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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045663
UUCD1 version UUC-HoS-00430
Ensembl Protein ID ENSP00000314004.2
UniProt Accession Q9UJX6; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; ANC2_HUMAN
Genbank Protein ID AAF05751.1; CAH72881.1; AAH32503.1; AAH01579.1; AAH09487.2; BAA92644.1
Protein Name Anaphase-promoting complex subunit 2; Cyclosome subunit 2
Genbank Nucleotide ID AF191337; AL929554; BC032503; BC001579; BC009487; AB037827
Gene Name ANAPC2; APC2; KIAA1406
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000176248.8 ENST00000323927.2 ENSP00000314004.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 21107322; 16763193
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 22.71 7.00e-25 110.00 IUUC-Sce-106292
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
 Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
Protein Sequence
(Fasta)
MAAAVVVAEG DSDSRPGQEL LVAWNTVSTG LVPPAALGLV SSRTSGAVPP KEEELRAAVE 60
VLRGHGLHSV LEEWFVEVLQ NDLQANISPE FWNAISQCEN SADEPQCLLL LLDAFGLLES 120
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Protein Fasta Sequence


>IUUC-Hsa-045663|E3,Cullin;E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAGTCGGTG GGTGCAGATG GCGGCGGCAG TTGTGGTGGC GGAGGGGGAC AGCGACTCCC 60
GGCCCGGACA GGAGTTGTTA GTGGCCTGGA ACACCGTGAG CACCGGCCTG GTGCCGCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045663|E3,Cullin;E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR014786--APC_su2_C
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50069--CULLIN_2
Pfam

PF08672--ANAPC2
PF00888--Cullin
SMART

SM01013--APC2
SM00182--CULLIN
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0045773--P:positive regulation of axon extension
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:29882
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000110 Aegilops tauschii 35.22 3.00e-90 326.00
IUUC-Aml-001248 Ailuropoda melanoleuca 95.02 0.00e+00 1412.00
IUUC-Atr-002679 Amborella trichopoda 39.76 4.00e-97 349.00
IUUC-Apl-003362 Anas platyrhynchos 71.92 0.00e+00 1060.00
IUUC-Aca-004655 Anolis carolinensis 68.73 0.00e+00 1010.00
IUUC-Aly-006274 Arabidopsis lyrata 34.75 3.00e-95 343.00
IUUC-Ath-007394 Arabidopsis thaliana 37.13 1.00e-95 344.00
IUUC-Ago-007945 Ashbya gossypii 20.73 8.00e-14 72.40
IUUC-Acl-008276 Aspergillus clavatus 33.73 3.00e-71 263.00
IUUC-Afl-008425 Aspergillus flavus 31.80 8.00e-69 255.00
IUUC-Afu-008876 Aspergillus fumigatus 34.79 2.00e-70 260.00
IUUC-Ani-009501 Aspergillus nidulans 33.06 9.00e-73 268.00
IUUC-Ang-009519 Aspergillus niger 33.27 3.00e-66 246.00
IUUC-Aor-009911 Aspergillus oryzae 31.90 1.00e-68 254.00
IUUC-Ate-010350 Aspergillus terreus 37.32 6.00e-61 229.00
IUUC-Ame-011184 Astyanax mexicanus 55.86 0.00e+00 779.00
IUUC-Bgr-011977 Blumeria graminis 32.08 8.00e-69 255.00
IUUC-Bta-013406 Bos taurus 95.76 0.00e+00 1095.00
IUUC-Bci-013817 Botrytis cinerea 34.48 1.00e-66 248.00
IUUC-Bdi-014198 Brachypodium distachyon 38.51 2.00e-91 330.00
IUUC-Bol-015766 Brassica oleracea 34.32 8.00e-95 342.00
IUUC-Bra-017977 Brassica rapa 34.65 1.00e-94 341.00
IUUC-Cel-018129 Caenorhabditis elegans 29.56 4.00e-50 193.00
IUUC-Cja-019940 Callithrix jacchus 96.48 0.00e+00 1503.00
IUUC-Cfa-020113 Canis familiaris 94.53 0.00e+00 1407.00
IUUC-Cpo-021669 Cavia porcellus 96.19 0.00e+00 1495.00
IUUC-Cre-022990 Chlamydomonas reinhardtii 37.59 9.00e-25 108.00
IUUC-Csa-023060 Chlorocebus sabaeus 95.01 0.00e+00 1491.00
IUUC-Cin-025736 Ciona intestinalis 39.36 7.00e-107 381.00
IUUC-Csv-026175 Ciona savignyi 30.98 1.00e-22 99.40
IUUC-Cgl-026442 Colletotrichum gloeosporioides 34.30 2.00e-65 244.00
IUUC-Cne-026902 Cryptococcus neoformans 33.33 4.00e-66 246.00
IUUC-Cme-027318 Cyanidioschyzon merolae 26.93 1.00e-22 102.00
IUUC-Dre-028318 Danio rerio 54.17 0.00e+00 832.00
IUUC-Dno-029026 Dasypus novemcinctus 89.38 0.00e+00 1291.00
IUUC-Dor-031148 Dipodomys ordii 96.08 0.00e+00 1343.00
IUUC-Dse-031458 Dothistroma septosporum 30.87 6.00e-33 136.00
IUUC-Dme-032025 Drosophila melanogaster 38.85 2.00e-140 493.00
IUUC-Ete-033154 Echinops telfairi 88.79 0.00e+00 713.00
IUUC-Eca-033812 Equus caballus 96.81 0.00e+00 1194.00
IUUC-Eeu-035246 Erinaceus europaeus 90.69 7.00e-116 411.00
IUUC-Fca-035890 Felis catus 92.46 0.00e+00 1399.00
IUUC-Fal-037639 Ficedula albicollis 72.11 0.00e+00 997.00
IUUC-Fox-037792 Fusarium oxysporum 30.91 2.00e-59 224.00
IUUC-Fso-038191 Fusarium solani 30.23 1.00e-59 225.00
IUUC-Gmo-039138 Gadus morhua 61.57 0.00e+00 697.00
IUUC-Ggr-040106 Gaeumannomyces graminis 29.55 1.00e-47 185.00
IUUC-Gga-040327 Gallus gallus 71.41 0.00e+00 1019.00
IUUC-Gac-042053 Gasterosteus aculeatus 55.56 0.00e+00 674.00
IUUC-Gma-043658 Glycine max 29.36 1.00e-96 347.00
IUUC-Ggo-045094 Gorilla gorilla 99.76 0.00e+00 1564.00
IUUC-Hvu-047677 Hordeum vulgare 40.33 8.00e-79 288.00
IUUC-Itr-047927 Ictidomys tridecemlineatus 96.65 0.00e+00 1486.00
IUUC-Kpa-049177 Komagataella pastoris 32.52 5.00e-68 252.00
IUUC-Lch-049435 Latimeria chalumnae 64.16 0.00e+00 1025.00
IUUC-Lpe-050728 Leersia perrieri 35.02 2.00e-87 317.00
IUUC-Loc-052561 Lepisosteus oculatus 57.92 0.00e+00 865.00
IUUC-Lma-052995 Leptosphaeria maculans 30.24 3.00e-51 197.00
IUUC-Laf-053447 Loxodonta africana 95.09 0.00e+00 1479.00
IUUC-Mcc-054960 Macaca mulatta 99.39 0.00e+00 1561.00
IUUC-Meu-056836 Macropus eugenii 71.23 0.00e+00 1030.00
IUUC-Mor-057155 Magnaporthe oryzae 31.63 2.00e-52 201.00
IUUC-Mpo-057560 Magnaporthe poae 29.85 6.00e-52 199.00
IUUC-Mtr-058784 Medicago truncatula 31.17 2.00e-107 384.00
IUUC-Mla-058965 Melampsora laricipopulina 37.74 8.00e-61 228.00
IUUC-Mga-059511 Meleagris gallopavo 70.63 0.00e+00 1012.00
IUUC-Mvi-060393 Microbotryum violaceum 33.45 3.00e-78 286.00
IUUC-Mmr-061594 Microcebus murinus 96.06 0.00e+00 1492.00
IUUC-Mdo-063009 Monodelphis domestica 73.56 0.00e+00 1086.00
IUUC-Mmu-063535 Mus musculus 94.50 0.00e+00 1429.00
IUUC-Mac-065167 Musa acuminata 34.14 7.00e-97 348.00
IUUC-Mpu-065758 Mustela putorius furo 95.53 0.00e+00 1443.00
IUUC-Nfi-068614 Neosartorya fischeri 34.65 1.00e-69 258.00
IUUC-Ncr-068900 Neurospora crassa 30.71 3.00e-35 144.00
IUUC-Nle-069236 Nomascus leucogenys 92.02 0.00e+00 1386.00
IUUC-Opr-070724 Ochotona princeps 91.74 0.00e+00 794.00
IUUC-Ont-072662 Oreochromis niloticus 50.89 0.00e+00 730.00
IUUC-Oan-073106 Ornithorhynchus anatinus 53.06 5.00e-77 281.00
IUUC-Oba-075268 Oryza barthii 38.64 4.00e-84 306.00
IUUC-Obr-076594 Oryza brachyantha 38.52 2.00e-94 340.00
IUUC-Ogl-077092 Oryza glaberrima 39.15 5.00e-94 339.00
IUUC-Ogu-078791 Oryza glumaepatula 38.72 4.00e-84 306.00
IUUC-Oin-079065 Oryza indica 39.15 5.00e-94 339.00
IUUC-Olo-080300 Oryza longistaminata 38.69 8.00e-83 301.00
IUUC-Ome-081502 Oryza meridionalis 38.80 2.00e-84 307.00
IUUC-Oni-082212 Oryza nivara 38.64 4.00e-84 306.00
IUUC-Opu-083508 Oryza punctata 39.46 5.00e-88 319.00
IUUC-Oru-084815 Oryza rufipogon 38.51 3.00e-84 306.00
IUUC-Osa-085494 Oryza sativa 39.15 5.00e-94 339.00
IUUC-Ola-087495 Oryzias latipes 54.59 0.00e+00 800.00
IUUC-Olu-087578 Ostreococcus lucimarinus 34.98 4.00e-94 339.00
IUUC-Oga-088026 Otolemur garnettii 95.13 0.00e+00 1519.00
IUUC-Oar-089448 Ovis aries 67.85 0.00e+00 867.00
IUUC-Ptr-090626 Pan troglodytes 92.21 0.00e+00 1419.00
IUUC-Pan-092841 Papio anubis 99.39 0.00e+00 1561.00
IUUC-Psi-093519 Pelodiscus sinensis 68.89 3.00e-144 506.00
IUUC-Pno-094923 Phaeosphaeria nodorum 25.10 8.00e-26 112.00
IUUC-Ppa-095741 Physcomitrella patens 40.17 1.00e-64 241.00
IUUC-Pfo-096798 Poecilia formosa 51.84 0.00e+00 762.00
IUUC-Pab-097600 Pongo abelii 99.51 0.00e+00 1560.00
IUUC-Pop-099171 Populus trichocarpa 31.59 3.00e-103 369.00
IUUC-Pca-101085 Procavia capensis 88.94 0.00e+00 1364.00
IUUC-Ppe-101600 Prunus persica 39.59 3.00e-103 369.00
IUUC-Pva-102210 Pteropus vampyrus 94.16 0.00e+00 1471.00
IUUC-Pgr-103279 Puccinia graminis 38.74 8.00e-76 278.00
IUUC-Ptt-103707 Puccinia triticina 35.60 3.00e-62 233.00
IUUC-Pte-104344 Pyrenophora teres 28.55 5.00e-49 189.00
IUUC-Pyt-104781 Pyrenophora triticirepentis 37.35 2.00e-35 145.00
IUUC-Rno-104923 Rattus norvegicus 95.57 0.00e+00 1419.00
IUUC-Sce-106292 Saccharomyces cerevisiae 23.19 9.00e-22 99.40
IUUC-Sha-107256 Sarcophilus harrisii 74.24 0.00e+00 1068.00
IUUC-Sja-107869 Schizosaccharomyces japonicus 34.50 2.00e-70 260.00
IUUC-Spo-108218 Schizosaccharomyces pombe 29.55 2.00e-53 203.00
IUUC-Smo-108710 Selaginella moellendorffii 43.34 1.00e-75 277.00
IUUC-Sit-110252 Setaria italica 37.81 1.00e-89 325.00
IUUC-Sly-111678 Solanum lycopersicum 35.33 3.00e-98 353.00
IUUC-Stu-112740 Solanum tuberosum 35.68 3.00e-100 360.00
IUUC-Sbi-114620 Sorghum bicolor 39.91 7.00e-83 301.00
IUUC-Sre-115165 Sporisorium reilianum 33.02 4.00e-22 100.00
IUUC-Ssc-116411 Sus scrofa 72.46 1.00e-63 235.00
IUUC-Tgu-116996 Taeniopygia guttata 71.77 0.00e+00 1052.00
IUUC-Tru-118128 Takifugu rubripes 56.92 0.00e+00 802.00
IUUC-Tni-120443 Tetraodon nigroviridis 56.30 0.00e+00 752.00
IUUC-Tca-121062 Theobroma cacao 35.62 4.00e-97 349.00
IUUC-Tre-121916 Trichoderma reesei 32.09 2.00e-65 244.00
IUUC-Tvi-122395 Trichoderma virens 30.58 2.00e-58 221.00
IUUC-Tae-122865 Triticum aestivum 35.23 5.00e-92 332.00
IUUC-Tme-126929 Tuber melanosporum 33.88 5.00e-69 255.00
IUUC-Ttr-128180 Tursiops truncatus 88.79 0.00e+00 1366.00
IUUC-Uma-129453 Ustilago maydis 31.86 5.00e-33 136.00
IUUC-Vda-129887 Verticillium dahliae 39.17 4.00e-34 139.00
IUUC-Vvi-130919 Vitis vinifera 34.19 3.00e-99 356.00
IUUC-Xtr-132418 Xenopus tropicalis 67.36 0.00e+00 1040.00
IUUC-Xma-133612 Xiphophorus maculatus 61.92 0.00e+00 694.00
IUUC-Yli-134637 Yarrowia lipolytica 34.69 3.00e-69 256.00
IUUC-Zma-135885 Zea mays 39.22 3.00e-91 330.00
Created Date 25-Jun-2017

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