iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.80e-88	293.7	8	386

Active Site

Position(s)	Description	Evidence
177	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 5    irlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesiteleeeiv. 105
           + ++Ge++ +kl+s++ llvGagg+G+EllK ++l+ +g+i++vD dt+++snlnrqFLfr++d++++K+ +a +a++ +n + ++++++ +++++ +    
   Q: 8    VTIIGEDSYKKLRSSRCLLVGAGGIGSELLKDIILMEFGEIHIVDLDTIDLSNLNRQFLFRQKDIKQPKSTTAVKAVQHFNNS-KLVPYQGNVMDISTFPLh 108
           6789*****************************************************************************87.888999999999877448 PP
   S: 106  FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa..vlfnklleeeageee 205
           +f++fd++++aldn++arr+vn++   ++ pliesgt G+ G+++ ii+g+tec +c+++++ kt+P+ct+++tp+++ h+i+wa   lfn+l++ e++ +e
   Q: 109  WFEQFDIIFNALDNLAARRYVNKISQFLSLPLIESGTAGFDGYMQPIIPGKTECFECTKKETPKTFPVCTIRSTPSQPIHCIVWAknFLFNQLFASETSGNE 210
           **************************************************************************************9999***966666555 PP
   S: 206  vlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikq.llksfecdivtkskspfwvsfcsnaealqvpekvekdeevvkasap..... 301
             ++   +    ++d+++ +  +++ ++  e ++i ++  a++    i++ l k f +di      + +++  +    l+  + ++  +++++as++     
   Q: 211  DDNN---Q-DWGTDDAEEIKRIKQETNELYELQKIIISRDASR----IPEiLNKLFIQDINKLLAIENLWKTRTKPVPLSDSQINTPTKTAQSASNSvgtiq 304
           5443...3.3334444444444445555666666666666632....4440445677777778889999988888888888888888878788887788888 PP
   S: 302  ..lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaq 382
             ++ ++ + +++  ++ ++ ++++f+kdd++ +++v++aan+r + ++i++  + ++ik+iagniipaiattna+v+G+ ++
   Q: 305  eqISNFINITQKLMDRYPKEQNHIEFDKDDADTLEFVATAANIRSHIFNIPM-KSVFDIKQIAGNIIPAIATTNAIVAGASSL 386
           88888889999999999999999*****************************.**************************8665 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1.

Protein Sequence
(Fasta)

MPRETSLVTI IGEDSYKKLR SSRCLLVGAG GIGSELLKDI ILMEFGEIHI VDLDTIDLSN 60
LNRQFLFRQK DIKQPKSTTA VKAVQHFNNS KLVPYQGNVM DISTFPLHWF EQFDIIFNAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAAGGG AAACAAGTTT GGTAACAATC ATCGGTGAAG ATAGTTACAA GAAATTACGG 60
TCCTCAAGAT GTCTTCTGGT CGGTGCTGGG GGCATAGGGT CTGAATTGTT AAAGGATATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR019572--UBA_E1_Cys
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF10585--UBA_e1_thiolCys

Gene Ontology

GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

sce:YDR390C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	36.59	5.00e-74	270.00
IUUC-Aml-001662	Ailuropoda melanoleuca	33.17	2.00e-81	294.00
IUUC-Atr-002636	Amborella trichopoda	37.88	1.00e-80	291.00
IUUC-Apl-003369	Anas platyrhynchos	33.72	4.00e-74	270.00
IUUC-Aca-004490	Anolis carolinensis	36.71	5.00e-64	236.00
IUUC-Aly-006359	Arabidopsis lyrata	36.69	1.00e-68	252.00
IUUC-Ath-007667	Arabidopsis thaliana	36.95	5.00e-71	260.00
IUUC-Ago-007844	Ashbya gossypii	49.21	1.00e-165	574.00
IUUC-Acl-008270	Aspergillus clavatus	43.02	5.00e-102	363.00
IUUC-Afl-008674	Aspergillus flavus	42.70	1.00e-110	391.00
IUUC-Afu-008883	Aspergillus fumigatus	40.00	2.00e-102	364.00
IUUC-Ani-009500	Aspergillus nidulans	42.08	2.00e-109	387.00
IUUC-Ang-009535	Aspergillus niger	40.42	2.00e-105	374.00
IUUC-Aor-010223	Aspergillus oryzae	43.43	3.00e-108	383.00
IUUC-Ate-010282	Aspergillus terreus	40.30	2.00e-90	323.00
IUUC-Ame-011736	Astyanax mexicanus	36.35	1.00e-81	295.00
IUUC-Bgr-012166	Blumeria graminis	40.14	7.00e-96	342.00
IUUC-Bta-012589	Bos taurus	33.54	9.00e-81	292.00
IUUC-Bci-013802	Botrytis cinerea	41.79	5.00e-95	339.00
IUUC-Bdi-014697	Brachypodium distachyon	37.47	1.00e-75	275.00
IUUC-Bol-016315	Brassica oleracea	36.36	2.00e-72	265.00
IUUC-Bra-017009	Brassica rapa	35.44	5.00e-72	263.00
IUUC-Cel-018708	Caenorhabditis elegans	35.19	7.00e-82	296.00
IUUC-Cja-019120	Callithrix jacchus	33.65	7.00e-79	286.00
IUUC-Cfa-021061	Canis familiaris	36.18	6.00e-80	289.00
IUUC-Cpo-021842	Cavia porcellus	33.07	1.00e-79	288.00
IUUC-Csa-024104	Chlorocebus sabaeus	35.98	2.00e-78	284.00
IUUC-Cho-024332	Choloepus hoffmanni	34.98	5.00e-63	233.00
IUUC-Cin-025363	Ciona intestinalis	36.89	2.00e-82	297.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	42.00	3.00e-87	314.00
IUUC-Cne-026888	Cryptococcus neoformans	36.06	2.00e-80	291.00
IUUC-Cme-027315	Cyanidioschyzon merolae	33.13	5.00e-64	236.00
IUUC-Dre-028420	Danio rerio	36.52	8.00e-81	292.00
IUUC-Dno-030041	Dasypus novemcinctus	32.59	1.00e-78	285.00
IUUC-Dse-031504	Dothistroma septosporum	38.04	2.00e-89	321.00
IUUC-Dme-031771	Drosophila melanogaster	49.48	1.00e-45	176.00
IUUC-Ete-033037	Echinops telfairi	34.39	9.00e-68	249.00
IUUC-Eca-033774	Equus caballus	36.34	3.00e-77	280.00
IUUC-Eeu-035074	Erinaceus europaeus	31.30	2.00e-50	191.00
IUUC-Fca-036508	Felis catus	36.66	1.00e-76	278.00
IUUC-Fal-036813	Ficedula albicollis	33.28	2.00e-74	271.00
IUUC-Fox-038056	Fusarium oxysporum	45.57	4.00e-91	327.00
IUUC-Fso-038223	Fusarium solani	44.00	2.00e-87	314.00
IUUC-Gmo-038526	Gadus morhua	39.42	7.00e-72	263.00
IUUC-Ggr-039767	Gaeumannomyces graminis	43.15	8.00e-88	316.00
IUUC-Gga-040981	Gallus gallus	33.08	3.00e-75	274.00
IUUC-Gac-041437	Gasterosteus aculeatus	38.14	9.00e-83	299.00
IUUC-Gma-044072	Glycine max	36.00	8.00e-80	289.00
IUUC-Ggo-045358	Gorilla gorilla	35.21	4.00e-77	280.00
IUUC-Hsa-046068	Homo sapiens	35.98	3.00e-78	284.00
IUUC-Hvu-047646	Hordeum vulgare	37.95	2.00e-75	274.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	33.12	1.00e-79	288.00
IUUC-Kpa-049301	Komagataella pastoris	65.10	7.00e-56	209.00
IUUC-Lch-049565	Latimeria chalumnae	37.25	1.00e-83	302.00
IUUC-Lpe-050884	Leersia perrieri	39.55	3.00e-77	280.00
IUUC-Loc-052493	Lepisosteus oculatus	37.17	4.00e-86	310.00
IUUC-Lma-053117	Leptosphaeria maculans	41.11	2.00e-98	350.00
IUUC-Laf-054518	Loxodonta africana	33.81	4.00e-79	287.00
IUUC-Mcc-055334	Macaca mulatta	37.02	1.00e-78	285.00
IUUC-Mor-057137	Magnaporthe oryzae	38.42	3.00e-84	303.00
IUUC-Mpo-057449	Magnaporthe poae	42.15	3.00e-91	327.00
IUUC-Mtr-058045	Medicago truncatula	35.70	7.00e-78	282.00
IUUC-Mla-058864	Melampsora laricipopulina	39.25	2.00e-77	281.00
IUUC-Mga-059422	Meleagris gallopavo	30.51	3.00e-56	210.00
IUUC-Mvi-060536	Microbotryum violaceum	35.96	4.00e-80	290.00
IUUC-Mmr-061161	Microcebus murinus	32.71	2.00e-78	284.00
IUUC-Mdo-061802	Monodelphis domestica	33.02	4.00e-78	283.00
IUUC-Mmu-064357	Mus musculus	34.06	2.00e-84	304.00
IUUC-Mac-065475	Musa acuminata	37.36	2.00e-76	278.00
IUUC-Mpu-066895	Mustela putorius furo	36.18	1.00e-79	288.00
IUUC-Mlu-067862	Myotis lucifugus	33.65	7.00e-83	299.00
IUUC-Nfi-068385	Neosartorya fischeri	41.65	2.00e-106	377.00
IUUC-Ncr-068885	Neurospora crassa	40.10	2.00e-98	351.00
IUUC-Nle-069524	Nomascus leucogenys	36.90	1.00e-78	285.00
IUUC-Opr-071038	Ochotona princeps	37.33	1.00e-84	305.00
IUUC-Ont-071719	Oreochromis niloticus	35.55	3.00e-83	300.00
IUUC-Oan-072877	Ornithorhynchus anatinus	37.16	4.00e-73	266.00
IUUC-Ocu-074080	Oryctolagus cuniculus	36.38	2.00e-78	284.00
IUUC-Oba-075936	Oryza barthii	38.55	3.00e-77	280.00
IUUC-Obr-076841	Oryza brachyantha	39.09	2.00e-76	278.00
IUUC-Ogl-077686	Oryza glaberrima	37.81	2.00e-77	281.00
IUUC-Ogu-078597	Oryza glumaepatula	37.50	3.00e-74	271.00
IUUC-Oin-079791	Oryza indica	38.55	3.00e-77	280.00
IUUC-Olo-081009	Oryza longistaminata	38.55	3.00e-77	280.00
IUUC-Ome-081327	Oryza meridionalis	35.05	6.00e-71	259.00
IUUC-Oni-082334	Oryza nivara	37.53	1.00e-74	271.00
IUUC-Opu-083447	Oryza punctata	38.18	3.00e-77	280.00
IUUC-Oru-084977	Oryza rufipogon	38.55	3.00e-77	280.00
IUUC-Osa-086160	Oryza sativa	40.36	2.00e-75	274.00
IUUC-Ola-087415	Oryzias latipes	35.51	2.00e-79	288.00
IUUC-Olu-087850	Ostreococcus lucimarinus	33.83	5.00e-78	283.00
IUUC-Oga-088434	Otolemur garnettii	34.02	5.00e-79	286.00
IUUC-Oar-089872	Ovis aries	33.12	4.00e-77	280.00
IUUC-Ptr-091212	Pan troglodytes	35.98	3.00e-78	284.00
IUUC-Pan-092708	Papio anubis	50.28	5.00e-48	183.00
IUUC-Psi-093703	Pelodiscus sinensis	36.57	1.00e-76	278.00
IUUC-Pno-094953	Phaeosphaeria nodorum	42.66	8.00e-102	362.00
IUUC-Ppa-095963	Physcomitrella patens	36.22	2.00e-71	261.00
IUUC-Pfo-097515	Poecilia formosa	38.31	1.00e-80	291.00
IUUC-Pab-097951	Pongo abelii	34.95	2.00e-62	231.00
IUUC-Pop-099703	Populus trichocarpa	36.60	6.00e-70	256.00
IUUC-Pca-100426	Procavia capensis	36.78	8.00e-80	289.00
IUUC-Ppe-101152	Prunus persica	38.39	5.00e-79	286.00
IUUC-Pva-102792	Pteropus vampyrus	33.93	3.00e-74	270.00
IUUC-Pgr-103592	Puccinia graminis	37.54	3.00e-89	320.00
IUUC-Ptt-103805	Puccinia triticina	35.30	7.00e-78	283.00
IUUC-Pte-104215	Pyrenophora teres	41.04	2.00e-109	387.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	40.73	8.00e-109	385.00
IUUC-Rno-106117	Rattus norvegicus	34.42	2.00e-86	311.00
IUUC-Sha-107006	Sarcophilus harrisii	36.31	3.00e-78	284.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	42.42	2.00e-102	364.00
IUUC-Spo-108020	Schizosaccharomyces pombe	39.40	1.00e-96	345.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	41.34	9.00e-95	338.00
IUUC-Smo-109264	Selaginella moellendorffii	38.62	1.00e-69	255.00
IUUC-Sit-110581	Setaria italica	39.09	3.00e-80	290.00
IUUC-Sly-111870	Solanum lycopersicum	37.14	2.00e-80	291.00
IUUC-Stu-112283	Solanum tuberosum	36.63	4.00e-78	283.00
IUUC-Sbi-114075	Sorghum bicolor	39.32	7.00e-79	286.00
IUUC-Sre-114926	Sporisorium reilianum	38.01	4.00e-93	333.00
IUUC-Ssc-116281	Sus scrofa	49.72	3.00e-47	179.00
IUUC-Tgu-117247	Taeniopygia guttata	33.55	1.00e-74	271.00
IUUC-Tru-118075	Takifugu rubripes	37.00	1.00e-69	255.00
IUUC-Tsy-119398	Tarsius syrichta	33.33	5.00e-26	110.00
IUUC-Tni-120771	Tetraodon nigroviridis	32.38	6.00e-52	196.00
IUUC-Tca-121651	Theobroma cacao	36.76	3.00e-79	287.00
IUUC-Tre-122224	Trichoderma reesei	41.81	8.00e-90	322.00
IUUC-Tvi-122634	Trichoderma virens	40.26	3.00e-86	310.00
IUUC-Tae-125665	Triticum aestivum	37.36	2.00e-74	271.00
IUUC-Tur-126417	Triticum urartu	36.11	8.00e-74	269.00
IUUC-Tme-127016	Tuber melanosporum	43.64	7.00e-92	329.00
IUUC-Ttr-128598	Tursiops truncatus	35.06	2.00e-77	281.00
IUUC-Uma-129612	Ustilago maydis	48.07	2.00e-68	251.00
IUUC-Vda-129811	Verticillium dahliae	45.73	3.00e-87	313.00
IUUC-Vpa-130732	Vicugna pacos	30.72	4.00e-52	197.00
IUUC-Vvi-130832	Vitis vinifera	38.01	4.00e-75	273.00
IUUC-Xtr-132823	Xenopus tropicalis	37.30	6.00e-72	263.00
IUUC-Xma-133552	Xiphophorus maculatus	38.31	1.00e-80	292.00
IUUC-Yli-134666	Yarrowia lipolytica	38.03	7.00e-91	325.00
IUUC-Zma-135547	Zea mays	38.64	2.00e-77	281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence