iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	87.38	0.00e+00	857.00	IUUC-Hsa-045784
E3 activity/RING/RING	26.77	3.00e-28	121.00	IUUC-Sce-106398

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 60
LYETRYAKKS AEPGPQAPRP LDPLALHSMP RTPLSGPTVD YPVLYGKYLN GLGRLPTKAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTGGGGG CGCGTGCGCG CGATGCCTCC TCCCGCCTCT CAGGCGCGGG GGCGTGGAGA 60
AAGGAGCCAG CACTTGCTTT TATTGGCTCT CGCGCAGGTC CCGCCCCACA GTCGAGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027224--PIAS4
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ

PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING

Pfam

PF14324--PINIT
PF02891--zf-MIZ

SMART

SM00513--SAP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:1990234--C:transferase complex
GO:0003677--F:DNA binding
GO:0008022--F:protein C-terminus binding
GO:0061665--F:SUMO ligase activity
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0010804--P:negative regulation of tumor necrosis factor-mediated signaling pathway
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902174--P:positive regulation of keratinocyte apoptotic process
GO:0033235--P:positive regulation of protein sumoylation

KEGG

rno:362827

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001745	Ailuropoda melanoleuca	86.13	0.00e+00	818.00
IUUC-Apl-003765	Anas platyrhynchos	78.19	0.00e+00	769.00
IUUC-Ame-010763	Astyanax mexicanus	60.41	4.00e-147	514.00
IUUC-Bta-012369	Bos taurus	88.18	0.00e+00	848.00
IUUC-Bol-015380	Brassica oleracea	29.48	2.00e-18	87.80
IUUC-Bra-017443	Brassica rapa	29.48	6.00e-19	89.40
IUUC-Cja-019450	Callithrix jacchus	86.99	0.00e+00	843.00
IUUC-Cfa-020933	Canis familiaris	88.35	0.00e+00	843.00
IUUC-Cpo-022112	Cavia porcellus	89.68	0.00e+00	825.00
IUUC-Csa-023913	Chlorocebus sabaeus	76.11	0.00e+00	684.00
IUUC-Cgl-026533	Colletotrichum gloeosporioides	26.95	6.00e-32	132.00
IUUC-Dre-027609	Danio rerio	59.68	8.00e-144	503.00
IUUC-Dno-029664	Dasypus novemcinctus	73.84	5.00e-151	528.00
IUUC-Ete-032988	Echinops telfairi	89.59	3.00e-165	575.00
IUUC-Eca-034430	Equus caballus	84.44	0.00e+00	815.00
IUUC-Fca-035968	Felis catus	91.44	2.00e-156	544.00
IUUC-Fal-037449	Ficedula albicollis	79.53	0.00e+00	761.00
IUUC-Gmo-038925	Gadus morhua	61.85	2.00e-140	492.00
IUUC-Gga-040362	Gallus gallus	80.58	0.00e+00	798.00
IUUC-Gac-042353	Gasterosteus aculeatus	59.27	6.00e-134	470.00
IUUC-Ggo-044810	Gorilla gorilla	85.05	0.00e+00	812.00
IUUC-Hsa-045784	Homo sapiens	87.38	0.00e+00	857.00
IUUC-Itr-048486	Ictidomys tridecemlineatus	86.96	0.00e+00	840.00
IUUC-Lch-049727	Latimeria chalumnae	71.43	7.00e-151	526.00
IUUC-Loc-052354	Lepisosteus oculatus	53.97	3.00e-124	438.00
IUUC-Laf-054261	Loxodonta africana	87.96	0.00e+00	858.00
IUUC-Mcc-054931	Macaca mulatta	87.57	0.00e+00	844.00
IUUC-Meu-056468	Macropus eugenii	81.98	0.00e+00	817.00
IUUC-Mpo-057405	Magnaporthe poae	32.92	2.00e-28	120.00
IUUC-Mtr-058267	Medicago truncatula	33.93	3.00e-19	90.90
IUUC-Mla-058882	Melampsora laricipopulina	36.60	3.00e-23	103.00
IUUC-Mga-059981	Meleagris gallopavo	87.04	0.00e+00	674.00
IUUC-Mvi-060421	Microbotryum violaceum	28.62	3.00e-27	117.00
IUUC-Mmr-061181	Microcebus murinus	85.57	0.00e+00	805.00
IUUC-Mdo-062345	Monodelphis domestica	81.59	0.00e+00	818.00
IUUC-Mmu-063197	Mus musculus	98.62	0.00e+00	918.00
IUUC-Mpu-066275	Mustela putorius furo	86.41	0.00e+00	826.00
IUUC-Mlu-067194	Myotis lucifugus	87.23	0.00e+00	842.00
IUUC-Ont-072227	Oreochromis niloticus	59.50	1.00e-140	493.00
IUUC-Obr-076179	Oryza brachyantha	32.58	8.00e-21	95.90
IUUC-Ola-086865	Oryzias latipes	58.68	3.00e-140	491.00
IUUC-Oga-088945	Otolemur garnettii	88.74	0.00e+00	862.00
IUUC-Oar-089412	Ovis aries	85.35	0.00e+00	811.00
IUUC-Ptr-091550	Pan troglodytes	80.53	7.00e-173	599.00
IUUC-Pan-092183	Papio anubis	87.57	0.00e+00	854.00
IUUC-Psi-093003	Pelodiscus sinensis	80.00	0.00e+00	790.00
IUUC-Ppa-095583	Physcomitrella patens	39.20	2.00e-21	97.80
IUUC-Pfo-096704	Poecilia formosa	59.04	2.00e-142	499.00
IUUC-Pab-097923	Pongo abelii	93.18	0.00e+00	727.00
IUUC-Pca-100249	Procavia capensis	76.24	9.00e-140	489.00
IUUC-Pva-102562	Pteropus vampyrus	82.77	0.00e+00	779.00
IUUC-Sce-106398	Saccharomyces cerevisiae	32.95	2.00e-28	121.00
IUUC-Sha-107253	Sarcophilus harrisii	80.81	0.00e+00	810.00
IUUC-Sja-107662	Schizosaccharomyces japonicus	28.24	2.00e-29	124.00
IUUC-Smo-109174	Selaginella moellendorffii	36.75	7.00e-16	79.30
IUUC-Sar-113149	Sorex araneus	86.19	2.00e-128	452.00
IUUC-Ssc-115241	Sus scrofa	88.57	0.00e+00	851.00
IUUC-Tgu-116884	Taeniopygia guttata	79.68	0.00e+00	763.00
IUUC-Tru-118031	Takifugu rubripes	59.82	5.00e-145	507.00
IUUC-Tni-119766	Tetraodon nigroviridis	59.64	1.00e-140	492.00
IUUC-Ttr-128556	Tursiops truncatus	79.26	0.00e+00	687.00
IUUC-Vda-129985	Verticillium dahliae	33.64	1.00e-30	127.00
IUUC-Xtr-131866	Xenopus tropicalis	74.00	0.00e+00	734.00
IUUC-Xma-133963	Xiphophorus maculatus	59.08	1.00e-135	476.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence