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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064223
UUCD1 version UUC-MuM-00695
Ensembl Protein ID ENSMUSP00000022791.8
UniProt Accession Q8CHQ0; E9QPM9; Q99JG8; FBX4_MOUSE
Genbank Protein ID AAH40086.1; CAC36404.1
Protein Name F-box only protein 4
Genbank Nucleotide ID AC137902; AJ300659
Gene Name Fbxo4; Fbx4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022184.8 ENSMUST00000022791.8 ENSMUSP00000022791.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 88.11 0.00e+00 715.00 IUUC-Hsa-046558
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity).
Protein Sequence
(Fasta)
MAGSEPRGAG SPPPASDWGR LEAAILSGWR TFWYSVAKER ATPTASRKEA AEETSALTRL 60
PVDVQLYILS FLSPHDLCQL GSTDHYWNKT IRDPILWRYF LLRDLPSWSS VDWKSLPDLE 120
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Protein Fasta Sequence


>IUUC-Mmu-064223|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GTTTGGGCTA ACGGGGTGAG TCATTCCGGG CCACCTCGGC CTGGAGCCCT GCCCAACCGA 60
CCAGCCCGGG TCGTACCAGC GGGGCGGAGG CGGAGGCCGA GCGGCTGGGG AGCCCGTGCG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064223|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0042803--F:protein homodimerization activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007568--P:aging
GO:0019725--P:cellular homeostasis
GO:0071479--P:cellular response to ionizing radiation
GO:0035726--P:common myeloid progenitor cell proliferation
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1900181--P:negative regulation of protein localization to nucleus
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0031398--P:positive regulation of protein ubiquitination
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:2000001--P:regulation of DNA damage checkpoint
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0000723--P:telomere maintenance
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:106052
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001232 Ailuropoda melanoleuca 88.62 0.00e+00 673.00
IUUC-Apl-004129 Anas platyrhynchos 62.41 5.00e-109 387.00
IUUC-Aca-005076 Anolis carolinensis 48.16 1.00e-107 383.00
IUUC-Ath-007114 Arabidopsis thaliana 31.25 6.00e-03 34.70
IUUC-Ame-011122 Astyanax mexicanus 46.39 2.00e-84 306.00
IUUC-Bta-012449 Bos taurus 86.30 0.00e+00 664.00
IUUC-Bdi-015059 Brachypodium distachyon 35.62 5.80e-02 32.00
IUUC-Bol-015278 Brassica oleracea 32.14 6.00e-04 38.50
IUUC-Cja-019890 Callithrix jacchus 87.34 0.00e+00 686.00
IUUC-Cfa-021134 Canis familiaris 87.86 0.00e+00 668.00
IUUC-Cpo-021693 Cavia porcellus 89.20 1.00e-169 588.00
IUUC-Csa-023540 Chlorocebus sabaeus 87.86 0.00e+00 676.00
IUUC-Dre-028667 Danio rerio 46.93 3.00e-84 305.00
IUUC-Dno-028997 Dasypus novemcinctus 87.70 0.00e+00 659.00
IUUC-Dor-030135 Dipodomys ordii 78.65 3.00e-152 531.00
IUUC-Ete-033149 Echinops telfairi 83.20 0.00e+00 637.00
IUUC-Eca-033292 Equus caballus 89.20 7.00e-171 592.00
IUUC-Eeu-034504 Erinaceus europaeus 71.91 6.00e-127 446.00
IUUC-Fca-036476 Felis catus 88.63 0.00e+00 721.00
IUUC-Fal-036711 Ficedula albicollis 63.36 5.00e-121 427.00
IUUC-Gmo-039592 Gadus morhua 48.62 4.00e-86 311.00
IUUC-Gga-040924 Gallus gallus 61.54 2.00e-121 428.00
IUUC-Gac-041791 Gasterosteus aculeatus 50.93 3.00e-85 308.00
IUUC-Ggo-044736 Gorilla gorilla 87.86 0.00e+00 671.00
IUUC-Hsa-046558 Homo sapiens 88.11 0.00e+00 673.00
IUUC-Itr-048956 Ictidomys tridecemlineatus 87.34 0.00e+00 664.00
IUUC-Lch-049817 Latimeria chalumnae 64.00 5.00e-127 447.00
IUUC-Loc-052226 Lepisosteus oculatus 51.77 3.00e-108 384.00
IUUC-Laf-054371 Loxodonta africana 86.30 0.00e+00 660.00
IUUC-Mcc-054904 Macaca mulatta 87.60 0.00e+00 675.00
IUUC-Meu-056192 Macropus eugenii 54.35 6.00e-88 317.00
IUUC-Mmr-061692 Microcebus murinus 86.56 0.00e+00 681.00
IUUC-Mdo-062666 Monodelphis domestica 74.59 6.00e-157 546.00
IUUC-Mpu-066290 Mustela putorius furo 88.11 0.00e+00 667.00
IUUC-Mlu-067882 Myotis lucifugus 86.56 0.00e+00 671.00
IUUC-Nle-070162 Nomascus leucogenys 87.60 0.00e+00 673.00
IUUC-Opr-070789 Ochotona princeps 86.30 4.00e-75 275.00
IUUC-Ont-071690 Oreochromis niloticus 44.96 9.00e-79 287.00
IUUC-Oan-072928 Ornithorhynchus anatinus 71.54 1.00e-111 395.00
IUUC-Ocu-073857 Oryctolagus cuniculus 89.16 0.00e+00 640.00
IUUC-Ogu-078061 Oryza glumaepatula 28.95 3.30e-01 32.00
IUUC-Oni-083091 Oryza nivara 29.03 1.20e+00 30.00
IUUC-Ola-086607 Oryzias latipes 46.88 8.00e-87 313.00
IUUC-Oga-088929 Otolemur garnettii 88.52 0.00e+00 643.00
IUUC-Oar-089305 Ovis aries 89.81 8.00e-173 599.00
IUUC-Ptr-090813 Pan troglodytes 83.46 0.00e+00 640.00
IUUC-Pan-092924 Papio anubis 86.35 3.00e-176 610.00
IUUC-Psi-093237 Pelodiscus sinensis 65.66 5.00e-130 457.00
IUUC-Pfo-096259 Poecilia formosa 45.89 3.00e-87 315.00
IUUC-Pab-098292 Pongo abelii 87.60 0.00e+00 673.00
IUUC-Pva-102221 Pteropus vampyrus 88.63 0.00e+00 692.00
IUUC-Pyt-104651 Pyrenophora triticirepentis 21.93 5.20e-02 33.90
IUUC-Rno-105910 Rattus norvegicus 96.10 0.00e+00 773.00
IUUC-Sha-106998 Sarcophilus harrisii 74.59 8.00e-157 546.00
IUUC-Sar-113033 Sorex araneus 78.11 8.00e-169 586.00
IUUC-Ssc-115507 Sus scrofa 86.82 0.00e+00 631.00
IUUC-Tgu-116502 Taeniopygia guttata 63.06 1.00e-117 416.00
IUUC-Tru-118203 Takifugu rubripes 46.44 9.00e-75 273.00
IUUC-Tni-120249 Tetraodon nigroviridis 45.00 4.00e-78 285.00
IUUC-Tbe-128100 Tupaia belangeri 65.92 3.00e-120 424.00
IUUC-Ttr-128299 Tursiops truncatus 78.04 4.00e-173 600.00
IUUC-Vpa-130394 Vicugna pacos 75.45 1.00e-157 549.00
IUUC-Xtr-131825 Xenopus tropicalis 54.47 2.00e-119 422.00
IUUC-Xma-133942 Xiphophorus maculatus 46.63 5.00e-88 318.00
Created Date 25-Jun-2017

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