.33 0.00e+00 1915.00
IUUC-Fal-037358 Ficedula albicollis 88.31 0.00e+00 2110.00
IUUC-Gmo-038836 Gadus morhua 78.51 0.00e+00 1762.00
IUUC-Gga-040443 Gallus gallus 88.36 0.00e+00 2233.00
IUUC-Gac-041634 Gasterosteus aculeatus 75.32 0.00e+00 1940.00
IUUC-Ggo-045263 Gorilla gorilla 92.19 0.00e+00 2387.00
IUUC-Hsa-046906 Homo sapiens 94.13 0.00e+00 2470.00
IUUC-Itr-048449 Ictidomys tridecemlineatus 94.84 0.00e+00 1100.00
IUUC-Lch-050213 Latimeria chalumnae 78.99 0.00e+00 1819.00
IUUC-Loc-051829 Lepisosteus oculatus 76.42 0.00e+00 1877.00
IUUC-Laf-053538 Loxodonta africana 93.40 0.00e+00 2453.00
IUUC-Mcc-054776 Macaca mulatta 94.27 0.00e+00 2477.00
IUUC-Mga-059636 Meleagris gallopavo 88.02 0.00e+00 2133.00
IUUC-Mmr-061323 Microcebus murinus 94.13 0.00e+00 2416.00
IUUC-Mdo-062146 Monodelphis domestica 90.63 0.00e+00 2328.00
IUUC-Mpu-066531 Mustela putorius furo 90.72 0.00e+00 2406.00
IUUC-Mlu-068181 Myotis lucifugus 89.27 0.00e+00 2370.00
IUUC-Nle-069758 Nomascus leucogenys 96.47 0.00e+00 2289.00
IUUC-Opr-070531 Ochotona princeps 88.02 0.00e+00 1467.00
IUUC-Ont-072014 Oreochromis niloticus 78.04 0.00e+00 1918.00
IUUC-Oan-073169 Ornithorhynchus anatinus 93.31 0.00e+00 2237.00
IUUC-Ocu-074050 Oryctolagus cuniculus 91.91 0.00e+00 2159.00
IUUC-Ola-086941 Oryzias latipes 80.44 0.00e+00 1555.00
IUUC-Oga-088796 Otolemur garnettii 93.12 0.00e+00 2397.00
IUUC-Oar-090445 Ovis aries 95.91 0.00e+00 2284.00
IUUC-Ptr-090846 Pan troglodytes 94.05 0.00e+00 2474.00
IUUC-Pan-091986 Papio anubis 94.34 0.00e+00 2480.00
IUUC-Psi-093805 Pelodiscus sinensis 88.58 0.00e+00 2224.00
IUUC-Pfo-097301 Poecilia formosa 76.32 0.00e+00 1923.00
IUUC-Pab-097662 Pongo abelii 95.53 0.00e+00 2420.00
IUUC-Pca-100755 Procavia capensis 93.45 0.00e+00 715.00
IUUC-Pva-102280 Pteropus vampyrus 85.13 0.00e+00 2199.00
IUUC-Rno-105547 Rattus norvegicus 96.81 0.00e+00 2484.00
IUUC-Sha-106859 Sarcophilus harrisii 89.76 0.00e+00 2279.00
IUUC-Sar-113714 Sorex araneus 83.06 0.00e+00 1919.00
IUUC-Tgu-117116 Taeniopygia guttata 87.15 0.00e+00 2179.00
IUUC-Tru-118088 Takifugu rubripes 76.75 0.00e+00 1948.00
IUUC-Tsy-119616 Tarsius syrichta 88.56 0.00e+00 1977.00
IUUC-Tni-120284 Tetraodon nigroviridis 75.89 0.00e+00 1902.00
IUUC-Tbe-127900 Tupaia belangeri 94.24 0.00e+00 844.00
IUUC-Ttr-128294 Tursiops truncatus 84.71 0.00e+00 2093.00
IUUC-Vpa-130470 Vicugna pacos 86.15 0.00e+00 2038.00
IUUC-Xtr-132396 Xenopus tropicalis 74.71 0.00e+00 1954.00
Created Date 25-Jun-2017

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