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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046657
UUCD1 version UUC-HoS-00031
Ensembl Protein ID ENSP00000407922.2
UniProt Accession O60683; B3KWD8; Q5T095; Q9BW90; PEX10_HUMAN
Genbank Protein ID AAC18133.1; BAA87895.1; BAG54100.1; CAI22603.1; EAW56105.1; AAH00543.1; AAH18198.1
Protein Name Peroxisome biogenesis factor 10; Peroxin-10; Peroxisomal biogenesis factor 10; Peroxisome assembly protein 10; RING finger protein 69
Genbank Nucleotide ID AF060502; AB013818; AK124816; AL513477; CH471183; BC000543; BC018198
Gene Name PEX10; RNF69
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000157911.9 ENST00000288774.7 ENSP00000288774.3
ENSG00000157911.9 ENST00000447513.6 ENSP00000407922.2
ENSG00000157911.9 ENST00000507596.5 ENSP00000424291.1
ENSG00000157911.9 ENST00000510434.1 ENSP00000423051.1
ENSG00000157911.9 ENST00000514502.1 ENSP00000425924.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19687296; 18644345
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.10e-07 31.1 273 311
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle+ ++ p  +pCgH+f+ +C+ +w       s ++ CPlCr
   Q: 273  CTLCLEERRH-PTATPCGHLFCWECITAW------CSSKAECPLCR 311
           9*******88.999***************......999999****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with PEX19.
 Interacts with PEX19.
Protein Sequence
(Fasta)
MAPAAASPPE VIRAAQKDEY YRGGLRSAAG GALHSLAGAR KWLEWRKEVE LLSDVAYFGL 60
TTLAGYQTLG EEYVSIIQVD PSRIHVPSSL RRGVLVTLHA VLPYLLDKAL LPLEQELQAD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046657|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCACAGCTG AGCTCCTGTA GATGGAACCA GAGGTGAGGC AAGGAACTGG AGGCCCTCCC 60
CACTGAGGTC AGCGGGGCGC AGACGCCCCC TTGTCGTGCC CTGCCTTCCT CCTGCAATCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046657|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0958--Peroxisome biogenesis disorder
KW-1185--Reference proteome
KW-0861--Zellweger syndrome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025654--PEX10
IPR006845--Pex_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF04757--Pex2_Pex12
SMART

SM00184--RING
Gene Ontology

GO:0005779--C:integral component of peroxisomal membrane
GO:0005622--C:intracellular
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008022--F:protein C-terminus binding
GO:0008270--F:zinc ion binding
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix
KEGG hsa:5192
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002056 Ailuropoda melanoleuca 80.31 4.00e-112 397.00
IUUC-Atr-003000 Amborella trichopoda 39.81 4.00e-16 79.30
IUUC-Apl-003238 Anas platyrhynchos 58.42 8.00e-98 350.00
IUUC-Aly-006189 Arabidopsis lyrata 31.42 1.00e-38 154.00
IUUC-Ath-007024 Arabidopsis thaliana 32.12 8.00e-40 157.00
IUUC-Ago-007728 Ashbya gossypii 25.57 2.00e-18 86.70
IUUC-Acl-008372 Aspergillus clavatus 26.91 1.00e-30 127.00
IUUC-Afl-008450 Aspergillus flavus 28.00 5.00e-35 141.00
IUUC-Afu-009049 Aspergillus fumigatus 27.97 2.00e-31 129.00
IUUC-Ani-009256 Aspergillus nidulans 27.20 9.00e-33 134.00
IUUC-Ang-009867 Aspergillus niger 25.77 6.00e-30 125.00
IUUC-Aor-010008 Aspergillus oryzae 28.00 5.00e-35 141.00
IUUC-Ate-010548 Aspergillus terreus 28.61 3.00e-34 139.00
IUUC-Ame-011719 Astyanax mexicanus 52.92 2.00e-92 332.00
IUUC-Bgr-012234 Blumeria graminis 28.26 9.00e-20 91.30
IUUC-Bci-013613 Botrytis cinerea 27.40 3.00e-24 105.00
IUUC-Bdi-015068 Brachypodium distachyon 28.65 1.00e-35 144.00
IUUC-Bol-016320 Brassica oleracea 33.52 1.00e-41 164.00
IUUC-Bra-018029 Brassica rapa 29.91 8.00e-27 114.00
IUUC-Cja-019237 Callithrix jacchus 90.18 6.00e-141 493.00
IUUC-Cfa-020353 Canis familiaris 74.35 4.00e-58 218.00
IUUC-Cpo-022370 Cavia porcellus 81.06 1.00e-120 426.00
IUUC-Cre-022661 Chlamydomonas reinhardtii 55.77 5.00e-15 74.30
IUUC-Csa-023279 Chlorocebus sabaeus 95.09 5.00e-140 490.00
IUUC-Cgl-026468 Colletotrichum gloeosporioides 56.86 8.00e-14 70.10
IUUC-Cne-026965 Cryptococcus neoformans 29.28 1.00e-15 77.00
IUUC-Cme-027215 Cyanidioschyzon merolae 48.78 2.00e-09 57.00
IUUC-Dre-027835 Danio rerio 52.29 2.00e-91 328.00
IUUC-Dno-029561 Dasypus novemcinctus 76.07 3.00e-100 358.00
IUUC-Dor-030772 Dipodomys ordii 73.98 2.00e-114 405.00
IUUC-Dse-031244 Dothistroma septosporum 31.03 3.00e-23 102.00
IUUC-Dme-031760 Drosophila melanogaster 30.86 5.00e-40 157.00
IUUC-Ete-032976 Echinops telfairi 65.97 8.00e-54 204.00
IUUC-Eca-034245 Equus caballus 80.41 4.00e-127 447.00
IUUC-Eeu-034911 Erinaceus europaeus 63.91 2.00e-98 352.00
IUUC-Fca-035785 Felis catus 69.14 4.00e-112 397.00
IUUC-Fal-036609 Ficedula albicollis 61.71 4.00e-101 361.00
IUUC-Fso-038131 Fusarium solani 27.67 2.00e-24 106.00
IUUC-Gmo-039623 Gadus morhua 54.15 2.00e-95 342.00
IUUC-Ggr-040036 Gaeumannomyces graminis 56.86 1.00e-13 71.20
IUUC-Gga-040589 Gallus gallus 58.28 5.00e-117 414.00
IUUC-Gac-041474 Gasterosteus aculeatus 54.32 7.00e-91 327.00
IUUC-Gma-043204 Glycine max 28.77 2.00e-35 143.00
IUUC-Ggo-044851 Gorilla gorilla 92.49 7.00e-151 526.00
IUUC-Hvu-047776 Hordeum vulgare 55.56 5.00e-12 63.50
IUUC-Itr-048857 Ictidomys tridecemlineatus 85.09 1.00e-112 399.00
IUUC-Kpa-049246 Komagataella pastoris 48.65 5.00e-06 47.00
IUUC-Lch-049916 Latimeria chalumnae 55.45 5.00e-96 344.00
IUUC-Lpe-051012 Leersia perrieri 30.12 3.00e-38 152.00
IUUC-Loc-051752 Lepisosteus oculatus 56.19 2.00e-92 332.00
IUUC-Lma-053179 Leptosphaeria maculans 32.24 9.00e-19 87.80
IUUC-Laf-053371 Loxodonta africana 71.08 1.00e-128 452.00
IUUC-Mcc-055582 Macaca mulatta 89.60 3.00e-136 477.00
IUUC-Meu-056560 Macropus eugenii 70.43 5.00e-121 427.00
IUUC-Mor-056982 Magnaporthe oryzae 58.82 5.00e-14 72.40
IUUC-Mpo-057519 Magnaporthe poae 56.86 1.00e-13 69.30
IUUC-Mtr-058245 Medicago truncatula 29.54 2.00e-35 143.00
IUUC-Mga-059233 Meleagris gallopavo 58.05 2.00e-107 382.00
IUUC-Mvi-060286 Microbotryum violaceum 33.95 3.00e-31 129.00
IUUC-Mmr-060841 Microcebus murinus 83.78 1.00e-113 402.00
IUUC-Mdo-061896 Monodelphis domestica 66.19 1.00e-115 409.00
IUUC-Mmu-063986 Mus musculus 82.97 1.00e-112 399.00
IUUC-Mac-064785 Musa acuminata 28.73 1.00e-34 140.00
IUUC-Mpu-065978 Mustela putorius furo 77.35 2.00e-103 369.00
IUUC-Mlu-067613 Myotis lucifugus 63.00 5.00e-83 300.00
IUUC-Nfi-068271 Neosartorya fischeri 28.25 1.00e-32 133.00
IUUC-Ncr-068697 Neurospora crassa 55.77 4.00e-14 72.40
IUUC-Nle-069662 Nomascus leucogenys 92.20 3.00e-150 524.00
IUUC-Opr-070595 Ochotona princeps 75.23 3.00e-99 354.00
IUUC-Ont-072321 Oreochromis niloticus 57.93 2.00e-99 355.00
IUUC-Oan-072739 Ornithorhynchus anatinus 70.85 1.00e-105 375.00
IUUC-Oba-075983 Oryza barthii 28.90 5.00e-31 129.00
IUUC-Obr-076297 Oryza brachyantha 28.57 3.00e-31 129.00
IUUC-Ogl-077266 Oryza glaberrima 28.85 3.00e-34 139.00
IUUC-Oin-079246 Oryza indica 28.85 3.00e-34 139.00
IUUC-Oni-082408 Oryza nivara 28.86 7.00e-31 129.00
IUUC-Oru-084691 Oryza rufipogon 28.86 2.00e-30 128.00
IUUC-Osa-085301 Oryza sativa 28.85 3.00e-34 139.00
IUUC-Ola-087206 Oryzias latipes 54.51 2.00e-71 262.00
IUUC-Olu-087804 Ostreococcus lucimarinus 28.25 8.00e-23 101.00
IUUC-Oga-088763 Otolemur garnettii 84.66 3.00e-122 431.00
IUUC-Oar-090235 Ovis aries 72.87 1.00e-100 359.00
IUUC-Ptr-091507 Pan troglodytes 98.47 3.00e-134 471.00
IUUC-Pan-091920 Papio anubis 95.09 2.00e-139 488.00
IUUC-Pno-095101 Phaeosphaeria nodorum 28.46 3.00e-29 122.00
IUUC-Ppa-095462 Physcomitrella patens 32.02 9.00e-29 121.00
IUUC-Pfo-097220 Poecilia formosa 52.28 3.00e-81 295.00
IUUC-Pab-098149 Pongo abelii 96.01 2.00e-144 505.00
IUUC-Pop-098873 Populus trichocarpa 29.08 3.00e-36 145.00
IUUC-Pca-100244 Procavia capensis 78.95 2.00e-38 152.00
IUUC-Ppe-101364 Prunus persica 31.58 4.00e-40 159.00
IUUC-Pgr-103455 Puccinia graminis 33.04 4.00e-19 89.40
IUUC-Ptt-103786 Puccinia triticina 41.03 4.00e-06 42.70
IUUC-Pte-104170 Pyrenophora teres 31.16 7.00e-15 75.10
IUUC-Pyt-104531 Pyrenophora triticirepentis 31.34 1.00e-14 73.90
IUUC-Rno-105929 Rattus norvegicus 84.83 3.00e-110 391.00
IUUC-Sce-106361 Saccharomyces cerevisiae 23.71 6.00e-24 104.00
IUUC-Sha-106867 Sarcophilus harrisii 62.80 2.00e-102 364.00
IUUC-Sja-107981 Schizosaccharomyces japonicus 27.88 3.00e-16 79.00
IUUC-Spo-108312 Schizosaccharomyces pombe 55.56 4.00e-14 72.00
IUUC-Ssl-108393 Sclerotinia sclerotiorum 27.95 6.00e-29 121.00
IUUC-Sit-109899 Setaria italica 28.33 1.00e-31 130.00
IUUC-Sly-111809 Solanum lycopersicum 29.97 7.00e-38 151.00
IUUC-Stu-112440 Solanum tuberosum 28.77 7.00e-38 151.00
IUUC-Sbi-114846 Sorghum bicolor 28.37 6.00e-34 138.00
IUUC-Sre-115184 Sporisorium reilianum 26.26 3.00e-15 76.60
IUUC-Ssc-115730 Sus scrofa 76.69 7.00e-136 476.00
IUUC-Tgu-116534 Taeniopygia guttata 61.92 2.00e-103 369.00
IUUC-Tru-118341 Takifugu rubripes 46.77 1.00e-76 279.00
IUUC-Tni-120642 Tetraodon nigroviridis 49.85 2.00e-87 315.00
IUUC-Tca-121102 Theobroma cacao 29.86 1.00e-40 160.00
IUUC-Tre-121931 Trichoderma reesei 29.56 6.00e-18 85.10
IUUC-Tvi-122477 Trichoderma virens 29.22 3.00e-33 135.00
IUUC-Tae-124781 Triticum aestivum 28.53 3.00e-27 115.00
IUUC-Tme-127099 Tuber melanosporum 28.82 1.00e-26 113.00
IUUC-Ttr-129156 Tursiops truncatus 72.30 6.00e-125 440.00
IUUC-Uma-129328 Ustilago maydis 28.09 2.00e-16 80.50
IUUC-Vvi-131549 Vitis vinifera 30.79 2.00e-38 153.00
IUUC-Xtr-131788 Xenopus tropicalis 54.46 1.00e-101 362.00
IUUC-Xma-133828 Xiphophorus maculatus 52.58 2.00e-80 292.00
IUUC-Yli-134363 Yarrowia lipolytica 27.20 6.00e-31 128.00
IUUC-Zma-135178 Zea mays 28.07 5.00e-34 138.00
Created Date 25-Jun-2017

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